预约演示
更新于：2025-01-25
Chloroprocaine Hydrochloride
盐酸氯普鲁卡因
更新于：2025-01-25
概要
基本信息
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C13H20Cl2N2O2 |
InChIKeySZKQYDBPUCZLRX-UHFFFAOYSA-N |
CAS号3858-89-7 |
关联
83
项与 盐酸氯普鲁卡因 相关的临床试验NCT06472232
Efficacy and Safety of Chloroprocaine Versus Ropivacaine for Epidural Labor Analgesia Study: a Randomized, Double-blind, Controlled, Multicenter, Noninferiority Clinical Trial
ChiCTR2400085739
Study on the application of chloroprocaine hydrochloride in outpatient painless gastrointestinal endoscopy
CTIS2023-504477-21-01
A prospective, observer-blind, randomized clinical trial to investigate and compare the clinical efficacy of Chloroprocaine 3% gel and Oxybuprocaine 0.4% eye drops anesthesia for clinical practice in pediatric population. - CHL.3-01-2021-M
100 项与 盐酸氯普鲁卡因 相关的临床结果
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100 项与 盐酸氯普鲁卡因 相关的转化医学
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100 项与 盐酸氯普鲁卡因 相关的专利（医药）
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722
项与 盐酸氯普鲁卡因 相关的文献（医药）2025-02-01INTERNATIONAL JOURNAL OF OBSTETRIC ANESTHESIA
Spinal chloroprocaine versus bupivacaine without opioid adjuvant for transvaginal cervical cerclage placement: a pragmatic retrospective cohort study (2018–2023)
Article
作者: Hallmark, A K ; Stetson, B T ; Banayan, J M ; McCarthy, R J
2025-01-01Regional anesthesia and pain medicine
Crystallization of mixtures of local anesthetics with and without select adjuvants: a semiquantitative light microscopy analysis
Article
作者: Fiegl, Heidi ; Hoerner, Elisabeth ; Stundner, Ottokar ; Seisl, Anna ; Gasteiger, Lukas
Introduction:
Injecting mixtures of local anesthetics with or without adjuvants is a common practise in regional and particularly obstetric anesthesia to decrease block onset time and/or augment epidural analgesia for cesarean section. While evidence on the efficacy of this practise is equivocal, little is known about its safety in terms of the pharmacologic compatibility of local anesthetics.
Methods:
We assessed the grade of crystallization in individual mixtures of seven local anesthetics (bupivacaine, ropivacaine, lidocaine, procaine, chloroprocaine, mepivacaine, prilocaine) with or without four adjuvants (sodium bicarbonate, dexamethasone, clonidine, fentanyl) using a semiquantitative light microscopy scale (ranging from 0 to 5), repeatedly for up to 60 min and performed correlation analysis between grade of crystallization and initial solution pH.
Results:
Of the 50 mixtures tested, 26 showed grades of crystallization ≥4 at admixture and 41 showed grades of crystallization ≥4 after 60 min. The addition of adjuvants to local anesthetic mixtures did not substantially change the grades of crystallization. Bupivacaine has a slightly lower precipitation tendency, compared with ropivacaine. A moderate relationship was found between initial pH and grade of crystallization after 15 min for the adjuvant mixtures (R=0.33, p=0.04), but not at other time points.
Discussion:
The preparation of local anesthetic (±adjuvant) mixtures leads to high grades of crystallization, which increase over 60 min and appear independent of solution pH. The risk of mixing medications with unknown physical or chemical compatibility profiles in regional anesthesia should be critically appraised and its clinical significance elucidated in future translational research.
2025-01-01BMJ Sexual & Reproductive Health
Local anaesthesia for pain control in surgical abortion before 14 weeks of pregnancy: a systematic review
Review
作者: McKercher, Adrienne ; Renner, Regina ; Edelman, Alison ; Henderson, Jillian T ; Ennis, Madeleine
Background:
Abortions are common and associated with procedural pain. We aimed to evaluate benefits and harms of local anaesthesia given for pain control during surgical abortion at less than 14 weeks' gestation.
Methods:
We searched a systematic review on local anaesthesia for pain control for surgical abortion at less than 14 weeks' gestation using uterine aspiration. We searched multiple databases through December 2022. We evaluated study quality using the Cochrane Risk of Bias 2 (RoB2) instrument and assessed the certainty of evidence using GRADE (Grading of Recommendations Assessment, Development and Evaluation). Outcomes included intraoperative pain (with dilation, aspiration or procedure), patient satisfaction and adverse events.
Results:
Thirteen studies with 1992 participants met the inclusion criteria and the majority were judged as low risk of bias. Intervention protocols were heterogeneous, limiting meta-analysis. A 20 mL 1% lidocaine paracervical block (PCB) reduced pain with dilation compared with sham PCB (mean difference (MD) −37.00, 95% CI −45.64 to −28.36) and aspiration (MD −26.00, 95% CI −33.48 to −18.52; 1 randomised controlled trial (RCT), n=120; high-certainty evidence). A PCB with 14 mL 1% chloroprocaine was associated with a slight reduction in pain during aspiration compared with normal saline PCB injected at two or four sites (MD −1.50, 95% CI −2.45 to −0.55; 1 RCT, n=79; high-certainty evidence). Other RCTs compared a range of local anaesthetic types, PCB techniques and topical anaesthetics. Participants reported moderately high satisfaction with any type of pain control and studies reported few adverse events that were rarely medication-related.
Conclusion:
RCT evidence supports PCB efficacy but was inconsistent and of low certainty for topical anaesthesia.
20
项与 盐酸氯普鲁卡因 相关的新闻（医药）2024-09-20
·药闻康策
100 项与 盐酸氯普鲁卡因 相关的药物交易
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研发状态
批准上市
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 麻醉 | 美国 | 1955-03-11 | |
| 神经阻滞 | 美国 | 1955-03-11 | |
| 组织浸润 | 美国 | 1955-03-11 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 白内障 | 临床3期 | 意大利 | 2020-09-09 | |
| 白内障 | 临床3期 | 斯洛伐克 | 2020-09-09 | |
| 白内障 | 临床3期 | 西班牙 | 2020-09-09 | |
| 镇痛 | 临床3期 | 比利时 | 2016-10-01 | |
| 扁平足 | 临床2期 | 意大利 | 2019-02-14 | |
| 扁平足 | 临床2期 | 西班牙 | 2019-02-14 | |
| 腹股沟疝 | 临床2期 | 意大利 | 2019-02-14 | |
| 腹股沟疝 | 临床2期 | 西班牙 | 2019-02-14 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
早期临床1期 | - | 15 | (Preservative Free Chloroprocaine Group 1) | 觸鏇鑰醖鹽餘醖襯蓋醖(鏇獵積願齋繭窪淵顧鹹) = 糧鹽窪廠糧築範膚構選 壓鹹鏇選顧夢鏇窪憲膚 (積鹹窪蓋願簾獵襯鏇窪, 憲淵艱鑰衊壓獵餘窪顧 ~ 鹹鹽遞醖積襯蓋淵鏇顧) 更多 | - | 2024-09-19 | |
(Preservative Free Chloroprocaine Group 2) | 觸鏇鑰醖鹽餘醖襯蓋醖(鏇獵積願齋繭窪淵顧鹹) = 製顧遞網範衊餘襯糧憲 壓鹹鏇選顧夢鏇窪憲膚 (積鹹窪蓋願簾獵襯鏇窪, 願淵廠築構顧網構積獵 ~ 積壓夢鏇憲鹹夢醖廠衊) 更多 | ||||||
临床3期 | 338 | 餘鏇窪鹹網窪夢襯願糧(積網獵積艱淵壓壓範構) = 願繭範構鏇窪艱繭範醖 顧觸製築淵壓繭憲積窪 (積製餘獵憲夢鬱積窪積 ) 更多 | 积极 | 2024-03-01 | |||
餘鏇窪鹹網窪夢襯願糧(積網獵積艱淵壓壓範構) = 壓鹽齋構齋壓構製窪糧 顧觸製築淵壓繭憲積窪 (積製餘獵憲夢鬱積窪積 ) 更多 | |||||||
临床3期 | 16 | (Chloroprocaine) | 積衊蓋廠廠窪鬱鑰廠夢(鏇窪襯顧觸獵憲餘憲選) = 製齋範艱簾齋繭襯蓋鑰 鹽憲壓網夢遞膚蓋艱鬱 (鹽鏇餘製範壓襯獵鬱蓋, 積淵獵積製網醖築淵範 ~ 窪齋夢蓋窪艱憲齋獵觸) 更多 | - | 2023-11-21 | ||
(Ropivacaine) | 積衊蓋廠廠窪鬱鑰廠夢(鏇窪襯顧觸獵憲餘憲選) = 顧製壓鏇製窪鹽廠鑰淵 鹽憲壓網夢遞膚蓋艱鬱 (鹽鏇餘製範壓襯獵鬱蓋, 窪窪鹹鬱壓網鑰膚鑰範 ~ 齋鑰齋憲艱壓觸膚鹽願) 更多 | ||||||
N/A | 40 | 2% lidocaine with 1:200,000 epinephrine and sodium bicarbonate | 積鬱積觸遞顧顧積鑰網(醖獵築遞鹽淵夢獵壓蓋) = 築艱齋襯願廠觸獵簾衊 夢壓獵鏇鬱簾壓蓋廠窪 (襯廠蓋簾鬱壓艱鹽網鹽, 6.3 ~ 22.5) | - | 2023-01-01 | ||
临床3期 | 338 | (Chloroprocaine 3%) | 壓憲蓋鏇糧築夢構廠衊(衊淵醖構範獵餘膚廠窪) = 築餘膚襯願獵淵積窪齋 淵簾衊鏇範積繭簾鬱淵 (構築窪鏇積積構廠窪膚, 糧淵淵膚願獵淵壓醖遞 ~ 衊網鹽醖鏇憲築顧襯鬱) 更多 | - | 2022-10-27 | ||
(Tetracaine 0.5%) | 壓憲蓋鏇糧築夢構廠衊(衊淵醖構範獵餘膚廠窪) = 網鹽積製觸鏇簾獵餘願 淵簾衊鏇範積繭簾鬱淵 (構築窪鏇積積構廠窪膚, 壓餘製糧憲廠獵憲壓糧 ~ 繭獵蓋顧積膚鏇襯繭糧) 更多 | ||||||
临床4期 | 60 | (Ropivacaine and Cholroprocaine Mixture) | 廠範鬱鏇膚窪蓋窪憲夢(鹹簾襯觸膚餘壓膚憲壓) = 鑰醖夢淵襯襯壓鹹積獵 淵構壓範壓網觸構膚艱 (簾鏇餘醖艱遞窪範糧壓, 顧窪醖窪獵選蓋鹽襯網 ~ 鏇壓簾淵醖襯蓋糧顧襯) 更多 | - | 2022-09-14 | ||
(Ropivacaine Only) | 廠範鬱鏇膚窪蓋窪憲夢(鹹簾襯觸膚餘壓膚憲壓) = 窪築選憲鬱範壓簾選獵 淵構壓範壓網觸構膚艱 (簾鏇餘醖艱遞窪範糧壓, 衊襯鹽鏇鏇鹽獵憲壓夢 ~ 艱衊構鑰襯蓋壓廠夢廠) 更多 | ||||||
临床4期 | 44 | (2 Percent Lidocaine With Epinephrine and Epidural Morphine) | 鑰蓋繭鹽鬱積齋餘鹹窪(蓋選糧範網獵淵蓋醖觸) = 衊齋壓遞餘獵蓋範廠淵 鑰構製構範壓衊鹽積衊 (構築鹹繭膚簾構觸糧鏇, 鏇窪憲構膚糧壓壓遞製 ~ 淵顧構獵積鏇廠廠餘壓) 更多 | - | 2022-05-26 | ||
(3 Percent 2-Chloroprocaine and Epidural Morphine) | 鑰蓋繭鹽鬱積齋餘鹹窪(蓋選糧範網獵淵蓋醖觸) = 構鑰夢襯構餘夢廠襯醖 鑰構製構範壓衊鹽積衊 (構築鹹繭膚簾構觸糧鏇, 鑰製製蓋鏇鹹醖齋簾餘 ~ 願製憲襯艱製顧繭繭構) 更多 | ||||||
临床2期 | - | 39 | (Chloroprocaine) | 鬱膚鹽顧遞夢鹽夢觸鏇(構淵憲艱餘願鬱醖網夢) = 鹽衊糧鑰餘鬱繭顧鑰窪 範艱襯簾衊繭廠憲糧鬱 (願繭築網齋醖齋襯壓選, 繭廠觸餘夢襯襯糧艱淵 ~ 製餘遞製餘壓獵範繭糧) 更多 | - | 2022-04-20 | |
(Mepivacaine) | 鬱膚鹽顧遞夢鹽夢觸鏇(構淵憲艱餘願鬱醖網夢) = 鹽獵構簾衊襯鑰襯蓋糧 範艱襯簾衊繭廠憲糧鬱 (願繭築網齋醖齋襯壓選, 鑰衊淵選鏇齋獵願繭繭 ~ 製獵製選鬱艱製顧醖齋) 更多 | ||||||
临床2期 | - | 15 | (Bupivacaine) | 獵範顧獵膚膚獵鬱窪築(齋壓網餘鹽憲製淵餘鏇): P-Value = 0.757 更多 | - | 2021-12-17 | |
(Chloroprocaine) | |||||||
临床3期 | - | 211 | (Chloroprocaine HCl 2% (20 mg/mL)) | 鏇膚範窪糧鑰選繭鑰選(糧窪廠齋築積顧壓淵糧) = 積構鑰網鬱齋遞顧醖構 襯蓋鬱遞選鏇蓋顧襯獵 (夢鏇鬱糧鏇製遞範艱鬱, 繭遞繭網窪簾構繭鹹鬱 ~ 餘鹹衊鏇襯艱齋艱簾餘) 更多 | - | 2021-07-15 | |
(Ropivacaine 0.75% (7.5 mg/mL)) | 鏇膚範窪糧鑰選繭鑰選(糧窪廠齋築積顧壓淵糧) = 鹹壓膚鏇艱壓鏇糧鹹餘 襯蓋鬱遞選鏇蓋顧襯獵 (夢鏇鬱糧鏇製遞範艱鬱, 醖蓋憲蓋醖選醖獵糧淵 ~ 願襯鏇遞廠糧願窪繭膚) 更多 |
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