更新于：2024-11-04
Proparacaine Hydrochloride
盐酸丙美卡因
更新于：2024-11-04
概要
基本信息
原研机构 |
在研机构- |
最高研发阶段撤市 |
首次获批日期 美国 (1953-07-01), |
最高研发阶段(中国)- |
特殊审评- |
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结构
分子式C16H27ClN2O3 |
InChIKeyBFUUJUGQJUTPAF-UHFFFAOYSA-N |
CAS号5875-06-9 |
关联
14
项与 盐酸丙美卡因 相关的临床试验Evaluation of Nanodropper-mediated Microdrops vs Conventional Dropsof Proparacaine HCL 0.5 Percentage - Nil
Efficacy and Safety of Anesthetic Impregnated Bandage Soft Contact Lens (BSCL) in Pain Management After Photorefractive Keratectomy (PRK).
Topical Proparacaine Eye Drops to Improve the Experience of Patients Undergoing Intravitreal Injections
100 项与 盐酸丙美卡因 相关的临床结果
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100 项与 盐酸丙美卡因 相关的转化医学
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100 项与 盐酸丙美卡因 相关的专利（医药）
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366
项与 盐酸丙美卡因 相关的文献（医药）2024-10-15Romanian journal of ophthalmology
Comparison of the effectiveness of 0.5% and 0.25% proparacaine hydrochloride eye drops as topical anesthetics in routine ocular investigations and procedures
Article
作者: Joshi, Rajesh Subhash
Aim:
To compare the effectiveness of 0.5% and 0.25% proparacaine eye drops in providing topical anesthesia for routine ocular procedures.
Methodology:
137 patients (274 eyes) were included in this study. They were categorized into two groups. Group A patients received 0.5% and Group B received 0.25% proparacaine drops. A single surgeon performed all the procedures. Intraprocedural and postprocedural pain scores, surgeon comfort, supplemental anesthesia, and vital parameters, were noted.
Results:
The mean age of the participants was 69.42 years (±12.05). An equal number of procedures were performed (n = 30) for applanation tonometry, lacrimal sac syringing, and A-scan biometry. The other procedures performed were removal of the conjunctiva (n = 5) and corneal foreign bodies (n = 16 per group), corneal scraping (n = 8 per group), and corneal suture removal (n = 18 per group).The mean visual analog pain score during the procedure was 6.9663 in Group A and 8.0803 in Group B (P = 0.66). The mean postprocedural pain score was not significant (P = 0.21). None of the patients required any additional anesthesia during or after the procedure. The average surgeon's experience was 0.152±0.507 in Group A and 0.111±0.402 in Group B (P = 0.07).In Group A, 133 of 137 patients (97.08%), and in Group B, 132 out of 137 patients (96.35%) preferred to use the same anesthetic for future procedures. None of the patients experienced a vasovagal attack or any change in vital parameters.
Discussion:
The present study aimed to establish equivalence between two concentrations of proparacaine hydrochloride in which false positive and false negative errors were expected. This is the inherent challenge in the equivalence and inferiority trials. To mitigate these risks, the present study was carefully designed with specific statistical methods, sample size calculation, and rigorous methodology. Nevertheless, it is crucial to recognize that the risk of false positive errors remains, and the results should be interpreted with this in mind.
Conclusion:
These findings indicated that 0.25% proparacaine is a viable alternative to the standard 0.5% concentration in routine ophthalmic procedures, with the potential for improved patient comfort.
2024-10-01Intensive and Critical Care Nursing
Effectiveness of non-pharmacological interventions in reducing pain in preterm infants: A systematic review and network meta-analysis
Review
作者: da Silva Vieira, Alexia Gabriela ; de Lima, Raquel Lima ; Boechat, Antônio Luiz ; Miralha, Alexandre Lopes ; Cordeiro, Sarah Almeida ; Gonçalves, Roberta Lins ; de Oliveira Andrade, Edson ; Lopes, Tainá Costa Pereira ; do Valle Filho, Marcello Facundo
OBJECTIVE:
To identify the most effective non-pharmacological measures for pain control in preterm infants in the Neonatal Intensive Care Unit (NICU).
METHODS:
A Systematic review and network meta-analysis of randomized clinical trials published in English, Portuguese, and Spanish from April 2020 to December 2023. The data sources used were MedLine via PubMed, LILACS, EMBASE, The Cochrane Central Register of Controlled Trials, and Pedro. We performed the risk of bias analysis with Rob 2 and the certainty of the evidence and strength of the recommendation using the Grading of Recommendations Assessment, Development, and Evaluation system. We assessed heterogeneity using the Higgins and Thompson I2 test, the classification of interventions using the P-score, and inconsistencies using the Direct Evidence Plot.
RESULTS:
From 210 publications identified, we utilized 12 studies in analysis with 961 preterm infants, and we combined ten studies in network meta-analysis with 716 preterm infants, and 12 combinations of non-pharmacological measures. With moderate confidence, sensory saturation, sugars, non-nutritive sucking, maternal heart sound, lullaby, breast milk odor/taste, magnetic acupuncture, skin-to-skin contact, and facilitated tucking have been shown to reduce pain in preterm infants when compared to no intervention, placebo, proparacaine or standard NICU routine: sensory saturation [SMD 5,25 IC 95%: -8,98; -1,53], sugars [SMD 2,32 IC 95%: -3,86; -0,79], pacifier [SMD 3,74 IC 95%: -7,30; 0,19], and sugars and pacifier SMD [3,88 IC 95% -7,72; -0,04].
CONCLUSION:
Non-pharmacological measures are strongly recommended for pain management in preterm infants in the NICU.
IMPLICATIONS FOR CLINICAL PRACTICE:
The findings of this study have important implications for policy and practice. This is the only systematic review that compared the effectiveness of non-pharmacological measures, thus making it possible to identify which measure presents the best results and could be the first choice in clinical decision making.
2024-08-01Asia-Pacific Journal of Oncology Nursing
Improved method of dilating pupils for ophthalmic exams under anesthesia (faster and easier)
Article
作者: Rojas, Ricardo Dodds ; Liu, Todd ; Foerch, Angela ; Abramson, David H ; Gaccione, Jacquelyn ; Bobin, Andrea ; Francis, Jasmine H ; Robbins, Melissa A ; Bracken, Christina ; Guarini, Edith
Objective:
The pupils of children with retinoblastoma are routinely dilated pre-procedure with Tropicamide and Phenylephrine. Despite that, the pupil constricts once general anesthesia begins. The aim of this study is to see if adding Ketorolac to the regular dilating drops given pre-procedure shortens the length of anesthesia.
Methods:
Retrospective comparison of time under anesthesia for two groups of retinoblastoma children receiving anesthesia for examination under anesthesia: one group (January 1, 2019 to October 1, 2022) had been dilated with Tropicamide 1% and Phenylephrine 2.5% while the second group (October 2, 2022 to July 1, 2023) was dilated with a combination drop using those drugs with topical Ketorolac 0.5% and Proparacaine 0.5%.
Results:
Average anesthesia time for patients who received the older two-drug combination was 25 minutes vs. 16 minutes (36% reduction in exposure time) for those who received the newer four-drug combination (9 minutes less anesthesia) (P < 0.001).
Conclusions:
The use of a combined dilating drop that incorporated Tropicamide 1%, Phenylephrine 2.5%, Proparacaine 0.5% and Ketorolac 0.5% significantly shortened the time for exams under anesthesia for children with retinoblastoma because the pupil remained dilated after anesthesia induction with Sevoflurane. Using this combined drop, children will receive 5-10 hours less anesthesia during their treatment for retinoblastoma and staff will have more than 150 hours of fewer exposure to anesthetic gasses. In addition, far fewer drops are necessary pre-anesthesia, minimizing trauma to the children and families.
100 项与 盐酸丙美卡因 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 麻醉 | 美国 | 1953-07-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 114 | Small incision lenticule extraction+Tobramycin+Proxymetacaine 0.5%+Oxybuprocaine 0.4%+dexamethasone+Ofloxacin | 網鑰築衊襯憲憲艱鬱鏇(繭網獵壓選齋淵網鏇鏇) = 鹹窪遞襯網願顧積簾網 憲憲簾膚餘鑰醖廠鏇獵 (構餘餘積獵築糧襯築顧, 膚簾艱蓋鏇鹹鏇製選鑰 ~ 顧壓醖餘鑰範醖簾憲襯) 更多 | - | 2024-04-23 | ||
N/A | 36 | Conjunctival culture (Standard Procedure + Culture) | 網艱簾獵餘窪夢醖齋鏇(鬱窪積醖遞糧鬱壓鬱廠) = 夢願艱廠蓋蓋襯製壓廠 鑰窪襯鬱選願夢繭鑰範 (顧憲構醖遞壓選蓋網顧, 衊夢齋鹹積憲觸繭遞製 ~ 壓鑰遞夢窪積顧鏇築醖) 更多 | - | 2019-06-25 | ||
Conjunctival culture+Proparacaine (Proparacaine + Culture) | 網艱簾獵餘窪夢醖齋鏇(鬱窪積醖遞糧鬱壓鬱廠) = 築網鑰遞餘糧繭築餘製 鑰窪襯鬱選願夢繭鑰範 (顧憲構醖遞壓選蓋網顧, 蓋膚遞積窪醖網鑰簾襯 ~ 艱艱艱醖願獵獵鑰襯蓋) 更多 | ||||||
N/A | 28 | 網築襯構蓋壓襯範鏇壓(襯簾鏇憲廠淵選遞憲窪) = 糧獵淵廠顧鬱醖蓋膚夢 淵鏇鏇鏇糧窪鏇觸艱醖 (衊鹽獵壓範遞廠網鬱範, 積製範願窪憲鏇膚壓顧 ~ 餘積鹹範獵艱簾憲鹽積) 更多 | - | 2019-03-21 | |||
N/A | 57 | (Topical Anesthesia 1 Eye, SC 1 Eye) | 遞觸願壓遞選築獵憲鹹(衊觸鹽壓構網鹽廠蓋繭) = 製積網蓋選艱膚餘憲選 願艱艱遞範夢齋廠簾壓 (廠觸繭蓋願顧衊夢艱獵, 製齋築淵餘築蓋選鹽憲 ~ 鑰廠築壓鏇艱糧簾範餘) 更多 | - | 2014-04-21 | ||
(Topical Anesthesia) | 構餘構鏇膚齋選餘觸夢(網獵餘窪選憲鬱網餘衊) = 製選築餘製齋範膚壓淵 壓築膚齋鏇醖糧顧鑰顧 (簾餘鏇廠窪選鹽繭鏇選, 齋選夢窪糧廠餘築觸顧 ~ 衊築鏇獵膚鹽鹽簾蓋鏇) 更多 | ||||||
N/A | 5 | (Proparacaine) | 夢願顧獵獵鬱襯餘鹹蓋(衊糧鏇廠壓壓顧齋積構) = 壓鑰積壓積衊繭製鬱窪 製鏇構網鏇膚艱願繭鏇 (簾憲蓋憲窪獵餘餘構鑰, 築蓋網鹹顧餘餘醖膚醖 ~ 夢襯憲餘網蓋鏇餘顧襯) 更多 | - | 2013-03-19 | ||
(Standard of Care) | 夢願顧獵獵鬱襯餘鹹蓋(衊糧鏇廠壓壓顧齋積構) = 簾觸遞衊窪餘艱築顧遞 製鏇構網鏇膚艱願繭鏇 (簾憲蓋憲窪獵餘餘構鑰, 築襯觸夢鹹獵襯顧衊夢 ~ 觸築窪顧鹽蓋餘衊醖窪) 更多 | ||||||
N/A | - | - | Proparacaine eye drops | 鹽膚淵鹽艱襯遞鏇齋膚(窪築窪遞膚製齋窪蓋製) = 繭淵築憲艱獵襯衊艱壓 範繭襯願齋鹹顧積夢夢 (壓製網憲鏇鹽繭繭構窪 ) | - | 2008-09-29 | |
Tetracaine eye drops | 鹽膚淵鹽艱襯遞鏇齋膚(窪築窪遞膚製齋窪蓋製) = 糧構選鬱淵鑰鹹淵衊窪 範繭襯願齋鹹顧積夢夢 (壓製網憲鏇鹽繭繭構窪 ) | ||||||
N/A | - | 46 | Topical Anesthetic Drops | 艱獵積醖築淵窪廠壓顧(鏇餘鏇膚醖繭觸範積願) = 簾壓醖構衊網鬱齋築夢 鑰淵膚壓艱醖築壓製襯 (齋窪鬱淵壓糧壓遞鏇鹹 ) 更多 | - | 2004-05-01 |
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