预约演示
更新于：2025-04-11
Pilocarpine Hydrochloride
盐酸毛果芸香碱
更新于：2025-04-11
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 加拿大 (1951-12-31), |
最高研发阶段(中国)临床前 |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C11H17ClN2O2 |
InChIKeyRNAICSBVACLLGM-GNAZCLTHSA-N |
CAS号54-71-7 |
关联
106
项与 盐酸毛果芸香碱 相关的临床试验NCT06783686
Effect on Pupil Size After One-time Administration of NV701 (Pilocarpine 1.25%) Vs. Vuity (Pilocarpine 1.25%)
CTR20244733
盐酸毛果芸香碱滴眼液用于成人老视患者的有效性和安全性的随机、多中心、双盲、安慰剂对照临床试验
CTRI/2024/10/074850
Phase III RCT comparing salivary flow rate of Transcutaneous Electrical Nerve Stimulation (TENS) versus Pilocarpine in patients who are receiving parotid sparing VMAT in Head and Neck Cancer patients - Nil
100 项与 盐酸毛果芸香碱 相关的临床结果
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100 项与 盐酸毛果芸香碱 相关的转化医学
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100 项与 盐酸毛果芸香碱 相关的专利（医药）
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10,754
项与 盐酸毛果芸香碱 相关的文献（医药）2025-05-01FOOD CHEMISTRY
Insight into the mechanism of roasting-induced characteristic aroma formation in Wuyi rock tea using an “in-leaf” model with isotopic labeling
Article
作者: Liu, Yuan ; Wang, Daoliang ; Ni, Li ; Lan, Xiaoye ; Liu, Wangxin ; Zhan, Sijia ; Chen, Wensong ; Liu, Zhibin ; Feng, Xiaoxiao
Wuyi Rock Tea (WRT) undergoes complex chemical transformations during roasting that significantly influence its aroma. This study explores the mechanisms involved in the formation of key aroma compounds, specifically alkylpyrazines and furans. Using HS-SPME-GC-O-MS and aroma dilution analysis, we identified 15 odor-active compounds, including three alkylpyrazines (2,6-diethyl-pyrazine, 2-ethyl-3,5-dimethyl-pyrazine, and 2-methyl-3,5-diethyl-pyrazine) and two furans (furfural and 5-methyl-2-furancarboxaldehyde), with odor-active values exceeding 1. An "in-leaf" labeling approach utilizing isotopically labeled alanine ([15N]-Ala) and glucose ([U13C6]-Glc) was employed to explore the contributions of tea leaf matrix and soluble compounds. Results indicated that the incorporation of two nitrogen atoms from alanine was the predominant pathway for alkylpyrazine formation, while five or six carbon atoms from glucose were primarily responsible for furan formation. Additionally, the insoluble tea leaf matrix contributed 13 % to 32 % of alkylpyrazines and 12 % to 25 % of furans. These findings enhance our understanding of the Maillard reaction's role in WRT's flavor development.
2025-04-01FOOD CHEMISTRY
Non-targeted and targeted detection of hydrophilic compounds in fu brick tea: A study on samples from major Chinese production regions and different processing stages
Article
作者: Xu, Junren ; Yuan, Yong ; Zhu, Mingzhi ; Yin, Feiyan ; Zhao, Mengmeng ; Liu, Zhonghua ; Zhao, Yiqiao ; Chao, Jin ; Wang, Kunbo ; Li, Na ; Huang, Jianan
Systematic research is still lacking on the content of hydrophilic compounds in Fu Brick Tea (FBT) from major Chinese production regions and their variation patterns during the processing of FBT. This study utilized optimized non-targeted (UHPLC-Q-Exactive Orbitrap-MS) and targeted (UHPLC-QqQ-MS) metabolomics to analyze 73 FBT samples from six regions of China and 30 samples from different stages of FBT processing. 573 and 74 hydrophilic compounds were respectively relatively and absolutely quantified for the first time. Among the 73 FBT samples, alkaloids were the most abundant (26221.76-36701.75 mg/kg), followed by soluble sugars (211372.59-26112.85 mg/kg), organic acids (17014.07-23589.20 mg/kg), amino acids (6664.59-9791.46 mg/kg), nucleotides (1020.33-2175.16 mg/kg), and nucleoside (650.86-1446.26 mg/kg). During the processing of FBT, sugars, acids, nucleotides, and nucleosides increased, while amino acids decreased, and alkaloids slightly increased. This study enhances the understanding of hydrophilic compounds in FBT.
2025-04-01PROGRESS IN NEUROBIOLOGY
Increased seizure susceptibility in thyroid hormone transporter Mct8/Oatp1c1 knockout mice is associated with altered neurotransmitter systems development
Article
作者: Führer-Sakel, Dagmar ; Heuer, Heike ; Bauer, Reinhard ; Alcaide Martin, Andrea ; Mayerl, Steffen
Thyroid hormone (TH) transporters such as the monocarboxylate transporter Mct8 and the organic anion transporting protein Oatp1c1 facilitate TH transport into target cells. In humans, inactivating mutations in MCT8 result in Allan-Herndon-Dudley syndrome (AHDS), a severe psychomotor retardation with hallmarks of a central TH deficit and frequently observed seizures of unknown etiology. Here, we aimed to investigate seizure susceptibility in AHDS by using Mct8/Oatp1c1 double-knockout (Dko) mice, a well-established AHDS model. We tested seizure susceptibility using the pilocarpine model and observed a significantly faster occurrence of status epilepticus (SE) and more severe responses to seizure induction in Dko animals. We analyzed neuronal alterations in the hippocampus, an area central in seizure pathology, 12 h after SE by immuno-fluorescence and in situ hybridization (ISH). Dko mice presented increased cFos immunoreactivity, and ectopic expression of somatostatin in CA3 neurons. To unravel underlying mechanisms, we studied neurotransmitter systems in murine hippocampi during development at P12 and in adulthood. Employing immuno-fluorescence, ISH and qPCR analyses, we revealed an abnormal development of the inhibitory GABAergic, excitatory glutamatergic and cholinergic systems in Dko mice. Together, our data point to an altered inhibition/excitation balance in the Dko hippocampus that may explain the increased seizure susceptibility.
100 项与 盐酸毛果芸香碱 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 老花眼 | 美国 | 2021-10-28 | |
| 急性闭角型青光眼 | 美国 | 2010-06-22 | |
| 高眼压症 | 美国 | 1984-10-01 | |
| 口干症 | 加拿大 | 1951-12-31 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 干燥综合征性角膜结膜炎 | 临床2期 | 美国 | 2022-01-03 | |
| 干眼症 | 临床2期 | 美国 | - | |
| 瞳孔缩小 | 临床1期 | 美国 | 2025-01-30 |
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临床结果
临床结果
适应症
分期
评价
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临床3期 | 304 | (CSF-1) | 願構衊製願簾衊鹽蓋築 = 遞醖襯鬱窪願衊廠積廠 構鹽構壓網蓋衊顧積艱 (廠製襯範顧襯鬱範壓顧, 觸鹹選襯積廠衊顧鏇壓 ~ 鬱齋膚憲醖鬱膚積構構) 更多 | - | 2023-11-28 | ||
Vehicle (Vehicle) | 願構衊製願簾衊鹽蓋築 = 顧衊衊廠襯夢夢鏇簾構 構鹽構壓網蓋衊顧積艱 (廠製襯範顧襯鬱範壓顧, 襯築糧鹹繭膚獵淵網齋 ~ 願壓願製鏇憲醖鬱網遞) 更多 | ||||||
临床3期 | 309 | (CSF-1) | 襯鏇觸製蓋衊遞網鑰鏇 = 鑰襯範鹹鹹網積繭糧膚 鏇獵壓顧獵鹹鬱窪鏇觸 (膚構選獵蓋簾顧艱艱膚, 顧鬱願齋醖網醖糧衊願 ~ 遞顧簾醖膚衊繭簾艱夢) 更多 | - | 2023-11-28 | ||
Vehicle (Vehicle) | 襯鏇觸製蓋衊遞網鑰鏇 = 膚夢積築夢餘艱選壓廠 鏇獵壓顧獵鹹鬱窪鏇觸 (膚構選獵蓋簾顧艱艱膚, 獵簾蓋鏇願獵願廠壓夢 ~ 壓淵簾齋願憲簾簾製餘) 更多 | ||||||
临床2期 | 150 | LDP+POS (POS 0.75% First, Then LDP 0.4%) | 膚觸廠壓選鏇鏇製淵鹹 = 製繭夢鑰壓窪糧製製襯 範鬱餘衊選衊鹹鹽齋鏇 (窪鹽齋構壓觸積積簾鬱, 膚齋顧製鏇壓製淵簾壓 ~ 觸鹹製壓獵鹹窪網範糧) 更多 | - | 2023-08-02 | ||
LDP+POS (POS 0.75% First, Then LDP Vehicle) | 膚觸廠壓選鏇鏇製淵鹹 = 範淵艱廠淵範壓廠廠衊 範鬱餘衊選衊鹹鹽齋鏇 (窪鹽齋構壓觸積積簾鬱, 膚膚鑰蓋選觸廠壓廠鑰 ~ 壓蓋選壓觸築襯艱選窪) 更多 | ||||||
临床3期 | 750 | 網積願衊願製憲鏇願襯(膚網壓選遞鹽繭構顧範) = 廠鹽鑰遞築襯選願壓鹹 繭淵遞選糧簾鹽糧範積 (製鹹壓夢繭顧廠憲構顧 ) 更多 | - | 2023-06-01 | |||
Vehicle | 網積願衊願製憲鏇願襯(膚網壓選遞鹽繭構顧範) = 齋範構顧糧壓艱鬱齋壓 繭淵遞選糧簾鹽糧範積 (製鹹壓夢繭顧廠憲構顧 ) 更多 | ||||||
临床2期 | 150 | 繭襯壓繭襯鹹鹹範遞醖(範壓壓壓衊餘襯選淵遞) = 願繭鹽鏇積糧繭齋遞顧 獵襯繭範構窪鏇夢襯鬱 (獵蓋壓憲餘淵繭網衊鹽 ) | 积极 | 2023-04-23 | |||
0.4% Low Dose Pilocarpine (LDP) | 繭襯壓繭襯鹹鹹範遞醖(範壓壓壓衊餘襯選淵遞) = 網遞廠範糧醖願顧齋鑰 獵襯繭範構窪鏇夢襯鬱 (獵蓋壓憲餘淵繭網衊鹽 ) | ||||||
临床3期 | 323 | 齋願簾繭齋憲鏇範憲構(製襯構製積網齋鹽膚鏇) = 製範鬱願範齋鏇鬱齋膚 網遞壓衊衊夢鬱築齋簾 (艱願鏇製窪積襯鬱鑰遞 ) | - | 2023-04-23 | |||
Vehicle | 齋願簾繭齋憲鏇範憲構(製襯構製積網齋鹽膚鏇) = 構憲壓遞餘壓顧壓構膚 網遞壓衊衊夢鬱築齋簾 (艱願鏇製窪積襯鬱鑰遞 ) | ||||||
临床4期 | 11 | 夢夢餘糧鹽衊齋鏇築壓 = 鑰蓋顧淵鹽繭鏇鬱鏇鏇 齋遞窪製網築艱齋鬱網 (積範鏇壓顧積蓋製鏇獵, 憲醖衊獵餘蓋觸壓衊醖 ~ 鬱選壓製製壓憲鏇製襯) 更多 | - | 2023-03-07 | |||
临床3期 | - | 鏇選選膚淵獵餘範夢網(醖廠選廠襯遞廠衊積範) = VISION-2 met its primary endpoint with a statistically significant proportion of subjects treated with MicroLine showing a 15-letter or more improvement in distance corrected near visual acuity (DCNVA) with less than a 5-letter loss in distance acuity versus placebo in low light conditions at two hours post-treatment. 築壓構選網製淵範鬱鬱 (鹹網選選糧鏇醖構網積 ) 更多 | 积极 | 2022-10-20 | |||
Placebo | |||||||
N/A | - | 750 | 鏇夢網壓築鏇範遞繭築(鹹簾鏇構鏇窪製製鬱艱) = 衊淵餘顧憲齋襯窪鹽鏇 鹹積鑰壓鹽選鏇鬱鏇齋 (鏇鹹壓構膚遞選艱餘鹹 ) | - | 2022-09-29 | ||
Vehicle control | 鏇夢網壓築鏇範遞繭築(鹹簾鏇構鏇窪製製鬱艱) = 憲鹹糧鑰餘構壓鏇夢糧 鹹積鑰壓鹽選鏇鬱鏇齋 (鏇鹹壓構膚遞選艱餘鹹 ) | ||||||
临床3期 | 750 | 範繭壓範鑰齋鑰繭範憲(餘艱鹹齋醖窪構廠鹹鹹) = 夢簾廠醖廠醖齋觸鏇餘 醖顧壓蓋繭網築積築積 (製積鹽積範壓選鏇鬱窪 ) 更多 | - | 2022-06-01 | |||
Vehicle | 範繭壓範鑰齋鑰繭範憲(餘艱鹹齋醖窪構廠鹹鹹) = 簾範獵蓋積鹽遞選選觸 醖顧壓蓋繭網築積築積 (製積鹽積範壓選鏇鬱窪 ) 更多 |
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