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Accelerates Globalization of Innovative Products with Operating Cash Flow Surging 31.13% YoY SHANGHAI, March 25, 2025 /PRNewswire/ -- On March 25, 2025, Shanghai Fosun Pharmaceutical (Group) Co., Ltd. ("Fosun Pharma"or "the Group"; Stock Code: 600196.SH, 02196.HK), a leading global pharmaceutical and healthcare company driven by innovation, announced its annual results for the year ended 31 December 2024 ("the Reporting Period"). In 2024, Fosun Pharma further focused on the business development of innovative drugs and high-value devices, achieving operating revenue of RMB41.07 billion and net profit attributable to shareholders of RMB2.77 billion, representing an increase of 16.08% YoY. Fosun Pharma continuously optimize supply chain management to enhance operational efficiency, recording an operating cash flow of RMB4.48 billion with an increase of 31.13% YoY, surpassing the growth rate of operating profit. In addition, Fosun Pharma continues to advance lean management across quality enhancement, cost control, efficiency improvement, cycle management, and innovation R&D, driving operational efficiency and expanding profitability. During the Reporting Period, the gross margin minus the selling and distribution expense ratio improved by 2.45 percentage points YoY; and, excluding the impact of newly acquired enterprises during the Reporting Period and the same period last year, administrative expenses declined by RMB355 million. Fosun Pharma always takes innovation as a core driving force in its development. Fosun Pharma has established an open and globally integrated pharmaceutical R&D ecosystem, focusing on core therapeutic areas including oncology (solid tumors and hematologic malignancies) and Immune-inflammatory disorders. The company is strategically enhancing its technological leadership in antibody/ADC platforms, cell therapies, and small molecule development, while collaborating with industry funds to pioneer next-generation modalities such as radiopharmaceuticals, RNA therapeutics, gene editing, and AI-powered drug discovery. During the Reporting Period, Fosun Pharma continuously optimized its innovative R&D system while maintaining stable R&D investment, focusing on key pipeline strengths and enhancing efficiency through system integration. In 2024, Fosun Pharma's total R&D expenditure amounted to RMB5.55 billion, with R&D expenses totaling RMB3.64 billion. The R&D expenditure in the pharmaceutical manufacturing segment amounted to RMB4.91 billion, accounting for 16.98% of pharmaceutical business revenue. There are over 80 major pipeline projects on innovative drugs and biosimilars (calculated by indications). In addition, during the Reporting Period, the pharmaceutical manufacturing segment of Fosun Pharma submitted 220 patent applications, including 3 American patent applications, 18 PCT applications, and Fosun Pharma has obtained 66 licensed invention patents authorization. Accelerating Innovation Transformation and the Internationalization of Innovative Products Focusing on unmet clinical needs, Fosun Pharma continuous to push forward its innovation transformation and the development and commercialization of innovative products, expanding into regulatory markets such as the U.S. and the EU. During the Reporting Period, 7 innovative products/biosimilars with a total of 16 indications independently developed and licensed-in by Fosun Pharma were approved for launch, and 8 innovative products/biosimilars had entered the pre-launch approval/critical clinical stage. Fosun Pharma also had 18 innovative products/biosimilar projects (calculated by indications) initiated clinical trials. In the field of lung cancer, Fosun Pharma has developed a comprehensive layout in innovative drugs and precision diagnostics and treatment to benefit patients globally. Fosun Pharma's self-developed innovative anti-PD-1 monoclonal antibody, Han Si Zhuang (Serplulimab Injection), is the world's first anti-PD-1 monoclonal antibody (mAb) approved for the first-line treatment of extensive-stage small cell lung cancer (ES-SCLC), and it remains the first and only anti-PD-1 mAb approved in the EU for the treatment of ES-SCLC. During the Reporting Period, Han Si Zhuang also received approval in Chinese mainland for the treatment of non-squamous non-small cell lung cancer (nsNSCLC), and this also marked its third indication in the field of lung cancer, further expanding its reach. To date, Han Si Zhuang has been approved for marketing in over 30 countries and regions, including China, the European Union, and several Southeast Asian nations, benefiting more than 100,000 patients. In addition, to help more lung cancer patients obtain early diagnosis and treatment in a more minimally invasive way, the Ion Bronchial Navigation Operation Control System (Ion System) of Intuitive Fosun, Fosun Pharma's associated company, received NMPA approval in March 2024 and has been commercially deployed. In high-incidence cancers such as breast and gastric cancers, Fosun Pharma's self-developed monoclonal antibody(mAb) biosimilar Han Qu You (Trastuzumab Injection) has been approved for launch in over 50 countries and regions, including China, the European Union, the U.S., Canada and Australia, and has been included in the health insurance directories in countries such as China, UK, France, and Germany. To date, Han Qu You has benefited over 240,000 patients. The HER2-targeted innovative monoclonal antibody HLX22 for gastric cancer treatment and the novel endocrine therapy HLX78 (lasofoxifene) for breast cancer are currently under international multi-center Phase III clinical trials. Additionally, the biosimilar candidate HLX11 (pertuzumab) has had its new drug applications submitted and accepted in both China and the U.S., injecting new momentum into global expansion. In addition, Fosun Pharma is also advancing the development of rare disease drugs. Its self-developed MEK1/2 selective inhibitor Luvometinib tablets, (Project Code: FCN-159), has had its new drug applications for two indications—treatment of adult dendritic cell and histiocytic tumors, and treatment of plexiform neurofibromas (PN) associated with Neurofibromatosis Type 1 (NF1) in children aged 2 years and older—accepted by the NMPA and placed in the priority review process . In the non-oncology field, during the Reporting Period, Fosun Pharma's self-developed and licensed-in rabies vaccine (Vero cell) for human use (freeze dried), Pu Rui Ni (Pretomanid Tablets), Han Da Yuan (Adalimumab Injection) received approval for four new indications, and Su ke Xin (Avatrombopag Malate Tablets) was approved for its second indication in China; meanwhile, the new drug applications for a biosimilar of denosumab HLX14 under development were accepted by the European Medicines Agency (EMA), Health Canada and the FDA, respectively. Continuously Enhancing Global Operations and Bilateral Licensing Cooperation Fosun Pharma continues to uphold the internationalization strategy in multiple dimensions, such as innovative R&D, licensing, manufacturing and operations as well as commercialization. In 2024, overseas revenue reached RMB11.30 billion, accounting for 27.51% of total revenue. During the reporting period, Fosun Pharma continues to promote the building of production system with international quality standard, laying a solid foundation for the overseas distribution of preparations. As of the end of 2024, all production lines of the domestic subsidiaries under the pharmaceutical manufacturing segment of Fosun Pharma obtained domestic GMP certifications and 10 production lines had passed GMP certification in major regulatory markets such as the U.S. and the EU. Fosun Pharma's pharmaceuticals and medical devices businesses now primarily cover major overseas markets, including the United States, Europe, Africa, India, and Southeast Asia, with an overseas commercialization team of over 1,000 employees. In the U.S., Fosun Pharma's in-house generic drug team has continued to grow, establishing partnerships with major distributors and group purchasing organizations (GPOs) to drive the sales of formulation products. Meanwhile, Fosun Pharma has established its innovative drug team in the U.S. and is preparing for the commercialization of its anti-PD-1 monoclonal antibody (mAb), serplulimab injection. In Europe, Gland Pharma has built localized manufacturing capabilities through its subsidiary, Cenexi. Sisram Medical has expanded its global direct sales offices to 12, with its marketing network now covering over 110 countries and regions. The share of direct sales revenue has further increased to 87%. Meanwhile, Breas Medical's marketing network has expanded across key mature markets, including Europe, the United States, Japan, and Australia. In emerging markets, Fosun Pharma's sales network in Africa now covers over 40 countries and regions. The company continues to advance the Côte d'Ivoire park project to establish localized pharmaceutical manufacturing and supply in Africa. In February 2025, Fosun Pharma launched a new pharmaceutical and medical device sales platform in Nanning, gradually enhancing its registration and commercialization capabilities in Southeast Asia to expand its presence in the region. Fosun Pharma is also actively expanding into the Middle East market. During the reporting period, Henlius, a subsidiary of Fosun Pharma, entered into a strategic partnership with SVAX to establish a joint venture in Saudi Arabia. This collaboration aims to enhance the accessibility of innovative and high-value products in the MENAT region (Middle East, North Africa, and Turkey). Fosun Pharma continues to strengthen its global licensing collaboration, further enhancing its international influence and competitiveness. On the out-licensing front, Henlius, a subsidiary of Fosun Pharma has forged deep partnerships with over 20 leading global biopharmaceutical companies, including Accord, Abbott, Eurofarma, KGbio, Organon, and Dr. Reddy's, to jointly expand global markets. These collaborations comprehensively cover major biologics markets in Europe and the U.S., as well as numerous emerging markets. To date, its approved biologics have benefited more than 750,000 patients worldwide. Fosun Pharma continues to expand its product pipeline in core therapeutic areas through strategic global collaborations. Licensed-in products such as the antiemetic Akynzeo® (netupitant/palonosetron capsules), long-lasting recombinant human granulocyte colony-stimulating factor product (Pei Jin) and the drug for heart failure and hypertension treatment (Yi Xin Tan) have been included in the National Medical Insurance Drugs Catalogue, benefiting a wide range of patients. Fosun Pharma has obtained exclusive development and commercialization rights for Tenapanor Hydrochloride Tablets (Wan Ti Le), a first-in-class phosphate-lowering drug with a novel mechanism. In February 2025, the drug received approval from the National Medical Products Administration (NMPA) in China for the treatment of hyperphosphatemia in adult dialysis patients with chronic kidney disease (CKD). This approval marks a new era of multi-mechanism phosphate control, bringing new hope to dialysis patients with hyperphosphatemia. During the reporting period, Fosun Pharma's licensed product Daxxify® (DaxibotulinumtoxinA-lanm) became the first of its kind approved in China. The product received NMPA approval for the improvement in the appearance of moderate to severe glabellar lines associated with corrugator and/or procerus muscle activity in adult patients. Accelerating Localization of Innovative Products in China to Achieve High-quality Development As a global innovation-driven pharmaceutical and healthcare company, Fosun Pharma actively introduces internationally advanced technologies and products to the Chinese market, benefiting patients and customers. During the reporting period, Fosun-Insightec, a joint venture established with Insightec in China, successfully achieved sales of magneticresonance image guided focused ultrasound brain therapy system ("MRgFUS brain therapy system") for brain treatment. Additionally, the headquarters and industrial base of Intuitive Fosun, an associated company, was officially inaugurated in the Zhangjiang International Medical Park in Shanghai. This facility integrates R&D, manufacturing, and training, further accelerating the localization of the da Vinci Robotic surgical systems in China. To further enhance its leading position in tumor immunotherapy, Fosun Pharma increased its stake in its cell therapy platform, Fosun Kairos, to 100% during the reporting period. The company will continue to collaborate with Kite Pharma to advance the development and commercialization of its licensed products, Axi-Cel (marketed as Yi Kai Da ) and Brexu-Cel (investigational project FKC889), in Chinese mainland, Hong Kong S.A.R and Macao S.A.R. Yi Kai Da became the first in China to introduce an innovative outcome-based payment model. As of the end of 2024, Yi Kai Da has benefited over 800 lymphoma patients, been included in more than 110 provincial and municipal government-backed insurance programs and over 80 commercial insurance plans, and has been registered in more than 180 treatment centers across 28 provinces and municipalities nationwide. While maintaining steady operations, Fosun Pharma remains committed to its corporate social responsibilities. In 2024, the company received multiple domestic and international accolades for its significant progress in ESG, including recognition as one of China's ESG Listed Company Pioneer 100, Deloitte's China Best Managed Companies, Charity Star, and Forbes 2024 China ESG 50 list. Additionally, Fosun Pharma's MSCI ESG rating remained at A. "Fosun Pharma will continue to adhere to innovation-driven and global development strategies, actively embrace AI, concentrate resources on core businesses, and persistently advance lean management and enhance operational efficiency." Wu Yifang, Chairman of Fosun Pharma said, "We aim to grow in tandem with China's biopharmaceutical industry and stride into a new phase of high-quality development. Upholding our mission to 'create better health for families worldwide', we will maintain a patient-centric approach, address unmet clinical needs, deepen innovation transformation and global expansion, and strive to become a global leader in healthcare innovation and integration." About Fosun Pharma Founded in 1994, Shanghai Fosun Pharmaceutical (Group) Co., Ltd. ("Fosun Pharma"; SSE: 600196, HKEX: 02196) is a leading innovation-driven global healthcare company operating in the fields of pharmaceuticals, medical devices & diagnostics, and healthcare services. Through its strategic alliance with Sinopharm Group Co., Ltd., Fosun Pharma further extends its capabilities in pharmaceutical commerce. Over the past 30 years since its establishment, Fosun Pharma has maintained deep roots in China while strategically expanding its global presence. The company has been actively implementing its "4IN" strategy -Innovation, Internationalization, Intelligentization, and Integration, with core business operations now spanning major overseas markets including the United States, Europe, Africa, India, and Southeast Asia. At present, Fosun Pharma has established an open and globally integrated pharmaceutical R&D ecosystem, focusing on core therapeutic areas including oncology (solid tumors and hematologic malignancies) and Immune-inflammatory disorders. The company is strategically enhancing its technological leadership in antibody/ADC platforms, cell therapies, and small molecule development, while collaborating with industry funds to pioneer next-generation modalities such as radiopharmaceuticals, RNA therapeutics, gene editing, and AI-powered drug discovery. This multidimensional approach accelerates the translation of innovative therapies into clinical practice, systematically addressing critical unmet medical needs worldwide. Looking ahead, Fosun Pharma remains anchored in its core values of "Care for life, Continuous innovation, Pursuit of excellence and Sustainable partnership". By advancing its global innovation engine and operational excellence, the company strives to be a global leader to integrate pharmaceutical and healthcare innovations, creating better health for families worldwide. SOURCE Fosun Pharma WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

点击蓝字 关注我们 【肺癌年度盘点】微专辑 扫描二维码 可查看更多内容 编者按 近年来，中国在肺癌领域研究取得了突破性进展，多项科研成果在国际舞台上崭露头角。从早期筛查技术的创新到靶向治疗、免疫疗法的突破，中国科研团队不断推动肺癌诊疗水平的提升，为全球肺癌防治提供了新思路。这些成果不仅彰显了中国在医学研究领域的实力，也为全球肺癌患者带来了新的希望。 2024年已圆满收官，回溯这一年，《肿瘤瞭望》与国内外肺癌领域专家携手，多维度、多角度为读者们传递肺癌领域前沿动态及研究进展。中山大学肿瘤防治中心在肺癌研究领域持续发力，多项科研成果在国际舞台上大放异彩，小编特此整理。期待未来，中国肺癌领域工作者持续深耕，探索肺癌防治的新技术和新策略，为全球肺癌患者带来更多福音，为人类健康事业贡献更多中国智慧与力量。 tips：点击如下各标题链接，即可查看原文内容 NSCLC围手术期免疫治疗——“免疫三明治”模式增效作用有限，不良反应增加 目前对于驱动基因阴性可手术NSCLC，免疫治疗奠定了其治疗地位，并涌现了三种围手术免疫治疗模式：包括单纯免疫新辅助（“餐前点心”模式）、单纯免疫辅助（“餐后甜点模式”）和免疫新辅助+术后免疫辅助巩固（“三明治”模式）。来自中山大学肿瘤防治中心的张力/洪少东团队公布了一项对比免疫“餐前点心”模式和免疫“三明治”模式的研究，为这些学术界热切关心的问题提供了一些初步答案，为指导后续临床实践和临床试验设计提供了研究数据。 中肿张力、洪少东团队：NSCLC围手术期免疫治疗，less is more！“免疫三明治”模式增效作用有限，不良反应增加 2024-03-08 ICTAN研究——为埃克替尼联合化疗在非小细胞肺癌（NSCLC）辅助治疗应用再焕新颜 埃克替尼作为我国首个原研的一代EGFR-TKI，在NSCLC治疗中均发挥了巨大作用。ICTAN研究是一项随机、多中心的Ⅲ期临床试验，旨在评估埃克替尼对EGFR突变（L858R和/或19外显子缺失）Ⅱ-ⅢA期NSCLC患者根治手术及辅助化疗后的疗效与安全性。2024年美国临床肿瘤学会（ASCO）年会上，中山大学附属肿瘤防治中心王思愚教授分享了ICTAN研究的最新结果，结果显示，化疗序贯埃克替尼辅助治疗12个月或6个月组的DFS和OS均较观察组有显著改善。 ASCO峰会· 领航者对话丨从ICTAN研究出发，聆听NSCLC辅助靶向治疗新动态 2024-06-09 局部晚期NSCLC巩固治疗 CA209-7AL研究——新辅助免疫联合化疗联合hypo-CCRT和免疫巩固的治疗模式为不可手术的LA-NSCLC患者带来明显PFS获益 对于不可手术的局部晚期非小细胞肺癌（LA-NSCLC）患者，PACIFIC模式仍然是目前针对同步放化疗后达到疾病稳定或者疾病缓解的患者最有效的治疗方案。在此基础上，探索免疫治疗介入的最佳时机，或能够为患者带来更多获益。在2024 ASCO年会上，由中山大学肿瘤防治中心刘慧教授、张力教授及夏良平教授牵头的II期CA209-7AL研究发布了中期分析结果，这项研究评估了局部晚期NSCLC患者接受新辅助化疗加纳武利尤单抗治疗以及同步大分割放化疗然后进行纳武利尤单抗巩固治疗的方案，结果显示，新辅助化疗联合纳武利尤单抗和hypo-CCRT，后使用纳武利尤单抗巩固治疗不可切除的III期NSCLC患者具有良好的有效性和耐受性。 ASCO中国之声丨刘慧教授报告CA209-7AL研究结果，为局限期NSCLC治疗提供参考 2024-06-18 EGFR突变阳性NSCLC一线治疗 FL-ALTER研究——EGFR-TKI联合抗血管生成“双口服”方案或为EGFR突变晚期NSCLC患者带来一种有效延缓耐药新方案 目前国内已经有多款靶向EGFR的药物，但针对EGFR突变阳性晚期非小细胞肺癌患者治疗中存在的耐药问题，亟需进一步的临床探索。既往临床前研究表明，EGFR-TKI和抗血管生成药物具有协同增效的作用。由中山大学肿瘤防治中心张力教授、方文峰教授团队牵头开展的“安罗替尼联合吉非替尼对比安慰剂联合吉非替尼一线治疗ⅢB-Ⅳ期EGFR基因突变型非小细胞肺癌患者多中心、随机、双盲、平行对照Ⅲ期临床研究”（FL-ALTER）在国际期刊《信号转导与靶向治疗》（Signal Transduction and Targeted Therapy）杂志发表。该研究有望为EGFR突变阳性晚期非小细胞肺癌（NSCLC）提供一种有效延缓耐药的治疗新方案。 肺癌前沿丨张力、方文峰团队提供了延缓EGFR突变肺癌靶向治疗耐药新方案，精准探索了联合方案优势人群 2024-08-14 BOOSTER研究——Becotarug联合方案治疗EGFR敏感突变晚期NSCLC疗效显著 表皮生长因子受体（EGFR）基因突变是我国非小细胞肺癌（NSCLC）人群最常见的致癌驱动突变，发生率远高于高加索人群。在2024年欧洲肿瘤内科学会亚洲年会（ESMO Asia Congress 2024）的微型口头报告专场，中山大学肿瘤防治中心张力教授汇报了Becotarug（JMT101）联合奥希替尼治疗经典型EGFR突变NSCLC患者的Ⅱ期BOOSTER临床研究结果，结果表明，JMT101联合奥希替尼一线治疗携带EGFR 经典突变的NSCLC患者具有良好的疗效和可耐受的安全性，为伴EGFR 经典突变NSCLC患者提供了新的治疗选择。 张力教授：BOOSTER研究结果对EGFR突变NSCLC治疗的启示丨ESMO ASIA 2024 2024-12-25 EGFR突变阳性NSCLC二线治疗 HARMONi-A研究——国产首创双抗新药方案突破EGFR-TKI耐药NSCLC治疗困境 EGFR-TKI是EGFR突变NSCLC的标准一线治疗，但获得性耐药不可避免。目前临床上EGFR-TKI尤其是第三代TKI治疗进展患者，最佳的治疗选择仍然有限，亟需开发新的治疗方案。中山大学肿瘤防治中心张力教授牵头开展的III期HARMONi-A研究是首个比较了依沃西单抗联合化疗与单独化疗在EGFR-TKI耐药的EGFR突变晚期或转移性nsq-NSCLC疗效的双盲、安慰剂对照、随机的III期研究。“依沃西单抗联合化疗”突破EGFR-TKI治疗后耐药的临床困境，为EGFR-TKI耐药的非小细胞肺癌患者带来全新的标准治疗方案。该研究分析结果被2024年美国临床肿瘤学会（ASCO）收录为口头报告，同步被国际顶尖权威期刊《美国医学会杂志》（Journal of the American Medical Association, JAMA）在线发表。 JAMA丨张力教授团队为肺癌患者带来免疫治疗新方案 2024-06-18 驱动基因阴性晚期NSCLC一线治疗 OptiTROP-Lung01研究——芦康沙妥珠单抗联合KL-A167在驱动基因阴性晚期NSCLC的一线治疗治疗中表现出令人鼓舞的抗肿瘤活性 PD-L1抑制剂是晚期非小细胞肺癌的标准一线治疗，但疗效因人而异，许多患者尽管接受治疗后仍会病情进展。在2024 ASCO年会上，由中山大学肿瘤防治中心张力教授团队牵头开展的II期OptiTROP-Lung01研究在大会上以口头报道形式进行了报告，该研究旨在探索TROP2 ADC芦康沙妥珠单抗联合免疫一线治疗驱动基因阴性晚期非小细胞肺癌（NSCLC）疗效及安全性，结果显示，芦康沙妥珠单抗与KL-A167的组合在驱动基因阴性晚期NSCLC的一线治疗中显示出有希望的疗效，为患者提供了一种潜在的新治疗选择。 方文峰教授点评肺癌领域TROP2 ADC研究进展丨ASCO中国之声 2024-06-25 恶性肿瘤化疗所致不良反应管理 PROFIT研究——HR20013“强强联合”，有效预防化疗所致恶心呕吐 化疗所致的恶心呕吐是抗肿瘤药物治疗最常见的化疗不良反应，严重影响患者生活质量及生存获益，探索止吐方案对于临床工作者和患者来说都有重要的意义。在2024年世界肺癌大会（WCLC）上，中山大学肿瘤防治中心张力教授报告了HR20013预防顺铂化疗引起的恶心呕吐的III期PROFIT研究结果，研究结果显示，HR20013作为罗拉匹坦和帕洛诺司琼的新型混合静脉制剂，预防以顺铂为基础的HEC-CINV显示出具有前景的临床疗效及可控的安全性，为化疗所致恶心呕吐的治疗提供了新的思路。 WCLC中国之声丨张力教授口头汇报PROFIT研究结果，新方案有效预防化疗所致恶心呕吐 2024-09-10 肺癌支持治疗 个性化音乐疗法 随着医疗模式的不断演进，非药物干预在提升患者生活质量、减轻心理压力方面日益受到重视。音乐疗法以其高安全性和无副作用的优点，逐渐被接受并应用于医疗实践中，以减轻患者的负面情绪和感受。在2024世界肺癌大会（WCLC）肺癌支持治疗相关报告环节中，中山大学肿瘤防治中心龙浩教授团队汇报了一项个性化音乐疗法对非小细胞肺癌（NSCLC）患者围术期疼痛和焦虑作用的研究结果，结果显示，个性化音乐疗法显著缓解了患者围手术期的焦虑情绪，并改善了术后的呼吸困难症状。 WCLC 2024丨口头报告摘选：优化支持治疗的时机 2024-09-02 （来源：《肿瘤瞭望》编辑部） 声 明 凡署名原创的文章版权属《肿瘤瞭望》所有，欢迎分享、转载。本文仅供医疗卫生专业人士了解最新医药资讯参考使用，不代表本平台观点。该等信息不能以任何方式取代专业的医疗指导，也不应被视为诊疗建议，如果该信息被用于资讯以外的目的，本站及作者不承担相关责任。