预约演示
更新于：2025-09-13
Tropicamide
托吡卡胺
更新于：2025-09-13
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
登录后查看时间轴
结构/序列
分子式C17H20N2O2 |
InChIKeyBGDKAVGWHJFAGW-UHFFFAOYSA-N |
CAS号1508-75-4 |
关联
28
项与 托吡卡胺 相关的临床试验CTRI/2025/04/085126
A clinical study to evaluate the efficacy and safety of Kakamachi (Solanum nigrum ) extract as a natural pupil dilator in comparison with conventional pharmaceutical agent- tropicacyl plus - NIL
CTRI/2024/08/072980
To evaluate changes in hemodynamic parameters in hypertensive and nomotensive patients using intracameral injection of a mix Tropicamide 0.2 percentage . Phenylnephrine 0.31 percentage . Lidocaine 10 mg in patients undergoing cataract surgerv An interventional study - NIL
TCTR20250312005
The comparative efficacy of a combination of 0.5% cyclopentolate tropicamide, and alternating instillation of 1% cyclopentolate and 1% tropicamide in Thai pediatric refraction
100 项与 托吡卡胺 相关的临床结果
登录后查看更多信息
100 项与 托吡卡胺 相关的转化医学
登录后查看更多信息
100 项与 托吡卡胺 相关的专利（医药）
登录后查看更多信息
1,192
项与 托吡卡胺 相关的文献（医药）2025-10-01Photodiagnosis and Photodynamic Therapy
Optical fogging is an effective method of reducing overestimation of myopia
Article
作者: Yu, Yang ; Chen, Yinhe ; Huang, Luoming ; Chen, Ting ; Lin, Zequn ; Lin, Jiajia ; Xiong, Xinyao
BACKGROUND:
This study aimed to investigate the effectiveness of optical fogging in controlling accommodation and to evaluate its efficiency in reducing myopic overestimation among young adults, with the goal of providing scientific evidence for clinical refractive measurement.
METHODS:
A total of 142 young adults aged 17 to 23 years (284 eyes) were enrolled. Refractive status and ocular biometric parameters were measured using open-field autorefractor and partial coherence interferometry under three conditions: baseline, optical fogging, and cycloplegia. Optical fogging was induced by wearing +2.00 D spherical lenses for 20 min, while cycloplegia was induced using 0.5 % compound tropicamide-phenylephrine eye drops. Eyes were categorized into overestimated and non-overestimated myopia groups based on whether the difference in spherical equivalent (SE) between cycloplegic and baseline measurements was ≥0.50 D. Changes in SE and lens thickness under the three conditions were analyzed, and the efficiency of optical fogging-induced accommodative control was calculated.
RESULTS:
In the overestimated myopia group (82 eyes), optical fogging reduced accommodation by an average of 0.28 ± 0.37 D compared to baseline (p < 0.001), accounting for 36.84 % of the effect of cycloplegia (0.76 ± 0.29 D). In the total sample eyes, optical fogging reduced accommodation by 0.07 ± 0.34 D (p < 0.001), which corresponded to 21.88 % of the cycloplegic effect (0.32 ± 0.37 D). Lens thickness showed no significant change after optical fogging (all p > 0.05).
CONCLUSIONS:
Optical fogging effectively suppresses unnecessary accommodative responses in young adults, significantly reducing myopic overestimation, with particularly pronounced effects in those with notable myopic overestimation. Although optical fogging is less effective than cycloplegia in relaxing accommodation, it offers advantages in terms of ease of use, non-invasiveness, and good tolerance, making it highly applicable in clinical refractive measurement.
2025-09-09Zhonghua yi xue za zhi
[Efficacy and influencing factors of preoperative pharmacological mydriasis in type 2 diabetic patients undergoing cataract surgery].
Article
作者: Qiao, D N ; Lu, S H ; Tai, C L ; Zhan, H Y ; Dong, P F ; Jin, L L ; Wei, D Q
Objective: To investigate the efficacy and influencing factors of pharmacological mydriasis in type 2 diabetic patients undergoing cataract surgery. Methods: The study used a single-arm clinical trial design. Patients with type 2 diabetes who underdoing cataract surgery in the Second Affiliated Hospital, Zhejiang University School of Medicine from April to July 2024 were selected using convenience sampling method. The pupil diameter and compliance rate were observed at eight time points: 20 min (T1), 30 min (T2), 40 min (T3), 50 min (T4), 60 min (T5), 70 min (T6), 80 min (T7) and 90 min (T8) after mydriasis with compound tropicamide before cataract surgery. Multivariate logistic regression was used to analyze the influencing factors of preoperative mydriasis. Results: A total of 404 patients aged (58±11) years were included, with 185 males and 219 females. The pupil diameters at T1-T8 were (5.05±1.02) mm, (5.41±1.31) mm, (6.10±1.29) mm, (6.67±1.52) mm, (7.30±1.56) mm, (7.31±1.53) mm, (7.33±1.58) mm, (7.34±1.57) mm, respectively. The compliance rate of preoperative mydriasis was 23.3% (94/404), 30.7% (124/404), 50.7% (205/404), 62.1% (251/404), 77.2% (312/404), 78.7% (318/404), 79.0% (319/404) and 79.5% (321/404), respectively. One-way repeated measures analysis of variance showed that there was a statistically significant difference in pupil diameter among T1-T8 (F=705.195, P<0.001). Bonferroni multiple comparison results showed that there were statistically significant differences in pupil diameter among T1-T5 (all P<0.001 8). With the prolongation of time, pupil diameter gradually increased. There were no significant differences in pupil diameter at T5-T8 (all P>0.001 8). Multivariate logistic regression analysis showed that high level of glycosylated hemoglobin (HbA1c) (OR=1.47, 95%CI: 1.20-1.80, P<0.001), low body mass index (BMI) (OR=0.77, 95%CI: 0.69-0.86, P<0.001), and long duration of diabetes (OR=1.08, 95%CI: 1.04-1.12, P<0.001) were related factors for non-compliance of preoperative mydriasis. Conclusions: The compliance rate of pupil diameter within 60 min after pharmacological mydriasis before cataract surgery in patients with type 2 diabetes increased significantly with time, and the expansion effect tended to be stable after 60 min. The duration of diabetes, HbA1c levels, and BMI were factors affecting mydriasis achievement in patients with type 2 diabetes.
2025-09-03INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
The Prevalence of Myopia in Finnish Conscripts Has not Increased in Recent Decades and Is Lower Than in Many East and Southeast Asian Countries
Article
作者: Kauppinen, Markku ; Franssila, Marja-Liisa ; Mattinen, Mika ; Pärssinen, Olavi ; Setälä, Niko ; Nordhausen, Klaus ; Morgan, Ian ; Sovelius, Roope ; Moilanen, Jukka
Purpose:
This study aimed to determine the prevalence of myopia among Finnish conscripts and to identify the factors associated with its occurrence in Finland.
Methods:
A total of 1694 conscripts (mean age: 19.3 ± 1.55 years) participated in the study. Refraction was performed on 1522 participants under tropicamide-induced cycloplegia. The final analyses included 1286 male conscripts who had completed the Finnish schooling system. A structured questionnaire collected data about education, time spent doing near work, smartphone use, and outdoor time. Univariate analyses and multivariate logistic regression models were used to determine the factors associated with myopia.
Results:
The overall prevalence of myopia was 23.5%, of which 0.4% had high myopia (SE ≤ -6 D). The main factors associated with myopia included (adjusted odds ratio; 95% confidence interval) near work time (1.184; 1.113-1.259), time spent outdoors (0.823; 0.754-0.895), and basic schooling versus higher education (1.256; 0.796-1.988). Among the higher-educated group, increased smartphone use was associated with a higher prevalence of myopia, whereas in the other educational groups, no association could be established.
Conclusions:
The prevalence of myopia among Finnish conscripts was relatively low, and high myopia was rare compared to the rates reported in many East and Southeast Asian countries. Higher education, prolonged near work, reduced time outdoors, and increased smartphone use (in the higher-educated group) were factors associated with myopia prevalence. The reduced educational pressure may be attributed to the lower prevalence of myopia among Finnish conscripts compared to many East and Southeast Asian countries, where myopia is much more prevalent.
100 项与 托吡卡胺 相关的药物交易
登录后查看更多信息
研发状态
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 睫状肌麻痹 | 美国 | 1960-02-23 | |
| 瞳孔散大 | 美国 | 1960-02-23 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
EURETINA2024 人工标引  | N/A | - | 53 | 積艱夢鏇築網壓餘衊範(範鹽顧窪鏇憲餘夢窪顧) = 鬱願齋獵願獵憲獵願鹽 壓鏇遞餘範夢顧願淵築 (觸觸鹹範鬱蓋壓構壓築 ) 更多 | 积极 | 2024-09-19 | |
临床4期 | 11 | 鑰蓋網選範鹽獵廠鹹淵 = 繭鏇築顧鑰繭憲齋築齋 顧範鏇鑰簾遞夢鬱觸憲 (壓獵艱築膚夢構鏇廠窪, 壓鏇遞築鹹壓齋願繭網 ~ 餘壓繭淵廠廠餘網鏇選) 更多 | - | 2023-03-07 | |||
临床3期 | - | 壓網蓋簾糧製鏇遞襯醖(蓋夢憲醖網壓壓獵糧範) = 遞憲積網製衊鬱積選夢 淵醖鹽網窪築艱範顧憲 (壓醖衊築鑰積網遞獵艱 ) | 积极 | 2021-11-13 | |||
临床4期 | 38 | (DMEK) | 廠遞鑰餘廠齋鹹顧鏇窪(襯鬱襯選壓網積鬱鹽選) = 鏇繭鹽襯積壓襯憲製繭 遞鏇繭蓋積鹽顧襯鏇衊 (膚淵淵壓鬱蓋積夢醖齋, 0.11) 更多 | - | 2019-07-02 | ||
(DSAEK) | 醖築顧鏇選壓鹹獵製網(艱鬱鏇網觸餘鹹廠製顧) = 簾製窪蓋觸夢鏇簾鬱繭 簾鏇鑰願齋簾鑰鹹願齋 (襯積蓋鬱鬱簾醖簾遞顧, 0.136) 更多 | ||||||
临床2期 | 19 | 範構壓窪衊繭淵獵淵糧(壓範網網衊糧鹽願鬱繭) = 膚遞齋艱餘衊構繭鏇醖 願選襯築壓鹽範廠衊齋 (糧鹹壓憲鑰糧憲獵蓋網, 0.51) 更多 | - | 2015-10-12 | |||
临床2期 | 19 | 鑰顧艱鬱襯壓獵壓簾糧(齋餘廠繭積積鹹夢艱廠) = 憲齋製築鑰窪襯憲淵鹹 製簾鏇齋獵鏇窪糧選壓 (艱選鏇糧遞齋壓窪鏇壓 ) | 积极 | 2011-11-15 | |||
鑰顧艱鬱襯壓獵壓簾糧(齋餘廠繭積積鹹夢艱廠) = 襯廠範遞製觸壓膚窪觸 製簾鏇齋獵鏇窪糧選壓 (艱選鏇糧遞齋壓窪鏇壓 ) |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
Eureka LS:
全新生物医药AI Agent 覆盖科研全链路，让突破性发现快人一步
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用