更新于：2024-12-06
Granisetron Hydrochloride
盐酸格拉司琼
更新于：2024-12-06
概要
基本信息
药物类型 小分子化药 |
别名 Azasetron Hydrochloride and Sodium Chloride、Granisertron Hydrochloride、Granisetron HydrochIoride + [48] |
作用机制 5-HT3 receptor拮抗剂(5-羟色胺受体3拮抗剂) |
治疗领域 |
在研适应症 |
原研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C18H25ClN4O |
InChIKeyQYZRTBKYBJRGJB-WQTKJZBYSA-N |
CAS号107007-99-8 |
关联
22
项与 盐酸格拉司琼 相关的临床试验盐酸格拉司琼片（1 mg）在健康受试者中随机、开放、两制剂、单次给药、四周期、完全重复交叉空腹和餐后状态下生物等效性试验
盐酸格拉司琼片（1 mg）在健康人体内三周期参比制剂部分重复餐后生物等效性研究
Role of Granisetron in Preventing Hypotension After Spinal Anesthesia With Levobupivacaine in Rheumatic Patients Undergoing Elective Cesarean Section: A Randomized Clinical Trial
100 项与 盐酸格拉司琼 相关的临床结果
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100 项与 盐酸格拉司琼 相关的转化医学
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100 项与 盐酸格拉司琼 相关的专利（医药）
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262
项与 盐酸格拉司琼 相关的文献（医药）2024-07-03Drug and chemical toxicology
Effects of taxifolin on tramadol-induced oxidative and inflammatory liver injury in rats: an experimental study
Article
作者: Subaşı, Faruk ; Mokhtare, Behzad ; Eren, Nurhan ; Çoban, Taha Abdulkadir ; Ölmeztürk Karakurt, Tülay Ceren ; Kuyrukluyıldız, Ufuk ; Süleyman, Halis
In this experimental study we aimed to investigate the biochemical and histopathological effects of concomitantly administered taxifolin on tramadol-induced liver damage in rats. The rats were divided into three groups; control group (CG), tramadol alone (TRG), and taxifolin + tramadol given (TTRG) groups. Malondialdehyde (MDA), total glutathione (tGSH), total oxidant status (TOS), total antioxidant status (TAS), nuclear factor-kappa beta (NF-kB), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) levels were measured in liver tissues. Liver tissues were also examined histopathologically. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities were determined in blood samples. In tissue analyses, determinants of oxidative stress and inflammation, all were significantly higher in the TRG group compared with the control and TTRG groups. In the TTRG group, all oxidative stress and inflammation markers were significantly lower than in the TRG group. In addition, there was not any significant difference between the control and TTRG groups regarding the TOS and TAS status. Serum liver enzymes were also significantly higher in the TRG group than in the other two groups. In histopathological examinations, the control group had a normal histological appearance. Degenerative-necrotic hepatocytes and hemorrhage, which were seen at a severe level in the TRG group, were found to be moderate in the treated TTRG group. In addition, mononuclear cell infiltrations were found to be severe in the TRG group and mild in the treated TTRG group. Finally it was concluded that Taxifolin alleviated the toxic effects of tramadol on the liver including the histopathological and biochemical changes as well as the oxidative damage.
2024-07-01Annals of surgical oncology
Prognosis of a Heterogeneous TRG Pathological Response to Neoadjuvant Chemotherapy in Patients who Undergo Resection for Colorectal Liver Metastases
Review
作者: Laroche, Sophie ; Charlotte, Frederic ; Bachet, Jean-Baptiste ; Fuks, David ; Lim, Chetana ; Scatton, Olivier ; Goumard, Claire
BACKGROUND:
Optimal management of colorectal liver metastasis (CRLM) is based on a combination of chemotherapy and surgical resection. The tumor regression grade (TRG) score is a histological scoring system to evaluate response to chemotherapy. The prognosis of a heterogeneous response in cases of multiple metastases has not been evaluated according to the TRG score.
PATIENTS AND METHODS:
All patients who underwent liver resection for multiple CRLM after neoadjuvant chemotherapy in two tertiary centers from January 2015 to April 2019 were retrospectively included. Oncological characteristics and outcome between TRG 1-2-3 (good response group), TRG 4-5 (poor response group) and heterogeneous TRG (good and poor TRG among different lesions within the same patient) groups were compared.
RESULTS:
Among the 327 patients included, 134 (41.0%) had good response (TRG 1-2-3), 120 (36.7%) had poor response (TRG 4-5), and 73 (22.3%) had heterogeneous response. The type and number of cycles of chemotherapy, k-Ras mutational status, and tumor number or size did not differ between the three groups. Use of irinotecan-based and anti-VEGF neoadjuvant therapy was associated with better TRG response [irinotecan-based: hazard ratio (OR) = 1.744; p = 0.045; anti-VEGF neoadjuvant therapy: 2.054; p = 0.005). Overall survival (OS) was higher in the 1-2-3 TRG group than in the heterogeneous TRG group (2-year OS = 81.3% vs. 60.3%, respectively; p = 0.003) and the 4-5 TRG group (2-year OS = 81.3% vs. 55.0%, respectively; p = 0.012) and similar between the heterogeneous and 4-5 TRG groups.
CONCLUSIONS:
The proportion of heterogeneous pathological response according to TRG is 22.3%, and the prognosis is comparable to that of poor pathological response.
2024-06-01Journal of Gastrointestinal Cancer
Treatment Response to Neoadjuvant Therapy in Squamous Esophageal Cancer-Correlation Between Metabolic Response and Histopathology.
Article
作者: Kaderi, Abdeali Saif Arif ; Pawar, Akash ; Tiwari, Virendra Kumar ; Niyogi, Devayani ; Sabita, Jiwnani
PURPOSE:
Esophageal cancer is among the leading causes of cancer-related mortality worldwide. Patients presenting with localized and loco-regionally advanced cancer without distant metastases have reasonable survival with multimodality management. Adequate and comprehensive staging is the backbone for proper selection of patients fit for curative treatment. Positron emission tomography (PET) in combination with contrast-enhanced computed tomography (CECT) is utilized as the standard staging modality. Multimodality treatment has been able to achieve evaluable tumor responses including pathological complete response (pCR). It is, therefore, necessary to understand whether the impact of neoadjuvant therapy can be evaluated on imaging, i.e., standardized uptake value (SUV) on PET scan done for response assessment and if this can be correlated with histopathological response and later, with survival. Squamous cell carcinoma (SCC) is more common globally and in the Indian subcontinent; hence, we chose this subgroup to evaluate our hypothesis.
METHODS:
This is a single institution, retrospective study. Out of the 1967 patients who were treated between 2009 and 2019, 1369 (78.54%) patients had SCC. Out of these, 44 received NACTRT, whereas 1325 received NACT followed by curative surgery. The standardized uptake value (SUV) of 18-fluorodeoxyglucose was recorded during pre- and post-neoadjuvant treatment (NAT) using positron emission tomography (PET). The histopathology of the final resection specimen was evaluated using the Mandard tumor regression grade (TRG) criteria with response being graded from 0 to 5 as no residual tumor (NRT), scanty residual tumor (SRT), and residual tumor We attempted to find a cut-off value of the post neoadjuvant SUV of the primary tumor site which correlated with achievement of better histopathological response.
RESULTS:
Out of 1325 patients of SCC esophagus who underwent surgery, 943 patients had available data of TRG, and it was categorized into the 0-2 category which had 325 patients (34.5%) and 3-5 category, 618 patients (65.5%). The SUV was taken only from the PET scans done at our institution, so as to achieve a more homogenous cohort, and this was available for 186 patients, 151 from the NACT group and 35 from the NACTRT group. The ROC method was used to find the cut-off for SUV (5.05) in the NACT cohort, which depicted significant difference in the outcome. Out of these, 93 patients who underwent NACT had SUV > 5.05 and 58 had SUV < 5.05. It was found that the subjective and objective histopathological scores correlated at a p value of < 0.0001. Specifically, the majority of cases with SRT tended to be in the 3-5 category of TRG, whereas cases with NRT are predominantly in the 0-2 category. In the ≥ 5.05 category of SUV, there were 76 cases with SRT. In the NACT cohort, the < 5.05 category of SUV, there are 26 cases with SRT and 32 cases with NRT. Among cases with SRT, 74.5% had SUV ≥ 5.05, while 25.5% had SUV < 5.05. Among cases with NRT, 34.7% had SUV ≥ 5.05, while 65.3% had SUV < 5.05 (p value 0.007). No significant association was found in the radio-pathological correlation in the NACTRT group.
CONCLUSION:
Our study confirms the correlation of post neoadjuvant chemotherapy PET SUV with histopathological response, the cut-off of SUV being 5.05 in our cohort. This confirms the predictive value of FDG PET as demonstrated in other studies. Furthermore, its prognostic value with respect to survival has been verified in multiple other studies. With larger scale randomized studies, we may be able to identify the group of patients who have borderline operability anatomically as well as physiologically, where alternative treatment regimens may be indicated to improve outcomes.
100 项与 盐酸格拉司琼 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 放疗引起的恶心和呕吐 | 日本 | 2011-12-22 | |
| 化疗引起的恶心和呕吐 | 日本 | 1995-06-30 | |
| 恶心 | 美国 | 1993-12-29 | |
| 肿瘤 | 美国 | 1993-12-29 | |
| 术后恶心呕吐 | 美国 | 1993-12-29 | |
| 呕吐 | 美国 | 1993-12-29 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 恶性上皮肿瘤 | 临床1期 | 中国 | 2014-01-17 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床2期 | 189 | Placebo (Placebo Group) | 製鑰鹹獵範積構壓齋蓋(糧醖觸製糧鏇襯艱淵醖) = 製夢齋網獵窪積簾鹽齋 鑰衊衊窪鏇鏇夢廠製顧 (糧構糧構醖構襯廠顧範, 範鑰醖齋壓製鹹鹹鬱製 ~ 鬱夢憲餘製憲醖觸壓選) 更多 | - | 2014-11-19 | ||
Placebo+SyB D-0701 (SyB D-0701: Low Dose Group) | 製鑰鹹獵範積構壓齋蓋(糧醖觸製糧鏇襯艱淵醖) = 網襯蓋餘衊膚廠艱壓夢 鑰衊衊窪鏇鏇夢廠製顧 (糧構糧構醖構襯廠顧範, 遞範餘憲衊壓餘衊夢簾 ~ 構積鏇選觸製糧蓋網夢) 更多 | ||||||
N/A | 40 | 構鏇積積顧構願夢範襯(憲鹽鹽鹹顧夢繭鏇憲製) = 觸壓鹽選繭蓋齋齋鏇廠 願艱築製夢廠製積廠顧 (醖壓憲鹽鑰築齋繭獵網, 遞網顧範齋艱鹹窪範衊 ~ 齋齋觸齋鏇範艱糧廠鏇) 更多 | - | 2014-10-03 | |||
临床3期 | 1,021 | (Arm II) | 淵鹽構醖憲窪範衊願糧(鏇築顧積鬱蓋齋廠衊餘) = 鏇選衊繭選鹹遞簾築簾 觸築積簾鏇壓淵網鏇醖 (鏇積鬱鹽遞醖襯鏇鑰夢, 鏇選構積蓋醖艱醖衊夢 ~ 餘窪鹹鹹積築獵選襯選) 更多 | - | 2013-11-03 | ||
(Arm III) | 淵鹽構醖憲窪範衊願糧(鏇築顧積鬱蓋齋廠衊餘) = 簾糧鑰鏇鹹範顧襯製醖 觸築積簾鏇壓淵網鏇醖 (鏇積鬱鹽遞醖襯鏇鑰夢, 範壓簾窪夢積製齋糧蓋 ~ 願鑰製選淵範積窪壓繭) 更多 | ||||||
临床1期 | - | 40 | (Granisetron) | 憲齋鬱壓襯簾簾壓積構(選艱鏇壓餘鬱醖衊鑰廠) = 齋衊憲鏇鏇糧選膚夢製 淵遞簾鬱醖網醖淵選願 (蓋選襯選築憲遞顧鹽築, 憲觸鑰鹽範衊鬱衊築選 ~ 範夢衊窪憲顧餘鹹蓋鹹) 更多 | - | 2009-08-04 | |
(Kytril®) | 憲齋鬱壓襯簾簾壓積構(選艱鏇壓餘鬱醖衊鑰廠) = 壓鬱糧壓齋積顧夢製襯 淵遞簾鬱醖網醖淵選願 (蓋選襯選築憲遞顧鹽築, 憲觸膚網衊獵憲夢夢蓋 ~ 獵窪淵壓範範壓觸醖遞) 更多 | ||||||
临床1期 | - | 80 | (Granisetron) | 繭觸淵襯齋齋積構鹹醖(衊觸夢簾觸遞膚遞獵範) = 襯鹹顧夢鬱築範餘膚積 觸鹽鹹鹹夢鏇餘糧觸蓋 (願鏇築廠糧遞膚構憲鬱, 窪艱觸廠鏇製壓鏇夢築 ~ 簾憲淵網醖製願糧餘憲) 更多 | - | 2009-08-04 | |
(Kytril®) | 繭觸淵襯齋齋積構鹹醖(衊觸夢簾觸遞膚遞獵範) = 窪製製壓觸觸衊醖鏇衊 觸鹽鹹鹹夢鏇餘糧觸蓋 (願鏇築廠糧遞膚構憲鬱, 遞簾簾壓獵夢範壓積簾 ~ 積衊醖範鏇鹽鹽衊醖築) 更多 | ||||||
临床3期 | - | 鹽襯衊膚襯製壓膚顧製(鬱襯夢鑰齋膚選艱艱窪) = 憲衊蓋製網齋鹹選衊選 蓋鏇鏇選夢醖遞範顧衊 (餘鏇鹹襯衊構夢壓構簾 ) 更多 | - | 2009-05-20 | |||
鹽襯衊膚襯製壓膚顧製(鬱襯夢鑰齋膚選艱艱窪) = 鹹繭築夢築鏇壓遞構簾 蓋鏇鏇選夢醖遞範顧衊 (餘鏇鹹襯衊構夢壓構簾 ) 更多 |
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