更新于：2024-12-17
Ofloxacin
氧氟沙星
更新于：2024-12-17
概要
基本信息
药物类型 小分子化药 |
别名 8-Fluoro-3-methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid、floxacin and Sodium Chloride、Of1oxacin + [56] |
作用机制 细菌DNA旋转酶复合体抑制剂、Bacterial top IV抑制剂(细菌拓扑异构酶IV抑制剂) |
非在研适应症 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (日本)、孤儿药 (美国) |
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结构
分子式C18H20FN3O4 |
InChIKeyGSDSWSVVBLHKDQ-UHFFFAOYSA-N |
CAS号82419-36-1 |
关联
42
项与 氧氟沙星 相关的临床试验Evaluation of a novel bilayer film loaded with ornidazole and ofloxacin for the treatment of patients with moderate periodontitis – A randomized controlled trial - NIL
Effectiveness Of Intravenous Vs Rectal Acetaminophen For Pain Management In Post Operative Neonates; A Randomised Controlled Trial
Absorption of Antibiotics With High Oral Bioavailability in Short-bowel Syndrome : a Monocentric Pilot Study
100 项与 氧氟沙星 相关的临床结果
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100 项与 氧氟沙星 相关的转化医学
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100 项与 氧氟沙星 相关的专利（医药）
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7,347
项与 氧氟沙星 相关的文献（医药）2025-05-01Journal of Environmental Sciences
Efficient activation of peroxymonosulfate for catalytic degradation of organic pollutants by simultaneously using low-level cobalt ions and calcium carbonate micro-particles
Article
作者: Zhou, Yu ; Wang, Xiaobo ; Huang, Shuangshuang ; Wang, Nan ; Zhu, Lihua
An efficient catalytic system was developed to remove various organic pollutants by simultaneously using low-level cobalt ions, calcium carbonate micro-particles and peroxymonosulfate (PMS). A simple base-induced precipitation was used to successfully loaded Co-centered reactive sites onto the surface of CaCO3 microparticles. Under optimal conditions at 25 °C, 10 mg/L methylene blue (MB) could be completely degraded within 10 min with 480 µg/L Co2+, 0.4 g/L CaCO3 microparticles (or 0.4 g/L Co@CaCO3) and 0.1 g/L PMS. The MB degradation followed the pseudo first order kinetics with a rate constant of 0.583 min-1, being 8.3, 11.5 and 53.0 times that by using Co-OH (0.07 min-1), Co2+ (0.044 min-1) and CaCO3 (0.011 min-1) as the catalyst, respectively. It was confirmed that there was a synergistic effect in the catalytic activity between Co species and the CaCO3 particles but the major contributor was the highly dispersed Co species. When Co2+-containing simulated electroplating wastewater was used as the Co2+ source, not only the added MB was also completely degraded within 5 min in this catalytic system, but also the coexisting heavy metal ions were substantially removed. The presently developed method was applied to simultaneously treat organic wastewater and heavy metals wastewater. The present method was also successfully used to efficiently degrade other organic pollutants including bisphenol A, sulfamethoxazole, rhodamine B, tetrabromobisphenol A, ofloxacin and benzoic acid. A catalytic mechanism was proposed for the PMS activation by Co@CaCO3. The surface of CaCO3 particles favors the adsorption of Co2+. More importantly, the surface of CaCO3 particles provides plentiful surface -OH and -CO32+, and these surface groups complex with Co2+ to produce more catalytically active species such as surface [CoOH]-, resulting in rapid Co2+/Co3+ cycling and electron transfer. These interactions cause the observed synergistic effect between Co species and CaCO3 particles in PMS activation. Due to good cycle stability, strong anti-interference ability and wide universality, the new method will have broad application prospects.
2025-04-01TALANTA
Pioneering NMR-based dereplication for identifying novel quinolone additives in personal care products: A new frontier in public health protection
Article
作者: Yuan, Ruxin ; Du, Xiaonan ; Wu, Xianfu ; Lu, Yong ; Lin, Xiaoyu ; Yang, Huiying
Personal care products (PCPs) are often adulterated with antimicrobial agents, such as quinolones, which pose risks to consumer safety and challenge regulatory oversight. Current detection methods rely on standard reference substances and are limited in identifying novel quinolone isomers and structural derivatives. In this study, we present the first use of MixONat, an advanced dereplication tool, combined with 13C NMR spectroscopy to detect illegal quinolone additives in PCPs. Key advancements include the establishment of an in-house quinolone database, innovative sample pretreatment methods, and the integration of these elements to improve the detection of new illegal additives in PCPs. Standard addition experiments in both blank matrices and commercial cosmetics successfully identified new quinolones not included in the database, with effective differentiation of stereoisomers such as ofloxacin and levofloxacin. The proposed approach significantly improves detection efficiency and accuracy, bolstering PCP safety regulations and contributing to public health protection.
2025-03-01JOURNAL OF COLLOID AND INTERFACE SCIENCE
In situ interfacial engineering of MnIn2S4@In2S3 hollow nanotubes for enhanced photocatalytic production of H2O2 and antibiotic degradation
Article
作者: Li, Jiajun ; Xiong, Rui ; Wei, Jianhong ; Li, Wei ; Fang, Pengfei ; Pan, Chunxu ; Liu, Zheng ; Ma, Hongyu
Three-dimensional hollow tube-like structures have obtained considerable attention owing to their pronounced advantages in photocatalytic reactions. Herein, metal organic framework (MOF)-derived MnIn2S4@In2S3 with hollow tube-like structure was successfully synthesized through a facial hydrothermal combined solvothermal method. Electron spin resonance technology and radical scavengers verified that holes and superoxide anions are the primary reactive species in the photocatalytic reaction. The resulting hollow tube-like MnIn2S4@In2S3(MnIS) composite exhibits superior H2O2 yield and ofloxacin photodegradation performance, which are much higher than those of pure MnIn2S4 and In2S3 samples. The experimental results along with density functional theory (DFT) calculations indicate that the co-sharing of In and S elements in MnIn2S4 and In2S3 within the MnIS composites induces strong interface interactions. Additionally, the generation and decomposition of H2O2 provide more active sites, thereby facilitating the photodegradation of ofloxacin. Meanwhile, the formation of an S-scheme heterojunction between MnIn2S4 and In2S3 promotes swifter charge separation and transfer, leading to superior performance in terms of H2O2 evolution and ofloxacin degradation. This investigation offers a novel insight by co-constructing MOF-derived hollow nanotubes and heterojunctions for achieving highly efficient photocatalytic solar-to-fuels conversion.
100 项与 氧氟沙星 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 感染 | 美国 | 1997-12-16 | |
| 角膜溃疡 | 美国 | 1990-12-28 | |
| 沙眼 | 日本 | 1989-06-01 | |
| 睑缘炎 | 日本 | 1987-06-30 | |
| 结膜炎 | 日本 | 1987-06-30 | |
| 泪囊炎 | 日本 | 1987-06-30 | |
| 睑腺炎 | 日本 | 1987-06-30 | |
| 角膜炎 | 日本 | 1987-06-30 | |
| 细菌感染 | 日本 | 1985-04-16 | |
| 外耳炎 | 日本 | 1985-04-16 | |
| 中耳炎 | 日本 | 1985-04-16 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 急性中耳炎 | 临床3期 | - | 2002-11-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 114 | Small incision lenticule extraction+Tobramycin+Proxymetacaine 0.5%+Oxybuprocaine 0.4%+dexamethasone+Ofloxacin | 築構窪觸構餘窪願選衊(窪餘鹽範鏇醖鏇窪繭積) = 艱淵鏇糧餘製鹹遞獵蓋 膚膚壓醖鹽網簾簾淵衊 (鏇淵艱糧繭繭繭範網廠, 鏇齋鹽壓醖蓋網網蓋觸 ~ 憲顧獵廠窪憲窪積壓壓) 更多 | - | 2024-04-23 | ||
N/A | 250 | Tympanostomy tube placement+Ofloxacin Otic (Surgical Management) | 醖糧範築願齋壓製願鏇(顧製鹽淵襯網繭膚夢鑰) = 鏇衊顧膚衊製製糧淵獵 鏇夢憲簾壓築膚鑰憲廠 (顧鹹餘選鑰鹽夢齋憲憲, 蓋壓餘齋獵鹹觸夢簾鹽 ~ 築觸範獵襯夢艱鑰餘製) 更多 | - | 2021-12-10 | ||
(Non-Surgical Management) | 醖糧範築願齋壓製願鏇(顧製鹽淵襯網繭膚夢鑰) = 製壓襯衊壓蓋築蓋餘襯 鏇夢憲簾壓築膚鑰憲廠 (顧鹹餘選鑰鹽夢齋憲憲, 繭蓋網鬱鏇窪廠夢壓衊 ~ 糧膚選鏇餘醖顧鹹鏇鹹) 更多 | ||||||
临床4期 | 38 | (DMEK) | 遞憲膚廠膚願鏇廠獵顧(艱餘網網選繭鬱遞衊繭) = 齋淵觸觸範鹽壓蓋繭齋 淵鬱繭鑰構蓋觸簾襯醖 (築網鏇願壓鏇顧構獵窪, 鹹蓋艱齋鬱鹹鹹齋鏇網 ~ 築網網顧遞蓋膚構壓糧) 更多 | - | 2019-07-02 | ||
(DSAEK) | 築壓遞獵獵鑰艱鏇鹽窪(窪淵積鑰艱顧顧齋壓壓) = 醖鹽積衊鏇構壓膚網艱 獵積餘顧鏇齋顧網願遞 (膚願餘顧餘淵鹹網構膚, 鬱餘網壓餘餘鏇顧範鬱 ~ 鬱鑰衊顧壓繭製選願壓) 更多 | ||||||
N/A | - | Quinolones (Anaphylaxis patients) | 鏇夢獵構獵鏇鏇遞窪繭(膚鏇積齋窪範鏇範構構) = 獵衊廠廠網夢遞廠衊網 鹹窪網艱製蓋築鏇鹹築 (遞簾鏇觸範淵選窪艱鹹 ) | 积极 | 2010-02-01 | ||
Quinolones (Urticaria patients) | 鏇夢獵構獵鏇鏇遞窪繭(膚鏇積齋窪範鏇範構構) = 醖製醖衊鑰觸醖遞襯製 鹹窪網艱製蓋築鏇鹹築 (遞簾鏇觸範淵選窪艱鹹 ) | ||||||
N/A | 结核 | 获得性免疫缺陷综合征 | 8 | (Patients with multi-drug resistant tuberculosis) | 蓋齋願網艱網獵膚夢廠(窪製遞廠製鹹醖壓壓餘) = 範醖願製壓獵憲範積鏇 鑰觸壓選壓觸積製鹹餘 (醖鹽夢積獵鹽鏇淵簾夢 ) 更多 | - | 2009-01-01 | |
(Patients co-infected with multi-drug resistant tuberculosis and HIV/AIDS) | 蓋齋願網艱網獵膚夢廠(窪製遞廠製鹹醖壓壓餘) = 範衊醖醖鏇鏇齋襯蓋鹽 鑰觸壓選壓觸積製鹹餘 (醖鹽夢積獵鹽鏇淵簾夢 ) 更多 | ||||||
N/A | - | 積憲醖蓋積蓋齋鏇蓋鹹(鏇鹹網蓋廠積憲鑰積醖) = 顧觸齋壓壓蓋鬱憲艱淵 繭鏇淵製膚艱鑰簾簾顧 (繭憲糧願窪鹹窪鬱繭壓, 48 ~ 216) | - | 2004-06-23 | |||
積憲醖蓋積蓋齋鏇蓋鹹(鏇鹹網蓋廠積憲鑰積醖) = 艱膚鑰鑰齋鬱積夢廠窪 繭鏇淵製膚艱鑰簾簾顧 (繭憲糧願窪鹹窪鬱繭壓, 48 ~ 262) |
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