预约演示
更新于：2025-06-27
China Resources Pharmaceutical Holdings Co., Ltd.
更新于：2025-06-27
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疾病领域得分
一眼洞穿机构专注的疾病领域
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CTR20251615
艾托格列净片人体生物等效性研究
CTR20251115
美阿沙坦钾片人体生物等效性研究
CTR20250683
碳酸锂片人体生物等效性研究
100 项与 华润医药控股有限公司 相关的临床结果
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2025-10-01FOOD CHEMISTRY
Identifying gelatin source by mass spectrometry: A review
Review
作者: Hu, Zi-Zi ; Tu, Zong-Cai ; Zhang, Li-Jun ; Cheng, Jie ; Luo, Hao-Sheng ; Sha, Xiao-Mei ; Yang, Le-Ying ; Wang, Hui
Gelatin is adulterated in various foods, which can be identified by mass spectrometry (MS) to detect characteristic peptides. The paper aims to review the application of MS in qualitative and quantitative analysis of gelatin. The identification results are affected by many factors, including the process of gelatin production and processing, the pre-treatment method and type of MS. At present, the traceability of gelatin mainly exists in pure gelatin, mixed gelatin and food systems. The quantification of gelatin is mainly through external reference and labeled internal standards. In the future, reducing the loss of gelatin during extraction, obtaining the maximum target characteristic peptide and improving the accuracy of MS should be focused on. In addition, the quantitative application of MS should be expanded to meet the market demand.
2025-08-01JOURNAL OF BIOTECHNOLOGY
Glutamate-related nitrogen metabolism regulates cold-adaptive synthesis of red pigment in polar fungus Geomyces sp. WNF-15A
Article
作者: Lu, Jian ; Long, Haoyu ; Cai, Menghao ; Zhou, Jiawei ; Guo, Yan ; Liu, Haifeng ; Zhou, Xiangshan ; Wang, Nengfei
The polar fungus Geomyces sp. WNF-15A produces high-quality red pigment (AGRP), but the cold-dependent characteristic of AGRP synthesis restricts its industrialization. This study employed transcriptome analysis to compare gene expression profiles of the wild-type strain with cold-independent mutants of scaffold1.t692 (Δ1-692) and scaffold2.t704 (Δ2-704). From the analysis, 23 candidate genes were identified and functionally characterized among 22,600 differentially expressed genes. Knockout and recovery of scaffold5.t61, scaffold7.t586, or scaffold7.t712 proved their regulatory functions in AGRP synthesis, among which scaffold5.t61 functioned as a transcription factor, while scaffold7.t586 and scaffold7.t712 were involved in the glutamate-related nitrogen metabolism. Exogenous addition of nitrate, glutamine, and glutamate, combined with transcriptional regulation studies, revealed the importance of glutamate metabolism for cold-adaptive synthesis of AGRP. Scaffold5.t61 responded to the cold environment and regulated the transcription of scaffold2.t704 and scaffold1.t692. It subsequently increased glutamate synthesis by regulating the key nitrogen metabolism genes of scaffold7.t586 and scaffold7.t712, ultimately resulting in cold-dependent synthesis of AGRP in Geomyces sp. WNF-15A. This study offers new insights into the mechanisms of cold adaptation in polar fungi and serves as a reference for the development of psychrophilic fungal resources.
2025-07-01MOLECULAR IMMUNOLOGY
Andrographolide and its sulfated metabolite alleviated DSS-induced inflammatory bowel disease through regulating inflammation and immune via MAPK/NLRP3 pathways and the balance of Th17/Treg cells
Article
作者: Huo, Zhi-Peng ; Zhang, Juan ; Hui, Si-Wen ; Jia, Ya-Xue ; Cai, Jin-Yong ; He, Yi ; Zhang, Hui-Lin ; Li, Peng-Yan ; Qiu, Feng ; Sun, Cheng-Peng ; Zhu, Qi-Meng ; Chang, Jing ; Feng, Yan-Li
Inflammatory Bowel Disease (IBD), is a chronic illness characterized by severe abdominal pain, diarrhea, and weight loss, seriously diminishing patients' quality of life. Andrographolide (AND), a natural diterpenoid from Andrographis paniculata, and its sulfated metabolite, andrographolide sodium bisulfite (ASB), have showed potential anti-inflammatory effects. However, their mechanism in IBD remains elusive. This study investigated the impact of AND and its sulfated derivative ASB, on inflammatory responses in IBD. Our findings revealed that AND and ASB significantly reduced disease activity index (DAI) scores and enhanced intestinal barrier function in dextran sodium sulfate (DSS)-induced mice, thereby ameliorating the course of IBD. Furthermore, AND and ASB inhibited both the mitogen-activated protein kinase (MAPK) and NLRP3 pathways to reduce the release of inflammatory cytokines IL-6 and TNF-α. This mechanism was accompanied by a restoration of immune balance through the modulation of T-helper 17 (Th17) and regulatory T (Treg) cells. The ability of AND and ASB to mitigate chronic inflammation and maintain immune equilibrium presented a promising therapeutic approach for IBD management. These findings suggested that AND and ASB might provide novel therapeutic approaches for IBD, thereby warranting further investigation into their clinical efficacy for disease treatment and maintenance of remission.
100 项与 华润医药控股有限公司 相关的药物交易
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100 项与 华润医药控股有限公司 相关的转化医学
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