2023年欧洲肿瘤内科学会(ESMO)大会将于10月20日至24日(中欧夏令时间CEST)在西班牙马德里召开。作为全球最具影响力的肿瘤学会议之一,ESMO官方近日公布了此次大会摘要题目,恒瑞医药共有13款抗肿瘤创新药的35项研究成果入围,其中2项入选优选口头(Proffered Paper)报告,5项研究入选简短口头(Mini Oral)报告,28项研究接收为壁报,覆盖消化道肿瘤、乳腺癌、宫颈癌、胰腺癌、肺癌、黑色素瘤、肉瘤、胆管癌等十余个领域。 LBA33:A first-in-human phase 1 study of a novel KRAS G12D inhibitor HRS-4642 in patients with advanced solid tumors harboring KRAS G12D mutation
656MO:The HER2-targeting ADC SHR-A1811 in HER2-expressing/mutated advanced non-breast solid tumors (STs): results from the global phase 1 study 658MO:Phase 1 study of SHR-A2009, a HER3-targeted ADC, in advanced solid tumors
1026MO:A phase 1b/2 study of SHR-1701 (a bifunctional anti-PD-L1/TGF-βRII agent) in combination with bevacizumab (BEV) in patients with advanced solid tumors 5. 局部晚期直肠癌新辅助短程放疗序贯卡瑞利珠单抗联合化疗与长程放化疗序贯化疗的比较:一项随机III期研究(UNION)(入选优选口头报告) LBA25:Neoadjuvant short-course radiotherapy followed by camrelizumab plus chemotherapy versus long-course chemoradiotherapy followed by chemotherapy in locally advanced rectal cancer:a randomized phase III trial(UNION) PI/汇报人:华中科技大学同济医学院附属协和医院 张涛、陶凯雄
1512MO:Perioperative camrelizumab (C) combined with rivoceranib (R) and chemotherapy (chemo) versus chemo for locally advanced resectable gastric or gastroesophageal junction (G/GEJ) adenocarcinoma: the first interim analysis of a randomized, phase 3 trial (DRAGON IV) 611P:SHR-1701 in combination with BP102 and XELOX as first-line (1L) treatment for patients (pts) with unresectable metastatic colorectal cancer (mCRC): data from a phase 2/3 study 644P:Phase 1b/2 Open-label Study (NCT04073615) to Evaluate the Safety, Tolerability, and Efficacy of Rivoceranib plus Trifluridine/Tipiracil in Patients with Previously Treated Metastatic Colorectal Cancer PI/汇报人:Vanderbilt University Medical Center Cathy Eng
684P:Phase 1 trial of SHR-A1811 in HER2-expressing advanced gastric cancer (GC) or gastroesophageal junction adenocarcinoma (GEJ) and colorectal cancer (CRC) 11. 卡瑞利珠单抗联合化疗对比同步放化疗作为可切除胸段食管鳞癌(REVO)的新辅助治疗:一项多中心、随机、开放标签、2期研究 1522P:Camrelizumab plus chemotherapy versus concurrent chemoradiotherapy as neoadjuvant therapy for resectable thoracic esophageal squamous cell cancer(REVO) : A multicenter, randomized, open-label, phase 2 trial 1541P:Neoadjuvant therapy of camrelizumab combined with chemotherapy in patients (pts) with resectable esophageal squamous cell cancer (ESCC) preliminary results of a preoperative phase exploratory clinical trial 1544P:Camrelizumab plus albumin-bound paclitaxel and S-1 as first-line treatment of advanced gastric/gastroesophageal junction cancer: a phase II clinical trial 1584P:Conversion effect of PD-1 antibody camrelizumab(Cam) combined with modified FLOT (mFLOT) regimen in patients(pts) with initially unresectable locally advanced or limited metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma 105P:A phase 2 study of SHR-1316 plus IBI310 in patients with advanced intrahepatic cholangiocarcinoma after failure of first-line therapy 17. 氟唑帕利联合mFOLFIRINOX 后维持氟唑帕利一线治疗不可切除的局部晚期或转移性(LA/M)胰腺癌(PC)患者:一项1b期研究 1627P:First-line (1L) fuzuloparib plus mFOLFIRINOX followed by maintenance fuzuloparib in patients (pts) with unresectable locally advanced or metastatic (LA/M) pancreatic cancer (PC): a phase 1b study 423P:A real-world study on the clinical value of apatinib-based regimens in metastatic triple-negative breast cancer 426P:The overall survival data of FUTURE-C-PLUS: combination of famitinib with camrelizumab plus nab-paclitaxel as first-line treatment for advanced, immunomodulatory triple-negative breast cancer, an open-label, single-arm, phase 2 trial 433P:Effectiveness and safety of vinorelbine + inetetamab + pyrotinib in ≥second-line treatment of HER2-positive metastatic breast cancer 436P:Preliminary results from a prospective study of inetetamab in combination with pyrotinib and utidelone for HER2-positive metastatic breast cancer (IPUtrial) PI/汇报人:中国人民解放军总医院第五医学中心 王涛
464P:Developing a Prognostic Risk Stratification Model and Treatment Options for HER2-Positive Breast Cancer Brain Metastasis
PI/汇报人:中国人民解放军总医院第五医学中心 王涛
868P:Phase 1 study of HRS8807, an oral selective ER covalent antagonist (SERCA), in ER+/HER2- locally advanced (LA) or metastatic (M) breast cancer (BC)
1296P:Neoadjuvant Camrelizumab and Apatinib in Patients with Resectable Non-Small-Cell Lung Cancer: One-Year Update From a Phase 2 Trial 1439P:Brain radiotherapy combined with camrelizumab and platinum-based chemotherapy as first-line treatment foradvanced NSCLC with brain metastases: a multicenter, open-label, single-arm, phase 2 study 1788P:Association between deep prostate-specific antigen decline and survival in patients with high-volume, metastatic hormone-sensitive prostate cancer treated with rezvilutamide in the CHART trial 1205TiP:Camrelizumab combined with EP/EC chemotherapy followed by camrelizumab plus apatinib for first-line therapy of advanced extrapulmonary neuroendocrine carinoma: a prospective, single-arm, multicenter clinical study 1941P:Preliminary efficacy and safety of SHR-2554 in advanced epithelioid sarcoma: a Phase 2 trial 1943P:Efficacy and safety of eribulin plus anlotinib and camrelizumab in advanced or metastatic retroperitoneal liposarcoma (RLPS) or leiomyosarcoma (RLMS): a single-center retrospective cohort study 本次ESMO大会,恒瑞医药将携13款抗肿瘤创新药的35项研究登上国际学术舞台,是国际肿瘤学术界对恒瑞医药抗肿瘤领域自主研发创新实力的认可,也是我国医药创新力量的一次展现。 作为创新型国际化制药企业,恒瑞医药多年来针对中国高发肿瘤领域持续推进创新研发。目前,公司已在中国获批上市自研创新药13款、引进创新药2款,其中肿瘤创新药达9款。未来,恒瑞医药将继续坚持“以患者为中心”的理念,重创新,强研发,力争研制出更多更好的新药,服务健康中国,惠及全球患者。