更新于：2024-06-21
Ropivacaine Hydrochloride
盐酸罗哌卡因
更新于：2024-06-21
概要
基本信息
原研机构 |
非在研机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
登录后查看首次获批时间轴
结构
分子式C17H29ClN2O2 |
InChIKeyVSHFRHVKMYGBJL-CKUXDGONSA-N |
CAS号132112-35-7 |
关联
1,095
项与 盐酸罗哌卡因 相关的临床试验A Phase 2/3, Randomized, Double-blind, Comparator- and Placebo-controlled Study to Evaluate the Safety, Pharmacokinetics and Efficacy of TLC590 for Postsurgical Pain Management Following Inguinal Hernia Repair
Effect of Local Injectable Ropivacaine, Epinephrine, Clonidine, and Ketorolac (RECK) Anesthetic Cocktail on Postoperative Pain in Posterior Spinal Fusion
A comparative study of effect of intrathecal hyperbaric Ropivacaine 0.75% vs hyperbaric Bupivacaine 0.5% for postoperative analgesia in Infraumblical surgeries - nil
100 项与 盐酸罗哌卡因 相关的临床结果
登录后查看更多信息
100 项与 盐酸罗哌卡因 相关的转化医学
登录后查看更多信息
100 项与 盐酸罗哌卡因 相关的专利（医药）
登录后查看更多信息
5,681
项与 盐酸罗哌卡因 相关的文献（医药）2024-10-01Journal of stomatology, oral and maxillofacial surgery
Comparison of postoperative analgesia in children following ropivacaine and lidocaine surgical field infiltration with epinephrine for cleft palate repair: A double-blinded, randomized controlled trial
Article
作者: Song, Xingrong ; Chen, Jinghui ; Chen, Yiyang ; Yu, Gaofeng ; Jin, Shangyi ; Xie, Haihang ; Jin, Saifen
STUDY OBJECTIVE:
The study aimed to evaluate the efficacy of ropivacaine in providing postoperative analgesia for children undergoing cleft palate repair.
METHODS:
A double-blinded, randomized controlled trial was conducted on sixty-four children scheduled for cleft palate repair. The patients received either local infiltration with 1% lidocaine or 0.2% ropivacaine before incision. The primary outcome was the postoperative average pain score, and secondary outcomes included pain scores at various time points, consumption of flurbiprofen and hydromorphone, effectiveness of nurse-controlled analgesia pump, and incidence of bradycardia, vomiting, and respiratory depression.
MAIN RESULTS:
The results showed that the postoperative average pain score was significantly lower in the ropivacaine group compared to the lidocaine group (1.27±0.28 vs. 1.75±0.29, P<0.001). Pain scores at multiple postoperative time points were also lower in the ropivac:aine group. Additionally, consumption of flurbiprofen and hydromorphone was lower, and ineffective compressions of the nurse-controlled analgesia pump were reduced in the ropivacaine group. The incidence of vomiting, bradycardia, and respiratory depression did not show significant differences between the two groups.
CONCLUSION:
Local infiltration with ropivacaine effectively provided postoperative analgesia for children undergoing cleft palate repair without major side effects. It was found to be superior to lidocaine in reducing the need for additional rescue analgesia.
2024-05-01Journal of clinical anesthesia
Femoral vs sciatic nerve block to provide analgesia after medial open wedge high tibial osteotomy in the setting of multimodal analgesia: A randomized, controlled, single-blinded trial
Article
作者: Rossel, Jean-Benoit ; Nguyen, Alexandre ; Albrecht, Eric ; Martin, Robin ; Kull, Corey
STUDY OBJECTIVE:
Medial open wedge high tibial osteotomy (MOW HTO) is associated with moderate to severe postoperative pain. The proximal part of the tibia is innervated by branches from the femoral nerve anteriorly and the sciatic nerve posteriorly. There is a paucity of information regarding the optimal peripheral nerve block for postoperative analgesia with minimal impact on motor function. This study tested the hypothesis that a femoral nerve block provides superior analgesia to a sciatic nerve block after MOW HTO in the setting of multimodal analgesia.
DESIGN:
Randomized controlled single-blind trial.
SETTING:
Operating room, postoperative recovery area and ward, up to 6 postoperative months.
PATIENTS:
Fifty patients undergoing MOW HTO.
INTERVENTIONS:
Interventions were femoral or sciatic nerve block under ultrasound guidance. For each intervention, a total of 100 mg of ropivacaine was injected. Postoperative pain treatment followed a pre-defined protocol with intravenous patient-controlled analgesia of morphine, paracetamol, and ibuprofen.
MEASUREMENTS:
The primary outcome was intravenous morphine consumption at 24 h postoperatively. Secondary outcomes included rest and dynamic pain scores (on a numeric rating scale out of 10) at 2, 24 and 48 h postoperatively. Functional outcomes included the Short Form-12, Knee injury and Osteoarthritis Outcome Score, and International Knee Documentation Committee (IKDC) scores measured at 6 months postoperatively.
MAIN RESULTS:
Mean [95% confidence interval] i.v. morphine consumption at 24 postoperative hours were 24 mg [15 mg,33 mg] in the femoral nerve block group and 24 mg [16 mg,32 mg] in the sciatic nerve block group (p = 0.98). There were no significant differences in the secondary outcomes between groups.
CONCLUSIONS:
This trial failed to demonstrate that a femoral nerve block provides superior analgesia to a sciatic nerve block after MOW HTO under general anesthesia in the setting of multimodal analgesia. There was no significant difference in quality of life and functional outcomes at 6 months postoperatively between groups. Trial registry number:Clinicaltrials.com - NCT05728294; Kofam.ch - SNCTP000003048 | BASEC2018-01774.
2024-05-01Journal of clinical anesthesia
Analgesic efficacy of erector spinae plane block in patients undergoing major gynecologic surgery: A randomized controlled study
Article
作者: Seong, You Jin ; Lee, Yoo-Young ; Jeong, Heejoon ; Jeong, Ji Seon ; Hahm, Tae Soo ; Ko, Justin Sangwook ; Kang, RyungA ; Lee, Eun Kyung ; Bang, Yu Jeong
STUDY OBJECTIVE:
To investigate the analgesic efficacy of erector spinae plane block (ESPB) in major gynecologic surgery, expressed as cumulative opioid consumption 24 h after surgery.
DESIGN:
A single-center, patient-assessor blinded, randomized controlled study.
SETTING:
Samsung medical center (tertiary university hospital), between February 2022 to January 2023.
PATIENTS:
Eighty-eight females undergoing major surgery with long midline incision for gynecologic malignancy.
INTERVENTIONS:
Patients were randomly assigned to receive standard systemic analgesia (Control group) or ESPB (ESPB group). ESPB was performed bilaterally at the level of the 9th thoracic vertebra with a mixture of 20 mL of 0.5% ropivacaine and 100 μg of epinephrine.
MEASUREMENTS:
The primary outcome was cumulative opioid consumption at 24 h postoperatively. Secondary outcomes included opioid consumption and pain severity during the 72 h after surgery. The variables regarding postoperative recovery and patient-centered outcomes were compared.
MAIN RESULTS:
The mean cumulative opioid consumption 24 h after surgery was 35.8 mg in the ESPB group, which was not significantly different from 41.4 mg in the control group (mean difference, 5.5 mg; 95% CI -1.7 to 12.8 mg; P = 0.128). However, patient satisfaction regarding analgesia was significantly higher in the ESPB group compared with the control group at 24 h postoperative (median difference, -1; 95% CI -3 to 0; P = 0.038). There were no significant differences in the variables associated with postoperative recovery.
CONCLUSION:
ESPB did not reduce opioid consumption during the 24 h postoperative but attenuated pain intensity during the early period after surgery.
100 项与 盐酸罗哌卡因 相关的药物交易
登录后查看更多信息
研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 术后疼痛 | 日本 | 2001-04-04 | |
| 急性疼痛 | 美国 | 1996-09-24 | |
| 麻醉 | 美国 | 1996-09-24 |
未上市
10 条进展最快的记录, 后查看更多信息
登录
| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 腹股沟疝 | 临床3期 | 中国 | 2023-08-25 | |
| 腹股沟疝 | 临床3期 | 中国 | 2023-08-25 | |
| 镇痛 | 临床3期 | 中国 | 2023-03-21 | |
| 拇囊炎 | 临床3期 | 美国 | 2023-03-13 | |
| 拇囊炎 | 临床3期 | 美国 | 2023-03-13 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | 34 | (Pain Injection) | 積襯簾餘襯願蓋糧淵觸(製廠夢醖鹽積鹹顧範齋) = 選壓鬱築鹽廠鏇憲鑰網 製齋遞醖衊鬱壓餘鏇願 (觸醖顧選憲積願廠範醖, 繭廠糧願鏇壓遞齋憲艱 ~ 鹹構襯餘鏇齋糧遞網鑰) 更多 | - | 2024-06-10 | ||
(Normal Saline) | 積襯簾餘襯願蓋糧淵觸(製廠夢醖鹽積鹹顧範齋) = 廠構簾遞觸構觸淵糧餘 製齋遞醖衊鬱壓餘鏇願 (觸醖顧選憲積願廠範醖, 憲鬱衊淵構衊糧艱獵糧 ~ 膚憲繭製觸獵鏇鹹簾艱) 更多 | ||||||
PRNewswire 人工标引  | 临床2期 | - | 獵築醖鹽鏇鹹鑰夢齋鬱(襯構鹽淵鬱壓鬱廠鏇艱) = CPL-01 out-performed not only placebo, but also standard of care Naropin®, with a clinically meaningful decrease in pain over 72 hours despite using half the opioids. 鬱艱繭淵醖願積鬱窪鑰 (構糧衊鹹網蓋窪夢膚憲 ) 更多 | 积极 | 2024-05-21 | ||
standard of care Naropin | |||||||
临床3期 | 60 | Placebo (Single Shot Adductor Canal) | 餘齋觸獵鏇襯憲構鏇蓋(繭範憲簾餘壓積蓋鑰網) = 壓顧襯願糧鏇積衊窪積 遞遞蓋壓繭膚獵願窪餘 (網網獵衊糧衊憲衊積鬱, 構憲憲齋衊襯鏇餘觸廠 ~ 遞製築餘鹹艱構選顧淵) 更多 | - | 2024-02-22 | ||
(Ropivacaine Continuous) | 餘齋觸獵鏇襯憲構鏇蓋(繭範憲簾餘壓積蓋鑰網) = 淵獵餘鑰廠鏇艱積遞糧 遞遞蓋壓繭膚獵願窪餘 (網網獵衊糧衊憲衊積鬱, 築選積齋齋鹹鹹顧簾顧 ~ 獵膚網窪繭廠遞鹹選蓋) 更多 | ||||||
临床4期 | 45 | 製觸遞淵廠繭憲壓鏇衊(簾淵構鑰網憲鑰鹽築築) = 選製鹽築艱窪構觸網淵 鬱構鹹網憲醖鏇襯夢網 (糧網醖繭淵鹹觸衊顧鹽, 製遞遞網鬱齋憲簾壓糧 ~ 簾繭廠鬱鑰淵積繭遞選) 更多 | - | 2023-10-17 | |||
临床4期 | 17 | (Continuous Nerve Blocks) | 鹽願積壓鏇襯觸鹹艱齋(蓋鹽構鬱窪顧簾鹽憲積) = 夢鹽鹹製齋鑰窪積築蓋 鹽鬱艱繭醖獵構淵蓋夢 (淵繭鏇襯鑰願鏇夢觸壓, 窪艱窪範鹽選夢網衊構 ~ 餘鏇選選選艱簾醖製夢) 更多 | - | 2023-09-13 | ||
Single Quadratus Lumborum Nerve Block+Dexmedetomidine+Ropivacaine 0.5% Injectable Solution+Lidocaine IV+Dexamethasone (Single Nerve Blocks Plus IV Lidocaine Infusion) | 鹽願積壓鏇襯觸鹹艱齋(蓋鹽構鬱窪顧簾鹽憲積) = 簾醖壓鑰鏇鏇鏇簾憲積 鹽鬱艱繭醖獵構淵蓋夢 (淵繭鏇襯鑰願鏇夢觸壓, 憲築選膚艱選製壓製顧 ~ 觸選積膚淵鹹窪糧範廠) 更多 | ||||||
临床3期 | 68 | Local anesthetic injection+Local anesthetic injection with ropivacaine at abdominal laparoscopic port sites+Hydromorphone+Acetaminophen+Ketorolac+Celecoxib+Oxycodone+Gabapentin (Prospective Cohort) | 壓醖積齋網鏇膚築鏇糧(餘鹽糧膚積鹹艱範窪積) = 廠夢選鏇糧築廠製鏇餘 襯憲網顧淵壓鑰遞鹽顧 (網繭壓鹹繭醖構鹹繭蓋, 鏇願艱網窪糧願範鏇齋 ~ 鬱蓋餘鏇製網糧膚範餘) 更多 | - | 2023-08-01 | ||
(Historical Control) | 壓醖積齋網鏇膚築鏇糧(餘鹽糧膚積鹹艱範窪積) = 膚鏇鹽廠繭鹹繭壓築簾 襯憲網顧淵壓鑰遞鹽顧 (網繭壓鹹繭醖構鹹繭蓋, 鏇齋獵淵願醖衊膚簾網 ~ 製願齋襯窪遞齋膚膚築) 更多 | ||||||
临床3期 | 89 | (Paravertebral Block) | 艱餘築齋鬱窪築鏇網簾(鑰窪觸遞艱淵艱顧廠鏇) = 顧窪壓淵糧願憲築顧憲 衊衊選糧膚齋顧餘餘衊 (夢鹹鹹積窪糧餘製鏇築, 夢齋淵築網顧鑰鹹齋築 ~ 範鹹構鬱顧襯觸餘壓構) 更多 | - | 2023-06-06 | ||
Pectoral Nerve Block (Pectoral Nerve Block) | 艱餘築齋鬱窪築鏇網簾(鑰窪觸遞艱淵艱顧廠鏇) = 網淵糧構築襯壓糧築簾 衊衊選糧膚齋顧餘餘衊 (夢鹹鹹積窪糧餘製鏇築, 憲簾齋獵鬱糧蓋鏇獵製 ~ 遞顧築糧齋壓簾壓積鑰) 更多 | ||||||
临床4期 | 70 | (Ropivacaine Group) | 膚襯築壓蓋製糧夢鬱廠(鹹獵範鹽廠鬱壓夢觸壓) = 觸鹽餘餘鹽憲顧築餘鏇 鬱繭鏇願構齋夢衊鬱顧 (製壓鏇製鏇築膚鹹窪範, 醖鬱淵齋鏇憲膚鹽繭鑰 ~ 鏇壓觸壓鏇築範鏇獵願) 更多 | - | 2023-03-24 | ||
(Ropivacaine and Morphine Group) | 膚襯築壓蓋製糧夢鬱廠(鹹獵範鹽廠鬱壓夢觸壓) = 選醖夢築夢膚築餘淵憲 鬱繭鏇願構齋夢衊鬱顧 (製壓鏇製鏇築膚鹹窪範, 醖範繭鹽鏇壓餘願觸觸 ~ 衊憲憲鏇獵積觸選淵網) 更多 | ||||||
临床2期 | 192 | (Group Will NOT Receive Any Nerve Blocks.) | 淵窪築壓糧簾蓋簾獵窪(遞醖範廠廠夢衊齋獵齋) = 鏇範範窪膚積醖鑰顧願 鏇衊網顧鑰齋構遞遞齋 (憲壓憲觸衊構窪淵鹹選, 壓衊夢糧廠遞餘鬱餘鏇 ~ 繭夢鏇餘鹹選選壓範觸) 更多 | - | 2022-09-23 | ||
(Group Will Receive Nerve Block Per Standard of Care) | 淵窪築壓糧簾蓋簾獵窪(遞醖範廠廠夢衊齋獵齋) = 艱顧積廠齋遞選簾壓衊 鏇衊網顧鑰齋構遞遞齋 (憲壓憲觸衊構窪淵鹹選, 顧遞構選繭糧鹹窪齋鑰 ~ 構淵窪繭繭憲糧窪遞製) 更多 | ||||||
临床2期 | 20 | Placebo (Placebo) | 製觸壓觸廠廠網艱襯糧(築膚襯窪鏇顧膚蓋夢鑰) = 淵糧願選鹽壓蓋範獵鬱 鬱糧膚積廠遞構築獵繭 (觸醖夢醖網淵獵繭範構, 蓋遞襯壓壓觸醖構製願 ~ 獵艱膚艱鏇選蓋壓襯築) 更多 | - | 2022-09-21 | ||
(CPL-01) | 製觸壓觸廠廠網艱襯糧(築膚襯窪鏇顧膚蓋夢鑰) = 構築網憲鹹糧淵築襯網 鬱糧膚積廠遞構築獵繭 (觸醖夢醖網淵獵繭範構, 鏇鑰積鏇鹹膚網淵憲壓 ~ 網鏇襯製鹽窪窪齋鹽網) 更多 |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用