Delving into the Latest Updates on Assiut University with Synapse

概览

疾病领域	数量

感染	3

排名前五的药物类型	数量

小分子化药	2
疫苗	1

关联

5

项与 Assiut University 相关的药物

Calcimycin

卡西霉素

靶点-

作用机制-

在研机构

Merck Serono SA

原研机构

Merck Serono SA

在研适应症

男性不育症

非在研适应症-

最高研发阶段临床3期

首次获批国家/地区-

首次获批日期-

Hepatitis B Virus Vaccine(Assiut University)

靶点-

作用机制

免疫刺激剂

在研机构

Assiut University

原研机构

Assiut University

在研适应症

乙型肝炎 [+1]

非在研适应症-

最高研发阶段早期临床1期

首次获批国家/地区-

首次获批日期-

4-ASA derivative 19 (Assiut University)

靶点-

作用机制-

在研机构

Assiut University

原研机构

Assiut University

在研适应症

炎症 [+1]

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

4,002

项与 Assiut University 相关的临床试验

NCT06631547 / Not yet recruiting临床1期IIT

Effect of Progesterone Administration on Severely Head Injured Patients: Hospital Based Study

To investigate the effectiveness of progesterone as a neuroprotective in patients severe traumatic brain injury in clinical outcome

开始日期2025-12-01

申办/合作机构

Assiut University

NCT06654765 / Not yet recruitingN/AIIT

Growth and Development of Children With Inborn Errors of Metabolism in Assiut Governorate

Assessment of growth and development of children with inborn errors of metabolism in Assiut Governorate

开始日期2025-08-01

申办/合作机构

Assiut University

NCT06606873 / Not yet recruitingN/AIIT

Anatomical Risk Factors for Orbital Complications in Patients With Acute Rhinosinusitis

Rhinosinusitis is among the most common conditions encountered in the primary care clinic.

开始日期2025-07-01

申办/合作机构

Assiut University

100 项与 Assiut University 相关的临床结果

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0 项与 Assiut University 相关的专利（医药）

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24,222

项与 Assiut University 相关的文献（医药）

2025-02-01·Journal of Molecular Structure

ZnO NPs-modified biochar derived from banana peels for adsorptive removal of methylene blue from water

作者: Amin, Susan ; Abo Zeid, Essam F ; Essa, Reem A. ; Abo Zeid, Essam F. ; Sedky, A. ; El-Aal, Mohamed Abd

In this work, biochar (BC) was synthesized from the thermal decomposition of banana peels and modified by different percentages of ZnO NPs using the wet impregnation method.The ZnO_x/BC_1-x nanocomposites′ (x = 0.00, 0.10, 0.20, 0.30, 0.50, 1.00 as a weight) phys. and chem. properties were estimated utilizing X-ray powder diffraction (XRD), Fourier-transform IR spectroscopy (FTIR), N₂ sorption, Transmission electron microscopy (TEM), and zeta potential.The synthesized nanocomposites were utilized as adsorbents for eliminating methylene blue toxic dye from water.Through the adsorption batches, several parameters have been tested, such as the impact of x value, duration time, adsorbent dose, initial pH, dye concentration, and medium temperatureCompared to the tested nanocomposites, the ZnO_0.10/BC_0.90 nanocomposite revealed the best adsorption efficiency (96.5 %) with a high adsorption capacity reaching 118.8 mg/g.To ensure accurate identification of adsorption process behavior, the adsorption isotherms, kinetic models, and thermodn. studies were investigated.Langmuir and pseudo-2^nd order were discovered to be the most appropriate models that ascribe the adsorption behavior.Furthermore, the thermodn. study reveals that the MB uptake on the nanocomposites is both spontaneous and exothermic.

2025-01-01·Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

pH-Sensitive blue and red N-CDs for L-asparaginase quantification in complex biological matrices

Article

作者: El-Wekil, Mohamed M ; Mostafa, Aya M ; Barker, James ; Bellah H Ali, Al-Montaser ; Alhazzani, Khalid ; Mostafa, Aya M. ; Ibrahim, Hossieny ; El-Wekil, Mohamed M. ; Alanazi, Ahmed Z ; Bellah H. Ali, Al-Montaser ; Mahmoud, Ashraf M ; Mahmoud, Ashraf M. ; Alanazi, Ahmed Z.

A novel fluorometric method for the determination of L-asparaginase, an enzyme crucial in cancer therapy and food industry applications, is presented. This sensitive and selective approach utilizes L-asparagine and two pH-sensitive carbon dots (blue-N-CDs and red-N-CDs) as probes. The interaction between L-asparagine and L-asparaginase liberates ammonia, causing an increase in pH. This pH change simultaneously decreases the fluorescence of blue-N-CDs while enhancing the emission of red-N-CDs, enabling ratiometric detection of L-asparaginase. Comprehensive characterization of both carbon dots and investigation of their response mechanism towards L-asparaginase were conducted using ultraviolet-visible spectrophotometry, fluorescence spectroscopy, and transmission electron microscopy (TEM) imaging techniques. The designed approach demonstrates outstanding linearity (20 to 2000 U L^-1) and a low detection limit (6.95 U L^-1) for L-asparaginase quantification. Moreover, when tested to human serum samples, the detection system exhibits outstanding selectivity and high recovery rates (96.15% to 99.75%) with low standard deviation, underscoring its suitability for practical implementation in clinical diagnostics.

2024-12-31·Designed Monomers and Polymers

Ionic Organic Network-based C3-symmetric@Triazine core as a selective Hg ⁺² sensor

Article

作者: Alamry, Khalid A ; Alam, M M ; Rahman, Mohammed M ; Alshubramy, Maha A ; Hussein, Mahmoud A ; Asiri, Abdullah M

The C3-symmetry ionic polymer PPyTri has been designed with multi-walled carbon nanotubes (MWCNTs) or graphene nanoplatelets (GNPs) and studied as an ultrasensitive electrochemical sensor for trace Hg(II) detection. The synthesis approach incorporated attaching three pyridinium cationic components with chloride anions to the triazine core. The precursors, BPy, were synthesized using a condensation process involving 4-pyridine carboxaldehyde and focused nicotinic hydrazide. The polymer PPyTri was further modified with either MWCNTs or GNPs. The resulting ionic polymer PPyTri and its fabricated nanocomposites were characterized using infrared (IR), nuclear magnetic resonance (NMR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and powder X-ray diffraction (XRD). The analysis revealed that both the polymer and its nanocomposites have semi-crystalline structures. The electroactivity of the designed nanocomposites toward Hg + 2 ions revealed that among the nanocomposites and bare copolymer, the glassy carbon electrode (GCE) adapted with the PPyTri GNPs-5% exhibited the greatest current response over a wide range of Hg + 2 concentrations. The nanocomposite-modified electrode presented an excellent sensitivity of 83.33 µAµM - 1 cm - 2, a low detection limit of 0.033 nM, and a linear dynamic range of 0.1 nM to 0.01 mM (R2 = 0.9945).

100 项与 Assiut University 相关的药物交易

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100 项与 Assiut University 相关的转化医学

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管线布局中药物为当前组织机构及其子机构作为药物机构进行统计，早期临床1期并入临床1期，临床1/2期并入临床2期，临床2/3期并入临床3期

临床前

2

1

临床1期

其他

2

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当前项目

药物(靶点)	适应症	全球最高研发状态

Hepatitis B Virus Vaccine(Assiut University)	疣更多	临床1期
4-ASA derivative 20 (Assiut University)	炎症更多	临床前
4-ASA derivative 19 (Assiut University)	炎症更多	临床前
卡西霉素	男性不育症更多	无进展
孜然籽提取物	外阴阴道念珠菌病更多	无进展