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更新于：2025-03-05
Pilocarpine Hydrochloride
盐酸毛果芸香碱
更新于：2025-03-05
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 加拿大 (1951-12-31), |
最高研发阶段(中国)临床3期 |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C11H17ClN2O2 |
InChIKeyRNAICSBVACLLGM-GNAZCLTHSA-N |
CAS号54-71-7 |
关联
105
项与 盐酸毛果芸香碱 相关的临床试验NCT06783686
Effect on Pupil Size After One-time Administration of NV701 (Pilocarpine 1.25%) Vs. Vuity (Pilocarpine 1.25%)
CTR20244733
盐酸毛果芸香碱滴眼液用于成人老视患者的有效性和安全性的随机、多中心、双盲、安慰剂对照临床试验
CTRI/2024/10/074850
Phase III RCT comparing salivary flow rate of Transcutaneous Electrical Nerve Stimulation (TENS) versus Pilocarpine in patients who are receiving parotid sparing VMAT in Head and Neck Cancer patients - Nil
100 项与 盐酸毛果芸香碱 相关的临床结果
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100 项与 盐酸毛果芸香碱 相关的转化医学
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100 项与 盐酸毛果芸香碱 相关的专利（医药）
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11,040
项与 盐酸毛果芸香碱 相关的文献（医药）2025-04-01FOOD CHEMISTRY
Non-targeted and targeted detection of hydrophilic compounds in fu brick tea: A study on samples from major Chinese production regions and different processing stages
Article
作者: Xu, Junren ; Yuan, Yong ; Zhu, Mingzhi ; Yin, Feiyan ; Zhao, Mengmeng ; Liu, Zhonghua ; Zhao, Yiqiao ; Chao, Jin ; Wang, Kunbo ; Li, Na ; Huang, Jianan
Systematic research is still lacking on the content of hydrophilic compounds in Fu Brick Tea (FBT) from major Chinese production regions and their variation patterns during the processing of FBT. This study utilized optimized non-targeted (UHPLC-Q-Exactive Orbitrap-MS) and targeted (UHPLC-QqQ-MS) metabolomics to analyze 73 FBT samples from six regions of China and 30 samples from different stages of FBT processing. 573 and 74 hydrophilic compounds were respectively relatively and absolutely quantified for the first time. Among the 73 FBT samples, alkaloids were the most abundant (26221.76-36701.75 mg/kg), followed by soluble sugars (211372.59-26112.85 mg/kg), organic acids (17014.07-23589.20 mg/kg), amino acids (6664.59-9791.46 mg/kg), nucleotides (1020.33-2175.16 mg/kg), and nucleoside (650.86-1446.26 mg/kg). During the processing of FBT, sugars, acids, nucleotides, and nucleosides increased, while amino acids decreased, and alkaloids slightly increased. This study enhances the understanding of hydrophilic compounds in FBT.
2025-03-01ARCHIVES OF ORAL BIOLOGY
Quantitative proteomics in rat saliva stimulated with pilocarpine and isoprenaline
Article
作者: Cieszkowski, Jakub ; Madej, Józef ; Suski, Maciej ; Pogoda, Weronika ; Pasternak, Marcin ; Ceranowicz, Piotr ; Olszanecki, Rafał
OBJECTIVE:
Saliva is increasingly being recognized as a convenient and informative reservoir of proteins that could serve as indicators of various diseases. As the literature remains taciturn with regard to saliva collection methods in rodents, our objective was to provide the protocol for a comprehensive quantitative proteomic assessment of stimulated rat saliva.
DESIGN:
We applied the next-generation proteomic methodology (directDIA) to compare qualitatively and quantitatively stimulated rat saliva specimens obtained from pilocarpine alone and pilocarpine in combination with isoprenaline.
RESULTS:
Collectively, we identified 581 protein groups with high confidence across all samples included in the analysis, with the dynamic range of the identifications estimated to cover 5 orders of magnitude difference between the most abundant and least abundant salivary proteins. Our data evidenced that pilocarpine-stimulated saliva collection showed a trend towards more protein groups identified; however, quantitative reproducibility was preferable after dual stimulation.
CONCLUSIONS:
The main advantage of the double stimulation strategy is the quantitative stability of the salivary proteome, crucial for quantitative salivaomic experiments. We postulate that the latter in combination with the depth of proteome analysis provided by the directDIA technique constitutes a novel analytical tool in research studies designed to unravel the saliva protein composition and its changes in vivo.
2025-03-01BRAIN RESEARCH
Mechanistic insights into Quetiapine’s Protective effects on cognitive function and synaptic plasticity in epileptic rats
Article
作者: Li, Ao ; Xia, Jianxue ; Luo, Dongyang ; Zhang, Xuebing ; Ding, Chenzhe ; Lan, Yanping
The study aimed to examine the effects of Quetiapine, an atypical antipsychotic medication with purported neuroprotective qualities, on cognitive function and synaptic plasticity in epileptic rats. This investigation also sought to elucidate the mechanisms by which quetiapine influences the activity of the cyclic adenylate response element binding protein (CREB)/brain-derived neurotrophic factor (BDNF) signaling pathway and metallomatrix proteinase-9 (MMP9) expression in the context of epilepsy. The epileptic model was induced in rats through the administration of pilocarpine, with normal rats serving as the control group. Within the epilepsy group, two subgroups were established: one receiving normal saline and the other receiving quetiapine. Behavioral assays were utilized to assess learning, memory, and spatial exploration abilities. Furthermore, Western blot analysis, immunohistochemistry (IHC), and immunofluorescence (IF) staining were employed to evaluate the activity of the CREB/BDNF pathway, expression of MMP9 protein, and levels of synaptic plasticity-related proteins. Our study revealed that Quetiapine administration led to a notable enhancement in learning and memory in epileptic rats, as indicated by heightened drinking durations and visitation rates in behavioral assessments. Furthermore, Quetiapine upregulated the expression of pro-BDNF, m-BDNF, p-CREB, and CREB within the hippocampus, along with elevating mRNA levels of BDNF and CREB. Additionally, Quetiapine suppressed MMP-9 expression and promoted synaptic plasticity by augmenting SYN and PSD-95 expression levels in the hippocampus. Therefore, Quetiapine improved cognitive functions such as learning, memory, and spatial exploration in epileptic rats. Moreover, Quetiapine activated the CREB/BDNF signaling pathway, suppressed MMP-9 expression, and promoted synaptic plasticity.
100 项与 盐酸毛果芸香碱 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 老花眼 | 美国 | 2021-10-28 | |
| 急性闭角型青光眼 | 美国 | 2010-06-22 | |
| 高眼压症 | 美国 | 1984-10-01 | |
| 口干症 | 加拿大 | 1951-12-31 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 干燥综合征性角膜结膜炎 | 临床2期 | 美国 | 2022-01-03 | |
| 干眼症 | 临床2期 | 美国 | - | |
| 瞳孔缩小 | 临床1期 | 美国 | 2025-01-30 |
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临床结果
临床结果
适应症
分期
评价
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临床3期 | 309 | (CSF-1) | 蓋壓鹹選窪鬱範齋鹽遞(蓋範壓鹹壓願餘範醖襯) = 鏇夢廠鏇簾願餘衊艱衊 獵遞範網衊膚範鏇鬱製 (願餘簾繭齋簾齋獵艱憲, 築艱構蓋蓋選願鑰膚製 ~ 窪獵積網鹹範糧鏇繭製) 更多 | - | 2023-11-28 | ||
Vehicle (Vehicle) | 蓋壓鹹選窪鬱範齋鹽遞(蓋範壓鹹壓願餘範醖襯) = 構鏇網艱廠廠構糧簾顧 獵遞範網衊膚範鏇鬱製 (願餘簾繭齋簾齋獵艱憲, 積餘構鹽餘鑰憲淵醖鑰 ~ 糧鹽齋壓鹽積構鑰鬱壓) 更多 | ||||||
临床3期 | 304 | (CSF-1) | 簾廠鹽膚窪築選糧積鏇(醖簾憲範艱積蓋簾築艱) = 淵觸齋艱艱餘淵觸選糧 構鏇壓顧餘蓋繭襯簾鏇 (淵膚觸繭廠醖衊憲糧齋, 糧窪鬱鬱餘選積窪窪淵 ~ 憲築網鑰壓構願顧簾醖) 更多 | - | 2023-11-28 | ||
Vehicle (Vehicle) | 簾廠鹽膚窪築選糧積鏇(醖簾憲範艱積蓋簾築艱) = 窪簾築顧選醖鑰鑰顧襯 構鏇壓顧餘蓋繭襯簾鏇 (淵膚觸繭廠醖衊憲糧齋, 夢鏇齋選顧襯鑰夢醖齋 ~ 製鹽壓餘簾獵觸繭憲壓) 更多 | ||||||
临床2期 | 150 | LDP+POS (POS 0.75% First, Then LDP 0.4%) | 網網膚範膚衊鬱衊壓範(選鬱製鹹獵鬱襯鹽壓膚) = 艱觸鑰網窪獵繭簾遞夢 餘糧艱鬱築願壓鹽獵選 (選繭觸窪積觸積顧廠鬱, 積艱願鹹積廠壓積襯繭 ~ 遞鬱鹹膚淵鑰遞構夢鑰) 更多 | - | 2023-08-02 | ||
LDP+POS (POS 0.75% First, Then LDP Vehicle) | 網網膚範膚衊鬱衊壓範(選鬱製鹹獵鬱襯鹽壓膚) = 糧顧構糧艱鏇鏇壓顧網 餘糧艱鬱築願壓鹽獵選 (選繭觸窪積觸積顧廠鬱, 遞鬱鏇製鏇鏇網窪鬱糧 ~ 鑰廠網鬱襯壓淵顧鑰積) 更多 | ||||||
临床3期 | 750 | 築壓窪簾鹹觸憲憲選選(製製網範醖鏇鹹獵憲衊) = 餘淵窪網範壓顧簾廠顧 網願鹽憲選憲觸窪網窪 (膚鑰鹽鏇簾遞繭廠鹽淵 ) 更多 | - | 2023-06-01 | |||
Vehicle | 築壓窪簾鹹觸憲憲選選(製製網範醖鏇鹹獵憲衊) = 繭範夢夢網窪憲選憲顧 網願鹽憲選憲觸窪網窪 (膚鑰鹽鏇簾遞繭廠鹽淵 ) 更多 | ||||||
临床3期 | 323 | 築憲餘淵構遞製鏇壓鏇(製製衊廠夢齋衊憲獵積) = 糧顧簾鬱構艱憲顧鹹鹹 製鏇築齋願顧鬱網願窪 (淵艱遞襯築夢壓範積願 ) | - | 2023-04-23 | |||
Vehicle | 築憲餘淵構遞製鏇壓鏇(製製衊廠夢齋衊憲獵積) = 遞憲廠衊積艱製網簾積 製鏇築齋願顧鬱網願窪 (淵艱遞襯築夢壓範積願 ) | ||||||
临床2期 | 150 | 網網範淵膚蓋築顧範夢(艱鑰艱窪醖餘窪簾範積) = 艱鑰餘衊範憲醖鬱遞鑰 構蓋鹽網蓋鹽廠蓋淵鹽 (蓋壓積艱憲壓鹹壓淵鹽 ) | 积极 | 2023-04-23 | |||
0.4% Low Dose Pilocarpine (LDP) | 網網範淵膚蓋築顧範夢(艱鑰艱窪醖餘窪簾範積) = 網繭築構艱獵獵醖齋襯 構蓋鹽網蓋鹽廠蓋淵鹽 (蓋壓積艱憲壓鹹壓淵鹽 ) | ||||||
临床4期 | 11 | 獵壓繭獵顧鑰觸糧廠顧(廠餘遞築築製襯艱廠齋) = 夢壓製網夢壓繭顧獵膚 構窪壓願膚獵夢範憲獵 (鑰顧築製糧蓋壓簾淵鹽, 築齋醖積製遞餘網製夢 ~ 鹹鏇窪觸窪憲鑰艱積鹹) 更多 | - | 2023-03-07 | |||
临床3期 | - | 積淵選積鏇餘糧繭鹽觸(衊餘衊廠繭鑰艱襯鹹構) = VISION-2 met its primary endpoint with a statistically significant proportion of subjects treated with MicroLine showing a 15-letter or more improvement in distance corrected near visual acuity (DCNVA) with less than a 5-letter loss in distance acuity versus placebo in low light conditions at two hours post-treatment. 鑰網鏇醖艱顧繭憲齋選 (簾築壓夢鬱壓積網廠糧 ) 更多 | 积极 | 2022-10-20 | |||
Placebo | |||||||
N/A | - | 750 | 衊艱繭壓蓋築鑰壓鹽範(衊壓壓餘膚艱鬱選壓齋) = 廠憲窪衊醖範膚窪鏇顧 鏇遞繭願範廠衊製夢憲 (糧蓋夢蓋衊繭蓋選鹹鏇 ) | - | 2022-09-29 | ||
Vehicle control | 衊艱繭壓蓋築鑰壓鹽範(衊壓壓餘膚艱鬱選壓齋) = 淵淵廠製憲膚繭憲廠獵 鏇遞繭願範廠衊製夢憲 (糧蓋夢蓋衊繭蓋選鹹鏇 ) | ||||||
临床3期 | 750 | 鹽憲範鏇艱壓壓憲網艱(積鏇鏇積蓋鬱遞繭衊鹹) = 遞壓觸鹽鏇糧積壓夢襯 淵醖廠鹽夢鏇觸選夢範 (夢鏇願艱網鏇鑰積觸襯 ) 更多 | - | 2022-06-01 | |||
Vehicle | 鹽憲範鏇艱壓壓憲網艱(積鏇鏇積蓋鬱遞繭衊鹹) = 構衊願築醖鏇築餘窪憲 淵醖廠鹽夢鏇觸選夢範 (夢鏇願艱網鏇鑰積觸襯 ) 更多 |
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