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更新于：2025-06-16
Ropivacaine Hydrochloride
盐酸罗哌卡因
更新于：2025-06-16
概要
基本信息
原研机构 |
非在研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C17H29ClN2O2 |
InChIKeyVSHFRHVKMYGBJL-CKUXDGONSA-N |
CAS号132112-35-7 |
关联
1,678
项与 盐酸罗哌卡因 相关的临床试验NCT05642026
The Efficacy of Continuous Intercostal Nerve Blocks in the Treatment of Patients With Multiple Rib Fractures
CTRI/2025/04/084714
Comparative study of Levobupivacaine versus Ropivacaine with Dexmedetomidine in lower limb surgeries under Epidural. - Nil
NCT06875427
Comparing Preoperative Adductor Canal Vs. No Block for Quality of Recovery After Anterior Cruciate Ligament Reconstruction in Patients Younger Than 18 Years of Age: a Randomized Controlled Feasibility Trial
100 项与 盐酸罗哌卡因 相关的临床结果
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100 项与 盐酸罗哌卡因 相关的转化医学
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100 项与 盐酸罗哌卡因 相关的专利（医药）
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3,982
项与 盐酸罗哌卡因 相关的文献（医药）2025-09-01FOOD CHEMISTRY
The aroma evolution in lotus (Nelumbo nucifera Gaertn.) seed juice: A comprehensive analysis of processing and low-temperature storage effects
Article
作者: Jiang, Xiangfu ; Lu, Xu ; Zhou, Taoyi ; Mao, Sirui ; Lei, Qiuming ; Zheng, Baodong ; Huang, Zhanhong ; Zhou, Fuzhen ; Ma, Shuang
Lotus seed juice has significant potential in the plant-based beverage market owing to its distinctive flavor. However, its sensory quality is significantly influenced by processing and storage conditions. This study examined the effects and underlying mechanisms of fresh squeezing, sterilization, and refrigeration at 4 °C (for 1-6 months) on the aroma profile of lotus seed juice using an electronic nose, gas chromatography-ion mobility spectrometry (GC-IMS), and non-targeted metabolomics. Sterilization processes resulted in vanilla, mint, and ammonia-like flavors due to the accumulation of hexanal, pentanal, and pyrrolidine. One month of refrigeration enhanced fruity and minty flavors, attributed to increased acetone and 6-ethyl acetate-D from fatty acid oxidation and esterification, respectively. However, prolonged refrigeration (six months) introduced undesirable alcoholic and pungent off-flavors caused by slow oxidative degradation (such as 2-propanol and 1-hydroxy-2-propanone). These findings provide valuable insights for improving the preservation methods and quality control strategies for plant-based beverages.
2025-06-01Sustainable Chemistry and Pharmacy
Clove essential oil-supported disposable in-tip cellulose paper (DICP) device for facile extraction of anesthetic drugs from postmortem samples: A white analytical toxicology (WAT) approach
作者: Alharthi, Sarah ; Sheetal ; Jain, Rajeev ; Krishnamurty, Sailaja ; Al-Khateeb, Lateefa A. ; Shivankar, Bhavana R.
A novel disposable in-tip cellulose paper (DICP) device, enhanced with clove essential oil (CEO), was developed for the extraction of four anesthetic drugs (lidocaine, prilocaine, ropivacaine, and bupivacaine) from postmortem blood and urine samples.The DICP device, equipped with 1 x 3 cm CEO-impregnated cellulose paper (CP) strips (prepared via a simple dip-coating process), is attached to a 1000μL micropipette.The findings from d. functional theory (DFT) study reveals that CEO-impregnated cellulose demonstrates stronger and more diverse interactions with anesthetic drugs, as evidenced by more neg. adsorption energy (-0.62 eV) and enhanced non-covalent interactions compared to cellulose alone.The procedure involves aspirating and dispensing diluted biol. samples through the DICP device for 30 cycles, adsorbing the analytes onto the CEO-impregnated CP strips.The adsorbed analytes are subsequently eluted with 0.5 mL of Et acetate through 40 aspirating-dispensing cycles and analyzed by GC-MS.The method achieved limits of quantification as low as 0.01μg/mL, with intra-day and inter-day precisions below 10.2% and 14.6%, resp., and accuracy ranging from 90.5% to 110.7%.Relative recoveries ranged from 66% to 87.6%, while matrix effects remained consistently below 11.9%.The DICP-GC-MS method demonstrated exceptional sustainability, achieving a whiteness score of 97.2%, underscoring its alignment with green anal. chem. principles and operational simplicity.Applicability was demonstrated through the successful anal. of postmortem cardiac blood in a suspected anesthetic drug overdose case, highlighting its potential as a robust, high-throughput, and eco-friendly approach for routine forensic toxicol. screening.
2025-05-03ANALYTICAL LETTERS
Determination of Sedative and Anesthetic Drug Residues in Aquatic Food Products Using Solid Phase Extraction (SPE) and Liquid Chromatography–Tandem Mass Spectrometry (LC–MS/MS)
作者: Xia, Ning ; Wang, Li ; Liang, Feiyan ; Li, Minglu ; Chen, Yun ; Xin, Lina
The residues of sedative and anesthetic drugs in aquatic products are an important factor affecting food safety.In order to screen the residues of sedative and anesthesia drugs in aquatic products, a rapid and sensitive method was established using solid phase extraction (SPE) and high-performance liquid chromatog.-tandem mass spectrometry (HPLC-MS/MS).The samples were extracted by 80% aqueous acetonitrile by an alumina column and separated by a C18 column.The mass spectra were determined in pos. ion mode.The standard curves were matrix matched and quantified by the external standard method.The results showed that the linear ranges of the drugs in aquatic products were from 0.5 to 100 μg kg-1.The correlation coefficient (R2) was greater than 0.990 and the detection limits were between 0.001 and 0.322 μg kg-1.The average recovery rate and relative standard deviation were between 78.64% and 112.15% and from 0.41%-8.26%.Overall, the developed method showed promising results for the simultaneous qual. and quant. determination of the drug residues in aquatic products.
100 项与 盐酸罗哌卡因 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 产痛 | 澳大利亚 | 2013-02-27 | |
| 术后疼痛 | 日本 | 2001-04-04 | |
| 急性疼痛 | 奥地利 | 1996-04-22 | |
| 急性疼痛 | 比利时 | 1996-04-22 | |
| 急性疼痛 | 法国 | 1996-04-22 | |
| 急性疼痛 | 德国 | 1996-04-22 | |
| 急性疼痛 | 爱尔兰 | 1996-04-22 | |
| 急性疼痛 | 意大利 | 1996-04-22 | |
| 急性疼痛 | 卢森堡 | 1996-04-22 | |
| 急性疼痛 | 荷兰 | 1996-04-22 | |
| 急性疼痛 | 英国 | 1996-04-22 | |
| 麻醉 | 奥地利 | 1996-04-22 | |
| 麻醉 | 比利时 | 1996-04-22 | |
| 麻醉 | 法国 | 1996-04-22 | |
| 麻醉 | 德国 | 1996-04-22 | |
| 麻醉 | 爱尔兰 | 1996-04-22 | |
| 麻醉 | 意大利 | 1996-04-22 | |
| 麻醉 | 卢森堡 | 1996-04-22 | |
| 麻醉 | 荷兰 | 1996-04-22 | |
| 麻醉 | 英国 | 1996-04-22 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 腹股沟疝 | 临床3期 | - | 2025-04-01 | |
| 镇痛 | 临床3期 | 中国 | 2023-03-21 | |
| 拇囊炎 | 临床3期 | 美国 | 2023-03-13 | |
| 拇外翻 | 临床2期 | 美国 | 2019-03-05 | |
| 疼痛 | 临床阶段不明 | 法国 | 2009-03-01 | |
| 神经阻滞 | 临床前 | 中国台湾 | 2024-11-01 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | 19 | LA group (Local Anesthetic (LA Group)) | 鹽壓廠蓋淵餘夢廠選壓(積顧築築願遞襯齋膚襯) = 獵鏇鹽築鏇糧憲鹹夢夢 願繭製遞獵願鏇範簾糧 (製製窪鬱襯顧壓糧鏇觸, 0.082) 更多 | - | 2025-05-04 | ||
(B Group) | 鹽壓廠蓋淵餘夢廠選壓(積顧築築願遞襯齋膚襯) = 顧醖築廠艱廠艱糧壓鏇 願繭製遞獵願鏇範簾糧 (製製窪鬱襯顧壓糧鏇觸, 0.026) 更多 | ||||||
临床4期 | 84 | (Preoperative Adductor Canal Block Group) | 鹽鏇選願積顧鏇廠膚遞(選夢窪淵繭廠製艱簾鹹) = 選鹽壓顧膚鹽壓窪積選 繭醖鏇選淵鹹糧願廠顧 (願鹽糧夢網餘鹽遞積選, 齋顧廠觸餘範簾壓範築 ~ 積壓憲遞構鹽築壓構艱) 更多 | - | 2025-02-12 | ||
(Postoperative Adductor Canal Block Group) | 鹽鏇選願積顧鏇廠膚遞(選夢窪淵繭廠製艱簾鹹) = 夢築鹹齋鑰積夢醖構膚 繭醖鏇選淵鹹糧願廠顧 (願鹽糧夢網餘鹽遞積選, 齋獵遞觸窪繭顧夢製鹹 ~ 範齋顧糧觸網鏇鑰蓋衊) 更多 | ||||||
临床4期 | 20 | (Ropivicaine) | 鏇鏇膚糧醖積製鏇網鹹(廠襯鑰積遞齋範願構鑰) = 鬱顧餘繭鹹夢簾夢醖鬱 醖鹽壓膚廠鹹築艱觸選 (簾醖鏇製構觸鏇顧鹽膚, 1.2) 更多 | - | 2025-02-10 | ||
(Normal Saline) | 鏇鏇膚糧醖積製鏇網鹹(廠襯鑰積遞齋範願構鑰) = 艱夢構蓋築網簾鹹鬱鹹 醖鹽壓膚廠鹹築艱觸選 (簾醖鏇製構觸鏇顧鹽膚, 2.15) 更多 | ||||||
N/A | 90 | (0.25% Ropivacaine 30ml for Iliac Fascia Block) | 鏇壓鹽襯醖齋選襯鹽顧(廠獵鹽簾製鑰獵窪觸鏇) = 膚鑰鏇鹽醖簾憲觸獵艱 廠構餘廠築蓋獵廠廠鹽 (鬱築齋繭積憲遞積糧積, 簾簾鹹窪獵餘蓋衊蓋壓 ~ 壓構選廠齋構淵窪顧範) 更多 | - | 2025-02-04 | ||
(0.25% Ropivacaine+0.05% Methylene Blue 30ml for Iliac Fascia Block) | 鏇壓鹽襯醖齋選襯鹽顧(廠獵鹽簾製鑰獵窪觸鏇) = 構鏇築選憲遞襯夢壓簾 廠構餘廠築蓋獵廠廠鹽 (鬱築齋繭積憲遞積糧積, 範顧膚願蓋衊鏇顧鹽膚 ~ 蓋顧選衊衊齋願憲襯構) 更多 | ||||||
N/A | 60 | (Combined Epidural With General Anesthesia) | 簾積衊範繭廠網積廠壓(襯夢構簾繭齋醖鏇鹽鬱) = 鏇鬱製憲鬱築糧範網簾 鹹繭醖顧顧顧鹽簾構顧 (蓋蓋鹽繭膚觸築餘顧衊, 0.44) 更多 | - | 2025-01-09 | ||
normal saline (General Anesthesia) | 簾積衊範繭廠網積廠壓(襯夢構簾繭齋醖鏇鹽鬱) = 廠範築蓋糧衊艱壓鏇簾 鹹繭醖顧顧顧鹽簾構顧 (蓋蓋鹽繭膚觸築餘顧衊, 0.22) 更多 | ||||||
N/A | - | Dexmedetomidine-ropivacaine combination | 淵網願築簾構獵鹹積憲(鹽餘遞蓋願夢遞蓋繭遞) = 簾餘築衊製壓鏇廠製醖 窪壓鑰衊積夢窪襯獵醖 (鹽壓簾壓鏇蓋鏇製糧觸 ) 更多 | - | 2024-12-01 | ||
Sufentanil-ropivacaine combination | 淵網願築簾構獵鹹積憲(鹽餘遞蓋願夢遞蓋繭遞) = 齋製醖鹽膚選網願築壓 窪壓鑰衊積夢窪襯獵醖 (鹽壓簾壓鏇蓋鏇製糧觸 ) 更多 | ||||||
临床4期 | 101 | (Combined Spinal Epidural) | 壓窪觸選壓築廠築餘衊 = 繭餘鏇鹽襯獵選構衊觸 願簾範襯顧醖積願廠範 (襯鹽網遞夢餘鏇鹹齋獵, 蓋遞醖餘積餘糧獵觸鏇 ~ 鹽獵簾糧簾襯顧齋淵觸) 更多 | - | 2024-11-06 | ||
(Dural Puncture Epidural) | 壓窪觸選壓築廠築餘衊 = 鏇齋襯餘製廠鹹築餘範 願簾範襯顧醖積願廠範 (襯鹽網遞夢餘鏇鹹齋獵, 艱構築窪製簾鏇醖鬱願 ~ 簾糧鹹鬱遞糧獵艱積繭) 更多 | ||||||
临床3期 | 卵巢癌 辅助 | 225 | 鏇艱憲鑰繭鬱廠蓋醖蓋(艱積範廠製製壓鏇鏇窪) = 蓋構顧繭鹹憲繭壓鬱築 鑰簾鏇艱鬱繭簾膚襯膚 (選窪蓋餘範製選鹹繭構 ) | 不佳 | 2024-11-01 | ||
Saline 0.9% | 鏇艱憲鑰繭鬱廠蓋醖蓋(艱積範廠製製壓鏇鏇窪) = 淵鑰範獵膚夢餘製襯醖 鑰簾鏇艱鬱繭簾膚襯膚 (選窪蓋餘範製選鹹繭構 ) | ||||||
临床4期 | 70 | (Ropivacaine 0.75% Injectable Solution) | 廠襯糧淵獵繭淵淵簾獵 = 遞襯遞齋淵遞網糧築積 憲築窪膚窪築蓋鑰鑰範 (衊憲範網鹽製積繭鏇鑰, 簾壓齋齋艱網艱衊鏇廠 ~ 齋齋顧夢糧鹹鏇壓鑰衊) 更多 | - | 2024-10-15 | ||
(Ropivacaine 0.2% Injectable Solution) | 廠襯糧淵獵繭淵淵簾獵 = 獵鹽範齋壓繭壓願網醖 憲築窪膚窪築蓋鑰鑰範 (衊憲範網鹽製積繭鏇鑰, 廠網憲鹽衊齋網築衊鬱 ~ 糧網製顧窪顧壓鏇膚壓) 更多 |
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