Mycophenolate Mofetil

LOS ANGELES, April 22, 2025 (GLOBE NEWSWIRE) -- Trethera Corporation (“Trethera”), a clinical stage biopharmaceutical company developing first-in-class therapies for cancer and autoimmune diseases, announces a forthcoming panel discussion and poster presentation at the 7th Annual Los Angeles Bioscience Ecosystem Summit 2025 (“LABEST”). Panel Discussion Details: Title: BioSuccess in Los AngelesCEO Panelists: Ken Schultz (Trethera), Daniel Gil (Pelage), Dina Leeds (CleopatraRx), and Bethany Mancilla (Capsida)Moderator: Amir Naiberg, Associate Vice Chancellor, UCLA; CEO and President, UCLA Technology Development GroupLocation: Centennial Ballroom, 1st floor, Luskin Conference CenterDate: Thursday, May 22, 2025 at 2PM Poster Details: Title: First-in-Class Clinical Stage Deoxycytidine Kinase Inhibitor Blocks Inflammatory Bowel Disease Symptoms in an Adoptive CD4 T Cell Transfer Mouse ModelAuthors: Peter M. Clark, PhD; Kenneth A. Schultz, MD; KM Ryan, BSCategory: Immunity, Inflammation, Infection and Transplantation (I3T)Location: Pearl Cohen Scientific Poster Competition, Luskin Conference CenterDate: Thursday, May 22, 2025 at 4PM LABEST 2025 is the premier showcase for bioscience innovation in Los Angeles County and is produced by the UCLA Technology Development Group. The conference attracts over 1,500 life science industry professionals from the world’s leading pharmaceutical companies, venture capital firms, and research institutions. LABEST is intended to promote awareness of the growing life science entrepreneurial ecosystem in Los Angeles and to foster partnerships with the biotechnology and life science industry. Poster co-author Peter M. Clark is an Associate Professor of Molecular and Medical Pharmacology at the David Geffen School of Medicine and Crump Institute for Molecular Imaging at UCLA. Dr. Clark identified the metabolic enzyme deoxycytidine kinase, dCK, as a key and targetable enzyme required for aberrant T and B cell activation in models of autoimmune diseases, such as Crohn’s disease and lupus. The Clark lab aims to develop novel, first-in-class, drug therapies for cancer and autoimmune diseases. Figure 1: Biochemical pathways for the supply of deoxyribonucleoside triphosphate pools. The salvage pathway becomes upregulated during autoimmune diseases. FDA approved drugs blocking the de novo pathway include Aubagio (teriflunomide), Mavenclad (cladribine), and CellCept (mycophenolate mofetil). About TretheraTrethera is a clinical stage, privately held, biopharmaceutical company dedicated to pioneering the development of novel treatments for autoimmune diseases and cancers. Founded by prominent UCLA scientists, Trethera is led by experienced management and board members. Trethera's innovative approach to targeting nucleotide metabolism led to the development of TRE-515, an orally administered capsule twice designated by the FDA as an Orphan Drug. TRE-515 is a first-in-class clinical stage drug that inhibits deoxycytidine kinase (dCK), the rate-limiting enzyme in the nucleoside salvage pathway, one of two biosynthetic pathways that generate DNA precursors. It is believed that some forms of cancer may be preferentially dependent on the salvage pathway to support tumor growth, and certain autoimmune diseases might also respond to TRE-515 treatment. Trethera is developing TRE-515 for use as a monotherapy or in combination to precisely target a metabolic vulnerability of cancer or autoimmune diseases that will transform outcomes for patients. For more information, please visit us at trethera.com or e-mail Investor Relations at ir@trethera.com. You can also follow Trethera on Facebook and LinkedIn. Note on Forward-Looking StatementsAll statements other than statements of historical facts included in this press release that address activities, events or developments that Trethera believes or anticipates will or may occur in the future are “forward-looking statements,” which may often, but not always, be identified by the use of such words as "may," "might," "will," "will likely result," "would," "should," "estimate," "plan," "project," "forecast," "intend," "expect," "anticipate," "believe," "seek," "continue," "target" or the negative of such terms or other similar expressions. Although Trethera has a reasonable basis for the forward-looking statements contained herein, Trethera cautions that such statements are based on current expectations about future events and are subject to risks, uncertainties and factors relating to medical and scientific research, all of which are difficult to predict and many of which are beyond Trethera’s control, that may cause actual results to differ materially from those expressed or implied by the forward-looking statements in this press release. These potential risks and uncertainties include, without limitation: the extent to which development of any novel cancer therapies or therapies for autoimmune diseases succeeds; whether Trethera would obtain the necessary regulatory approvals to commence human trials or commercialize TRE-515 or any novel therapies resulting from such research; Trethera successfully implementing its growth strategy, including that relating to its disease therapies; the effects of the global Covid-19 pandemic; changes in economic conditions; competition; and risks and uncertainties applicable to the business of Trethera. The statements in this press release speak only as of the date hereof and Trethera does not undertake any obligation to update, amend or clarify these forward-looking statements whether as a result of new information, future events or otherwise. The Company intends that all forward-looking statements be subject to the safe-harbor provisions of the Private Securities Litigation Reform Act of 1995. A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/a3669834-fb66-4439-930d-931d3a67f1b7

4月17日，华东医药发布2024年业绩报告：营收达419亿元，同比微增3%；归属于上市公司股东的净利润超过35亿元，同比增长达23.72%。去年是华东医药成立以来净利润最好的一年，已经连续四年净利润增长。4月21日收盘，华东医药股价上涨近2%，来到39.33元/股。2024年，华东医药引进的多个创新药密集上市，自研GLP-1等产品管线也取得进展。2025年，华东医药还想获得更多：公司管理层在业绩会上表示，2025年有信心拿到自研管线的首次BD收入。这意味着，今年华东医药业绩可能会有较大的变动。守住基本面华东医药的净利润基本仰赖子公司中美华东，达到28.76亿元，同比增长近30%。中美华东的具体销售成绩没有被披露，不过公司的创新药2024年才上市，业绩增长应该还是依靠老品种。2019年起，中美华东百令胶囊、阿卡波糖、吗替麦考酚酯、吲哚布芬片等核心品种相继受到集采、国谈、竞品等因素冲击，大单品红利逐渐消失。尤其是百令胶囊，这是华东医药最大的单品，销售额超30亿元，但在去年1月迎来竞品。佐力药业研发的百令胶囊获批上市，一下子打乱了华东的经营节奏。华东医药嘴上说着“增加一家企业，不会对市场竞争格局带来重大影响”，但专利官司打得比谁都积极。类似的情况也发生在吲哚布芬片身上，因受到华东医药专利狙击，九典制药等3家企业相继被暂停采购资格。靠着四处出击，华东医药守住了基本面。年报特别提到百令胶囊，说百令胶囊由于医保报销扩大到慢性支气管炎、慢性肾功能不全患者，后续增长还有望提速。华东医药近几年新引进的品种，2024年开始贡献业绩。其中从科济药业引进的CAR-T泽沃基奥仑赛注射液去年3月上市，用于治疗复发或难治性多发性骨髓瘤成人患者，成为国内上市的第二款BCMA CAR-T。年报披露，去年这款CAR-T已有154份有效订单。按照115万/针的价格，华东医药光这一款创新药就获得近1.8亿元的销售额。首战告捷的华东医药已经备好下一个 CAR-T品种。去年8月，华东医药引入艺妙神州的CD19自体CAR-T产品IM19 注射液，该品种有望于今年上市。从引进到对外授权创新药可能会是华东医药今年业绩的最大看点。去年11月，华东医药与荃信生物合作开发的乌司奴单抗生物类似药上市，成为国内首款，华东医药借此扩展到自免领域。业绩会上，公司表示该产品已经在各省市挂网销售，今年有望加速推进。同样在11月，华东医药引进的FRα ADC获批，用于二线治疗卵巢癌。公司表示：今年这款药物将会积极参与医保谈判。华东医药手里引进的新药还包括一款依达拉奉片改良型新药，目前已提交上市申请；一款已上市独家中成药伤科灵，是目前国内获批的唯一一款处方药/OTC双跨的国家医保中成药喷雾剂。华东医药有重销售的传统，走license in的路线回报周期更短，风险也低。不过，华东医药董事长吕梁对外驳斥过“BD狂人”的标签，表示公司不会只靠BD，一定是自研创新和引进相结合。2024年，华东医药研发投入增长12.2%至14.3亿元，目前在手创新药管线超80项。其中GLP-1是华东医药的重点，公司集齐了单一靶点、GLP-1/GIP双靶点、FGF21R/GCGR/GLP-1三靶点等不同路线品种。在去年国内减肥管线密集BD的风潮下，华东医药竟然毫无动静，这可能与公司的BD能力不强有关。老牌企业闷头做事的多，吆喝外联的少。BD本身也是一门玄学，能不能卖掉偶然性非常大。华东医药手里不是没有好品种，要做的是努力寻找合适的买家。业绩会上，华东医药介绍，公司自主研发的口服小分子GLP-1受体激动剂HDM1002去年10月II期临床结束，结果不错。公司有信心今年实现首个对外BD。撰稿丨李傲编辑丨江芸 贾亭运营｜雾纪插图｜视觉中国声明：健识局原创内容，未经许可请勿转载第十一批集采将启动；广东通报药代行贿案；多家药企面临退市GLP-1竞争新动向：礼来后来居上？国家医保局：医保支付方式改革仍有三大挑战