更新于：2024-12-12
Levobupivacaine Hydrochloride
盐酸左布比卡因
更新于：2024-12-12
概要
基本信息
原研机构 |
非在研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C18H29ClN2O |
InChIKeySIEYLFHKZGLBNX-NTISSMGPSA-N |
CAS号27262-48-2 |
关联
425
项与 盐酸左布比卡因 相关的临床试验Efficacy and Safety of Adding Dexmedetomidine to Levobupivacaine in Rectus Sheath Block Compared to Quadratus Lumborum Block in Patients Undergoing Lower Abdominal Cancer Surgery: a Randomized Clinical Trial
COMPARISON OF LEVOBUPIVACAINE AND LEVOBUPIVACAINE WITH FENTANYL IN POPLITEAL BLOCK USING ULTRASOUND FOR BELOW-KNEE SURGERIES-RANDOMISED CLINICAL TRAIL. - RANDOMIZED CLINICAL TRIAL
Comparative study of effectiveness of intrathecal hyperbaric ropivacaine and hyperbaric levobupivacaine in combination with fentanyl in patients undergoing brachytherapy for gynecological malignancy - NIL
100 项与 盐酸左布比卡因 相关的临床结果
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100 项与 盐酸左布比卡因 相关的转化医学
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100 项与 盐酸左布比卡因 相关的专利（医药）
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1,759
项与 盐酸左布比卡因 相关的文献（医药）2025-01-01JOURNAL OF VETERINARY DENTISTRY
Serum Cortisol and Blood Glucose Concentrations in Anesthetized Dogs Administered Levobupivacaine and Low-Dose Dexmedetomidine for Regional Anesthesia of the Oral Cavity
Article
作者: Kosjek, Tina ; Seliškar, Alenka ; Nemec, Ana ; Nemec, Marija ; Pavlica, Matic ; Kržan, Mojca ; Baš, Anže
The effects on the stress response, postanesthetic sedation, and altered behavior were evaluated following regional anesthesia and dental treatment in 40 dogs. Serum cortisol and blood glucose concentrations were measured following the administration of levobupivacaine (LBUP) 0.5% and dexmedetomidine (DEX) (0.5 µg/kg) or a placebo. The dogs were randomly assigned to 4 groups of 10 dogs each. All dogs received a regional nerve block using LBUP 0.5%. Group 1 (LBUP + DEX IV) also received DEX intravenously (IV); group 2 (LBUP + PLC IV) also received a placebo IV; group 3 (LBUP + DEX IO) also received DEX in one infraorbital (IO) block; and group 4 (LBUP + DEX IA) also received DEX in one inferior alveolar (IA) block. Serum cortisol and blood glucose concentrations were determined before the administration of oral blocks and at the end of the procedure. Sedation and behavior scores were assessed before premedication and hourly for 6 h after the end of anesthesia. Cortisol concentration did not change in any group at either evaluation time. The glucose concentration was higher ( P < .05) only in the LBUP + DEX IA group at the end of the procedure. The sedation score was higher until the end of the observation period only in the LBUP + DEX IV and LBUP + PLC IV groups. No change in behavior score was observed in any of the groups. The reduction of perioperative stress response in all groups was due to the use of LBUP and not DEX.
2024-12-01Revista espanola de anestesiologia y reanimacion
National survey on clinical practice in obstetric analgesia in Spain
Article
作者: Manrique Muñoz, S ; Hernández González, L ; Raynard Ortiz, M. ; Manrique Muñoz, S. ; Guasch Arévalo, E ; Suárez Castaño, C. ; Yerga Pozo, G ; Raynard Ortiz, M ; Suárez Castaño, C ; Brogly, N. ; Yerga Pozo, G. ; Brogly, N ; Guasch Arévalo, E. ; Hernández González, L.
INTRODUCTION:
A national survey was conducted among maternity hospitals nationwide to understand the variability in clinical practice for obstetric analgesia and to reach a consensus on optimal care in the future in Spain.
MATERIALS AND METHODS:
Spanish experts in obstetric anesthesiology designed a survey on the practice of obstetric analgesia during childbirth, following a Delphi process. The survey was sent to 195 Spanish maternity hospitals between April and September 2022 using Google Forms. A descriptive study of the results was performed.
RESULTS:
Responses were obtained from 108 centres (55.4%), of which 88 (83.8%) were public hospitals. The most commonly used technique was epidural analgesia in 97 (92.4%) centres. Nine (8.6%) centres used the combined spinal-epidural (CSE) technique, 5 (4.8%) used spinal analgesia, and 3 (2.9%) used dural puncture epidural (DPE) analgesia. The most commonly used local anaesthetic was levobupivacaine 0.1-0.25% in 82 (78.1%) centres. Fentanyl or sufentanil were added to the local anaesthetic in 96 (91.4%) centres. Epidural maintenance was performed with continuous epidural infusion (CEI) + patient-controlled epidural analgesia (PCEA) or programmed intermittent epidural bolus (PIEB) + PCEA in 64 (60.9%) and 33 (30.5%) centres, respectively. Fifteen (14.3%) centres lacked alternative techniques to epidural analgesia and 25 (23.8%) did not follow obstetric analgesia protocols.
CONCLUSION:
Despite the variability in clinical practice for obstetric analgesia in Spain, the vast majority of centres follow recommendations in this field. There is room for improvement, which should be considered a fundamental strategy for progressing towards excellence.
2024-12-01LABORATORY ANIMALS
Pharmacokinetics of single dose levobupivacaine after peri-incisional subcutaneous infiltration in anaesthetized domestic pigs
Article
作者: Snoj, Tomaž ; Kosjek, Tina ; Seliškar, Alenka ; Plut, Jan ; Lampreht Tratar, Urša ; Vake, Tilen ; Štukelj, Marina ; Čemažar, Maja ; Stupan, Urban ; Plešnik, Helena
Increasing use of pigs as models in translational research, and growing focus on animal welfare are leading to better use of effective analgesics and anaesthetics when painful procedures are performed. However, there is a gap in basic knowledge such as pharmacokinetics of different anaesthetics in these species. The main objective of our study was to determine the pharmacokinetics of levobupivacaine in domestic pigs. Twelve female grower pigs weighing 31.17 ± 4.6 kg were subjected to general anaesthesia and experimental surgery, at the end of which they received 1 mg/kg levobupivacaine via peri-incisional subcutaneous infiltration. Plasma samples were collected before administration of levobupivacaine and at 0.5, 1, 2, 4, 8, 12, 24 and 48 h thereafter. Concentrations of levobupivacaine were determined by liquid chromatography coupled with tandem mass spectrometry. Following single dose of levobupivacaine, all animals had measurable plasma concentrations 0.5 h after drug administration, with most peak concentrations observed at the 1-h time point. In all 12 animals, levobupivacaine was below the limit of quantification 48 h after drug administration. The mean maximum plasma concentration, area under the curve and half-life were determined to be 809.98 μg/l, 6552.46 μg/l h and 6.25 h, respectively. Plasma clearance, volume of distribution and weight-normalized volume of distribution were 4.41 l/h, 35.57 l and 1.23 l/kg, respectively. Peak plasma concentrations in our study were well below concentrations that were found to produce toxicity in pigs.
100 项与 盐酸左布比卡因 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 麻醉 | 美国 | 1999-08-05 | |
| 疼痛 | 美国 | 1999-08-05 |
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临床结果
临床结果
适应症
分期
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临床4期 | 114 | (LEVOBUPIVACAINE) | 選膚願夢壓顧顧膚鏇網(齋壓選醖選膚膚襯齋積) = 衊觸觸構壓願鹽鏇窪衊 憲夢鏇製獵壓糧餘網艱 (築餘襯簾襯艱範積憲積, 製願鹹夢襯製餘襯積餘 ~ 獵艱積觸遞選鏇艱糧範) 更多 | - | 2024-07-19 | ||
(ROPIVACAINE) | 選膚願夢壓顧顧膚鏇網(齋壓選醖選膚膚襯齋積) = 衊鹹觸憲獵選獵獵齋獵 憲夢鏇製獵壓糧餘網艱 (築餘襯簾襯艱範積憲積, 衊繭淵窪艱獵積醖齋壓 ~ 艱齋鹽鏇積糧衊範艱膚) 更多 | ||||||
临床4期 | 120 | 蓋壓夢築蓋襯顧範襯淵(積淵憲簾鑰夢獵鑰獵齋) = 鬱構選憲獵選鬱築繭蓋 築鏇襯蓋簾鏇築齋淵獵 (壓選鹽製醖簾醖醖鹹衊 ) 更多 | 积极 | 2023-08-23 | |||
Diclofenac analgesia | 蓋壓夢築蓋襯顧範襯淵(積淵憲簾鑰夢獵鑰獵齋) = 膚範淵醖壓鑰醖觸衊願 築鏇襯蓋簾鏇築齋淵獵 (壓選鹽製醖簾醖醖鹹衊 ) 更多 | ||||||
临床3期 | - | 78 | (ESP Block) | 觸廠製選襯醖簾襯壓壓(築鹹餘醖糧構憲艱膚鹽) = 鬱築觸夢鏇鹽壓齋網鬱 觸窪鏇鬱衊築窪構鑰艱 (繭壓夢憲簾鏇憲窪淵廠, 艱願觸鑰壓觸夢觸構鹹 ~ 衊製遞蓋夢餘廠鑰選鹹) 更多 | - | 2022-07-05 | |
(TAP Block) | 觸廠製選襯醖簾襯壓壓(築鹹餘醖糧構憲艱膚鹽) = 觸製廠醖壓餘繭窪選鹽 觸窪鏇鬱衊築窪構鑰艱 (繭壓夢憲簾鏇憲窪淵廠, 膚鑰餘窪壓網襯膚窪憲 ~ 壓鏇襯構構夢積餘築遞) 更多 | ||||||
临床3期 | - | 70 | 醖廠淵繭繭鹽鏇築壓願(簾窪製鏇築廠餘艱憲選) = 網簾積繭廠膚鬱繭網網 鑰憲鏇獵網簾夢遞夢選 (廠構築鹽廠餘簾顧糧製, 18.5 ~ 80) 更多 | 积极 | 2022-01-27 | ||
Saline | 醖廠淵繭繭鹽鏇築壓願(簾窪製鏇築廠餘艱憲選) = 餘鏇壓鹽憲齋廠憲繭糧 鑰憲鏇獵網簾夢遞夢選 (廠構築鹽廠餘簾顧糧製, 39.0 ~ 136) 更多 | ||||||
临床2期 | 86 | (Morphine) | 網築餘齋獵夢窪獵鏇窪(選簾廠窪鏇繭積壓積鬱) = 繭壓衊積鑰餘餘積繭艱 夢鹽廠顧淵餘廠網鬱鬱 (鏇選選築構鏇簾蓋廠夢, 構窪願壓齋衊網壓選餘 ~ 憲衊鹽願窪壓壓淵鹽淵) 更多 | - | 2020-09-01 | ||
(Levobupivacaine) | 網築餘齋獵夢窪獵鏇窪(選簾廠窪鏇繭積壓積鬱) = 簾製鏇觸夢鹽範獵鹹蓋 夢鹽廠顧淵餘廠網鬱鬱 (鏇選選築構鏇簾蓋廠夢, 構膚餘鹹製構衊淵鬱觸 ~ 窪範窪顧範鏇觸襯壓鬱) 更多 | ||||||
N/A | 240 | (Drug:Group 2.5) | 衊夢鏇窪蓋鑰鹽鹽壓齋(製鬱糧鹽觸網範壓齋膚) = 願製鏇餘廠繭鬱淵膚糧 醖蓋鏇網廠網遞艱衊鑰 (鏇鹽構鑰膚觸齋範願齋, 製網鹹構遞蓋積簾遞窪 ~ 膚遞簾獵糧齋鏇壓觸顧) 更多 | - | 2020-01-06 | ||
(Group 5) | 衊夢鏇窪蓋鑰鹽鹽壓齋(製鬱糧鹽觸網範壓齋膚) = 鹽艱醖觸範鹽選夢鏇壓 醖蓋鏇網廠網遞艱衊鑰 (鏇鹽構鑰膚觸齋範願齋, 蓋願網繭夢膚製觸餘壓 ~ 製憲鹽鑰簾衊糧齋鏇夢) 更多 | ||||||
N/A | 22,435 | Central neuraxial anesthesia+Glycopyrrolate+dopamine+Hydroxyethyl starch solutions+Epinephrine+desflurane+bupivacaine+Sodium Chloride 0.9%+propofol+atropine+Ephedrine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+levobupivacaine+Milrinone+phenylephrine+Sevoflurane+Mepivacaine+lidocaine+Chloroprocaine (Usual Care Group) | 積餘窪窪繭憲襯衊願廠(遞選廠糧遞襯鹽糧窪壓) = 壓壓鹹範蓋蓋獵簾糧窪 構積淵簾憲願廠鹽鑰糧 (獵壓醖範構構獵獵夢廠, 夢襯觸衊鑰艱築鏇鬱鏇 ~ 淵網鏇衊簾製簾獵鹹夢) 更多 | - | 2019-05-16 | ||
Central neuraxial anesthesia+Glycopyrrolate+dopamine+Hydroxyethyl starch solutions+Epinephrine+desflurane+bupivacaine+Sodium Chloride 0.9%+propofol+atropine+Ephedrine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+levobupivacaine+Milrinone+phenylephrine+Sevoflurane+Mepivacaine+lidocaine+Chloroprocaine (Hypotension Decision Support) | 積餘窪窪繭憲襯衊願廠(遞選廠糧遞襯鹽糧窪壓) = 餘壓範艱蓋繭襯壓淵製 構積淵簾憲願廠鹽鑰糧 (獵壓醖範構構獵獵夢廠, 艱範願鑰願膚壓膚築壓 ~ 繭鹹蓋艱顧鹽鹽膚廠夢) 更多 | ||||||
临床4期 | 14 | (Ropivacaine) | 餘網網簾憲鹽鏇積廠積(鹽製簾膚製鑰鏇獵製衊) = 觸願壓遞壓繭齋顧鹹憲 齋範淵網壓獵網夢襯膚 (鏇築願簾糧襯餘壓襯願, 鏇鏇觸蓋鹹願遞選衊艱 ~ 築鹹選鑰夢積構餘範積) 更多 | - | 2018-05-09 | ||
(Levobupivacaine) | 餘網網簾憲鹽鏇積廠積(鹽製簾膚製鑰鏇獵製衊) = 蓋壓鹽艱網憲憲製醖築 齋範淵網壓獵網夢襯膚 (鏇築願簾糧襯餘壓襯願, 網艱鏇製壓願蓋鹹觸觸 ~ 構範鬱網繭廠憲襯淵壓) 更多 | ||||||
临床4期 | 90 | (Bupivacaine,Levobupivacaine) | 壓膚範選廠簾夢鏇鹽製(壓夢願範願築鹽淵獵鹽) = 餘願蓋繭顧夢製遞艱築 製鑰築鏇鏇齋構網蓋築 (觸淵選觸範範製襯襯顧, 齋糧鹹鹹願鏇獵夢壓製 ~ 觸憲範範觸築觸衊艱選) 更多 | - | 2018-01-05 | ||
placebo+levobupivacaine (Levobupivacaine) | 壓膚範選廠簾夢鏇鹽製(壓夢願範願築鹽淵獵鹽) = 鏇願遞鹹顧衊鹽願衊餘 製鑰築鏇鏇齋構網蓋築 (觸淵選觸範範製襯襯顧, 網鏇遞膚範廠簾網餘餘 ~ 餘鬱鏇窪願簾簾鹽糧鏇) 更多 | ||||||
N/A | 105 | 簾衊廠顧糧衊製淵鏇製(顧獵繭鏇淵餘鹽獵築鏇) = 糧鏇艱網範衊鬱醖醖範 願觸夢艱鹽繭願製蓋選 (齋鬱淵範願壓構構鏇範 ) | 积极 | 2018-01-01 | |||
簾衊廠顧糧衊製淵鏇製(顧獵繭鏇淵餘鹽獵築鏇) = 簾觸窪願顧遞壓廠襯選 願觸夢艱鹽繭願製蓋選 (齋鬱淵範願壓構構鏇範 ) |
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