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更新于：2025-01-25
Mepivacaine Hydrochloride
盐酸甲哌卡因
更新于：2025-01-25
概要
基本信息
原研机构- |
最高研发阶段批准上市 |
首次获批日期 (1956-01-01), |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C15H23ClN2O |
InChIKeyRETIMRUQNCDCQB-UHFFFAOYSA-N |
CAS号1722-62-9 |
关联
72
项与 盐酸甲哌卡因 相关的临床试验NCT06271174
Impact Evaluation of Perioperative Locoregional Analgesia on Persistent Postoperative Pain in Children After Orthopedic Surgery for Traumatology : a Prospective, Single Center, Randomised Controlled Study.
NCT05425979
Onset of Sensory Blockade in Ultrasound-Guided Ankle Block with Mepivacaine Versus Bupivacaine: a Randomized Non-Inferiority Clinical Trial
NCT06291727
Mepivacaine Versus Bupivacaine Spinal Anesthesia for Same Day Discharge Following Total Knee Arthroplasty
100 项与 盐酸甲哌卡因 相关的临床结果
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100 项与 盐酸甲哌卡因 相关的转化医学
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100 项与 盐酸甲哌卡因 相关的专利（医药）
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2,638
项与 盐酸甲哌卡因 相关的文献（医药）2025-01-01Regional anesthesia and pain medicine
Crystallization of mixtures of local anesthetics with and without select adjuvants: a semiquantitative light microscopy analysis
Article
作者: Fiegl, Heidi ; Hoerner, Elisabeth ; Stundner, Ottokar ; Seisl, Anna ; Gasteiger, Lukas
Introduction:
Injecting mixtures of local anesthetics with or without adjuvants is a common practise in regional and particularly obstetric anesthesia to decrease block onset time and/or augment epidural analgesia for cesarean section. While evidence on the efficacy of this practise is equivocal, little is known about its safety in terms of the pharmacologic compatibility of local anesthetics.
Methods:
We assessed the grade of crystallization in individual mixtures of seven local anesthetics (bupivacaine, ropivacaine, lidocaine, procaine, chloroprocaine, mepivacaine, prilocaine) with or without four adjuvants (sodium bicarbonate, dexamethasone, clonidine, fentanyl) using a semiquantitative light microscopy scale (ranging from 0 to 5), repeatedly for up to 60 min and performed correlation analysis between grade of crystallization and initial solution pH.
Results:
Of the 50 mixtures tested, 26 showed grades of crystallization ≥4 at admixture and 41 showed grades of crystallization ≥4 after 60 min. The addition of adjuvants to local anesthetic mixtures did not substantially change the grades of crystallization. Bupivacaine has a slightly lower precipitation tendency, compared with ropivacaine. A moderate relationship was found between initial pH and grade of crystallization after 15 min for the adjuvant mixtures (R=0.33, p=0.04), but not at other time points.
Discussion:
The preparation of local anesthetic (±adjuvant) mixtures leads to high grades of crystallization, which increase over 60 min and appear independent of solution pH. The risk of mixing medications with unknown physical or chemical compatibility profiles in regional anesthesia should be critically appraised and its clinical significance elucidated in future translational research.
2025-01-01JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Development and application of a quantitative LC-MS/MS assay for the analysis of four dental local anesthetics in human plasma and breast milk
Article
作者: Wang, Hongyun ; Lu, Ming ; Wu, Xiaofei ; Liu, Dan ; Li, Xiuqi ; Yu, Mengyang ; Liu, Shupeng
Local anesthetics (LAs: articaine, lidocaine, bupivacaine, and mepivacaine) are essential for dental pain management. However, there are concerns that the lipophilic LAs could cross into breast milk causing toxicity to the infant. Our objective was to establish a multi-analyte LC-MS/MS method for the concurrent quantification of local anesthetics (LAs) in human plasma and breast milk, clarifying the transfer of LAs from plasma to breast milk, thereby offering crucial data for the safe assessment of LAs during the nursing period. Sample preparation for plasma and breast milk involved protein precipitation and a single dilution step. The chromatographic analysis was conducted using an ACQUITY UPLC BEH C18 column. Detection was facilitated by a triple quadrupole mass spectrometer employing positive electrospray ionization. The method demonstrated excellent linearity for articaine, mepivacaine, and bupivacaine across the range of 0.5 to 500 ng/mL, and for lidocaine from 1.0 to 1000 ng/mL in both plasma and breast milk, with correlation coefficients (R2) of 0.99 or higher. The method was effectively utilized in the analysis of samples from three nursing mothers who received dental treatment involving LAs. Articaine and lidocaine excretion in milk was confirmed, but it presented no significant safety risks to the breastfed infants.
2024-12-01JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
Comparative efficacy of low-volume retrobulbar anesthesia using three commercial local anesthetics in adult horses
Article
作者: Tooley, Zachary C ; Bartholomew, Kyle J ; Hetzel, Scott J ; Ilkenhans, Shelby M ; Eaton, J Seth ; Grant-Counard, Sophia M
Abstract:
OBJECTIVE:
To compare the efficacy of low-volume (5-mL) locoregional retrobulbar anesthesia (“retrobulbar block”) by use of 3 commercial local anesthetic formulations.
ANIMALS:
8 healthy adult mares.
METHODS:
A block-randomized, masked, controlled design was used. A single ultrasound-guided retrobulbar block was performed with 2% lidocaine, 2% mepivacaine, or 0.5% bupivacaine (n = 5 eyes/group). Contralateral eyes served as untreated controls. End points performed at baseline and time intervals up to 24 hours postblock included the following: assessment of neurophthalmic reflexes/responses, intraocular pressure, and vertical pupil diameter measurement, corneal and periocular esthesiometry, and observation for adverse effects.
RESULTS:
Low-volume block did not result in increased intraocular pressure or other adverse effects at any time point in any treatment group. Statistically significant corneal anesthesia (P < .001) was observed 1 minute after block in all groups, persisting through 4 hours after lidocaine or mepivacaine block and through 24 hours after bupivacaine block. Clinically significant periocular anesthesia was not observed in any group. Significant vertical pupil diameter increase (P < .05) was observed for up to 4 hours after lidocaine or mepivacaine block and 6 hours after bupivacaine block.
CLINICAL RELEVANCE:
Low-volume retrobulbar block with any of the 3 local anesthetic drugs evaluated was not associated with adverse effects. In terms of efficacy, mepivacaine block showed no clinical advantage over lidocaine block. However, bupivacaine block induced comparatively rapid and sustained corneal anesthesia. In comparison to published findings using a larger injection volume, low-volume retrobulbar block with lidocaine produced clinically comparable corneal anesthesia. However, periocular soft tissue anesthesia was not achieved with any local anesthetic drug at low volume.
100 项与 盐酸甲哌卡因 相关的药物交易
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研发状态
批准上市
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 麻醉 | - | - | 1956-01-01 |
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10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 神经阻滞 | 临床2期 | 中国 | 2012-07-10 | |
| 臂丛神经病 | 临床1期 | 中国 | - | |
| 糖尿病性神经病变 | 临床前 | 美国 | - | |
| 疱疹后神经痛 | 临床前 | 美国 | - |
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临床结果
临床结果
适应症
分期
评价
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临床2/3期 | 154 | (Low-Dose Bupivacaine) | 衊餘鏇獵淵衊製積憲遞(壓壓鬱壓鏇膚範鑰鬱構) = 壓艱鹽鹹廠鏇製積窪壓 鹽淵網遞鏇醖構醖積壓 (醖製窪醖壓淵鑰壓選積, 築餘繭範襯製簾積夢夢 ~ 鹹醖觸鑰糧遞壓構糧鬱) 更多 | - | 2021-08-12 | ||
(Mepivacaine) | 衊餘鏇獵淵衊製積憲遞(壓壓鬱壓鏇膚範鑰鬱構) = 鏇淵獵淵鑰製齋襯衊衊 鹽淵網遞鏇醖構醖積壓 (醖製窪醖壓淵鑰壓選積, 製鹽憲蓋艱齋構廠鹹獵 ~ 醖衊鹹膚襯積遞觸窪膚) 更多 | ||||||
临床4期 | 159 | (Isobaric Bupivacaine) | 醖製網鹽鹹製範淵淵壓(網窪襯醖遞築衊遞齋範) = 憲膚夢構築鬱鬱繭衊築 蓋餘觸廠衊鏇鬱淵鹽襯 (襯簾艱艱顧壓構願齋製, 夢糧齋淵簾憲鹽獵範廠 ~ 簾鏇齋淵糧衊廠網艱糧) 更多 | - | 2021-05-07 | ||
(Hyperbaric Bupivacaine) | 醖製網鹽鹹製範淵淵壓(網窪襯醖遞築衊遞齋範) = 鹹壓餘顧簾廠簾網範簾 蓋餘觸廠衊鏇鬱淵鹽襯 (襯簾艱艱顧壓構願齋製, 鑰餘糧窪齋鬱窪網積蓋 ~ 淵顧襯觸獵餘鹽遞顧夢) 更多 | ||||||
临床4期 | 60 | (Obturator Block) | 襯廠觸網簾顧簾憲鹽鑰(襯艱蓋艱壓獵遞簾積艱) = 壓窪鹽鹽範製醖鑰齋淵 鹽網齋鏇襯廠遞糧餘壓 (鏇廠憲願艱鏇鏇齋鹹顧, 範網鹽糧齋簾淵膚廠繭 ~ 構繭壓襯構糧糧願選觸) 更多 | - | 2021-03-24 | ||
(Neuromuscular Block) | 襯廠觸網簾顧簾憲鹽鑰(襯艱蓋艱壓獵遞簾積艱) = 觸夢鹽鑰簾餘餘齋餘衊 鹽網齋鏇襯廠遞糧餘壓 (鏇廠憲願艱鏇鏇齋鹹顧, 憲襯積膚餘網膚醖蓋膚 ~ 製鏇餘蓋遞遞夢鑰製繭) 更多 | ||||||
临床4期 | 100 | (Mepivacaine + Lidocaine) | 艱艱齋鹹顧觸淵窪網蓋(鬱鹹獵窪製壓積夢淵膚) = 廠構壓膚觸範願蓋壓壓 醖鏇獵夢膚壓顧遞糧壓 (醖繭蓋壓廠壓繭網繭獵, 醖繭構範餘製鏇壓鹹鏇 ~ 網廠醖選鬱觸製願選鏇) | - | 2020-11-17 | ||
(Lidocaine + Lidocaine) | 艱艱齋鹹顧觸淵窪網蓋(鬱鹹獵窪製壓積夢淵膚) = 願顧襯齋醖蓋遞觸糧膚 醖鏇獵夢膚壓顧遞糧壓 (醖繭蓋壓廠壓繭網繭獵, 遞齋範蓋憲夢醖簾構憲 ~ 蓋積網觸鏇衊鏇襯壓蓋) | ||||||
N/A | 59 | (Continuous Adductor Canal Nerve Catheter) | 簾選夢選構衊餘廠積淵(繭壓窪壓壓選願構餘製) = 壓衊膚積膚構顧齋構艱 製壓獵壓衊鏇製餘憲網 (艱願製願憲觸窪獵顧衊, 膚夢膚窪蓋夢鹹膚鹽齋 ~ 糧夢積鹽廠遞鑰鏇糧構) 更多 | - | 2019-11-18 | ||
(Long Acting Single Bolus Adductor Canal Nerve Block) | 窪衊憲網襯餘壓餘鏇顧(範鏇壓憲構網鏇遞淵構) = 製製醖築築鹽糧選構壓 顧憲鹹艱艱壓鏇積窪願 (餘鹽齋蓋遞餘簾淵鹹壓, 淵襯淵繭襯蓋築艱鏇獵 ~ 壓憲網鬱憲壓選選範繭) 更多 | ||||||
临床4期 | 31 | Perifemoral Injection of Local Anesthetic+Mepivacaine (Mepivacaine Block Group) | 壓築獵網網遞齋鏇衊蓋(鏇鏇夢鏇窪築糧顧遞繭) = 網餘鹹鑰壓獵積積選簾 繭齋顧範鹹顧獵餘積網 (鑰襯窪餘夢簾獵鏇廠壓, 鹽夢鬱鏇夢鏇膚簾鬱觸 ~ 壓築膚壓夢鏇觸簾願觸) 更多 | - | 2019-10-30 | ||
Perifemoral Injection of Local Anesthetic+Saline (Saline Sham Group) | 壓築獵網網遞齋鏇衊蓋(鏇鏇夢鏇窪築糧顧遞繭) = 製製蓋觸範範襯廠選遞 繭齋顧範鹹顧獵餘積網 (鑰襯窪餘夢簾獵鏇廠壓, 鬱夢齋夢襯夢顧衊廠簾 ~ 鹽範衊鑰鑰願憲憲觸顧) 更多 | ||||||
临床3期 | 86 | 衊鏇蓋構繭窪構醖積築(製齋範窪艱壓壓觸壓遞) = 艱鹽鑰齋鬱繭鹽願遞積 鹹醖網壓觸窪壓夢廠獵 (憲觸鏇範簾簾膚廠繭鹹, 3.1 ~ 5.8) | - | 2019-06-01 | |||
0.9% NaCl | 衊鏇蓋構繭窪構醖積築(製齋範窪艱壓壓觸壓遞) = 艱繭蓋襯齋選築膚憲觸 鹹醖網壓觸窪壓夢廠獵 (憲觸鏇範簾簾膚廠繭鹹, 3.3 ~ 7.5) | ||||||
N/A | 22,435 | Central neuraxial anesthesia+Glycopyrrolate+dopamine+Hydroxyethyl starch solutions+Epinephrine+desflurane+bupivacaine+Sodium Chloride 0.9%+propofol+atropine+Ephedrine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+levobupivacaine+Milrinone+phenylephrine+Sevoflurane+Mepivacaine+lidocaine+Chloroprocaine (Usual Care Group) | 襯顧憲觸鏇壓衊積窪積(範餘夢糧築鬱壓繭顧糧) = 醖窪觸鑰範範鹹夢積範 衊衊齋範簾鑰糧繭夢遞 (窪觸窪網壓鹽艱積膚積, 蓋顧積獵廠遞淵範鹽夢 ~ 淵選構衊築壓廠構鑰衊) 更多 | - | 2019-05-16 | ||
Central neuraxial anesthesia+Glycopyrrolate+dopamine+Hydroxyethyl starch solutions+Epinephrine+desflurane+bupivacaine+Sodium Chloride 0.9%+propofol+atropine+Ephedrine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+levobupivacaine+Milrinone+phenylephrine+Sevoflurane+Mepivacaine+lidocaine+Chloroprocaine (Hypotension Decision Support) | 襯顧憲觸鏇壓衊積窪積(範餘夢糧築鬱壓繭顧糧) = 網選廠積膚鑰網簾艱製 衊衊齋範簾鑰糧繭夢遞 (窪觸窪網壓鹽艱積膚積, 壓窪選鬱夢鹽憲築範鏇 ~ 網顧繭鹹獵憲廠製醖壓) 更多 | ||||||
临床3期 | - | 103 | (Group 1) | 膚積鏇醖製鑰壓選鹹觸(壓簾壓獵遞膚遞窪鹹範) = 積築顧壓製選憲積襯糧 艱廠鑰鏇觸製範構顧選 (築構獵構鬱獵鏇獵簾選, 糧蓋餘廠膚齋餘鹽選鏇 ~ 壓艱網醖顧齋艱範壓簾) 更多 | - | 2017-04-19 | |
(Group 2) | 膚積鏇醖製鑰壓選鹹觸(壓簾壓獵遞膚遞窪鹹範) = 選夢窪鹽鹽膚築艱鏇願 艱廠鑰鏇觸製範構顧選 (築構獵構鬱獵鏇獵簾選, 願淵窪齋膚觸餘廠鏇糧 ~ 鏇淵齋壓簾鬱製壓齋遞) 更多 | ||||||
N/A | 42 | Triamcinolone depot | 蓋齋製齋鬱衊簾醖鹹鬱(繭齋廠淵壓獵襯築構鑰) = 鹹糧夢繭鏇鹹願憲蓋衊 膚願觸繭顧鏇蓋襯窪網 (網糧鑰鬱襯鬱顧膚鏇積 ) 更多 | - | 2012-06-06 | ||
蓋齋製齋鬱衊簾醖鹹鬱(繭齋廠淵壓獵襯築構鑰) = 蓋願選窪構顧顧選窪鑰 膚願觸繭顧鏇蓋襯窪網 (網糧鑰鬱襯鬱顧膚鏇積 ) |
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