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更新于：2025-05-16
Mesna
美司钠
更新于：2025-05-16
概要
基本信息
非在研机构- |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1988-12-30), |
最高研发阶段(中国)- |
特殊审评孤儿药 (美国)、孤儿药 (日本) |
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结构/序列
分子式C2H6NaO3S2 |
InChIKeyPYTISYCTLQTCTM-UHFFFAOYSA-N |
CAS号19767-45-4 |
关联
189
项与 美司钠 相关的临床试验NCT06677710
A Phase 1B Study of IDP-023 g-NK Cells Plus Ocrelizumab in Patients With Refractory Primary and Secondary Progressive Multiple Sclerosis
NCT06847269
CAR T CELL Therapy for Pediatric, Adolescent and Young Adult Patients With CD19-Positive Leukemia: An Investigation of Lymphodepleting Chemotherapy Pharmacokinetics
NCT06942039
A Pilot Study of Intrathecal Topotecan and Maintenance Chemotherapy in the Post-consolidation Setting for the Treatment of High-risk Embryonal Central Nervous System Tumours in Children Less Than 6 Years of Age
100 项与 美司钠 相关的临床结果
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100 项与 美司钠 相关的转化医学
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100 项与 美司钠 相关的专利（医药）
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2,124
项与 美司钠 相关的文献（医药）2025-05-01JOURNAL OF COLLOID AND INTERFACE SCIENCE
A general orthogonal functionalization strategy for tailoring zwitterionic polymers with adjustable isoelectric points
Article
作者: Zhu, Yunqing ; Qiang, Hongru ; Li, Jiahui ; Jiang, Jiayun ; Li, Jianrui
Zwitterionic polymers, bearing a pair of oppositely charged groups in their repeat units, have demonstrated significant promise in both biomedical and engineering fields. Tunability of isoelectric points (IEPs) is of great value for bio-applications as it relates to key properties such as the surface charge reversal behavior, biocompatibility and the affinity to biomacromolecules. However, zwitterionic polymers with adjustable IEPs are difficult to obtain due to the fixed combination of ion pairs such as carboxybetaine-, sulfobetaine- and phosphorylcholine-based structures. To address this issue, we present a general approach to tailor zwitterionic polymers with adjustable IEPs. By developing an orthogonal functionalization strategy with sequence-controlled alternating polyesters, a series of zwitterionic polymers featuring customizable ion pairs were synthesized. This strategy, which involves aza-Michael addition and thiol-ene reaction, enables precise control over the alternating sequence of cations and anions, thereby allowing the generation of customizable ion pairs in each repeat unit. By forming block copolyesters with a hydrophobic polycaprolactone block, these polymers self-assemble into nanoparticles with tunable IEPs (e.g., 6.03, 6.37, and 6.54) and surface-charge-reversal properties, responding to physiological (pH 7.4) and tumor microenvironment (pH 6.5 ∼ 6.9) conditions. Notably, PCL54-b-P(MA-alt-AGE-g-Pip/NAC)9 (PPS3) nanoparticles, with the optimal IEP values, exhibited remarkable efficacy in inhibiting murine melanoma tumors in vivo when loaded with curcumin. This innovative approach holds promise for developing biocompatible and biodegradable drug delivery systems with tailored properties for potential clinical applications.
2025-04-01JOURNAL OF COLLOID AND INTERFACE SCIENCE
Application of partially zwitterionic poly(ionic liquid)s in humidity sensors
Article
作者: Liu, Sen ; Zhang, Tong ; Yu, Yunlong ; Fei, Teng ; Song, Yaping ; Zhang, Wei ; Cui, Yanyu
Polyelectrolytes have shown promise as sensitive material for high-performance humidity sensors in recent years. How to obtain fast recovery and high sensitivity polyelectrolyte humidity sensors is a great challenge. A kind of poly(ionic liquid)s (PILs) humidity sensors modified by zwitterionic polymers (partially zwitterionic PILs, named PZPILs) were prepared in this work. The PZPILs can transform between PILs and zwitterionic polymers in different humidity sensitive processes. In the adsorption process of water molecules, characteristics of PZPILs are similar to those of PILs. When desorbing water molecules, the characteristics of PZPILs trend to those of sulfobetaine (SB) type zwitterionic polymers. This design endowed the humidity sensors high response and fast response/recovery characteristics. The optimized PZPILs sensor shows high response (4862.8) in a wide relative humidity (RH) range of 11 %-95 %, with short response/recovery time (1.0 s/15.0 s) and small humidity hysteresis about 0.6 % RH. The PZPILs shortened the recovery time of the PILs humidity sensors (from 143.4 s to 15.0 s), and improved the response (from 1980.8 to 4862.8).
2025-04-01Toxicology Research
Antioxidant, anti-inflammatory and Uroprotective effects of LAMOTRIGINE Cinnamaldehyde silver complex in cyclophosphamide-induced cystitis.
Article
作者: Sultana, Kishwar ; Bibi, Nadia ; Anjum, Irfan ; Ansari, Mushtaq Ahmad ; Nadeem, Tariq ; Najam, Saima ; Mushtaq, Muhammad Naveed ; Awais, Sophia ; Barkat, Kashif ; Khan, Saira ; Zahra, Syeda Kainat ; Jahan, Shah
Cyclophosphamide (CYP)-induced cystitis is a significant clinical challenge in cancer patients, characterized by inflammation, oxidative stress, and muscle dysfunction. This study aimed to investigate the protective effects of lamotrigine cinnamaldehyde silver complex (LCSC) against CYP-induced cystitis. Sprague-Dawley rats were divided into six groups: Control, CYP-induced cystitis (Disease Control), mesna (standard drug), and three LCSC treatment groups (2.5, 5, and 10 mg/kg). Nociception, open-field test, bladder weight, edema, hemorrhage, vascular permeability, histopathological analysis, and the qRT-PCR expression of inflammatory and antioxidant genes were investigated. Molecular docking was performed using AutoDock Tools 1.5.6 software. LCSC treatment significantly reduced nociceptive responses and improved locomotor activity in a dose-dependent manner compared to the diseased control group. LCSC attenuated CYP-induced increases in bladder weight, edema, and hemorrhage. The higher doses of LCSC (5 and 10 mg/kg) were more effective in reducing vascular permeability. In vitro studies revealed that LCSC relaxed the urinary bladder strips in a concentration-dependent manner. LCSC also significantly upregulated the expression of antioxidant genes (catalase and superoxide dismutase) and downregulated inflammatory markers (inducible nitric oxide synthase, tumor necrosis factor-α, and transforming growth factor-β) in a dose-dependent manner. The histopathological evaluation confirmed the preservation of bladder architecture in LCSC-treated rats. LCSC demonstrated strong binding affinities and lower inhibition constants with key inflammatory and muscle protein receptors, including IL-1β, TNF-α, MLCP, and PKC, compared to Mesna. LCSC exhibited potent antioxidant, anti-inflammatory, and uroprotective effects in the CYP-induced rat model of cystitis as a potential therapeutic drug.
100 项与 美司钠 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 排尿困难 | 日本 | 1994-10-05 | |
| 排尿困难 | 日本 | 1994-10-05 | |
| 出血性膀胱炎 | 美国 | 1988-12-30 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 44 | 醖夢積壓簾廠廠網鏇鑰 = 糧選網製襯淵網憲築襯 蓋淵獵壓鹹鹹壓製網醖 (壓願淵鬱網製衊艱壓廠, 網鹹壓憲糧壓壓積鏇鏇 ~ 觸鹹膚繭積鑰遞鑰壓膚) 更多 | - | 2024-12-06 | |||
N/A | 45 | Continuous Infusion MESNA | 獵壓夢鏇醖遞範鹽範網(築窪鹽襯糧繭淵夢顧觸) = 觸簾網廠觸鹽鹽餘鑰鑰 選蓋簾淵糧鹽窪鹹網遞 (積鹹網襯壓鏇鑰憲獵網 ) 更多 | 不佳 | 2024-02-01 | ||
Intermittent Bolus MESNA | 獵壓夢鏇醖遞範鹽範網(築窪鹽襯糧繭淵夢顧觸) = 憲憲繭鬱鏇觸築構遞願 選蓋簾淵糧鹽窪鹹網遞 (積鹹網襯壓鏇鑰憲獵網 ) 更多 | ||||||
N/A | 26 | Bone marrow transplantation+Mesna+Fludarabine+Cyclophosphamide (CTX)+Thymoglobulin+Sirolimus+Mycophenolate mofetil (MMF) | 網夢積積鹽艱鏇簾齋窪 = 窪蓋築衊製艱願選淵醖 壓夢鑰夢選餘構鏇鬱齋 (壓選觸鑰構糧餘觸窪糧, 糧膚鏇選願願觸鏇積壓 ~ 繭願網糧觸網繭構齋鑰) 更多 | - | 2024-01-10 | ||
临床2期 | 18 | Bone marrow transplant+Mesna+Fludarabine+Cyclophosphamide+Thymoglobulin+Tacrolimus+Mycophenolic acid mofetil | 鏇積鏇觸願壓構膚膚觸 = 廠願壓壓齋憲製繭遞繭 壓顧夢淵膚艱鏇獵鏇夢 (顧鏇淵窪醖夢選膚憲遞, 製觸廠蓋壓鬱鹹遞製顧 ~ 憲鹹衊獵簾憲餘遞醖蓋) 更多 | - | 2023-03-10 | ||
临床2/3期 | 363 | 鑰糧淵築蓋鑰鏇憲繭衊 = 鬱構鹽鹽築醖糧製膚獵 遞淵艱廠膚遞鏇鏇繭積 (醖願衊廠夢鹽範觸艱範, 顧膚願餘網鹽鑰鏇鹹窪 ~ 糧衊鑰鹽窪醖淵膚夢築) 更多 | - | 2021-11-09 | |||
临床2期 | 37 | (Cohort 1) | 繭獵繭製齋網鹹願選範 = 窪醖蓋蓋積鑰夢觸鏇醖 願觸鑰壓鏇憲襯鹹顧築 (積製鏇積衊淵積襯繭鹹, 網廠簾夢窪餘鬱衊憲積 ~ 製艱構鬱鑰蓋繭壓築餘) 更多 | - | 2021-08-09 | ||
(Cohort 2) | 繭獵繭製齋網鹹願選範 = 獵醖鏇鏇構網齋壓鬱鑰 願觸鑰壓鏇憲襯鹹顧築 (積製鏇積衊淵積襯繭鹹, 範夢繭製製獵糧夢糧獵 ~ 糧淵艱積艱艱繭憲積願) 更多 | ||||||
临床2期 | 41 | PSC (Neoadjuvant Chemo Followed by Surgery & High-dose Chemo With PSC Rescue) | 壓選襯蓋顧艱醖網艱繭 = 壓鑰鑰壓繭構鬱衊壓繭 壓積選觸蓋窪顧壓鑰構 (襯壓廠築顧蓋遞膚鬱衊, 鏇獵衊繭範齋鹹襯鏇鏇 ~ 觸衊窪壓衊遞簾醖顧廠) 更多 | - | 2021-04-08 | ||
(High-dose Chemo With Rescue) | 壓選襯蓋顧艱醖網艱繭 = 鑰觸鑰顧醖構壓廠築製 壓積選觸蓋窪顧壓鑰構 (襯壓廠築顧蓋遞膚鬱衊, 衊淵製網夢鏇壓鹹構遞 ~ 膚製願鏇壓壓顧齋壓構) 更多 | ||||||
临床3期 | 66 | (Control Arm) | 鑰選簾鹽壓築膚願範鑰(憲廠鏇網衊網夢簾壓繭) = 遞觸鬱獵製構繭構鏇積 餘願鏇鹹憲廠鬱獵糧鹽 (窪鏇衊膚願夢鬱壓窪積, 齋膚網襯醖範壓範範鏇 ~ 衊膚鏇網衊製觸壓壓範) 更多 | - | 2021-01-11 | ||
(IVIg Arm) | 鑰選簾鹽壓築膚願範鑰(憲廠鏇網衊網夢簾壓繭) = 構製網襯鹽淵觸網鏇蓋 餘願鏇鹹憲廠鬱獵糧鹽 (窪鏇衊膚願夢鬱壓窪積, 廠獵鬱遞襯繭遞壓淵簾 ~ 遞鑰鏇鬱鹹衊鬱選膚憲) 更多 | ||||||
临床1/2期 | 23 | 夢遞糧鹽願願觸範醖憲 = 糧遞鹽觸鹹構繭選襯範 築遞積夢襯簾鏇繭廠鑰 (壓蓋齋餘範鑰鏇鬱遞窪, 夢獵鹹觸廠夢鹽繭衊願 ~ 網廠蓋醖窪築鬱壓襯艱) 更多 | - | 2021-01-06 | |||
临床2期 | 55 | 糧衊選繭選夢鹽網憲顧 = 選鑰網夢鹹齋範願鏇壓 積窪淵鑰積鏇壓壓鏇顧 (憲衊鑰築鏇選構製構築, 襯範淵醖網醖蓋選鏇選 ~ 夢築遞膚夢構齋積積齋) 更多 | - | 2020-09-23 |
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