Rolapitant Hydrochloride

- Company’s inaugural development candidate, targeting dark genome's first therapeutic target in autoimmune disease, now in IND-enabling studies - BOSTON--(BUSINESS WIRE)-- ROME Therapeutics, a biotechnology company harnessing the power of the dark genome to develop breakthrough medicines for autoimmune diseases and cancer, today announced the appointment of Keith Wilcoxen, Ph.D., as Executive Vice President, Early Development. Dr. Wilcoxen is a translational leader with more than 25 years of experience advancing new therapies through preclinical and early clinical development, most recently as Senior Vice President, Global Research, at Zenas BioPharma, an autoimmune-focused biotechnology company. “We are pleased to welcome Keith to ROME’s management team at this exciting moment in our company’s growth. We recently nominated ROME’s first development candidate, the LINE-1 reverse transcriptase inhibitor RPT-2950, providing a powerful demonstration of the progress we have made toward illuminating the dark genome’s role in disease,” said Rosana Kapeller, M.D., Ph.D., President, Chief Executive Officer and Co-founder of ROME. “Keith’s expertise in early clinical development and experience leading high-performing scientific teams will be valuable assets as we advance our development candidate to the clinic and progress our pipeline of first-in-class therapies for autoimmune diseases and cancer.” Dr. Wilcoxen’s career spans more than two decades in the biopharmaceutical industry. He joins ROME from Zenas BioPharma where he served as Senior Vice President, Global Research, overseeing all pre-clinical and translational activities for a portfolio of autoimmune therapeutic candidates. Prior to joining Zenas, Dr. Wilcoxen was Vice President of Diligence and Non-Clinical Development, followed by Vice President of Translational Research at Boston Pharmaceuticals where he was a core member of the Research and Development leadership team. In previous roles at TESARO, culminating in the role of Executive Director and Head of Strategic Drug Hunting Partnerships, Preclinical Research, Dr. Wilcoxen supported three Investigational New Drug submissions, including for cancer therapies TSR-011, Jemperli™ (dostarlimab) and cobolimab, and New Drug Application submissions for cancer therapies Varubi™ (rolapitant) and Zejula™ (niraparib). He previously held roles of increasing responsibility with Eisai, Neurocrine Biosciences and Pfizer. Dr. Wilcoxen holds a Ph.D. in chemistry from Scripps Research Institute and a B.A. in chemistry from Northwestern University. “I am excited to join ROME to help drive forward their groundbreaking portfolio of therapies targeting the dark genome’s role in autoimmune diseases and cancer. I believe research into the dark genome is key to the next wave of therapeutic breakthroughs,” said Dr. Wilcoxen. “I look forward to working with the team to bring these important medicines to patients.” About ROME Therapeutics ROME Therapeutics is developing novel therapies for autoimmune diseases and cancer by illuminating the role of the dark genome in human health and disease. Leveraging the company’s unprecedented data sciences platform, ROME has built a deep pipeline of therapies targeting the dark genome. To lead this exploration, ROME has assembled a team of world-class leaders across immunology, oncology, virology and machine learning. ROME is based in Boston, Mass. For more information, please visit .

DiaMedica Continues Building Out Board Of Directors With Key Biopharma Industry Leaders MINNEAPOLIS--(BUSINESS WIRE)-- DiaMedica Therapeutics Inc. (Nasdaq: DMAC), a clinical-stage biopharmaceutical company focused on developing novel treatments for neurological disorders and kidney diseases, announced today the appointment of Tanya Lewis to its board of directors effective March 1, 2023. Ms. Lewis, a recognized leader in the biopharma industry, brings over 25 years of experience in drug development, having played a key role in the approval of multiple new drugs. Ms. Lewis currently serves as the Chief Development Operations Officer at Replimune Group, Inc. where she has oversight for development of an integrated clinical, regulatory and CMC strategy for the successful registration of the company’s compounds. Ms. Lewis joined the executive management team at Replimune in May 2021 after serving on Replimune’s board of directors since November 2020. Prior to her officer position with Replimune, Tanya was Executive Vice President, Chief Regulatory Strategy and Strategic Operations at Karyopharm Therapeutics Inc., a publicly traded biopharmaceutical company (Nasdaq: KPTI), where she navigated the approval of XPOVIO®. Prior to joining Karyopharm, Ms. Lewis held leadership positions at several companies, including Tesaro and Millennium Pharmaceuticals, where she developed approval strategies and led interactions with U.S. and European regulators for registration trial designs and approvals. Ms. Lewis started her career at Genzyme Corporation in regulatory affairs. Ms. Lewis’s past accomplishments include the successful negotiations for registration trial designs, approval, and/or commercialization of VELCADE®, VARUBI®, INTEGRILIN® and ZEJULA®. “Tanya is a respected and highly accomplished pharmaceutical industry executive with experience in global drug development and regulatory affairs. We’re very excited to have Tanya join our board of directors at this critical time as we work to resolve the clinical hold on our ReMEDy2 AIS trial,” commented Rich Pilnik, DiaMedica’s Board Chairman. Ms. Lewis commented, “DiaMedica is at an exciting moment in its evolution and I look forward to working with the board of directors and management team to help the company on its mission to bring DM199 to benefit the millions of stroke patients without a treatment option today.” Ms. Lewis holds a Bachelor of Science degree in Biology from Northeastern University and a Master of Science degree in Regulatory Affairs and Health Policy from Massachusetts College of Pharmacy and Allied Health Sciences. About DiaMedica Therapeutics Inc. DiaMedica Therapeutics Inc. is a clinical stage biopharmaceutical company committed to improving the lives of people suffering from serious diseases. DiaMedica’s lead candidate DM199 is the first pharmaceutically active recombinant (synthetic) form of the KLK1 protein, an established therapeutic modality for the treatment of acute ischemic stroke and chronic kidney disease. For more information visit the Company’s website at .