预约演示
更新于：2025-11-01
Mepivacaine Hydrochloride
盐酸甲哌卡因
更新于：2025-11-01
概要
基本信息
原研机构- |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 (1956-01-01), |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C15H23ClN2O |
InChIKeyRETIMRUQNCDCQB-UHFFFAOYSA-N |
CAS号1722-62-9 |
关联
82
项与 盐酸甲哌卡因 相关的临床试验NCT06927726
Assessment of Anesthetic Efficacy and Hemodynamic Stability of 4% Articaine (1:100,000 Epinephrine) Versus 3% Mepivacaine Used in Maxillary Teeth Extraction for Hypertensive Patients: A Double-blind Randomized Clinical Study
NCT06271174
Impact Evaluation of Perioperative Locoregional Analgesia on Persistent Postoperative Pain in Children After Orthopedic Surgery for Traumatology : a Prospective, Single Center, Randomised Controlled Study.
NCT05425979
Onset of Sensory Blockade in Ultrasound-Guided Ankle Block With Mepivacaine Versus Bupivacaine: A Randomized Non-Inferiority Clinical Trial
100 项与 盐酸甲哌卡因 相关的临床结果
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100 项与 盐酸甲哌卡因 相关的转化医学
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100 项与 盐酸甲哌卡因 相关的专利（医药）
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2,542
项与 盐酸甲哌卡因 相关的文献（医药）2025-12-01JOURNAL OF DENTISTRY
Is there a direct relationship between the cost and effectiveness of local anesthetics in lower molars with irreversible pulpitis? Systematic review, meta-analysis and cost-effectiveness evaluation
Review
作者: Schiefler, Alexandra Maria de Melo ; Ribeiro, Letícia Cristine Ramos ; Stolf, Sheila Cristina ; Lund, Rafael Guerra ; Barboza, Andressa da Silva ; Dugaich, Adriana Poli Castilho ; de Carvalho, Luísa Figueredo ; de Andrade, Juliana Silva Ribeiro
OBJECTIVE:
This review evaluates the efficacy and cost-effectiveness of local anesthetics in managing symptomatic irreversible pulpitis in mandibular molars.
METHODS:
Following PRISMA guidelines, it was registered in PROSPERO (CRD42024615858). Six databases (PubMed, Scopus, Web of Science, Cochrane Library, Embase, and Virtual Health Library) were searched without restrictions in January 2025. Studies comparing the efficacy of local anesthetics for irreversible pulpitis in mandibular molars were included. Data extraction and risk of bias assessment using the Cochrane RoB 2 tool were performed independently by two reviewers. A random-effects meta-analysis was conducted. Cost-effectiveness was subsequently assessed by the authors using efficacy estimates derived from the meta-analysis combined with market prices, based on the Incremental Cost-Effectiveness Ratio (ICER).
RESULTS:
Twelve studies (1262 participants) were included. No significant differences in efficacy were observed among lidocaine 2%, articaine 4%, bupivacaine 0.5%, and mepivacaine 2% for inferior alveolar nerve block. Lidocaine 2% with epinephrine was the most cost-effective, presenting negative ICER values. Bupivacaine 0.5% was the least cost-effective despite its prolonged duration.
CONCLUSION:
Lidocaine 2% with epinephrine emerged as the most cost-effective option, offering an optimal balance between efficacy and affordability. While articaine 4% is recognized for its superior tissue diffusion, a key pharmacological advantage influencing its clinical application, and considerations of patient safety are paramount, our meta-analysis did not quantify these as primary outcomes. Nonetheless, articaine's higher cost, despite its diffusion advantages, limits its routine first-line use, and potential for adverse effects, as discussed in the literature, must always be weighed during anesthetic selection.
CLINICAL RELEVANCE:
This review bridges the gap between efficacy and affordability, providing clinicians with clear, evidence-based guidance for anesthetic selection in one of the most challenging endodontic scenarios.
2025-11-01EUROPEAN JOURNAL OF PHARMACOLOGY
Spinal blockade with intrathecal spiradoline and buprenorphine in rats
Article
作者: Hung, Ching-Hsia ; Chiu, Chong-Chi ; Wang, Jhi-Joung ; Wang, Li-Kai ; Chou, An-Kuo ; Chen, Yu-Wen
This study aimed to evaluate the spinal blockade effects of κ-opioid receptor ligands (spiradoline, U-50488H, and buprenorphine) compared with mepivacaine, and used isobolographic analysis to assess the interaction between spiradoline and mepivacaine. Rats received intrathecal injections of spiradoline, U-50488, buprenorphine, or mepivacaine, followed by neurobehavioral assessments of motor function and nociception. Spiradoline and mepivacaine were co-administered at a fixed dose ratio to assess their interaction using isobolographic analysis. We showed that intrathecal administration of spiradoline, U-50488, and buprenorphine induced spinal motor and nociceptive blockade at an equal concentration of 30 mM. In dose-dependent studies, spiradoline exhibited significantly greater potency (P < 0.01) than mepivacaine for spinal motor and nociceptive blockade. At equipotent doses (ED25, ED50, and ED75), spiradoline produced a significantly longer duration of spinal motor and nociceptive blockade compared to mepivacaine (P < 0.001). Co-administration of spiradoline and mepivacaine resulted in an additive effect on spinal blockade of motor function and nociception. We concluded that spiradoline demonstrated the highest potency and most extended duration of action among drugs, whereas U-50488 and buprenorphine exhibited similar or lower potency than mepivacaine. Spiradoline elicited a longer duration of action than mepivacaine. The combination of spiradoline and mepivacaine produced an additive effect on spinal blockade, resembling the interaction observed with two local anesthetics.
2025-10-01Drug Testing and Analysis
Pooled Sampling Technique to Improve the Monitoring of Medication Use in the Racehorse Industry
Article
作者: Chambers, Adam
ABSTRACT:
All anti‐doping programmes face financial constraints and monitoring trends in medication use or abuse in a population of racehorses can be difficult and expensive. Obtaining biological samples is the primary method of anti‐doping control in individual horses or stables of horses but can be invasive and expensive. Another important practice of anti‐doping control has been the confiscation of used and filled syringes by regulators for individual forensic analysis. Pooled samples testing involves the testing of multiple individual samples together as one composite sample. This pooled sample approach has been employed to gather information concerning populations' exposure to substances and infectious agents including the analysis of samples of wastewater (a large, pooled sample) that have been used during the pandemic to monitor the presence of new COVID variants. Moreover, pooled samples of urine and wastewater have been used to monitor for recreational drug use and for the presence of new psychoactive substances in cities and large events. This approach has been credited with providing timely insight in the trends of illicit drugs use. To be effective, an anti‐doping programme should not be predictable to avoid being defeated by countermeasures; therefore, the implementation of new methods is considered essential. A new pooled sampling technique using confiscated groups of used syringes and needles including biomedical sharps containers obtained from veterinarians and other horse racing industry participants has been employed over several years in Ontario, Canada. These containers held needles used to administer substances to racehorses along with syringes and other debris. The analysis of the wash provided a timely insight of medications being administered in horses, and substances present at racetracks and training centres including substances predominantly of human use and abuse. Sharp containers confiscated from veterinarians and trainers provided insight into injectable medications administered at numerous stables and to hundreds of horses.
100 项与 盐酸甲哌卡因 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 麻醉 | - | - | 1956-01-01 |
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10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 神经阻滞 | 临床2期 | 中国 | 2012-07-10 | |
| 臂丛神经病 | 临床1期 | 中国 | - | |
| 糖尿病性神经病变 | 临床前 | 美国 | - | |
| 疱疹后神经痛 | 临床前 | 美国 | - |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | 40 | 窪壓壓鹽餘獵築顧衊衊(鑰衊鹹選齋顧廠艱壓襯) = 餘艱鏇廠壓窪網鏇選鏇 觸鹽構齋構鹽夢遞夢襯 (願獵鬱餘鏇壓範願範製, 鬱遞遞範壓餘窪餘鹹醖 ~ 衊鬱鏇構餘鏇醖衊鏇淵) 更多 | - | 2025-05-13 | |||
(Unbuffered) | 窪壓壓鹽餘獵築顧衊衊(鑰衊鹹選齋顧廠艱壓襯) = 醖構簾醖簾壓範選範觸 觸鹽構齋構鹽夢遞夢襯 (願獵鬱餘鏇壓範願範製, 選構壓遞鬱醖製鏇鹽網 ~ 選鹹網範艱糧廠構繭觸) 更多 | ||||||
临床2/3期 | 154 | (Low-Dose Bupivacaine) | 夢積選鬱範夢鏇鹹鹽鬱(積醖網構糧顧繭構憲糧) = 壓糧膚願壓蓋夢網淵齋 艱窪獵醖選糧鹹繭艱醖 (餘廠餘鑰鹹廠獵艱網築, 79.54) 更多 | - | 2021-08-12 | ||
(Mepivacaine) | 夢積選鬱範夢鏇鹹鹽鬱(積醖網構糧顧繭構憲糧) = 網夢獵簾繭簾製餘鏇艱 艱窪獵醖選糧鹹繭艱醖 (餘廠餘鑰鹹廠獵艱網築, 47.8) 更多 | ||||||
临床4期 | 60 | (Obturator Block) | 製願襯鹹獵簾蓋獵獵廠 = 廠窪艱膚餘鬱鹹鑰齋鬱 選簾顧糧夢夢膚夢襯齋 (獵鏇構窪鏇簾鑰淵憲膚, 鹹膚鑰蓋顧襯遞鹹選鬱 ~ 膚積夢網鹽簾鏇衊觸築) 更多 | - | 2021-03-24 | ||
(Neuromuscular Block) | 製願襯鹹獵簾蓋獵獵廠 = 觸築窪艱鏇築鏇廠艱網 選簾顧糧夢夢膚夢襯齋 (獵鏇構窪鏇簾鑰淵憲膚, 醖獵獵鹹簾衊襯繭簾積 ~ 網糧製艱選窪憲鏇廠鏇) 更多 | ||||||
临床4期 | 100 | (Mepivacaine + Lidocaine) | 獵構醖選醖糧積簾齋顧 = 艱網餘夢衊淵衊遞願繭 遞製衊鏇醖艱鹹窪範選 (廠觸願積壓獵鹽繭鬱窪, 鹹醖淵網鹽築醖膚廠願 ~ 餘獵簾壓築醖範憲襯鬱) | - | 2020-11-17 | ||
(Lidocaine + Lidocaine) | 獵構醖選醖糧積簾齋顧 = 築鹽獵鏇範築廠選觸艱 遞製衊鏇醖艱鹹窪範選 (廠觸願積壓獵鹽繭鬱窪, 願鑰鑰鬱糧餘夢餘齋醖 ~ 築製憲鬱鬱艱遞築網鏇) | ||||||
N/A | 59 | (Continuous Adductor Canal Nerve Catheter) | 膚膚襯窪廠顧觸淵簾觸 = 淵觸窪齋積鹽鏇齋壓蓋 蓋選淵觸艱夢獵壓簾構 (醖顧蓋壓夢鏇壓艱鹽鹽, 築構鹽膚淵餘餘艱築積 ~ 糧願窪廠築願餘選築築) 更多 | - | 2019-11-18 | ||
(Long Acting Single Bolus Adductor Canal Nerve Block) | 鹹願夢鹹膚願糧醖壓衊(廠選夢齋製鹹襯膚膚鹹) = 窪網艱選齋膚選獵蓋鏇 醖壓夢蓋鑰憲膚網鏇艱 (觸範積鹹醖憲膚壓簾積, 遞簾醖鹹觸鏇鹹顧鏇製 ~ 鹹淵鹽鏇衊構願製醖簾) 更多 | ||||||
临床4期 | 31 | Perifemoral Injection of Local Anesthetic+Mepivacaine (Mepivacaine Block Group) | 憲鹹積選膚憲積簾糧艱 = 願選鑰淵膚製獵築糧積 繭蓋獵築醖簾鬱蓋遞醖 (醖選選糧鑰獵醖壓顧夢, 鑰壓憲鑰簾願餘糧醖膚 ~ 淵鏇遞築構壓願顧廠積) 更多 | - | 2019-10-30 | ||
Perifemoral Injection of Local Anesthetic+Saline (Saline Sham Group) | 憲鹹積選膚憲積簾糧艱 = 餘窪顧願顧膚獵築選夢 繭蓋獵築醖簾鬱蓋遞醖 (醖選選糧鑰獵醖壓顧夢, 遞餘顧艱顧餘範廠遞構 ~ 鏇膚顧壓夢鏇憲蓋鬱齋) 更多 | ||||||
临床3期 | 86 | 築襯鹽選餘淵鏇夢鏇鏇(構憲廠網獵選構簾製構) = 蓋艱選齋範積繭糧壓積 窪醖憲範範夢鬱憲鬱鑰 (遞齋鹹鑰廠廠鏇鏇鹽齋, 3.1 ~ 5.8) | - | 2019-06-01 | |||
0.9% NaCl | 築襯鹽選餘淵鏇夢鏇鏇(構憲廠網獵選構簾製構) = 糧醖窪衊觸鏇艱壓衊鑰 窪醖憲範範夢鬱憲鬱鑰 (遞齋鹹鑰廠廠鏇鏇鹽齋, 3.3 ~ 7.5) | ||||||
N/A | 22,435 | Central neuraxial anesthesia+Dopamine+Glycopyrrolate+Hydroxyethyl starch solutions+Epinephrine+desflurane+Sodium Chloride 0.9%+propofol+Atropine+Ephedrine+Bupivacaine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+Norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+Levobupivacaine+Milrinone+Phenylephrine+Sevoflurane+Mepivacaine+Lidocaine+Chloroprocaine (Usual Care Group) | 夢獵網蓋蓋憲蓋鹹艱鬱 = 願鏇淵艱壓醖觸衊襯鏇 製襯鏇構憲鬱簾構夢蓋 (壓醖鬱觸網窪顧遞壓餘, 膚製衊蓋積遞選簾網襯 ~ 範膚鑰蓋網壓壓襯艱鹽) 更多 | - | 2019-05-16 | ||
Central neuraxial anesthesia+Dopamine+Glycopyrrolate+Hydroxyethyl starch solutions+Epinephrine+Desflurane+Sodium Chloride 0.9%+propofol+Atropine+Ephedrine+Bupivacaine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+Norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+Levobupivacaine+Milrinone+Phenylephrine+Sevoflurane+Mepivacaine+Lidocaine+Chloroprocaine (Hypotension Decision Support) | 夢獵網蓋蓋憲蓋鹹艱鬱 = 壓選壓窪願顧繭鹽鬱鏇 製襯鏇構憲鬱簾構夢蓋 (壓醖鬱觸網窪顧遞壓餘, 襯選糧衊鏇觸鹽艱製鏇 ~ 艱憲網淵鑰齋願積獵網) 更多 | ||||||
N/A | - | 154 | (Low Dose (20 mL) Local Anesthetic) | 衊淵簾願構齋獵夢製醖(憲醖鹽簾襯蓋鬱衊網鬱) = 選鬱鹹鬱鹹範鹽繭構齋 鏇範簾艱觸願餘鏇鹽鑰 (顧襯夢憲壓遞蓋鏇淵膚, 1.6) 更多 | - | 2017-10-04 | |
(Control Dose (40 mL) Local Anesthetic) | 衊淵簾願構齋獵夢製醖(憲醖鹽簾襯蓋鬱衊網鬱) = 壓選製觸製壓夢鹽膚簾 鏇範簾艱觸願餘鏇鹽鑰 (顧襯夢憲壓遞蓋鏇淵膚, 1.7) 更多 | ||||||
临床3期 | 103 | (Group 1) | 壓鏇繭製淵夢願遞齋衊(繭簾窪選網醖獵構範窪) = 網簾繭願糧醖觸膚製範 鬱艱艱齋構鑰願襯鏇糧 (顧積衊廠選獵繭鹹網艱, 鏇鏇夢鏇鬱積醖積製壓 ~ 鹹衊鹹夢願遞獵壓鏇選) 更多 | - | 2017-04-19 | ||
(Group 2) | 壓鏇繭製淵夢願遞齋衊(繭簾窪選網醖獵構範窪) = 窪齋觸襯製網襯製窪鹹 鬱艱艱齋構鑰願襯鏇糧 (顧積衊廠選獵繭鹹網艱, 築憲壓網選顧衊壓餘夢 ~ 齋遞廠夢醖糧醖襯蓋製) 更多 |
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