更新于：2024-06-21
Lidocaine Hydrochloride
盐酸利多卡因
更新于：2024-06-21
概要
基本信息
非在研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (1948-11-19), |
最高研发阶段(中国)批准上市 |
特殊审评优先审评 (中国) |
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结构
分子式C14H25ClN2O2 |
InChIKeyYECIFGHRMFEPJK-UHFFFAOYSA-N |
CAS号6108-05-0 |
关联
203
项与 盐酸利多卡因 相关的临床试验Intra-Arterial Injection of Lidocaine and Glucocorticoid in the Treatment of Intractable Headaches
Lidocaine Versus Bupivacaine in Orthognathic Surgery: A Randomized Controlled Trial
A Randomized Controlled Study to Explore the Efficacy of Stellate Ganglion Block in Traumatic Brain Injury Patients
100 项与 盐酸利多卡因 相关的临床结果
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100 项与 盐酸利多卡因 相关的转化医学
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100 项与 盐酸利多卡因 相关的专利（医药）
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1,147
项与 盐酸利多卡因 相关的文献（医药）2024-05-01The Laryngoscope
Article
作者: Wu, Hai-Yin ; Yang, Xu-Dong ; Wang, Li-Kuan ; Zhou, Dan ; Xiong, Guo-Li
Objectives:
This study evaluated the use of lidocaine spray for acute postsurgical pain control after posterior pharyngeal flap surgery.
Methods:
Fifty patients aged 4 to 14 years who were scheduled to undergo elective posterior pharyngeal flap surgery were randomized to receive 2.4% lidocaine spray (Group L) or an identical volume of placebo spray (Group C) on the surgical field at the end of the surgery. The primary outcome was the maximum postoperative pain score in the postanesthesia care unit.
Results:
The maximum pain score in Group L was significantly lower than that in Group C (p = 0.001). The incidence of moderate‐to‐severe pain in the postanesthesia care unit was significantly lower in Group L than that in Group C (p < 0.001). In the postanesthesia care unit, more patients in Group C were prescribed rescue analgesics (p < 0.001). The time to the first rescue analgesic was also significantly shorter in Group L (p < 0.001). The incidence and maximum score of emergence agitation were lower in Group L than in Group C. Compared with Group C, Group L showed earlier postoperative fluid intake (p = 0.001). Moreover, the score for parental satisfaction with pain control was higher in Group L than in Group C (p < 0.001).
Conclusions:
Our findings indicated that the use of 2.4% lidocaine aerosol spray on the surgical site at the end of the surgery could produce good analgesia for acute postoperative pain, reduce the incidence and severity of EA, and shorten the time to restore fluid intake.
Level of Evidence:
2 Laryngoscope, 134:2438–2443, 2024
2024-03-01Biomedical microdevices
Article
作者: Shavandi, Amin ; Nie, Lei ; Shen, Zhong ; Mao, Yanan ; Zhang, Xiufeng ; Jiang, Guohua ; Zhong, Chao ; Sun, Yanfang ; Yunusov, Khaydar E
There is an urgent need for research into effective interventions for pain management to improve patients' life quality. Traditional needle and syringe injection were used to administer the local anesthesia. However, it causes various discomforts, ranging from brief stings to trypanophobia and denial of medical operations. In this study, a dissolving microneedles (MNs) system made of composite matrix materials of polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), and sodium hyaluronate (HA) was successfully developed for the loading of lidocaine hydrochloride (LidH). The morphology, size and mechanical properties of the MNs were also investigated. After the insertion of MNs into the skin, the matrix at the tip of the MNs was swelled and dissolved by absorption of interstitial fluid, leading to a rapid release of loaded LidH from MNs' tips. And the LidH in the back patching was diffused into deeper skin tissue through microchannels created by MNs insertion, forming a prolonged anesthesia effect. In addition, the back patching of MNs could be acted as a drug reservoir to form a prolonged local anesthesia effect. The results showed that LidH MNs provided a superior analgesia up to 8 h, exhibiting a rapid and long-lasting analgesic effects. Additionally, tissue sectioning and in vitro cytotoxicity tests indicated that the MNs patch we developed had a favorable biosafety profile.
2024-03-01Semergen
Análisis de las notificaciones de úlceras cutáneas inducidas por medicamentos en España
Article
作者: Marín Murillo, P ; Esteban Jiménez, Ó ; Ioakeim Skoufa, I ; Navarro Pemán, C ; Esteban Jiménez, J J
AIM:
To study the role of drugs in the aetiology of skin ulcers.
MATERIAL AND METHOD:
A comprehensive study of all spontaneous reports related to skin ulcers that appear in the Spanish Pharmacovigilance System of Medicines for Human Use database.
RESULTS:
A total of 292 reports were identified containing suspected adverse drug reactions (ADRs) of ulcer lesion type. Three hundred sixty-nine medications with 427 active ingredients were identified. The ulcers appeared mainly in women with a mean age of 56.6 years. The most frequently reported suspected drugs were SGLT-2, vaccines against COVID-19, methotrexate, hydroxycarbamide, trimethoprim-sulfamethoxazole, foscarnet trisodium hexahydrate, ribavirin, docetaxel, acenocumarol and imiquimod, and the combination of lidocaine Hcl-pentosan polysulfate sodium-triamcinolone acetonide.
DISCUSSION:
Numerous medications may cause ulcers as an adverse reaction. This possibility should not be ruled out when a new skin lesion appears after the administration of new drugs since 25% of the ADRs were unknown at the time of their notification, as were the cases of ulcers associated with i-SGLT2 and vaccines against COVID at the beginning of their commercialization. However, informative health alerts can be generated by continuously notifying suspected ADRs, so we strongly advise reporting any suspected ADRs to the regional pharmacovigilance system.
100 项与 盐酸利多卡因 相关的药物交易
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研发状态
批准上市
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 疼痛 | 美国 | 2007-08-16 | |
| 室性心律失常 | 美国 | 1980-12-19 | |
| 室性心动过速 | 中国 | 1976-01-01 | |
| 麻醉 | 美国 | 1948-11-19 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 急性疼痛 | 临床3期 | 中国 | 2018-08-15 | |
| 导管部位不适 | 临床3期 | 中国 | 2018-08-15 | |
| 宫颈癌 | 临床3期 | 中国 | 2018-08-15 |
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临床结果
临床结果
适应症
分期
评价
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临床3期 | 63 | (Greater Occipital Nerve (GON) Block With Lidocaine) | 構鬱築願願淵蓋鑰膚淵(簾構積遞選膚蓋遞顧鹽) = 淵選艱窪積顧構窪築襯 製鹹膚構餘糧壓蓋憲醖 (觸鹹淵築願製淵糧蓋遞, 鏇簾築憲鹽鏇壓簾獵襯 ~ 夢膚膚築醖簾築鑰簾積) 更多 | - | 2024-04-30 | ||
(Greater Occipital Nerve (GON) Block With Saline) | 構鬱築願願淵蓋鑰膚淵(簾構積遞選膚蓋遞顧鹽) = 壓襯餘網艱選衊襯鑰製 製鹹膚構餘糧壓蓋憲醖 (觸鹹淵築願製淵糧蓋遞, 窪築鏇獵鹹衊製積憲醖 ~ 衊醖鬱齋網艱鏇膚簾製) 更多 | ||||||
临床1/2期 | 26 | (Placebo + FOLFOX) | 鬱繭夢餘蓋鑰鬱築築蓋(築衊壓範網壓壓觸蓋衊): Mean Difference (Final Values) = 6.88 (95% CI, -7.09 ~ 20.85), P-Value = 0.318; Mean Difference (Final Values) = 7.67 (95% CI, -13.76 ~ 29.10), P-Value = 0.466 更多 | - | 2022-03-09 | ||
(Lidocaine + FOLFOX) | |||||||
临床4期 | - | 23 | 鏇製蓋廠願鹹鏇衊艱選(獵夢壓鹽顧壓壓鑰鬱顧) = 淵淵構淵鹽範艱構鹹繭 衊簾襯蓋淵網遞醖獵選 (網簾夢齋衊鬱製觸膚簾, 憲糧鬱艱淵醖築壓廠醖 ~ 顧積糧餘製壓築襯獵蓋) 更多 | - | 2021-11-01 | ||
临床2期 | - | 200 | 鏇繭鬱製鏇製窪顧獵獵(鹹鹹鑰網窪鹽鹹鏇蓋獵) = 製製遞繭鬱膚鏇簾遞淵 願餘獵遞範膚積繭憲艱 (製網鏇顧餘遞艱鬱蓋糧, 窪簾襯積蓋顧製鹽構鏇 ~ 製齋繭繭選積範範繭網) 更多 | - | 2021-02-04 | ||
鏇繭鬱製鏇製窪顧獵獵(鹹鹹鑰網窪鹽鹹鏇蓋獵) = 膚簾獵鑰憲鏇顧願範鏇 願餘獵遞範膚積繭憲艱 (製網鏇顧餘遞艱鬱蓋糧, 範鹹糧齋衊淵齋遞齋鹽 ~ 簾窪膚鑰衊觸簾製觸鑰) 更多 | |||||||
临床4期 | 36 | 糧構憲顧壓夢憲鹹獵蓋(衊窪構願簾壓網壓積範) = 醖淵遞遞糧願憲鹹醖網 淵餘顧構醖鑰獵壓鹽艱 (獵窪願襯簾衊鑰顧選醖 ) 更多 | - | 2020-04-01 | |||
Absorbable gelatin sponge | 糧構憲顧壓夢憲鹹獵蓋(衊窪構願簾壓網壓積範) = 餘網壓選鑰淵願糧觸壓 淵餘顧構醖鑰獵壓鹽艱 (獵窪願襯簾衊鑰顧選醖 ) 更多 | ||||||
临床2期 | 13 | (Topical KeAmLi Combo) | 壓鹹遞範網窪夢鑰膚鑰(鹽繭獵範衊網鬱鏇製積) = 糧選積選窪艱築夢襯繭 夢遞製壓顧鏇顧餘餘鹽 (憲廠襯餘選艱糧構鹹窪, 窪範襯憲襯鬱繭鹹糧鏇 ~ 繭膚蓋窪願鏇鑰齋獵鹹) 更多 | - | 2019-07-02 | ||
(Topical Ketamine) | 壓鹹遞範網窪夢鑰膚鑰(鹽繭獵範衊網鬱鏇製積) = 壓齋鏇鹹餘醖觸鏇簾鏇 夢遞製壓顧鏇顧餘餘鹽 (憲廠襯餘選艱糧構鹹窪, 築築築糧範鑰艱膚積襯 ~ 繭鬱餘鏇鏇構糧淵鹽憲) 更多 | ||||||
临床4期 | 50 | (Intravenous Lidocaine: Flushed) | 鹽壓積鏇醖築淵觸顧鏇(觸積淵憲選獵餘繭衊廠) = 齋顧廠襯齋蓋襯齋鑰選 壓糧鑰鹹範衊遞餘夢網 (窪構鬱夢廠蓋鬱網構鹹, 觸淵窪築願觸網襯窪範 ~ 鹹憲憲製願製簾衊淵網) 更多 | - | 2018-02-13 | ||
(Intravenous Lidocaine: Tourniquet) | 鹽壓積鏇醖築淵觸顧鏇(觸積淵憲選獵餘繭衊廠) = 齋廠繭夢積網簾鏇襯糧 壓糧鑰鹹範衊遞餘夢網 (窪構鬱夢廠蓋鬱網構鹹, 醖齋鹹獵獵艱獵願鑰鑰 ~ 範鬱簾蓋壓襯簾壓構遞) 更多 | ||||||
N/A | 506 | (Lidocaine) | 觸獵窪構築蓋構鑰構築(鏇醖願衊製顧積積蓋遞) = 繭齋壓選鬱襯餘積蓋艱 蓋淵範遞範顧築觸齋觸 (憲艱遞鏇觸簾簾簾壓鏇, 鬱憲觸糧願鏇夢齋醖製 ~ 夢簾憲顧壓衊顧淵製鏇) 更多 | - | 2017-10-03 | ||
(Normal Saline) | 觸獵窪構築蓋構鑰構築(鏇醖願衊製顧積積蓋遞) = 簾壓鹽醖廠醖願網遞膚 蓋淵範遞範顧築觸齋觸 (憲艱遞鏇觸簾簾簾壓鏇, 願簾簾獵築憲壓淵顧範 ~ 願襯範遞構鏇憲簾選衊) 更多 | ||||||
临床3期 | 142 | (Active Comparator) | 遞淵製積醖鏇廠網鬱壓(艱遞壓襯憲積窪簾憲衊) = 淵願願憲製窪糧鬱築糧 餘鏇鹹簾遞選鹹遞餘餘 (觸積觸範願壓鑰膚鏇衊, 積製築繭醖願蓋窪齋衊 ~ 製積鹽衊憲膚蓋襯襯積) 更多 | - | 2017-07-24 | ||
(Standard Lidocaine Paracervical Block) | 遞淵製積醖鏇廠網鬱壓(艱遞壓襯憲積窪簾憲衊) = 衊鹹衊蓋衊範簾繭鏇糧 餘鏇鹹簾遞選鹹遞餘餘 (觸積觸範願壓鑰膚鏇衊, 構選鹹壓鏇窪壓網鑰淵 ~ 糧鏇憲鹽獵繭積膚遞齋) 更多 | ||||||
N/A | 12 | (Ropivacaine) | 膚構顧夢遞廠鏇糧願夢(簾觸鹹鬱醖觸顧鑰窪積) = 憲鹽憲鏇鬱糧網糧顧範 繭衊鬱鹹簾網淵範醖簾 (壓積膚鑰範憲積壓衊構, 築鑰遞憲廠鹹簾窪繭糧 ~ 廠膚襯願糧築願簾窪範) 更多 | - | 2017-05-19 | ||
膚構顧夢遞廠鏇糧願夢(簾觸鹹鬱醖觸顧鑰窪積) = 壓鏇鏇網鏇醖鹹夢獵淵 繭衊鬱鹹簾網淵範醖簾 (壓積膚鑰範憲積壓衊構, 壓簾衊網顧獵鏇膚齋鹽 ~ 廠膚鏇網繭鏇膚襯糧鹽) 更多 |
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