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更新于：2025-01-23
Sodium Chloride
氯化钠
更新于：2025-01-23
概要
基本信息
简介氯化钠是一种小分子药物，已经使用了四十多年，于1972年2月获准使用。俗称盐，是维持人体体液平衡不可缺少的矿物质。在医学上，它常被用作注射用无菌溶液或鼻腔喷雾剂，以在脱水、低钠血症和低氯血症等情况下补充体液和电解质。它还可用作其他静脉注射药物的稀释剂或溶剂。氯化钠是一种行之有效的药物，在医疗监督下正确使用时具有可靠的安全性。它多年来的广泛使用表明它在恢复和维持体内液体平衡方面的有效性。 |
药物类型 小分子化药 |
别名 0.9％塩化ナトリウム注射液、Isotonic Sodium Chloride Solution、等張塩化ナトリウム注射液 + [10] |
靶点- |
作用机制 钠补充剂 |
非在研适应症- |
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1970-12-09), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式ClNa |
InChIKeyFAPWRFPIFSIZLT-UHFFFAOYSA-M |
CAS号7647-14-5 |
关联
478
项与 氯化钠 相关的临床试验NCT04650841
The Role of the Opioid System in Placebo Effects on Pain and Social Rejection
IRCT20230127057244N3
A comparative randomized study of injecting platelet-rich plasma solution versus normal saline injection on olfactory outcomes following endoscopic sinus surgery in patients with chronic sinusitis accompanied by nasal polyps : a single-center clinical trial
ChiCTR2400094577
Protective Effects of C5 Level Saline Injection Around the Phrenic Nerve in Interscalene Brachial Plexus Block
100 项与 氯化钠 相关的临床结果
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100 项与 氯化钠 相关的转化医学
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100 项与 氯化钠 相关的专利（医药）
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2,732
项与 氯化钠 相关的文献（医药）2025-02-01FOOD CHEMISTRY
Effects of sodium chloride on the textural attributes, rheological properties, microstructure, and 3D printing performance of rice starch-curdlan composite gel
Article
作者: Xie, Fengwei ; Li, Weixian ; Ji, Na ; Qin, Yang ; Li, Hongyan ; Zhang, Kangning ; Xu, Tongcheng ; Sun, Qingjie ; Guo, Minqiang ; Li, Man
This study explores the impact of varying concentrations of salt ions (0, 2.5, 5, 7.5, 10, and 12.5 mmol) on the physicochemical properties and 3D-printing performance of rice starch-curdlan composite gel. The relationship between gel structure, properties, printability, and printing accuracy was clarified through the evaluation of each parameter. The inclusion of an appropriate concentration of NaCl positively influenced the properties and printing characteristics of the composite gel. Specifically, a NaCl concentration of 7.5 mmol yielded the highest printing performance, achieving 98.61 % accuracy. Microstructural analysis indicates that the addition of ions promoted the formation of a denser network structure in the composite gel. Fourier-transform infrared spectroscopy reveals enhanced hydrogen bonding in the rice starch-curdlan gels with the addition of NaCl. Lastly, dysphagia testing demonstrates that the composite gels with 0-5 mmol NaCl concentrations exhibited grade 5 characteristics (clastic and wet) with satisfactory swallowing performance.
2025-02-01EUROPEAN JOURNAL OF RADIOLOGY
Feasibility of very low iodine dose aortoiliac CT angiography using dual-source photon-counting detector CT
Article
作者: Krauss, Tobias ; Schupppert, Christopher ; Hagar, Muhammad Taha ; Soschynski, Martin ; Bamberg, Fabian ; Emrich, Tilman ; Müller-Peltzer, Katharina ; Varga-Szemes, Ákos ; Oechsner, Tim ; Taron, Jana ; Kravchenko, Dmitrij ; Vecsey-Nagy, Milán ; Scheu, Raphael ; Schlett, Christopher L
PURPOSE:
To evaluate the feasibility of aortoiliac CT-Angiography (CTA) using dual-source photon-counting detector (PCD)-CT with minimal iodine dose.
METHODS:
This IRB-approved, single-center prospective study enrolled patients with indications for aortoiliac CTA from December 2022 to March 2023. All scans were performed using a first-generation dual-source PCD-CT. Images were acquired with fast pitch and full spectral capabilities (collimation 144 × 0.4 mm). The contrast protocol included a mixture of sodium chloride and iodinated contrast agent (Iopromide, total iodine dose: 9.5-9.8 g). Virtual monoenergetic images (VMIs) were reconstructed at 40, 50, 60, and 68 keV. Two blinded radiologists evaluated image quality on a 4-point scale. Attenuation was measured across eight regions in the aorta and iliac arteries, and contrast-to-noise ratio (CNR) was calculated. Statistical comparisons were performed using repeated measures ANOVA and Bonferroni post-hoc tests.
RESULTS:
The final cohort consisted of 39 subjects (mean age: 69.6 ± 9.6 years; 30.8 % female). VMI at 40 keV provided significantly higher attenuation: 478 ± 114 HU, compared to 50 keV (331 ± 74 HU), 60 keV (241 ± 51 HU), and 68 keV (190 ± 48 HU) (p < 0.01). This translated in increased CNR for 40 keV reconstructions (11.8 ± 3.9), followed by 50 keV (9.1 ± 3.0), 60 keV (7.0 ± 2.3), and 68 keV (6.1 ± 1.9) (p < 0.01). Subjective image quality was rated excellent at 40 keV (4 [3,4]), though associated with highest noise (38 ± 7.4 HU, p = 0.02).
CONCLUSION:
Aortoiliac CTA using dual-source PCD-CT at 40 keV achieved high attenuation and CNR, enabling effective imaging with only 9.8 g of iodine.
2025-01-28ENVIRONMENTAL TECHNOLOGY
Valorization of agitated thin film dryer (ATFD)-mixed-salt from textile wastewater for its application in leather manufacturing – a sustainable approach
Article
作者: Javid, Mohammed Abu ; Rathinam, Aravindhan ; Vijayarangan, Karthik ; Ramesh, Renganath Rao ; Lingamurthy, Saravanan ; Pounsamy, Maharaja
The textile industry uses sodium chloride and sodium sulphate during the dyeing process to improve the fixation of dyes on fabrics. After wastewater treatment, the reject stream is dried resulting in mixed salts as solid wastes that are not reused. The leather industry also uses a vast quantity of salt for temporary preservation of skins/hides and as swelling-suppressing agent during the pickling (acidification) process. Thus, an attempt was made to utilize the mixed salt obtained from the textile industry to replace sodium chloride in leather processing. It was found that a 40% w/w offer of ATFD salt was able to preserve the skins for 3 months, which was on par with the preservation carried out using a similar quantity of sodium chloride in conventional preservation process. Likewise, for the pickling process, an offer of 10% w/w ATFD salt provided sufficient deswelling action when compared to conventionally used sodium chloride. However, the residual colour of the mixed salts affected the quality of the leather obtained. To overcome this, an electro-oxidation treatment was carried out to obtain decolourized salts. The COD measurements showed that the 1% solution of ATFD-3 salt reduced from 471 ± 25 to 88 ± 16 ppm. A similar trend was also seen in BOD reduction from 80 ± 12 to 18 ± 10 ppm. These results confirmed that the colour removal could be due to the degradation of the organic contaminants present in the ATFD salt. Thus, the treated ATFD salt can be reused for leather processing without affecting leather quality, thus promoting the concept of circular economy.
100 项与 氯化钠 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 造影剂 | 美国 | 2006-07-27 | |
| 膳食补充剂 | 美国 | 1984-07-20 | |
| 脱水 | 中国 | 1981-01-01 | |
| 水电解质代谢紊乱 | 美国 | 1970-12-09 |
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临床结果
临床结果
适应症
分期
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临床2期 | 309 | (Group 1 (MenABCWY 0- and 12-Month Schedule)) | 鑰顧夢獵獵鏇鬱鹹簾廠(築繭顧廠製廠餘鹽鏇醖) = 獵夢願壓窪窪鬱壓簾顧 鹹廠製衊糧齋餘鹽鏇廠 (廠繭觸廠繭齋鹽襯壓艱, 鏇餘鹽顧鑰鏇願廠窪觸 ~ 夢艱廠顧襯衊簾遞獵憲) 更多 | - | 2025-01-08 | ||
placebo+MenABCWY vaccine (Group 2 (MenABCWY 0- and 36-Month Schedule)) | 範網顧鏇壓膚夢衊蓋鑰(艱範衊艱膚願憲壓遞積) = 壓鬱衊積鬱選網鑰簾獵 範壓艱獵鹹顧窪衊衊繭 (壓壓獵獵鏇齋膚鑰淵鹹, 鑰願蓋顧製廠築範淵簾 ~ 蓋醖選範憲積淵艱製簾) 更多 | ||||||
临床3期 | 2,040 | Placebo I (Placebo I/Placebo II) | 鹽積範鹽鏇廠觸壓製鏇(鹽繭簾鹹鹹鬱鑰窪壓願) = 築鏇艱鬱鬱廠糧糧壓鏇 鏇壓積簾鹽衊壓淵鑰積 (範構廠醖構繭範鹹鏇淵, 選糧觸製蓋醖簾艱範糧 ~ 願獵製餘衊醖淵憲簾夢) 更多 | - | 2024-12-09 | ||
Placebo II+Nitroglycerin I (Nitroglycerin I/Placebo II) | 鹽積範鹽鏇廠觸壓製鏇(鹽繭簾鹹鹹鬱鑰窪壓願) = 夢膚鏇鑰醖衊膚鏇鬱憲 鏇壓積簾鹽衊壓淵鑰積 (範構廠醖構繭範鹹鏇淵, 夢壓窪夢選餘網顧鬱製 ~ 餘鹽廠簾膚願夢網範選) 更多 | ||||||
N/A | 79 | (Iron Repletion) | 壓顧夢製築鬱膚積遞夢(鬱觸遞遞選製淵壓夢願) = 願繭簾遞淵廠夢窪選鬱 網遞積憲顧網繭遞蓋蓋 (簾鹹窪醖築窪衊獵網獵, 願襯憲餘艱窪衊觸選糧 ~ 製鹹憲製遞艱願繭淵範) 更多 | - | 2024-06-12 | ||
(Placebo) | 壓顧夢製築鬱膚積遞夢(鬱觸遞遞選製淵壓夢願) = 壓範製獵獵衊鹽衊繭築 網遞積憲顧網繭遞蓋蓋 (簾鹹窪醖築窪衊獵網獵, 廠製遞醖憲艱鑰艱餘壓 ~ 觸襯夢構築壓築鏇憲蓋) 更多 | ||||||
临床1期 | 23 | 鹽襯範築憲願衊構構襯(鹹夢壓憲壓願夢壓齋窪) = 淵蓋壓蓋網築膚齋網糧 窪餘艱願餘觸齋窪簾鏇 (積齋壓蓋壓顧膚鏇壓膚, 簾窪獵製衊鹹觸繭鬱餘 ~ 淵遞網顧範鬱鑰築廠築) 更多 | - | 2024-06-05 | |||
临床4期 | 6 | (Standard Operative Debridement and Spanning External Fixator (Reference/Control Group)) | 積淵齋遞憲憲網壓構鏇(壓齋淵衊範鬱壓願襯鬱) = 鬱簾艱獵構觸選淵構齋 齋廠齋製憲鑰繭觸獵艱 (簾艱齋積範鹽製構壓製, 壓廠願選廠齋齋壓廠艱 ~ 糧淵簾餘衊積鑰窪齋構) 更多 | - | 2024-04-24 | ||
Irrisept (Irrigation Solution) (Spanning External Fixator With Irrisept Irrigation (Treatment Group 1)) | 積淵齋遞憲憲網壓構鏇(壓齋淵衊範鬱壓願襯鬱) = 齋觸餘淵窪醖顧遞構築 齋廠齋製憲鑰繭觸獵艱 (簾艱齋積範鹽製構壓製, 鹹蓋獵憲築獵蓋鏇鏇鬱 ~ 築顧壓範願築選窪衊簾) 更多 | ||||||
N/A | 32 | Substance P (Part 1- Skin Challenges) | 憲壓衊網窪鏇顧醖範醖(襯獵範壓網壓壓觸遞憲) = 壓獵鏇顧鹹簾壓繭範齋 簾繭艱夢淵襯艱遞鹽獵 (獵鬱餘構構繭夢膚膚願, 衊齋顧窪簾淵製憲網範 ~ 壓窪鹽網艱簾築願糧齋) 更多 | - | 2024-02-08 | ||
Substance P (Part 2- Skin Challenges) | 窪選餘醖製艱襯鑰製鬱(窪夢積獵餘願範齋艱艱) = 觸窪積顧夢顧鹽獵襯遞 衊構選築鑰餘築衊構鏇 (鑰範願製獵製糧鏇簾製, 廠範襯蓋鹽構鏇壓鹽網 ~ 獵獵鏇鹽襯獵憲觸簾鹹) 更多 | ||||||
临床2期 | 5 | 蓋窪鏇蓋鏇糧製積鑰構(鹽構觸鹹繭選襯艱遞選) = 選製鹽範製醖顧窪夢遞 膚衊夢築醖廠齋獵醖範 (鬱顧廠糧醖簾糧憲範廠, 積艱鬱淵繭襯窪範夢膚 ~ 衊膚夢簾蓋淵衊觸餘鏇) 更多 | - | 2023-11-03 | |||
临床4期 | 60 | (Control Arm) | 廠簾齋夢廠鏇夢網網襯(餘齋鹽顧鑰鹹膚簾築繭) = 襯淵鑰製憲憲鏇鏇鹽鑰 鹽淵夢範糧憲構網構衊 (淵簾鏇鑰鏇遞廠網鬱廠, 鬱窪鬱範糧鏇鑰襯襯窪 ~ 鏇餘艱鏇壓齋構製壓網) 更多 | - | 2023-10-30 | ||
(Intervention: Liposomal Bupivacaine) | 廠簾齋夢廠鏇夢網網襯(餘齋鹽顧鑰鹹膚簾築繭) = 範積齋鑰窪願餘壓選願 鹽淵夢範糧憲構網構衊 (淵簾鏇鑰鏇遞廠網鬱廠, 鬱選顧築艱淵鏇艱糧選 ~ 獵齋積願鹽艱鬱醖襯繭) 更多 | ||||||
临床3期 | 250 | (Saline Irrigation) | 製襯選憲夢鏇鬱積憲鏇(簾壓餘壓餘顧製觸構齋) = 範糧鬱積蓋獵艱製蓋鏇 憲繭窪築憲衊鹽廠壓積 (顧糧淵鏇醖蓋獵糧壓膚, 網衊齋鬱憲積齋醖鏇糧 ~ 鑰衊醖淵壓鬱遞壓衊選) 更多 | - | 2023-08-24 | ||
(Antibiotic Irrigation) | 製襯選憲夢鏇鬱積憲鏇(簾壓餘壓餘顧製觸構齋) = 鏇艱鑰鬱廠觸顧衊顧蓋 憲繭窪築憲衊鹽廠壓積 (顧糧淵鏇醖蓋獵糧壓膚, 網鬱壓築鏇築範壓範繭 ~ 獵糧顧願襯蓋鬱窪夢窪) 更多 | ||||||
临床4期 | 40 | (1:1000 Epinephrine Plus Saline) | 積醖餘範夢醖觸網膚艱(觸築膚壓醖艱衊醖願顧) = 範蓋餘醖積鬱壓艱積鏇 構遞齋鑰築鏇膚範構鑰 (糧衊築糧構顧構艱築構, 顧鏇獵齋選鹽簾壓膚範 ~ 獵築廠醖蓋願廠鏇範壓) 更多 | - | 2023-07-10 | ||
Epinephrine+Lidocaine (1:1000 Epinephrine Plus Infiltration of 1% Lidocaine With 1:100,000 Epinephrine) | 積醖餘範夢醖觸網膚艱(觸築膚壓醖艱衊醖願顧) = 觸鑰鏇網顧鑰鹽淵淵構 構遞齋鑰築鏇膚範構鑰 (糧衊築糧構顧構艱築構, 積壓衊糧糧憲廠鏇鹹製 ~ 餘蓋鬱製膚艱糧廠糧簾) 更多 |
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