更新于：2024-11-23
Proparacaine Hydrochloride
盐酸丙美卡因
更新于：2024-11-23
概要
基本信息
原研机构 |
在研机构- |
最高研发阶段撤市 |
首次获批日期 美国 (1953-07-01), |
最高研发阶段(中国)- |
特殊审评- |
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结构
分子式C16H27ClN2O3 |
InChIKeyBFUUJUGQJUTPAF-UHFFFAOYSA-N |
CAS号5875-06-9 |
关联
14
项与 盐酸丙美卡因 相关的临床试验Evaluation of Nanodropper-mediated Microdrops vs Conventional Dropsof Proparacaine HCL 0.5 Percentage - Nil
Efficacy and Safety of Anesthetic Impregnated Bandage Soft Contact Lens (BSCL) in Pain Management After Photorefractive Keratectomy (PRK).
Topical Proparacaine Eye Drops to Improve the Experience of Patients Undergoing Intravitreal Injections
100 项与 盐酸丙美卡因 相关的临床结果
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100 项与 盐酸丙美卡因 相关的转化医学
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100 项与 盐酸丙美卡因 相关的专利（医药）
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368
项与 盐酸丙美卡因 相关的文献（医药）2024-10-15Romanian journal of ophthalmology
Comparison of the effectiveness of 0.5% and 0.25% proparacaine hydrochloride eye drops as topical anesthetics in routine ocular investigations and procedures
Article
作者: Joshi, Rajesh Subhash
Aim:
To compare the effectiveness of 0.5% and 0.25% proparacaine eye drops in providing topical anesthesia for routine ocular procedures.
Methodology:
137 patients (274 eyes) were included in this study. They were categorized into two groups. Group A patients received 0.5% and Group B received 0.25% proparacaine drops. A single surgeon performed all the procedures. Intraprocedural and postprocedural pain scores, surgeon comfort, supplemental anesthesia, and vital parameters, were noted.
Results:
The mean age of the participants was 69.42 years (±12.05). An equal number of procedures were performed (n = 30) for applanation tonometry, lacrimal sac syringing, and A-scan biometry. The other procedures performed were removal of the conjunctiva (n = 5) and corneal foreign bodies (n = 16 per group), corneal scraping (n = 8 per group), and corneal suture removal (n = 18 per group).The mean visual analog pain score during the procedure was 6.9663 in Group A and 8.0803 in Group B (P = 0.66). The mean postprocedural pain score was not significant (P = 0.21). None of the patients required any additional anesthesia during or after the procedure. The average surgeon's experience was 0.152±0.507 in Group A and 0.111±0.402 in Group B (P = 0.07).In Group A, 133 of 137 patients (97.08%), and in Group B, 132 out of 137 patients (96.35%) preferred to use the same anesthetic for future procedures. None of the patients experienced a vasovagal attack or any change in vital parameters.
Discussion:
The present study aimed to establish equivalence between two concentrations of proparacaine hydrochloride in which false positive and false negative errors were expected. This is the inherent challenge in the equivalence and inferiority trials. To mitigate these risks, the present study was carefully designed with specific statistical methods, sample size calculation, and rigorous methodology. Nevertheless, it is crucial to recognize that the risk of false positive errors remains, and the results should be interpreted with this in mind.
Conclusion:
These findings indicated that 0.25% proparacaine is a viable alternative to the standard 0.5% concentration in routine ophthalmic procedures, with the potential for improved patient comfort.
2024-10-01Intensive and Critical Care Nursing
Effectiveness of non-pharmacological interventions in reducing pain in preterm infants: A systematic review and network meta-analysis
Review
作者: da Silva Vieira, Alexia Gabriela ; de Lima, Raquel Lima ; Boechat, Antônio Luiz ; Miralha, Alexandre Lopes ; Cordeiro, Sarah Almeida ; Gonçalves, Roberta Lins ; de Oliveira Andrade, Edson ; Lopes, Tainá Costa Pereira ; do Valle Filho, Marcello Facundo
OBJECTIVE:
To identify the most effective non-pharmacological measures for pain control in preterm infants in the Neonatal Intensive Care Unit (NICU).
METHODS:
A Systematic review and network meta-analysis of randomized clinical trials published in English, Portuguese, and Spanish from April 2020 to December 2023. The data sources used were MedLine via PubMed, LILACS, EMBASE, The Cochrane Central Register of Controlled Trials, and Pedro. We performed the risk of bias analysis with Rob 2 and the certainty of the evidence and strength of the recommendation using the Grading of Recommendations Assessment, Development, and Evaluation system. We assessed heterogeneity using the Higgins and Thompson I2 test, the classification of interventions using the P-score, and inconsistencies using the Direct Evidence Plot.
RESULTS:
From 210 publications identified, we utilized 12 studies in analysis with 961 preterm infants, and we combined ten studies in network meta-analysis with 716 preterm infants, and 12 combinations of non-pharmacological measures. With moderate confidence, sensory saturation, sugars, non-nutritive sucking, maternal heart sound, lullaby, breast milk odor/taste, magnetic acupuncture, skin-to-skin contact, and facilitated tucking have been shown to reduce pain in preterm infants when compared to no intervention, placebo, proparacaine or standard NICU routine: sensory saturation [SMD 5,25 IC 95%: -8,98; -1,53], sugars [SMD 2,32 IC 95%: -3,86; -0,79], pacifier [SMD 3,74 IC 95%: -7,30; 0,19], and sugars and pacifier SMD [3,88 IC 95% -7,72; -0,04].
CONCLUSION:
Non-pharmacological measures are strongly recommended for pain management in preterm infants in the NICU.
IMPLICATIONS FOR CLINICAL PRACTICE:
The findings of this study have important implications for policy and practice. This is the only systematic review that compared the effectiveness of non-pharmacological measures, thus making it possible to identify which measure presents the best results and could be the first choice in clinical decision making.
2024-08-01Asia-Pacific Journal of Oncology Nursing
Improved method of dilating pupils for ophthalmic exams under anesthesia (faster and easier)
Article
作者: Rojas, Ricardo Dodds ; Liu, Todd ; Foerch, Angela ; Abramson, David H ; Gaccione, Jacquelyn ; Bobin, Andrea ; Francis, Jasmine H ; Robbins, Melissa A ; Bracken, Christina ; Guarini, Edith
Objective:
The pupils of children with retinoblastoma are routinely dilated pre-procedure with Tropicamide and Phenylephrine. Despite that, the pupil constricts once general anesthesia begins. The aim of this study is to see if adding Ketorolac to the regular dilating drops given pre-procedure shortens the length of anesthesia.
Methods:
Retrospective comparison of time under anesthesia for two groups of retinoblastoma children receiving anesthesia for examination under anesthesia: one group (January 1, 2019 to October 1, 2022) had been dilated with Tropicamide 1% and Phenylephrine 2.5% while the second group (October 2, 2022 to July 1, 2023) was dilated with a combination drop using those drugs with topical Ketorolac 0.5% and Proparacaine 0.5%.
Results:
Average anesthesia time for patients who received the older two-drug combination was 25 minutes vs. 16 minutes (36% reduction in exposure time) for those who received the newer four-drug combination (9 minutes less anesthesia) (P < 0.001).
Conclusions:
The use of a combined dilating drop that incorporated Tropicamide 1%, Phenylephrine 2.5%, Proparacaine 0.5% and Ketorolac 0.5% significantly shortened the time for exams under anesthesia for children with retinoblastoma because the pupil remained dilated after anesthesia induction with Sevoflurane. Using this combined drop, children will receive 5-10 hours less anesthesia during their treatment for retinoblastoma and staff will have more than 150 hours of fewer exposure to anesthetic gasses. In addition, far fewer drops are necessary pre-anesthesia, minimizing trauma to the children and families.
100 项与 盐酸丙美卡因 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 麻醉 | 美国 | 1953-07-01 |
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临床结果
临床结果
适应症
分期
评价
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N/A | 114 | Small incision lenticule extraction+Tobramycin+Proxymetacaine 0.5%+Oxybuprocaine 0.4%+dexamethasone+Ofloxacin | 願鏇夢鬱製餘願憲顧膚(獵獵鑰製鬱顧蓋艱網餘) = 襯糧蓋製憲簾夢網鹽鬱 鏇醖廠選遞夢憲觸簾蓋 (廠願鏇夢觸蓋鑰糧遞選, 觸鏇觸遞構鹹廠範鹽鬱 ~ 鹽製齋顧鹹範餘繭鏇鹹) 更多 | - | 2024-04-23 | ||
N/A | 36 | Conjunctival culture (Standard Procedure + Culture) | 壓選觸鑰夢蓋範構簾築(製觸淵製憲淵鹽壓蓋窪) = 鬱選積艱夢齋憲憲醖夢 糧醖網膚繭壓鹹窪膚餘 (壓構顧網蓋顧遞選糧衊, 製餘艱觸觸醖衊淵顧簾 ~ 簾積淵鹽鏇鹽窪餘淵壓) 更多 | - | 2019-06-25 | ||
Conjunctival culture+Proparacaine (Proparacaine + Culture) | 壓選觸鑰夢蓋範構簾築(製觸淵製憲淵鹽壓蓋窪) = 鏇顧齋齋憲憲觸網蓋襯 糧醖網膚繭壓鹹窪膚餘 (壓構顧網蓋顧遞選糧衊, 網獵鬱遞艱獵選醖繭鏇 ~ 觸製鏇糧觸範壓積顧築) 更多 | ||||||
N/A | 28 | 鏇製鬱膚醖糧築憲觸鏇(顧膚觸鑰製醖鑰鑰廠糧) = 壓蓋壓憲願膚齋廠顧鹹 顧糧製夢齋糧醖艱積鏇 (襯積壓繭憲衊遞壓糧簾, 襯壓鏇簾鏇衊餘鑰鹽窪 ~ 憲窪壓鹽膚艱範襯夢壓) 更多 | - | 2019-03-21 | |||
N/A | 57 | (Topical Anesthesia 1 Eye, SC 1 Eye) | 艱鑰築鹹壓餘築憲鬱繭(觸製襯獵觸顧選顧糧醖) = 觸網願窪製獵蓋範獵憲 壓繭製構襯醖網憲範窪 (構鑰夢選鹽壓鹽築遞艱, 獵構鏇糧鹽遞鏇壓顧簾 ~ 糧糧廠鑰淵構蓋艱醖製) 更多 | - | 2014-04-21 | ||
(Topical Anesthesia) | 構獵構糧齋築鑰觸醖範(構淵壓繭構鹹夢襯醖網) = 壓製鹽蓋窪繭糧選顧蓋 憲遞膚製衊鑰積鑰膚構 (網範網遞鬱簾鹹窪衊構, 齋顧構淵艱鹹憲淵糧壓 ~ 鬱選獵鹽範糧齋遞鹹鹽) 更多 | ||||||
N/A | 5 | (Proparacaine) | 構壓獵築顧製襯築鏇淵(鹹艱廠壓選獵獵遞廠鑰) = 簾鹹蓋觸選鑰蓋製願憲 鏇鹹簾製鬱衊憲憲簾壓 (糧醖餘獵鏇獵顧顧選夢, 糧衊衊蓋鑰夢觸構鬱襯 ~ 繭夢繭夢積鹹築築齋選) 更多 | - | 2013-03-19 | ||
(Standard of Care) | 構壓獵築顧製襯築鏇淵(鹹艱廠壓選獵獵遞廠鑰) = 蓋鏇壓鬱製餘築餘範蓋 鏇鹹簾製鬱衊憲憲簾壓 (糧醖餘獵鏇獵顧顧選夢, 鹹鑰選鑰襯選淵窪憲膚 ~ 憲簾繭膚衊艱壓艱顧積) 更多 | ||||||
N/A | - | - | Proparacaine eye drops | 襯蓋鬱範繭願獵夢夢衊(夢餘齋衊鏇鬱蓋鏇觸鹹) = 網構鏇願獵鑰廠積醖糧 夢構鏇鹽襯窪餘糧簾窪 (築蓋淵獵構鑰鑰憲選遞 ) | - | 2008-09-29 | |
Tetracaine eye drops | 襯蓋鬱範繭願獵夢夢衊(夢餘齋衊鏇鬱蓋鏇觸鹹) = 願壓鏇窪襯蓋鹽築淵窪 夢構鏇鹽襯窪餘糧簾窪 (築蓋淵獵構鑰鑰憲選遞 ) | ||||||
N/A | - | 46 | Topical Anesthetic Drops | 簾淵選齋艱衊鏇糧壓鑰(餘淵觸憲鬱繭蓋遞廠餘) = 遞範繭選鑰鬱廠願衊糧 遞簾觸憲製鑰齋淵鹹醖 (簾醖觸鹽遞鹽膚餘網鬱 ) 更多 | - | 2004-05-01 |
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