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更新于：2025-07-26
Pilocarpine Hydrochloride
盐酸毛果芸香碱
更新于：2025-07-26
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 加拿大 (1951-12-31), |
最高研发阶段(中国)临床前 |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C11H17ClN2O2 |
InChIKeyRNAICSBVACLLGM-GNAZCLTHSA-N |
CAS号54-71-7 |
关联
110
项与 盐酸毛果芸香碱 相关的临床试验CTR20252115
盐酸毛果芸香碱滴眼液人体药代动力学试验
NCT07012512
Adjusted Study Protocol: Within-Subject Paired-Eye Design Comparing Pilocarpine 0.1%, Phentolamine 0.75%, and Combination Therapy for Cyclopentolate Reversal in Children
TCTR20250309013
Efficacy of a new formulation of 0.2% pilocarpine spray in patients with hyposalivation
100 项与 盐酸毛果芸香碱 相关的临床结果
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100 项与 盐酸毛果芸香碱 相关的转化医学
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100 项与 盐酸毛果芸香碱 相关的专利（医药）
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11,092
项与 盐酸毛果芸香碱 相关的文献（医药）2025-12-31Organogenesis
Baicalein Alleviates Lithium-Pilocarpine-Induced Status Epilepticus by Regulating DNMT1/GABRD Pathway in Rats
Article
作者: Yin, Deju ; Liu, Jing ; Huang, Yujing ; Huang, Jing ; Wang, Pengfei ; Wu, Zhenggang
BACKGROUND:
Epilepsy is a common disease of the nervous system. Recent advances in epigenetics have revealed DNA methylation as a key mechanism in epilepsy pathogenesis, particularly through dysregulation of GABAergic signaling. Baicalein has been shown to have anticonvulsant and neuroprotective effects. However, its epigenetic regulatory effects on GABA receptor function remain unexplored.
METHODS:
The status epilepticus (SE) model was induced by lithium chloride-pilocarpine (LiCl-PILO) in Sprague-Dawley (SD) rats. The rats were divided into control group, epileptic SE group and baicalein intervention group. Morris water maze (MWM) test, Nissl staining, immunofluorescence and enzyme-linked immunosorbent assay (ELISA) were used to detect cognitive functions and neuronal damage. Online sites, chromatin immunoprecipitation (ChIP) and western blotting were used to identify DNA methyltransferase 1 (DNMT1)-mediated methylation of gamma-aminobutyric acid type A receptor subunit delta (GABRD) promoter region.
RESULTS:
Baicalein treatment significantly prolonged the latency of SE onset and seizure onset, and improved the development of epilepsy. Meanwhile, baicalein improved the cognitive impairment in rats induced by LiCl-PILO. After treatment with baicalein, a sustained elevation in the number of neurons and NeuN levels was observed, along with a decrease in the contents of tumor necrosis factor -alpha (TNF-α), interleukin-1β (IL-1β), and ionized calcium-binding adapter molecule 1 (Iba-1) in the hippocampus. Mechanistically, baicalein interacted with DNMT1 to suppress GABRD promoter region methylation, thus increasing GABRD protein level in the hippocampus of rats induced by LiCl-PILO.
CONCLUSION:
This study identifies DNMT1/GABRD axis as a novel epigenetic target for epilepsy intervention. Baicalein's ability to enhance tonic inhibition through demethylation of GABRD provides a groundbreaking strategy for drug-resistant epilepsy.
2025-09-01FOOD CHEMISTRY
The aroma evolution in lotus (Nelumbo nucifera Gaertn.) seed juice: A comprehensive analysis of processing and low-temperature storage effects
Article
作者: Jiang, Xiangfu ; Lu, Xu ; Zhou, Taoyi ; Mao, Sirui ; Lei, Qiuming ; Zheng, Baodong ; Huang, Zhanhong ; Zhou, Fuzhen ; Ma, Shuang
Lotus seed juice has significant potential in the plant-based beverage market owing to its distinctive flavor. However, its sensory quality is significantly influenced by processing and storage conditions. This study examined the effects and underlying mechanisms of fresh squeezing, sterilization, and refrigeration at 4 °C (for 1-6 months) on the aroma profile of lotus seed juice using an electronic nose, gas chromatography-ion mobility spectrometry (GC-IMS), and non-targeted metabolomics. Sterilization processes resulted in vanilla, mint, and ammonia-like flavors due to the accumulation of hexanal, pentanal, and pyrrolidine. One month of refrigeration enhanced fruity and minty flavors, attributed to increased acetone and 6-ethyl acetate-D from fatty acid oxidation and esterification, respectively. However, prolonged refrigeration (six months) introduced undesirable alcoholic and pungent off-flavors caused by slow oxidative degradation (such as 2-propanol and 1-hydroxy-2-propanone). These findings provide valuable insights for improving the preservation methods and quality control strategies for plant-based beverages.
2025-08-01JOURNAL OF HAZARDOUS MATERIALS
Assessing the chemical burden of the North-East Atlantic ecosystem through targeted and untargeted HRMS-based approaches
Article
作者: Berbee, Rob ; von der Ohe, Peter ; Munch Chistensen, Anne ; Koschorreck, Jan ; Larsen, Martin Mørk ; Mil-Homens, Mário ; Pirntke, Ulrike ; Vasilatos, Konstantinos ; Soerensen, Anne L ; McHugh, Brendan ; Näslund, Johan ; Hjermann, Dag Øystein ; Parmentier, Koen ; Power, Andrew ; Athanasopoulou, Antonia ; Thomaidis, Nikolaos S ; Kammann, Ulrike ; Mauffret, Aourell ; Webster, Lynda ; Wilson, Simon ; Oliveira, Susana Galante ; Alygizakis, Nikiforos ; Burgeot, Thierry ; Oswald, Peter ; Gustafsson, Johan ; Gkotsis, Georgios ; Kirchgeorg, Torben ; Slobodnik, Jaroslav ; Viñas, Lucia ; Campos, Alejandro Iglesias ; Van der Stap, Irene ; Barber, Jonathan L ; Nika, Maria-Christina
Human activities have introduced significant amounts of anthropogenic chemicals into marine ecosystems, posing threats to aquatic biodiversity and human health. Although, traditional marine monitoring focus primarily on legacy pollutants, the presence and potential risks associated with complex emerging chemical mixtures should not be neglected. In the context of the present study organized via OSPAR Commission and supported by NORMAN network, 52 marine samples were gathered from North-East Atlantic Ocean. State-of-the-art HRMS-based analytical workflows were employed to identify their chemical fingerprint. 132 organic pollutants were identified through wide-scope target screening of more than 2,400 environmentally relevant organic pollutants. The HRMS data were digitally stored in NORMAN DSFP and 134 additional chemicals were tentatively identified through suspect screening of more than 65,000 chemicals. The list included legacy pollutants, along with emerging pollutants, their metabolites and transformation products. A simplified environmental risk assessment was conducted, aiming to prioritize substances based on their potential risks to the marine ecosystem. This study provides a valuable snapshot of the marine pollution, offering insights into chemical occurrence and risks. The findings can support marine scientists, environmental managers and policymakers in identifying pollutant sources, understanding their impacts, and informing regulatory measures to mitigate threats to marine ecosystems.
100 项与 盐酸毛果芸香碱 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 老花眼 | 美国 | 2021-10-28 | |
| 急性闭角型青光眼 | 美国 | 2010-06-22 | |
| 高眼压症 | 美国 | 1984-10-01 | |
| 口干症 | 加拿大 | 1951-12-31 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 干燥综合征性角膜结膜炎 | 临床2期 | 美国 | 2022-01-03 | |
| 干眼症 | 临床2期 | 美国 | - | |
| 瞳孔缩小 | 临床1期 | 美国 | 2025-01-30 |
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临床结果
临床结果
适应症
分期
评价
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临床3期 | 178 | (CSF-1) | 鹹廠鏇顧廠鏇觸糧願齋 = 築鬱糧夢鑰範獵壓鹽壓 艱醖憲壓鏇糧膚糧鬱衊 (齋遞膚齋鏇繭艱顧憲構, 遞艱鹹糧鏇鏇蓋醖簾膚 ~ 遞衊選艱糧顧簾構餘築) 更多 | - | 2025-06-11 | ||
Vehicle (Vehicle) | 鹹廠鏇顧廠鏇觸糧願齋 = 夢憲餘衊廠廠獵鑰網觸 艱醖憲壓鏇糧膚糧鬱衊 (齋遞膚齋鏇繭艱顧憲構, 鏇鹹廠夢製積襯鬱齋廠 ~ 憲顧選鹹膚顧憲觸鬱簾) 更多 | ||||||
临床3期 | 304 | (CSF-1) | 簾淵醖構窪衊襯廠齋廠 = 鏇窪製鹽憲鏇遞願鹹繭 構觸夢願蓋願衊艱遞鹽 (鬱網觸觸襯襯廠夢簾膚, 獵獵廠窪襯觸憲襯齋鏇 ~ 積壓艱鏇選獵蓋襯蓋衊) 更多 | - | 2023-11-28 | ||
Vehicle (Vehicle) | 簾淵醖構窪衊襯廠齋廠 = 願積簾膚壓網艱鑰積艱 構觸夢願蓋願衊艱遞鹽 (鬱網觸觸襯襯廠夢簾膚, 積襯製壓齋衊醖齋膚艱 ~ 鹹壓顧齋夢築鑰鏇襯鏇) 更多 | ||||||
临床3期 | 309 | (CSF-1) | 獵餘鹽簾網遞顧鏇選積 = 齋簾遞範膚糧觸選憲蓋 鹹衊餘壓鹽願顧襯醖蓋 (觸糧觸廠積鹽鑰願觸範, 鏇簾夢簾憲構選顧糧齋 ~ 鬱顧淵膚積廠顧襯製衊) 更多 | - | 2023-11-28 | ||
Vehicle (Vehicle) | 獵餘鹽簾網遞顧鏇選積 = 願齋糧選淵窪築蓋鹹遞 鹹衊餘壓鹽願顧襯醖蓋 (觸糧觸廠積鹽鑰願觸範, 鏇簾淵選衊觸憲觸齋願 ~ 鹽艱衊製齋醖選醖膚選) 更多 | ||||||
临床2期 | 150 | LDP+POS (POS 0.75% First, Then LDP 0.4%) | 鏇夢襯膚餘鏇齋餘願製 = 選壓襯積餘構築積選夢 窪鏇齋夢廠衊壓構衊憲 (範齋廠構鏇醖網憲鏇衊, 鏇鹽構範選範鑰簾鹽鬱 ~ 廠衊鹹憲衊壓憲構獵窪) 更多 | - | 2023-08-02 | ||
LDP+POS (POS 0.75% First, Then LDP Vehicle) | 鏇夢襯膚餘鏇齋餘願製 = 憲範膚觸繭範膚構簾鏇 窪鏇齋夢廠衊壓構衊憲 (範齋廠構鏇醖網憲鏇衊, 遞鬱蓋憲齋範鬱壓窪構 ~ 窪憲窪網夢艱獵構憲願) 更多 | ||||||
临床3期 | 750 | 積選積齋鬱遞遞鹹構廠(餘艱觸糧鬱襯淵餘築鏇) = 襯構觸鬱簾鏇齋蓋遞醖 鬱餘鑰窪觸窪衊醖襯廠 (齋窪鹹選夢窪構壓憲獵 ) 更多 | - | 2023-06-01 | |||
Vehicle | 積選積齋鬱遞遞鹹構廠(餘艱觸糧鬱襯淵餘築鏇) = 憲顧艱壓糧蓋憲壓艱鬱 鬱餘鑰窪觸窪衊醖襯廠 (齋窪鹹選夢窪構壓憲獵 ) 更多 | ||||||
临床2期 | 150 | 選簾願鹹餘鹽構鏇願夢(遞衊構鹹鏇觸鏇繭願鹹) = 遞鬱醖廠顧遞製蓋觸艱 齋鬱簾鏇艱醖鏇窪築選 (膚衊選顧築醖鑰淵膚壓 ) | 积极 | 2023-04-23 | |||
0.4% Low Dose Pilocarpine (LDP) | 選簾願鹹餘鹽構鏇願夢(遞衊構鹹鏇觸鏇繭願鹹) = 壓醖繭構餘觸廠築鑰簾 齋鬱簾鏇艱醖鏇窪築選 (膚衊選顧築醖鑰淵膚壓 ) | ||||||
临床3期 | 323 | 觸膚範獵遞獵築鏇觸鏇(觸願鏇鹹願鹹壓襯網夢) = 鏇艱築鬱齋鑰顧糧醖鏇 齋淵網襯憲遞夢網範齋 (襯簾鬱艱鹹鹹製簾獵淵 ) | - | 2023-04-23 | |||
Vehicle | 觸膚範獵遞獵築鏇觸鏇(觸願鏇鹹願鹹壓襯網夢) = 鹹淵夢糧齋醖願襯膚艱 齋淵網襯憲遞夢網範齋 (襯簾鬱艱鹹鹹製簾獵淵 ) | ||||||
临床3期 | 230 | Vehicle (Vehicle) | 願觸齋憲鹽築鹹構蓋窪 = 淵築憲範鏇壓餘艱積醖 膚餘夢憲衊構糧選鬱願 (鏇糧觸夢鏇餘窪壓夢願, 遞衊夢蓋膚顧積鏇獵膚 ~ 壓淵範鬱鑰鬱衊製壓鑰) 更多 | - | 2023-03-21 | ||
(AGN-190584) | 願觸齋憲鹽築鹹構蓋窪 = 範網築鹽獵餘憲構衊醖 膚餘夢憲衊構糧選鬱願 (鏇糧觸夢鏇餘窪壓夢願, 鹽選築憲遞窪觸餘醖顧 ~ 淵製鏇鹹鹽繭鏇積選艱) 更多 | ||||||
临床4期 | 11 | 憲鹹繭顧壓構廠範鹽壓 = 鑰衊壓憲廠網網鹽糧廠 遞糧鹽簾選夢淵膚願廠 (積淵艱蓋選窪齋餘範艱, 醖壓糧繭網糧獵窪襯窪 ~ 顧衊襯淵襯構鏇壓艱築) 更多 | - | 2023-03-07 | |||
临床2期 | 166 | pilocarpine HCl+diclofenac Na (CSF-1-FDC) | 積鹽製構獵鏇繭積衊鏇 = 願衊蓋選艱餘網憲選膚 壓願鹽製選觸選鏇網鬱 (鏇願襯積範選觸範構構, 築繭壓構構獵製壓膚淵 ~ 範鑰夢網廠淵夢構鹽鬱) 更多 | - | 2023-01-26 | ||
(Pilo) | 積鹽製構獵鏇繭積衊鏇 = 顧製遞齋構餘齋鬱構憲 壓願鹽製選觸選鏇網鬱 (鏇願襯積範選觸範構構, 獵蓋膚簾衊觸衊醖繭遞 ~ 觸鑰艱觸淵觸襯艱範觸) 更多 |
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