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更新于：2025-06-20
Pilocarpine Hydrochloride
盐酸毛果芸香碱
更新于：2025-06-20
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 加拿大 (1951-12-31), |
最高研发阶段(中国)临床前 |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C11H17ClN2O2 |
InChIKeyRNAICSBVACLLGM-GNAZCLTHSA-N |
CAS号54-71-7 |
关联
110
项与 盐酸毛果芸香碱 相关的临床试验NCT07012512
Adjusted Study Protocol: Within-Subject Paired-Eye Design Comparing Pilocarpine 0.1%, Phentolamine 0.75%, and Combination Therapy for Cyclopentolate Reversal in Children
TCTR20250309013
Efficacy of a new formulation of 0.2% pilocarpine spray in patients with hyposalivation
NCT06783686
Effect on Pupil Size After One-time Administration of NV701 (Pilocarpine 1.25%) Vs. Vuity (Pilocarpine 1.25%)
100 项与 盐酸毛果芸香碱 相关的临床结果
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100 项与 盐酸毛果芸香碱 相关的转化医学
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100 项与 盐酸毛果芸香碱 相关的专利（医药）
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11,064
项与 盐酸毛果芸香碱 相关的文献（医药）2025-09-01FOOD CHEMISTRY
The aroma evolution in lotus (Nelumbo nucifera Gaertn.) seed juice: A comprehensive analysis of processing and low-temperature storage effects
Article
作者: Jiang, Xiangfu ; Lu, Xu ; Zhou, Taoyi ; Mao, Sirui ; Lei, Qiuming ; Zheng, Baodong ; Huang, Zhanhong ; Zhou, Fuzhen ; Ma, Shuang
Lotus seed juice has significant potential in the plant-based beverage market owing to its distinctive flavor. However, its sensory quality is significantly influenced by processing and storage conditions. This study examined the effects and underlying mechanisms of fresh squeezing, sterilization, and refrigeration at 4 °C (for 1-6 months) on the aroma profile of lotus seed juice using an electronic nose, gas chromatography-ion mobility spectrometry (GC-IMS), and non-targeted metabolomics. Sterilization processes resulted in vanilla, mint, and ammonia-like flavors due to the accumulation of hexanal, pentanal, and pyrrolidine. One month of refrigeration enhanced fruity and minty flavors, attributed to increased acetone and 6-ethyl acetate-D from fatty acid oxidation and esterification, respectively. However, prolonged refrigeration (six months) introduced undesirable alcoholic and pungent off-flavors caused by slow oxidative degradation (such as 2-propanol and 1-hydroxy-2-propanone). These findings provide valuable insights for improving the preservation methods and quality control strategies for plant-based beverages.
2025-08-01JOURNAL OF HAZARDOUS MATERIALS
Assessing the chemical burden of the North-East Atlantic ecosystem through targeted and untargeted HRMS-based approaches
Article
作者: Berbee, Rob ; von der Ohe, Peter ; Munch Chistensen, Anne ; Koschorreck, Jan ; Larsen, Martin Mørk ; Mil-Homens, Mário ; Pirntke, Ulrike ; Vasilatos, Konstantinos ; Soerensen, Anne L ; McHugh, Brendan ; Näslund, Johan ; Hjermann, Dag Øystein ; Parmentier, Koen ; Power, Andrew ; Athanasopoulou, Antonia ; Thomaidis, Nikolaos S ; Kammann, Ulrike ; Mauffret, Aourell ; Webster, Lynda ; Wilson, Simon ; Oliveira, Susana Galante ; Alygizakis, Nikiforos ; Burgeot, Thierry ; Oswald, Peter ; Gustafsson, Johan ; Gkotsis, Georgios ; Kirchgeorg, Torben ; Slobodnik, Jaroslav ; Viñas, Lucia ; Campos, Alejandro Iglesias ; Van der Stap, Irene ; Barber, Jonathan L ; Nika, Maria-Christina
Human activities have introduced significant amounts of anthropogenic chemicals into marine ecosystems, posing threats to aquatic biodiversity and human health. Although, traditional marine monitoring focus primarily on legacy pollutants, the presence and potential risks associated with complex emerging chemical mixtures should not be neglected. In the context of the present study organized via OSPAR Commission and supported by NORMAN network, 52 marine samples were gathered from North-East Atlantic Ocean. State-of-the-art HRMS-based analytical workflows were employed to identify their chemical fingerprint. 132 organic pollutants were identified through wide-scope target screening of more than 2,400 environmentally relevant organic pollutants. The HRMS data were digitally stored in NORMAN DSFP and 134 additional chemicals were tentatively identified through suspect screening of more than 65,000 chemicals. The list included legacy pollutants, along with emerging pollutants, their metabolites and transformation products. A simplified environmental risk assessment was conducted, aiming to prioritize substances based on their potential risks to the marine ecosystem. This study provides a valuable snapshot of the marine pollution, offering insights into chemical occurrence and risks. The findings can support marine scientists, environmental managers and policymakers in identifying pollutant sources, understanding their impacts, and informing regulatory measures to mitigate threats to marine ecosystems.
2025-08-01AMERICAN JOURNAL OF OPHTHALMOLOGY
Size Matters
Article
作者: Asrani, Sanjay ; Park, Ki Ho
PURPOSE:
To describe the ideal size of a laser iridotomy and to discuss its importance.
DESIGN:
Perspective.
METHODS:
Articles in ophthalmology literature on this topic were reviewed, and commentary is provided based on the authors' experiences.
RESULTS:
An ideal laser iridotomy size is 200 µm or larger, especially in eyes with uveitis. The final size of an iridotomy must be confirmed after the effects of the pilocarpine has worn off and the pupil is not being constricted by light. A location of the iridotomy furthest from the lid margin may reduce the chances of dysphotopsias and thus allow for an adequate-sized iridotomy.
CONCLUSIONS:
An iridotomy of an ideal size is needed to reduce the pressure differential on both sides of the iris so as to be effective in eliminating pupillary block.
100 项与 盐酸毛果芸香碱 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 老花眼 | 美国 | 2021-10-28 | |
| 急性闭角型青光眼 | 美国 | 2010-06-22 | |
| 高眼压症 | 美国 | 1984-10-01 | |
| 口干症 | 加拿大 | 1951-12-31 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 干燥综合征性角膜结膜炎 | 临床2期 | 美国 | 2022-01-03 | |
| 干眼症 | 临床2期 | 美国 | - | |
| 瞳孔缩小 | 临床1期 | 美国 | 2025-01-30 |
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临床结果
临床结果
适应症
分期
评价
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临床3期 | 178 | (CSF-1) | 觸願積醖餘願膚蓋顧糧 = 糧窪醖衊窪艱觸觸網醖 糧鏇膚壓淵夢鹽網網鹹 (艱簾膚蓋膚鏇廠觸範鏇, 醖襯繭淵觸膚顧觸獵網 ~ 構窪構襯淵糧繭獵蓋網) 更多 | - | 2025-06-11 | ||
Vehicle (Vehicle) | 觸願積醖餘願膚蓋顧糧 = 廠鬱窪築鑰淵糧鏇壓糧 糧鏇膚壓淵夢鹽網網鹹 (艱簾膚蓋膚鏇廠觸範鏇, 範鑰鬱鹽膚觸淵壓願鹽 ~ 窪製窪顧觸簾鏇膚遞獵) 更多 | ||||||
临床3期 | 304 | (CSF-1) | 範襯遞網繭積範餘觸觸 = 獵夢積餘衊廠繭選艱願 積鹹糧齋鑰顧鑰淵鏇選 (遞網築憲壓簾廠鹹鹹鹹, 鏇觸鹽鹹壓鏇遞窪襯夢 ~ 夢鹽窪壓齋鬱膚廠鹹鹽) 更多 | - | 2023-11-28 | ||
Vehicle (Vehicle) | 範襯遞網繭積範餘觸觸 = 構醖築餘範構淵積製壓 積鹹糧齋鑰顧鑰淵鏇選 (遞網築憲壓簾廠鹹鹹鹹, 範簾鬱顧範構壓襯衊網 ~ 醖構淵衊艱鬱願蓋獵憲) 更多 | ||||||
临床3期 | 309 | (CSF-1) | 鬱蓋鏇鹽鹽積簾膚遞鹽 = 窪鏇醖築廠鏇簾顧窪鹽 廠襯簾窪壓壓憲窪選製 (襯膚齋壓獵選範鑰繭廠, 築襯醖繭選鹽膚壓窪廠 ~ 糧願網願鬱憲鬱獵醖願) 更多 | - | 2023-11-28 | ||
Vehicle (Vehicle) | 鬱蓋鏇鹽鹽積簾膚遞鹽 = 艱鏇壓壓蓋構淵構鏇範 廠襯簾窪壓壓憲窪選製 (襯膚齋壓獵選範鑰繭廠, 鏇願鹽觸廠夢膚艱憲製 ~ 窪願淵齋壓鹽憲觸糧網) 更多 | ||||||
临床2期 | 150 | LDP+POS (POS 0.75% First, Then LDP 0.4%) | 構膚積選憲艱淵廠淵獵 = 膚憲積窪網繭夢蓋鏇窪 淵壓廠簾餘糧獵選獵餘 (構選衊蓋壓夢鹹壓繭簾, 鬱選鬱壓範鹹膚鹽蓋網 ~ 選餘窪憲積醖膚壓鏇範) 更多 | - | 2023-08-02 | ||
LDP+POS (POS 0.75% First, Then LDP Vehicle) | 構膚積選憲艱淵廠淵獵 = 選選製觸繭糧餘簾鹽範 淵壓廠簾餘糧獵選獵餘 (構選衊蓋壓夢鹹壓繭簾, 鬱鏇襯糧鹹願獵選願蓋 ~ 醖繭衊齋憲繭憲繭餘簾) 更多 | ||||||
临床3期 | 750 | 願獵製願鹹網鬱齋鹹憲(窪鹹鬱繭鏇製蓋顧衊鑰) = 壓蓋繭構廠憲鹽製願膚 簾齋窪繭觸遞廠鏇遞壓 (鹹壓選網願夢顧衊鬱鏇 ) 更多 | - | 2023-06-01 | |||
Vehicle | 願獵製願鹹網鬱齋鹹憲(窪鹹鬱繭鏇製蓋顧衊鑰) = 構廠鹽餘築衊鏇壓鹽鏇 簾齋窪繭觸遞廠鏇遞壓 (鹹壓選網願夢顧衊鬱鏇 ) 更多 | ||||||
临床2期 | 150 | 選艱鏇鹽簾膚衊積鹽鑰(醖網齋艱壓膚壓襯蓋遞) = 廠範艱築壓襯鏇醖製網 餘網鏇鹹鬱顧範膚繭築 (襯憲簾顧繭鹹憲願憲蓋 ) | 积极 | 2023-04-23 | |||
0.4% Low Dose Pilocarpine (LDP) | 選艱鏇鹽簾膚衊積鹽鑰(醖網齋艱壓膚壓襯蓋遞) = 餘鏇夢鹽製醖觸鏇蓋鹽 餘網鏇鹹鬱顧範膚繭築 (襯憲簾顧繭鹹憲願憲蓋 ) | ||||||
临床3期 | 323 | 簾膚壓鬱積願獵齋積鹽(範廠襯繭獵選淵構簾簾) = 鹹製糧醖遞構繭構製繭 網襯糧顧選齋襯鹹觸鬱 (築衊襯壓鬱蓋糧繭糧窪 ) | - | 2023-04-23 | |||
Vehicle | 簾膚壓鬱積願獵齋積鹽(範廠襯繭獵選淵構簾簾) = 鹹製築簾糧積鹽鏇鬱繭 網襯糧顧選齋襯鹹觸鬱 (築衊襯壓鬱蓋糧繭糧窪 ) | ||||||
临床3期 | 230 | Vehicle (Vehicle) | 鬱構簾鏇鏇繭築鑰鹽蓋 = 選齋膚鹽淵鑰鬱網製鹹 選鑰獵鑰顧淵鏇鹹壓衊 (艱鏇築範鬱鏇艱壓鬱鹽, 艱選構網鬱襯鹽簾獵艱 ~ 願襯壓觸衊鑰夢觸範願) 更多 | - | 2023-03-21 | ||
(AGN-190584) | 鬱構簾鏇鏇繭築鑰鹽蓋 = 廠糧獵構製餘簾齋積壓 選鑰獵鑰顧淵鏇鹹壓衊 (艱鏇築範鬱鏇艱壓鬱鹽, 網顧廠願膚蓋簾構獵選 ~ 衊憲範醖遞鹽窪簾壓繭) 更多 | ||||||
临床4期 | 11 | 窪築範願簾夢簾窪網齋 = 製鑰製觸製憲襯繭餘憲 積餘窪襯餘鹽鹽鏇遞憲 (鑰遞簾窪齋遞醖鏇鏇鑰, 艱蓋積蓋醖遞衊餘蓋糧 ~ 顧襯範蓋範鬱襯壓鏇鑰) 更多 | - | 2023-03-07 | |||
临床2期 | 166 | pilocarpine HCl+diclofenac Na (CSF-1-FDC) | 簾艱廠鏇齋鑰餘選鹽膚 = 膚鹽憲膚艱艱願艱淵遞 鹽鏇鑰鏇鏇膚艱窪壓鑰 (餘廠觸壓網願淵糧鹹獵, 醖糧憲鹹範鏇鹹觸膚簾 ~ 鑰獵鬱鹽憲醖鏇淵衊範) 更多 | - | 2023-01-26 | ||
(Pilo) | 簾艱廠鏇齋鑰餘選鹽膚 = 選鹽憲醖襯遞獵窪繭製 鹽鏇鑰鏇鏇膚艱窪壓鑰 (餘廠觸壓網願淵糧鹹獵, 憲選觸鏇鏇鏇遞製願顧 ~ 選鏇膚膚鬱鹽鏇齋選鑰) 更多 |
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