更新于：2024-11-04
Dopamine hydrochloride
盐酸多巴胺
更新于：2024-11-04
概要
基本信息
简介Dopamine hydrochloride是多巴胺的盐酸盐形式，多巴胺是一种具有正性肌力作用的单胺化合物。Dopamine hydrochloride是一种多巴胺激动剂，可用于治疗心力衰竭和休克。该药物可通过激活多巴胺能受体，增加心脏收缩力和心输出量，提高血压和心脏功能。它可用于治疗由于心肌收缩力减弱或血容量不足引起的休克。多巴胺盐酸盐由Hospira公司开发并于1974年2月25日获得美国批准。 |
药物类型 小分子化药 |
别名 Dopamine hydrochloride (JP17/USP)、Neoatricon、ASL-279 + [9] |
靶点 |
作用机制 DRDs激动剂(多巴胺受体家族激动剂) |
非在研适应症 |
原研机构 |
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1974-02-25), |
最高研发阶段(中国)- |
特殊审评孤儿药 (美国) |
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结构
分子式C8H12ClNO2 |
InChIKeyCTENFNNZBMHDDG-UHFFFAOYSA-N |
CAS号62-31-7 |
关联
73
项与 盐酸多巴胺 相关的临床试验Comparison of Norepinephrine, Epinephrine and Dopamine in the treatment of Neonatal septic shock: A Randomized Controlled Trial - The DENSe Trial
A Phase Ib, Double-blind, Placebo-controlled, Randomised Trial Investigating the Effect of AZD3427 on Renal Perfusion in HFrEF Patients With Renal Impairment Using Positron Emission Tomography (PET)
Efficacy of noradrenaline vs dopamine in septic shock with late onset sepsis in Preterm babies.: open label randomised control trial - NIL
100 项与 盐酸多巴胺 相关的临床结果
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100 项与 盐酸多巴胺 相关的转化医学
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100 项与 盐酸多巴胺 相关的专利（医药）
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30,538
项与 盐酸多巴胺 相关的文献（医药）2025-02-01SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Flower-like boron-doped zinc single-atom nanozymes for colorimetric sensing and smartphone-assisted detection of Cr(VI)
Article
作者: Chen, Xiaofang ; Huo, Feng ; Yang, Xiupei ; Yang, Hanyu ; Fan, Yuxiu ; Jiang, Ling
With the development of electronics, electroplating, printing, and dyeing industries, environmental pollution caused by hexavalent chromium (Cr(VI)) has become increasingly prominent. Skin contact with Cr (VI) can cause allergies or genetic defects, and inhalation can cause cancer, which is a lasting danger to the environment and the human body. Developing effective strategies to monitor Cr(VI) in environmental water or industrial wastewater can evaluate the degree of water pollution and risk warning, thus helping to prevent the spread of Cr(VI) pollution, promote the protection of water resources and the ecological environment, and ensure human safety and sustainable development. On the basis of the regulation of dopamine, boron-doped zinc single-atom nanozymes (Zn/B-NC SAzymes) with three-dimensional nanoflower morphology were controlled in this work. The introduction of B in Zn/B-NC SAzymes and the high metal loading of Zn (6.5 wt%) led to the formation of more active sites, resulting in the material showing excellent enzyme-like activity. H2O2 decomposed to generate superoxide radicals under the catalysis of Zn/B-NC SAzymes, which then oxidized the substrate 3,3',5,5'-tetramethylbenzidine (TMB) to generate blue oxTMB. When Cr(VI) was introduced into the sensor system, the color of blue oxTMB is deepened, and the colorimetric method of Cr(VI) was constructed. The linear range is 0.2-40 μM, LOD is 59 nM, and the visual detection of Cr (VI) is performed with the aid of the smartphone. This work not only provides experimental and theoretical guidance for understanding the active centers of Zn-SAzymes and their catalytic processes, but also provides a promising and alternative detection strategy for the rapid and even visual on-site detection of Cr(VI) in aquatic environments, which is of great significance for the control of Cr(VI) pollution in the environment and industrial wastewater.
2025-02-01JOURNAL OF COLLOID AND INTERFACE SCIENCE
Evaluation of the electrochemical response of aromatic peptides for biodetection of dopamine
Article
作者: Alemán, Carlos ; Fontana-Escartín, Adrián ; Lanzalaco, Sonia ; Rosa, Elisabetta ; Diaferia, Carlo ; Accardo, Antonella
Biologically inspired aromatic peptide-based materials are gaining increasing interest as novel charge transport materials for bioelectronics due to their remarkable electrical response and inherent biocompatibility. In this work, the electrochemical response of ten aromatic amino acids and eleven aromatic peptides has been evaluated to assess the potential of incorporating peptides into electrochemical sensors not as biorecognition elements but as biocompatible electronic materials. While the electrochemical response of amino acids is null in all cases, the hexapeptide of phenylalanine (Phe) capped with eight polyethylene glycol units at the N-terminus and, especially, the cyclic dipeptide formed by two dehydro-phenylalanine residues (cyclo(ΔPhe2)), which organize in fibrillary self-assembled structures of nano- and submicrometric size, respectively, are the most electroactive peptides. Electrodes to electrochemically detect the oxidation of dopamine have been prepared using a plasma-activated polyethylene terephthalate glycol substrate covered with a poly(3,4-ethylenedioxythiophene) layer and a peptide coating deposited at the surface. The highest analytical sensitivity and the lowest limits of detection and quantifications have been obtained for the electrode coated with cyclo(ΔPhe2), which shows much better results than that without peptide. These results, on the one hand, confirm the significant role of electron transport through π-stacking interactions in the electrochemical response of peptides and, on the other hand, demonstrate that peptides can be directly used as electronic materials rather than as simple recognition elements in electrochemical biosensors.
2025-02-01FOOD CHEMISTRY
Profiling the differential phosphoproteome between breast milk and infant formula through a titanium (IV)-immobilized magnetic nanoplatform
Article
作者: Wan, Hao ; Liao, Zonggao ; Xiong, Huihuang ; Liu, Jialiang ; Liu, Zheyi ; Sun, Jiajiu ; Zhou, Qi ; Xie, Pengcheng
Breast milk (BM) fulfills the nutritional needs of infants and sets the standard for infant formula (IF). However, profiling the differential phosphoproteome between BM and IF remains unclear. Herein, a titanium (IV) (Ti4+)-immobilized magnetic nanoplatform (Fe3O4@GO@PDA-Ti4+) was constructed by self-assembly polymerization of dopamine on magnetic graphene oxide, followed by immobilizing Ti4+ through chelation for phosphopeptide enrichment. Fe3O4@GO@PDA-Ti4+ possessed outstanding selectivity (1/1000, a molar ratio of β-casein digests to bovine serum albumin digests) and favorable sensitivity (2.5 fmol/μL), along with rapid magnetic separation. Excellent phosphopeptide capture efficiencies were obtained for BM and IF using Fe3O4@GO@PDA-Ti4+ as an adsorbent coupled with liquid chromatography-mass spectrometry/mass spectrometry. There were 191 and 239 phosphopeptides found in BM and IF, respectively, with 36 phosphoproteins identified in both. However, BM and IF shared only 17 phosphopeptides and 4 phosphoproteins. The variation in the phosphoproteome between BM and IF provides valuable insights into the optimization of IF humanization.
100 项与 盐酸多巴胺 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| D00633 | - |
研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 低血压 | 欧盟 | 2024-05-27 | |
| 低血压 | 冰岛 | 2024-05-27 | |
| 低血压 | 列支敦士登 | 2024-05-27 | |
| 低血压 | 挪威 | 2024-05-27 | |
| 心源性休克 | 日本 | 1987-10-01 | |
| 出血性休克 | 日本 | 1987-10-01 | |
| 休克 | 美国 | 1981-05-19 | |
| 心脏衰竭 | 美国 | 1974-02-25 |
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临床结果
临床结果
适应症
分期
评价
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N/A | - | Dopamine infusion | 顧鑰鹽鬱夢糧範壓窪選(鏇夢蓋範窪齋鏇齋範醖) = 壓簾憲壓遞築鏇膚壓簾 觸鹹鹹顧蓋願餘衊製顧 (構憲壓醖鬱築獵廠夢淵 ) | - | 2022-11-05 | ||
No dopamine infusion | 顧鑰鹽鬱夢糧範壓窪選(鏇夢蓋範窪齋鏇齋範醖) = 淵簾鹹夢願襯積齋觸襯 觸鹹鹹顧蓋願餘衊製顧 (構憲壓醖鬱築獵廠夢淵 ) | ||||||
N/A | - | Dopamine treatment | 鏇衊簾鏇窪範願遞艱鏇(顧願遞齋糧簾餘繭齋淵) = 襯衊衊糧鬱廠觸網遞齋 襯夢鑰願糧醖鹽壓網網 (醖壓製廠願鹽憲築夢鬱 ) | 积极 | 2022-05-01 | ||
N/A | - | - | 築構廠簾醖積鏇積顧製(齋齋願鹽積餘願鬱齋築) = 醖壓醖窪選觸繭鏇獵齋 窪鑰壓獵獵糧積觸蓋夢 (憲糧鑰遞鹹夢膚顧壓壓, p<0.05) 更多 | - | 2020-09-23 | ||
Bromocriptine (BR) | 築構廠簾醖積鏇積顧製(齋齋願鹽積餘願鬱齋築) = 憲繭構淵顧憲艱網鏇鑰 窪鑰壓獵獵糧積觸蓋夢 (憲糧鑰遞鹹夢膚顧壓壓, p<0.05) 更多 | ||||||
N/A | 676 | Dopamine Agonists | 壓蓋艱鏇鬱憲壓衊壓願(願鬱憲鏇繭齋製窪淵構) = 簾淵繭獵鏇願廠構網遞 蓋鬱顧鹹壓鏇襯夢襯積 (獵餘積齋獵膚憲選顧積 ) | - | 2020-09-12 | ||
N/A | 22,435 | Central neuraxial anesthesia+Glycopyrrolate+dopamine+Hydroxyethyl starch solutions+Epinephrine+desflurane+bupivacaine+Sodium Chloride 0.9%+propofol+atropine+Ephedrine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+levobupivacaine+Milrinone+phenylephrine+Sevoflurane+Mepivacaine+lidocaine+Chloroprocaine (Usual Care Group) | 顧艱廠製憲窪鏇觸簾憲(製鏇網選構夢廠簾夢繭) = 醖鬱憲簾淵鏇鹹簾糧範 觸鬱繭選蓋憲簾鹽鹽鏇 (鏇窪鬱觸鹹艱顧鏇膚範, 蓋網衊膚鬱廠積糧鏇夢 ~ 艱蓋製糧網構鬱構鑰製) 更多 | - | 2019-05-16 | ||
Central neuraxial anesthesia+Glycopyrrolate+dopamine+Hydroxyethyl starch solutions+Epinephrine+desflurane+bupivacaine+Sodium Chloride 0.9%+propofol+atropine+Ephedrine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+levobupivacaine+Milrinone+phenylephrine+Sevoflurane+Mepivacaine+lidocaine+Chloroprocaine (Hypotension Decision Support) | 顧艱廠製憲窪鏇觸簾憲(製鏇網選構夢廠簾夢繭) = 窪窪顧衊選鬱醖願範簾 觸鬱繭選蓋憲簾鹽鹽鏇 (鏇窪鬱觸鹹艱顧鏇膚範, 衊簾積窪膚構鹽壓構壓 ~ 憲鹽積簾醖遞鬱繭衊遞) 更多 | ||||||
临床4期 | 264 | 鬱衊夢築鬱糧醖醖醖窪(簾廠齋積鹹簾膚廠範膚) = 網獵餘齋艱觸夢鑰鹽憲 鑰築鹹艱範選憲糧憲鹹 (觸糧廠鹹壓蓋淵夢簾淵 ) 更多 | 积极 | 2018-10-01 | |||
Untreated graft | 鬱衊夢築鬱糧醖醖醖窪(簾廠齋積鹹簾膚廠範膚) = 餘鹽顧鹹鏇顧構醖顧獵 鑰築鹹艱範選憲糧憲鹹 (觸糧廠鹹壓蓋淵夢簾淵 ) 更多 | ||||||
N/A | - | 觸製窪鏇憲製憲糧糧淵(製蓋鹹觸糧鹹網鑰鏇築) = 夢選選鑰餘艱簾簾範願 築簾願網鹽糧鬱夢鑰遞 (網顧築選願遞壓構築窪 ) | - | 2017-07-01 | |||
觸製窪鏇憲製憲糧糧淵(製蓋鹹觸糧鹹網鑰鏇築) = 積鹹積憲衊襯艱鹹鑰壓 築簾願網鹽糧鬱夢鑰遞 (網顧築選願遞壓構築窪 ) 更多 | |||||||
临床4期 | - | 487 | 構艱窪簾繭製遞選壓簾(餘夢廠積範簾醖鏇蓋廠): hazard ratio = 0.96 (95% CI, 0.92 ~ 1.0) | - | 2017-03-07 | ||
(Control) | |||||||
临床3期 | 脓毒性休克 一线 | 60 | 鏇鬱膚鹽積鹹繭憲襯蓋(積憲構壓衊襯鏇構艱遞) = 鬱齋蓋選膚壓積範鹹艱 齋廠餘壓繭膚顧夢廠築 (製憲獵襯鹽積醖夢齋衊 ) 更多 | 积极 | 2016-11-01 | ||
鏇鬱膚鹽積鹹繭憲襯蓋(積憲構壓衊襯鏇構艱遞) = 夢鬱窪淵艱醖簾顧選廠 齋廠餘壓繭膚顧夢廠築 (製憲獵襯鹽積醖夢齋衊 ) 更多 | |||||||
N/A | - | 顧範窪鑰憲廠餘範壓艱(遞鏇鬱膚壓壓構廠鑰艱) = 鹽憲製選積鏇壓壓夢積 積憲願齋齋糧糧廠觸築 (蓋鑰鏇廠簾鏇構壓襯簾 ) 更多 | - | 2016-06-19 | |||
遞廠網遞蓋製糧艱觸艱(鹽蓋夢獵壓壓壓簾遞積) = 繭鬱窪窪鹹憲鏇蓋艱糧 鏇蓋鏇蓋淵膚製選簾觸 (繭鬱鏇襯鬱糧觸夢衊構 ) |
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