Salbutamol sulfate

阿斯利康（AstraZeneca）近期宣布，3b期临床试验BATURA的完整结果显示，其“first-in-class”哮喘疗法Airsupra（沙丁胺醇/布地奈德），在所有主要和次要终点上均较沙丁胺醇组实现具有统计学显著性和临床意义的改善。该研究结果已发表于《新英格兰医学杂志》。该试验比较了按需使用Airsupra与按需使用沙丁胺醇在轻度哮喘患者中的疗效。试验结果显示，使用Airsupra治疗可将疾病严重恶化风险显著降低47%（HR=0.53；95% CI：0.39，0.73；p<0.001）。由于在预设中期分析中观察到Airsupra的显著疗效，独立数据监查委员会建议提前终止试验。在一项关键性次要终点中，12岁及以上的青少年和成人在使用Airsupra治疗期间，系统性糖皮质激素（SCS）暴露总量较沙丁胺醇组降低63%（p<0.001），从而减少了累积使用SCS带来的已知风险。Airsupra是一种“first-in-class”短效β2受体激动剂（SABA）和吸入型糖皮质激素（ICS）组合，可按需使用。该药物为固定剂量吸入制剂，含有沙丁胺醇与布地奈德，采用阿斯利康的Aerosphere加压定量吸入器（pMDI）递送技术开发而成。推荐阅读打一针管3个流行季？保护效力约63%！《柳叶刀》子刊：新型疫苗有效预防呼吸道感染平常症状较轻，发作起来可能要命！JAMA：联合疗法治疗哮喘，效果或更佳影响全球近3亿人！《柳叶刀》：超90%重度哮喘患者或可安全减少糖皮质激素用量改善呼吸道症状竟如此简单？《柳叶刀》子刊：用鼻喷剂、多运动、缓解压力都可以参考资料：[1] Statistically significant and clinically meaningful BATURA Phase III trial results provide new evidence for Airsupra as standard of care for as-needed rescue treatment in asthma. Retrieved May 19, 2025, from https://www.astrazeneca.com/media-centre/press-releases/2025/statistically-significant-clinically-meaningful-batura-phase-iii-trial-provide-evidence-airsupra-standard-care-as-needed-rescue-treatment-asthma.html免责声明：本文仅作信息交流之目的，文中观点不代表药明康德立场，亦不代表药明康德支持或反对文中观点。本文也不是治疗方案推荐。如需获得治疗方案指导，请前往正规医院就诊。版权说明：欢迎个人转发至朋友圈，谢绝媒体或机构未经授权以任何形式转载至其他平台。转载授权请在「药明康德」微信公众号回复“转载”，获取转载须知。分享，点赞，在看，传递医学新知

Teresa Victoria almost didn't make it to the medical appointment that would save her life. Suffering from end-stage pulmonary fibrosis , Victoria was on a flight to Chicago last December when the battery in her portable oxygen concentrator died. While flight attendants provided an emergency oxygen canister, her need was so great that it ran out after 15 minutes. "That's when I felt I was going to die," said Victoria, 68, a resident of Lakeland, Florida. "I couldn't breathe." But Victoria made it to a consultation with Pablo Sanchez, MD , surgical director of the University of Chicago Medicine's Lung Transplant Program . She hoped for the seemingly impossible: a double-lung transplant using no transfused blood to align with her religious beliefs. "I think that she never expected for us to say, ‘Let's see what we can do,’” Sanchez said. A devastating discovery Forty years earlier, Victoria was hospitalized with pneumonia. She later experienced periods of phlegm build-up and coughing. Her doctors in Florida routinely prescribed medications, including an albuterol inhaler, to help. But it wasn't until 2023 that a doctor in Mexico diagnosed her with stage 2 idiopathic pulmonary fibrosis — a condition characterized by scarring of the lung tissue. The scarring damages the lung tissue, including the air sacs and small blood vessels that help bring oxygen into the body. "Your lungs are not as flexible and elastic," Sanchez said. "Oxygen doesn't transfer well because the lungs start getting harder and harder." The irreversible scarring of both of Victoria's lungs led her to be hospitalized for breathing issues every few months and to use a portable oxygen concentrator constantly. Most of her days were spent sitting or lying down. "It was bad," said her husband, Patalla, shaking his head. "Really bad." With her condition worsening, Victoria was given roughly a year to live. She was approved for a double-lung transplant in 2024. Nevertheless, several surgeons in Florida would not operate because of her age, frailty or decision not to receive blood. Victoria is deeply committed to her faith as a Jehovah's Witness, which doesn’t support the use of blood transfusions. "I was more afraid of blood than the transplant because I didn't want blood," she said. Minimizing blood loss for better outcomes Sanchez was confident he and his team could help Victoria become one of the first bloodless double-lung transplant recipients in Illinois. "Everybody else said ‘no’ to Teresa, but we didn't say ‘yes’ because we were crazy," said Sanchez, who approaches every transplant surgery with the goal to lose as little blood as possible — because the less blood lost, the better the outcome. "We said ‘yes’ because we knew we could help her through all of this." Bloodless transplant surgeries were developed to treat patients with certain religious beliefs, and UChicago Medicine’s transplant team has adapted these techniques for lung transplants. Rade Tomic, MD , medical director of UChicago Medicine's Lung Transplant Program, said the method produces better outcomes and has a lower risk of graft dysfunction, arrhythmias and stroke. Nevertheless, few medical centers are able to undertake the procedure when both lungs are being transplanted. "Nobody in our region is doing it because without the ability to transfuse the patient, it's a technically challenging procedure," Tomic said. Successful bloodless lung transplant surgery and recovery Shortly after her arrival, Victoria was admitted to stabilize her health, build up her iron and hemoglobin levels and gain weight before the operation. On February 19 — after weeks of nervous anticipation and musings from Patalla that one of the medical helicopters they could see landing from his wife's hospital room might be carrying her donor's gift — Sanchez began the operation to replace Victoria's diseased lungs. He began by opening Victoria's chest and connecting her heart to an extracorporeal membrane oxygenation (ECMO) system to temporarily replace the work being done by her lungs. He first removed the left lung and ensured there was minimal blood loss. "We paid a lot of attention because we did not want this patient to bleed in the ICU later," Sanchez said. After carefully connecting the new lung's pulmonary arteries and veins to Victoria's existing blood vessels, Sanchez allowed blood to flow into the lung and made sure it would ventilate before repeating the same procedures with the right lung. After 10 hours of work, the transplant was complete. Sanchez asked Victoria to open her eyes. "I opened my eyes and smiled," Victoria said. "I was so happy." Breathing easier after double-lung transplant With her breathing improving by the day, Victoria no longer needs a portable oxygen concentrator. She still has frequent check-ups in order for doctors to fine-tune her medications and monitor her health, but the couple is renting an apartment in Chicago for one year so that she can easily attend her rehabilitation appointments. Other than being readmitted once to the hospital due to being weak after a planned scope of her lungs, Victoria continues to make progress. Patalla keeps a pill organizer the size of an iPad to store the dozens of pills his wife takes every day. Victoria is looking forward to those pills being reduced over time — and she's excited about an upcoming visit from her son and grandchildren. "Before the transplant I couldn't do anything anymore, and now I can do life's daily activities," she said. "It was worth it." 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