预约演示
更新于：2025-02-05
Metoclopramide Hydrochloride
盐酸甲氧氯普胺
更新于：2025-02-05
概要
基本信息
简介甲氧氯普胺是一种多巴胺-2（D2）拮抗剂的小分子药物。用于治疗胃食管反流病（GERD）和急性或复发性糖尿病胃轻瘫（胃淤滞）等疾病，该药最初由赛诺菲开发，于1967年3月首次在日本批准使用。是一种可用于口服和注射的药物。 |
药物类型 小分子化药 |
别名 2-methoxy-4-amino-5-chloro-N,N-(dimethylaminoethyl)benzamide、2-methoxy-5-chloroprocainamide、4-amino-5-chloro-2-methoxy-N-(β-diethylaminoethyl)benzamide + [32] |
靶点 |
作用机制 DRDs拮抗剂(多巴胺受体家族拮抗剂) |
在研适应症 |
非在研适应症 |
原研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C14H25Cl2N3O3 |
InChIKeyKJBLQGHJOCAOJP-UHFFFAOYSA-N |
CAS号54143-57-6 |
关联
221
项与 盐酸甲氧氯普胺 相关的临床试验NCT06789614
Comparison of the Effect of Cyclizine Versus Metoclopramide on Gastric Residual Volume in Patients Undergoing Bariatric Surgery: A Randomized Double-blinded Clinical Trial
NCT06793267
Ultrasonoraphic Asessment of Metoclopramide Effect on Gastric Volume in Urgent Surgical Trauma Pediateric Patients. Randomozed Controlled Double Blind Study.
CTRI/2024/12/077793
Effect of metoclopramide on gastric residual volume as measured by ultrasonography in diabetes mellitus patients undergoing elective surgeries: A randomized controlled study - NIL
100 项与 盐酸甲氧氯普胺 相关的临床结果
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100 项与 盐酸甲氧氯普胺 相关的转化医学
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100 项与 盐酸甲氧氯普胺 相关的专利（医药）
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8,769
项与 盐酸甲氧氯普胺 相关的文献（医药）2025-02-01Expert Opinion On Drug Safety
Effect of chloroquine pre-treatment on the metoclopramide’s pharmacokinetics after their co-administration
Article
作者: Umar, Muhammad Ihtisham ; Kharaba, Zelal ; Murtaza, Ghulam ; Naeem, Abdul Rafay ; Yasin, Haya ; Shah, Syed Nisar Hussain ; Alotaibi, Badriyah Shadid ; Kaukab, Iram
BACKGROUND:
This study evaluated the pharmacokinetic interactions of orally administered chloroquine and metoclopramide.
METHODS:
The study employed a randomized and two-phase cross-over design with 4-week washout plan. Twelve healthy male volunteers were shortlisted according to the set criteria and were administered with metoclopramide 10 mg PO and chloroquine (a total of 1500 mg) at different intervals which were (500 mg at 0, 6, and 24 h). The concentration of chloroquine and metoclopramide in the blood samples was estimated using a validated HPLC-UV technique to affirm the maximum concentration (Cmax), time to reach Cmax (Tmax), and area under the curve (AUC).
RESULTS:
Cmax, T1/2, and AUC of metoclopramide were increased up to 20, 10, and 47.8%, respectively, by the concomitantly administering Chloroquine. Chloroquine-treated phase showed increased values of Cmax (ng/ml), AUC (ng.h/ml), and T½ (h), i.e. 41.35 ± 1.61, 504.12 ± 66.25, and 5.72 ± 2.63, as compared to that reference phase i.e. 34.52 ± 4.92, 341.14 ± 112.8, and 5.19 ± 1.14, respectively.
CONCLUSIONS:
Chloroquine was found to attenuate CYP2D6 activity in healthy Pakistani male volunteers. Hence, patients that are prescribed with metoclopramide or other CYP2D6-substrate drugs require a dose adjustment when administered with chloroquine.
2025-02-01CURRENT PROTEIN & PEPTIDE SCIENCE
Comparative Study of Lactogenic Effect and Milk Nutritional Density of Oral Galactagogue in Female Rabbit
Article
作者: Maru, Saurabh ; Belemkar, Sateesh
Background::
Hypogalactia and agalactia in lactating mothers are the major causes of
child malnutrition, mortality, morbidity, and overall ill health. The development of such treatments
requires a well-designed preclinical study with suitable laboratory animals, which needs to
be improved. Thus, a suitably designed study with a laboratory animal to analyse galactagogue activity,
along with an assessment of the quality and quantity of milk, is required.
Objectives::
This study aimed to evaluate the potential of rabbits as an animal model for studying
lactogenic activity.
Methods::
The structural homology of prolactin, prolactin, and prolactin in humans, rabbits, and
rats was studied using BLAST and PyMol to assess similarity in the lactogenic system. Daily and
cumulative milk production and pre-treatment (control) and post-treatment (three drugs) in rabbits
were recorded and evaluated by analysing protein, fat, lactose, solid non-fat, and ash values. All
parameters were recorded on the 0th day and at the end of weeks 1, 2, and 3. Mammary gland histopathology
was performed to evaluate the effects on mammary glands.
Results::
Homology studies revealed that the sequences of the human and rabbit prolactin genes, receptors,
and hormones had a high similarity index. Treatment with Domperidone, Metoclopramide,
and Shatavari significantly enhanced milk production by enhancing prolactin secretion;
only Shatavari increased milk nutrition. Enlargement of the tubuloalveolar ducts of the mammary
glands was observed.
Conclusion::
Our findings suggest that rabbits are robust, reproducible, ethically superior, and preclinically
relevant animals for assessing lactogenic activity.
2025-02-01Legal Medicine
Suicide by sodium nitrite: Autopsy case report
Article
作者: Pavlekić, Snežana ; Marković, Suzana ; Ječmenica, Dragan ; Repić, Aleksandra ; Živković, Vladimir ; Milošević, Veljko
INTRODUCTION:
Suicide by sodium nitrite poisoning (SNP) is not common. In the last decade, an increase in the number of suicides caused by SNP was observed.
CASE REPORT:
A 47-year-old female was found dead in her apartment. Four cups with a yellowish liquid and a scale for precise measurement were found at the scene. Also, an empty plastic bag labeled "Sodium Nitrite NaNO2". In the external examination, general signs of asphyxia were noticed. Bluish and slightly brownish hypostasis, which was prominent on the face and thighs, was present. The blood and all tissues were somewhat darker in appearance than usual. Toxicological analysis showed high levels of nitrites, nitrates, methemoglobin, and metoclopramide in blood and stomach content. It was concluded that this was a suicide by SNP.
DISCUSSION:
Autopsy signs of SNP are nonspecific. The grayish-brown color of the hypostasis is a characteristic sign of SNP but is very subjective and may be missed. Sodium nitrite cannot be legally purchased for domestic use in Serbia. Even though sodium nitrite commerce is strictly regulated, the victim was able to illegally obtain it and use it in combination with the antiemetic drug metoclopramide, which shows the knowledge that exceeds the common knowledge regarding this substance and is an example of suicide committed by intellectuals.
CONCLUSION:
Cases of the fatal SNP may present a significant challenge in forensic practice due to their rarity and nonspecific presentation. Without any information about the circumstances of the case, it is often unrecognizable.
100 项与 盐酸甲氧氯普胺 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 药物引起的恶心和呕吐 | 澳大利亚 | 1991-08-13 | |
| 放疗引起的恶心和呕吐 | 澳大利亚 | 1991-08-13 | |
| 呕吐 | 澳大利亚 | 1991-08-13 | |
| 胃食管反流 | 美国 | 1980-12-30 | |
| 化疗引起的恶心和呕吐 | 美国 | 1979-02-07 | |
| 糖尿病性胃轻瘫 | 美国 | 1979-02-07 | |
| 术后恶心呕吐 | 美国 | 1979-02-07 | |
| 食欲减退 | 日本 | 1967-03-25 | |
| 恶心和呕吐 | 日本 | 1967-03-25 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 危重病 | 临床2期 | 美国 | 2018-08-25 | |
| 危重病 | 临床2期 | 澳大利亚 | 2018-08-25 | |
| 危重病 | 临床2期 | 加拿大 | 2018-08-25 | |
| 危重病 | 临床2期 | 英国 | 2018-08-25 | |
| 胃轻瘫 | 临床2期 | 美国 | 2009-04-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
GlobeNewswire 人工标引  | N/A | 92 | 餘糧繭醖積遞餘遞廠選(網獵憲鹽願膚鹽築範築) = 蓋遞憲鑰遞獵餘願積糧 壓願製鹹膚憲艱餘獵願 (願範顧鹹願膚鏇膚願獵 ) 更多 | 积极 | 2024-10-28 | ||
Oral Metoclopramide | - | ||||||
N/A | P-glycoprotein | pregnane X receptor | 10 | St. John's wort extract (SJW) | 築鹹積齋範築簾積鏇鬱(壓醖餘構鏇夢膚遞獵襯) = 製齋構築衊窪遞糧餘範 壓鹽窪壓鏇鬱鬱願選憲 (齋鑰繭簾夢遞衊網觸製 ) | 不佳 | 2024-09-27 | |
临床3期 | 65 | Remote electrical neuromodulation (Active REN stimulation with matched normal saline placebo intravenously) | 壓鬱蓋築製製憲鬱壓鹹(齋襯醖網鏇醖膚製壓鏇) = One participant in the typical care group and none in the REN group experienced adverse events 獵鹹夢鹹窪餘齋醖遞簾 (壓積鹹觸繭糧簾鏇繭鏇 ) | 积极 | 2024-09-17 | ||
N/A | - | - | (Diabetic controls treated with recurrent saline (STZ+RS)) | 願廠鬱廠餘遞鹽遞願選(窪鏇齋製醖廠鬱齋鏇襯) = 糧蓋顧襯鑰壓鬱廠鬱膚 廠構積選願窪簾窪選願 (蓋鬱鏇醖獵醖遞廠艱築, 0.8) | - | 2024-06-14 | |
(Diabetic rats preconditioned with recurrent hypoglycemia (STZ+RH)) | 願廠鬱廠餘遞鹽遞願選(窪鏇齋製醖廠鬱齋鏇襯) = 夢獵選齋齋齋壓壓獵襯 廠構積選願窪簾窪選願 (蓋鬱鏇醖獵醖遞廠艱築, 0.9) | ||||||
临床4期 | 83 | dexmedetomidine+Compazine+Total intravenous anesthesia+scopolamine transdermal+sugammadex+Reglan+Propofol+Fentanyl+Ondansetron+Aprepitant 80 mg Oral Capsule+Dexamethasone (Intervention Arm) | 淵積膚壓艱獵膚膚衊齋(積鑰襯觸顧鹹鏇糧窪簾) = 範廠鏇醖繭糧鬱艱淵願 膚襯鏇鹹築鑰壓積構觸 (鬱淵艱獵積構鑰鹽構繭, 窪鏇壓鏇積鬱衊構構鏇 ~ 艱簾艱淵壓製壓獵淵觸) 更多 | - | 2024-02-14 | ||
(Control Arm) | 淵積膚壓艱獵膚膚衊齋(積鑰襯觸顧鹹鏇糧窪簾) = 糧遞壓範夢襯繭遞憲鹹 膚襯鏇鹹築鑰壓積構觸 (鬱淵艱獵積構鑰鹽構繭, 製鹹遞夢衊觸襯蓋鏇鹹 ~ 夢鹽鏇構構鏇願壓廠廠) 更多 | ||||||
临床2期 | 30 | (Intervention Group) | 繭夢觸醖鏇壓鏇淵鏇窪(繭構鏇餘艱築餘積蓋鬱) = 鹽鏇襯餘鏇網構憲願獵 構衊蓋壓鏇觸夢膚構鏇 (鹹廠製獵獵廠願鬱顧廠, 觸構鏇鹽憲窪膚顧餘獵 ~ 簾壓襯鬱壓鹹願夢鏇簾) 更多 | - | 2024-02-07 | ||
(Placebo Group) | 繭夢觸醖鏇壓鏇淵鏇窪(繭構鏇餘艱築餘積蓋鬱) = 艱選襯齋蓋壓窪夢範艱 構衊蓋壓鏇觸夢膚構鏇 (鹹廠製獵獵廠願鬱顧廠, 觸襯齋簾襯網壓網蓋獵 ~ 餘構繭淵構憲壓積鹹簾) 更多 | ||||||
临床4期 | 62 | 遞願製壓糧蓋膚範顧襯(壓簾選築顧衊構願顧顧) = 壓鏇網網襯糧糧壓構憲 艱衊淵淵觸願憲範糧糧 (窪廠餘夢顧鏇糧窪遞繭 ) 更多 | 不佳 | 2024-01-05 | |||
Placebo | 遞願製壓糧蓋膚範顧襯(壓簾選築顧衊構願顧顧) = 觸窪醖淵鹽鹹窪衊憲憲 艱衊淵淵觸願憲範糧糧 (窪廠餘夢顧鏇糧窪遞繭 ) 更多 | ||||||
N/A | - | - | Levosulpiride, Metoclopramide, Clebopride | 醖壓鬱膚襯壓鏇製窪窪(簾簾窪齋艱襯鹹壓願獵) = 餘構醖構餘遞鹽憲積憲 艱鑰膚醖積衊醖壓鑰觸 (顧鑰鏇廠齋鑰網鏇醖壓 ) | - | 2023-06-28 | |
临床2期 | 15 | 網淵製繭艱繭壓醖鹽衊(艱餘窪餘鏇齋願遞網簾) = 齋夢鹽願鏇範鬱願積醖 鏇窪遞窪鹹繭襯淵壓鏇 (憲艱願觸製餘廠淵糧淵, 膚選衊鏇遞餘獵餘壓獵 ~ 遞襯餘憲簾夢選衊憲範) 更多 | - | 2022-11-29 | |||
N/A | 154 | 窪鑰衊繭築簾簾鹹廠獵(繭廠夢願獵夢齋觸夢選) = 網窪簾積範艱鬱膚繭鑰 鹽積積獵遞淵鏇醖鏇糧 (膚淵齋鹹廠餘蓋鑰淵鏇 ) 更多 | 不佳 | 2022-10-09 | |||
Placebo | 窪鑰衊繭築簾簾鹹廠獵(繭廠夢願獵夢齋觸夢選) = 顧醖膚顧蓋遞窪簾積鏇 鹽積積獵遞淵鏇醖鏇糧 (膚淵齋鹹廠餘蓋鑰淵鏇 ) 更多 |
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