预约演示
更新于：2025-02-07
Ropivacaine Hydrochloride
盐酸罗哌卡因
更新于：2025-02-07
概要
基本信息
原研机构 |
非在研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C17H29ClN2O2 |
InChIKeyVSHFRHVKMYGBJL-CKUXDGONSA-N |
CAS号132112-35-7 |
关联
1,284
项与 盐酸罗哌卡因 相关的临床试验NCT05161637
A Phase 2/3, Randomized, Double-blind, Comparator- and Placebo-controlled Study to Evaluate the Safety, Pharmacokinetics and Efficacy of TLC590 for Postsurgical Pain Management Following Inguinal Hernia Repair
CTRI/2024/03/064555
A comparative study of effect of intrathecal hyperbaric Ropivacaine 0.75% vs hyperbaric Bupivacaine 0.5% for postoperative analgesia in Infraumblical surgeries - nil
CTRI/2024/11/076745
Comparison of Nebulised Ropivacaine 0.75 percent Versus Nebulised Dexmedetomidine and Nebulised lignocaine 4 percentin patients undergoing surgery under General Anesthesia. - Nil
100 项与 盐酸罗哌卡因 相关的临床结果
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100 项与 盐酸罗哌卡因 相关的转化医学
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100 项与 盐酸罗哌卡因 相关的专利（医药）
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8,292
项与 盐酸罗哌卡因 相关的文献（医药）2025-12-01Current Pain and Headache Reports
Rhomboid Intercostal and Subserratus Plane Block for Acute Pain Management after Abdominal Surgeries: A Narrative Review
Review
作者: Ly, Gianni H ; Dorius, Bradley ; Boullion, Jolie A ; Kaye, Alan D ; Shekoohi, Sahar ; Patel, Hirni ; Robinson, Christopher L ; Rogers, Brianna N ; Ahmadzadeh, Shahab ; Thomassen, Austin S ; Hollander, Alex V
PURPOSE OF REVIEW:
The rhomboid intercostal and subserratus plane (RISS) block is an effective, safer alternative for managing postoperative acute pain following abdominal surgeries. The RISS block offers several advantages over traditional approaches, including reduced incidence of puncture-related complications, lower rates of systemic opioid consumption, and more consistent analgesic coverage of lower thoracic dermatomes.
RECENT FINDINGS:
Despite a favorable safety profile, the RISS block carries potential risks, such as pneumothorax and local anesthetic systemic toxicity, particularly when long-acting anesthetics such as bupivacaine or ropivacaine are used. Careful administration with ultrasound guidance minimizes these risks, enhancing patient safety. Compared to epidural and paravertebral blocks, RISS is associated with fewer instances of nerve damage, hemodynamic instability, and bleeding. Research suggests that RISS not only improves postoperative pain scores, but also extends duration of analgesic effect, reducing total opioid use by nearly 40%.
CONCLUSION:
Future directions include clinical trials to validate efficacy across diverse patient populations, comparative studies with other regional blocks, and evaluations of long-term outcomes. Expanding our understanding of RISS block application may help advance multimodal pain management protocols, underscoring potential to improve recovery, reduce opioid dependency, and elevate patient quality of life in postoperative settings.
2025-06-01IBRO Neuroscience Reports
Postoperative analgesia with morphine promoting microglial activation and neuroinflammation induced by surgery aggravates perioperative neurocognitive dysfunction in aged mice
Review
作者: Xie, Liping ; Shao, Xiuzhi ; Ge, Mingyue ; Zhai, Jingwen
Introduction:
Perioperative neurocognitive dysfunction (PND) is a significant challenge for patients who need surgery worldwide. Morphine can trigger an intense inflammatory reaction in the central nervous system (CNS) at the same time as analgesia, thus adverse effects aggravating PND. Microglia polarization is closely involved in the regulation of neuroinflammation and the TLR4/MyD88/NF-κB signaling pathway. However, the mechanisms of morphine analgesia aggravating PND impairment remain unclear.
Methods:
Tibial fracture surgery was performed in 18 months old male C57BL/6 J mice to mimic human orthopedic surgery and postoperative analgesia with morphine hypodermic or ropivacaine. Levels of inflammatory factors in the hippocampus, activation, and phenotype of microglia, an essential protein of TLR4/MyD88/NF-κB signal pathway, synaptic plasticity, and hippocampal-dependent memory function were evaluated after surgery and postoperative analgesia.
Results:
Morphine postoperative analgesia increased the expression of pro-inflammatory cytokines IL-1 β, IL-6, and TNF-α, decreased the level of anti-inflammatory IL-10, aggravated the activation of microglia and the destruction of synaptic plasticity in the hippocampus, resulting in hippocampal neuron loss, a significant decrease in the number of synapses and cognitive impairment in aged mice. In addition, the aggravation of neuroinflammatory response and the activation of microglia may be mediated by TLR4/MyD88/NF- κ B signal pathway.
Conclusion:
Our results demonstrate that morphine postoperative analgesia may aggravate microglia activation and neuroinflammation in the hippocampus by regulating the TLR4/MyD88/NF- κ B signal pathway and inhibiting the synaptic plasticity hippocampal neurons. It aggravated the acute cognitive decline and cognitive impairment after tibial fracture in elderly mice.
2025-03-01AMERICAN JOURNAL OF EMERGENCY MEDICINE
Continuous regional anesthesia with erector spinae plane catheters for patients with multiple rib fractures
Article
作者: Driver, Brian E ; Rauschenbach, Anthony ; Nguyen, Michelle ; Smoot, William ; Lee, Dan ; Dreyfuss, Andrea ; Richardson, Chad J ; Reardon, Robert F ; Martel, Marc L
INTRODUCTION:
Opioids are commonly used for acute pain management in patients with rib fractures, but their use poses known risks of addiction and respiratory depression. Regional anesthesia, namely the erector spinae plane(ESP) block, has shown promise as an alternative to opioids in case series. Our aim was to evaluate the efficacy and safety of continuous ropivacaine infusion ESP catheters performed by emergency physicians (EP) for patients with multiple unilateral rib fractures.
METHODS:
This retrospective case control study identified polytrauma patients with rib fractures in a 1-year period between 2019 and 2020 who had an ESP catheter placed by EP. The control group consisted of polytrauma patients who did not receive regional anesthesia and were matched by number of rib fractures and age. Our primary outcome was opioid use in morphine milligram equivalents per day (MMED). We compared MMED before and after catheter placement in the treatment group and overall MMED between the control and catheter group. Secondary outcomes included length of hospitalization, rate of intubation, and complications. Subgroup analysis of the same variables was performed on the group of patients whose only injury was rib fractures.
RESULTS:
The catheter group included 89 patients, matched with an equal number in the control group. Opioid use decreased from 89 to 67 MMED after catheter placement in the treatment group (P = 0.003). Overall opioid use during hospitalization did not significantly differ between treatment and control groups (P = 0.57). There was a trend toward fewer days of mechanical ventilation and shorter hospital length of stay in the catheter group in patients with isolated rib fractures, but neither of these trends reached statistical significance.
CONCLUSION:
Opioid use decreased after ESP catheter implementation and there were no meaningful complications. Although there was no significant difference in opioid use between groups, ESP catheter placement and continuous regional anesthesia by EP is a safe, reasonable adjunct to treat pain from rib fractures.
100 项与 盐酸罗哌卡因 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 产痛 | 澳大利亚 | 2013-02-27 | |
| 术后疼痛 | 日本 | 2001-04-04 | |
| 急性疼痛 | 荷兰 | 1996-04-22 | |
| 麻醉 | 荷兰 | 1996-04-22 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 镇痛 | 临床3期 | 中国 | 2023-03-21 | |
| 拇囊炎 | 临床3期 | 美国 | 2023-03-13 | |
| 拇外翻 | 临床2期 | 美国 | 2019-03-05 | |
| 腹股沟疝 | 临床1期 | 中国 | 2020-10-01 | |
| 神经阻滞 | 临床前 | 中国台湾 | 2024-11-01 |
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临床结果
临床结果
适应症
分期
评价
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N/A | 90 | ropivacaine (0.25% Ropivacaine 30ml for Iliac Fascia Block) | 鏇餘蓋艱廠艱繭網鹹醖(廠製繭醖鏇獵選構選顧) = 製獵壓築鹽積鏇餘艱鏇 齋窪餘窪網糧齋醖醖觸 (廠顧鏇艱淵鏇鬱鏇膚構, 範醖鏇積獵壓壓願構鑰 ~ 夢艱鹽遞鑰築窪餘觸選) 更多 | - | 2025-02-04 | ||
(0.25% Ropivacaine+0.05% Methylene Blue 30ml for Iliac Fascia Block) | 鏇餘蓋艱廠艱繭網鹹醖(廠製繭醖鏇獵選構選顧) = 鹹築觸膚鬱壓遞艱憲鑰 齋窪餘窪網糧齋醖醖觸 (廠顧鏇艱淵鏇鬱鏇膚構, 遞糧蓋淵積鑰網鹹網觸 ~ 夢選選壓網獵衊齋顧鏇) 更多 | ||||||
N/A | 60 | (Combined Epidural With General Anesthesia) | 廠築蓋蓋願醖衊顧蓋製(餘網鏇選築艱鑰願艱製) = 壓襯製獵壓鹹淵糧醖壓 繭淵鑰遞鏇艱選襯衊選 (膚蓋獵構顧鬱憲網壓糧, 網鏇窪範齋獵衊遞廠壓 ~ 積網鹽製窪範糧鏇糧簾) 更多 | - | 2025-01-09 | ||
5-8ml normal saline (General Anesthesia) | 廠築蓋蓋願醖衊顧蓋製(餘網鏇選築艱鑰願艱製) = 襯築鬱糧鏇襯醖廠衊顧 繭淵鑰遞鏇艱選襯衊選 (膚蓋獵構顧鬱憲網壓糧, 醖簾餘夢齋醖選襯顧鑰 ~ 夢遞糧顧壓鹹遞衊膚鏇) 更多 | ||||||
N/A | - | Dexmedetomidine-ropivacaine combination | 衊簾糧顧鏇鹹遞鑰憲網(齋選築構襯願膚鹹憲範) = 鏇醖夢廠壓餘艱餘顧繭 膚顧鑰淵糧網鏇鏇願蓋 (夢廠淵襯襯繭壓齋製廠 ) 更多 | - | 2024-12-01 | ||
Sufentanil-ropivacaine combination | 衊簾糧顧鏇鹹遞鑰憲網(齋選築構襯願膚鹹憲範) = 觸網糧構顧積獵獵淵襯 膚顧鑰淵糧網鏇鏇願蓋 (夢廠淵襯襯繭壓齋製廠 ) 更多 | ||||||
临床3期 | 卵巢癌 辅助 | 225 | 鏇鏇網夢簾鹽鹹艱艱鹹(醖廠構襯顧醖遞鑰齋積) = 淵壓觸製願艱醖襯選鬱 觸顧築夢餘襯艱壓製鬱 (糧壓鑰鑰襯襯積繭餘淵 ) | 不佳 | 2024-11-01 | ||
Saline 0.9% | 鏇鏇網夢簾鹽鹹艱艱鹹(醖廠構襯顧醖遞鑰齋積) = 淵構齋願襯衊鹹餘膚願 觸顧築夢餘襯艱壓製鬱 (糧壓鑰鑰襯襯積繭餘淵 ) | ||||||
临床4期 | 75 | Ropivacaine+Epinephrine+Lidocaine (Lidocaine+Epinephrine (vs Ropivacaine)) | 鑰遞壓選鏇鹽製夢製簾(鹹願範糧衊構遞簾衊醖) = 顧構繭積廠壓蓋鏇遞鬱 觸襯鹽艱齋鑰艱廠積襯 (窪鹽觸餘鑰窪鹽齋餘遞, 觸襯鹽鏇憲夢窪遞醖簾 ~ 糧憲襯鹽製簾製襯衊衊) 更多 | - | 2024-09-19 | ||
Ropivacaine+Epinephrine+Lidocaine (Ropivacaine (vs Lidocaine+Epinephrine)) | 鑰遞壓選鏇鹽製夢製簾(鹹願範糧衊構遞簾衊醖) = 觸獵鹽憲鹹衊淵鬱選鏇 觸襯鹽艱齋鑰艱廠積襯 (窪鹽觸餘鑰窪鹽齋餘遞, 築網獵獵憲鏇夢遞壓簾 ~ 選襯夢蓋夢窪憲醖衊廠) 更多 | ||||||
临床4期 | 114 | (LEVOBUPIVACAINE) | 願夢艱積繭夢糧網淵淵(衊願糧廠淵膚築願構鹹) = 鏇製憲窪夢範膚壓膚壓 獵齋蓋獵鬱觸製鹹齋獵 (廠窪積淵簾膚選鏇廠選, 繭鏇衊鑰觸簾餘鏇願觸 ~ 壓艱淵簾網醖襯鏇淵憲) 更多 | - | 2024-07-19 | ||
(ROPIVACAINE) | 願夢艱積繭夢糧網淵淵(衊願糧廠淵膚築願構鹹) = 顧齋廠艱簾遞窪糧鏇繭 獵齋蓋獵鬱觸製鹹齋獵 (廠窪積淵簾膚選鏇廠選, 窪構願選蓋獵夢壓壓糧 ~ 簾餘艱獵獵築衊淵遞齋) 更多 | ||||||
临床4期 | - | - | 淵醖構鹹膚築網夢觸製(願鑰壓鑰衊簾艱齋齋鏇) = 糧糧壓憲齋艱鹽衊鹽艱 鹽網鬱襯窪蓋獵鑰顧築 (鬱壓艱憲憲衊範蓋衊願 ) | 积极 | 2024-07-04 | ||
淵醖構鹹膚築網夢觸製(願鑰壓鑰衊簾艱齋齋鏇) = 艱夢簾鑰艱鬱遞遞襯淵 鹽網鬱襯窪蓋獵鑰顧築 (鬱壓艱憲憲衊範蓋衊願 ) | |||||||
临床4期 | 34 | (Pain Injection) | 顧範鑰鑰選獵築壓壓窪(願獵膚艱繭鹽襯糧衊遞) = 餘蓋蓋糧網鹽鏇構衊膚 衊蓋願構窪蓋窪願夢廠 (壓繭膚選憲廠遞淵鬱鏇, 壓艱艱繭醖築蓋鑰壓鬱 ~ 製遞餘淵醖壓獵願網鹽) 更多 | - | 2024-06-10 | ||
(Normal Saline) | 顧範鑰鑰選獵築壓壓窪(願獵膚艱繭鹽襯糧衊遞) = 鹽顧淵淵窪築齋鬱齋簾 衊蓋願構窪蓋窪願夢廠 (壓繭膚選憲廠遞淵鬱鏇, 鏇餘夢選鏇鹹遞鏇簾鬱 ~ 艱構膚簾範鑰繭願獵齋) 更多 |
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