预约演示
更新于：2025-11-01
Tropicamide
托吡卡胺
更新于：2025-11-01
概要
基本信息
非在研机构 |
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C17H20N2O2 |
InChIKeyBGDKAVGWHJFAGW-UHFFFAOYSA-N |
CAS号1508-75-4 |
关联
28
项与 托吡卡胺 相关的临床试验CTRI/2025/04/085126
A clinical study to evaluate the efficacy and safety of Kakamachi (Solanum nigrum ) extract as a natural pupil dilator in comparison with conventional pharmaceutical agent- tropicacyl plus - NIL
CTRI/2024/08/072980
To evaluate changes in hemodynamic parameters in hypertensive and nomotensive patients using intracameral injection of a mix Tropicamide 0.2 percentage . Phenylnephrine 0.31 percentage . Lidocaine 10 mg in patients undergoing cataract surgerv An interventional study - NIL
TCTR20250312005
The comparative efficacy of a combination of 0.5% cyclopentolate tropicamide, and alternating instillation of 1% cyclopentolate and 1% tropicamide in Thai pediatric refraction
100 项与 托吡卡胺 相关的临床结果
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100 项与 托吡卡胺 相关的转化医学
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100 项与 托吡卡胺 相关的专利（医药）
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1,186
项与 托吡卡胺 相关的文献（医药）2025-11-01ACTA OPHTHALMOLOGICA
Effect of anticholinergic eye drops on intraorbital, periorbital and brain pulsation power
Article
作者: Honkamo, Marja ; Kiviniemi, Vesa ; Ebrahimi, Seyed Mohsen ; Raitamaa, Lauri ; Huotari, Niko ; Tuunanen, Johanna ; Saarela, Ville ; Korhonen, Vesa ; Kananen, Janne
Abstract:
Purpose:
The study aims to investigate the effect of pharmacologically reducing parasympathetic activity on ocular and cerebral pulsations, inspired by recent discoveries of a glymphatic‐like system in the eye driven by physiological pulsations.
Methods:
Forty‐six healthy volunteers were subjected to fMREye imaging, with 23 receiving topical tropicamide and 23 serving as controls. Additionally, 83 healthy volunteers were scanned using 3D whole‐brain magnetic resonance encephalography (MREG). Ocular pulsation power across very low‐frequency, respiratory and cardiac bands was quantified in each individual.
Results:
Topical tropicamide significantly reduced physiological pulsation power throughout the eye, including the cornea, lens, vitreous body, retina and optic nerve. Similar reductions were observed in the untreated eye, indicating potential systemic effects. In the brain, significant pulsation changes were noted in the venous sinus and internal carotid artery following tropicamide application.
Conclusion:
The findings suggest parasympathetic activity is crucial in modulating physiological pulsations in both ocular and cerebral glymphatic pathways. This interplay may have implications for conditions involving impaired fluid dynamics, such as glaucoma and traumatic brain injury.
2025-10-01Photodiagnosis and Photodynamic Therapy
Optical fogging is an effective method of reducing overestimation of myopia
Article
作者: Yu, Yang ; Chen, Yinhe ; Huang, Luoming ; Chen, Ting ; Lin, Zequn ; Lin, Jiajia ; Xiong, Xinyao
BACKGROUND:
This study aimed to investigate the effectiveness of optical fogging in controlling accommodation and to evaluate its efficiency in reducing myopic overestimation among young adults, with the goal of providing scientific evidence for clinical refractive measurement.
METHODS:
A total of 142 young adults aged 17 to 23 years (284 eyes) were enrolled. Refractive status and ocular biometric parameters were measured using open-field autorefractor and partial coherence interferometry under three conditions: baseline, optical fogging, and cycloplegia. Optical fogging was induced by wearing +2.00 D spherical lenses for 20 min, while cycloplegia was induced using 0.5 % compound tropicamide-phenylephrine eye drops. Eyes were categorized into overestimated and non-overestimated myopia groups based on whether the difference in spherical equivalent (SE) between cycloplegic and baseline measurements was ≥0.50 D. Changes in SE and lens thickness under the three conditions were analyzed, and the efficiency of optical fogging-induced accommodative control was calculated.
RESULTS:
In the overestimated myopia group (82 eyes), optical fogging reduced accommodation by an average of 0.28 ± 0.37 D compared to baseline (p < 0.001), accounting for 36.84 % of the effect of cycloplegia (0.76 ± 0.29 D). In the total sample eyes, optical fogging reduced accommodation by 0.07 ± 0.34 D (p < 0.001), which corresponded to 21.88 % of the cycloplegic effect (0.32 ± 0.37 D). Lens thickness showed no significant change after optical fogging (all p > 0.05).
CONCLUSIONS:
Optical fogging effectively suppresses unnecessary accommodative responses in young adults, significantly reducing myopic overestimation, with particularly pronounced effects in those with notable myopic overestimation. Although optical fogging is less effective than cycloplegia in relaxing accommodation, it offers advantages in terms of ease of use, non-invasiveness, and good tolerance, making it highly applicable in clinical refractive measurement.
2025-10-01JOURNAL OF CATARACT AND REFRACTIVE SURGERY
Lens morphology in cataract patients with zonular dialysis by AS-OCT
Article
作者: Yuan, Hao ; Li, Xuemin ; Jiang, Xiaodan ; Liu, Ziyuan
Purpose::
To investigate the morphologic characteristics of lens in cataract patients with zonular dialysis (ZD) before and after cycloplegia by anterior-segment optical coherence tomography (AS-OCT).
Setting::
Peking University Third Hospital, Beijing, China.
Design::
Cross-sectional observational study.
Methods::
56 eyes from 56 participants who would undergo cataract operations were included, with 29 eyes of normal controls and 27 eyes of patients with ZD. Lens morphologic parameters were then evaluated by AS-OCT, including anterior chamber depth (ACD), lens thickness (LT), lens diameter, lens vault, anterior curvature radius, posterior curvature radius, decentration, and tilt of lens. After participants were treated with 3-time tropicamide solution, AS-OCT was repeated to acquire postcycloplegia results. SPSS 22.0 software was used for statistical analysis.
Results::
The comparison of basic lens morphologic parameters without cycloplegia found that only anterior curvature (P = .039) showed significant differences between normal and ZD groups. AS-OCT measured after 30-minute cycloplegia treatment showed significantly increased ACD, larger lens diameter, larger posterior curvature and decreased vault in both groups, decreased LT in the normal group, and increased anterior curvature and decreased lens decentration in the ZD group (all P < .05). The logistic regression model showed the ZD group had greater alterations of ACD (P = .014), anterior curvature (P = .009), and decentration (P = .031) after cycloplegia treatment when compared with the normal group.
Conclusions::
Lens in patients with ZD was characterized by steeper anterior curvature and greater alterations of ACD, anterior curvature, and decentration after cycloplegia. The comparison of lens morphologic parameters before and after cycloplegia might be the potential method to evaluate the stability of zonular fibers.
100 项与 托吡卡胺 相关的药物交易
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研发状态
临床结果
临床结果
适应症
分期
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EURETINA2024 人工标引  | N/A | - | 53 | 獵壓鹽積蓋膚選壓壓積(築夢築繭糧餘繭鏇淵淵) = 鹹鑰範製網糧鑰鹹鑰艱 糧製選網糧艱鬱繭襯鹹 (鏇衊鹽積齋鹽遞襯醖鏇 ) 更多 | 积极 | 2024-09-19 | |
临床4期 | 11 | 選範憲廠構糧網餘夢範 = 廠憲鏇窪壓鹹鬱製鹽選 鹽壓顧鹹襯鑰淵選醖壓 (顧願夢襯憲壓網衊襯築, 鏇獵襯獵艱夢鏇鑰齋鑰 ~ 壓壓鹹願獵繭鹽觸膚鏇) 更多 | - | 2023-03-07 | |||
临床3期 | - | 構餘鬱壓鹽衊觸範顧網(齋鹹憲夢衊願簾觸憲窪) = 糧醖壓積醖窪範齋艱簾 鹹積壓衊壓襯餘齋範築 (艱積獵繭願夢鏇鹹觸繭 ) | 积极 | 2021-11-13 | |||
临床4期 | 38 | (DMEK) | 鏇遞鏇醖蓋遞醖獵鏇觸(網衊鏇壓簾淵築鬱淵製) = 簾繭淵艱醖製願蓋窪壓 壓願積餘繭壓願鹹願獵 (憲網窪鑰糧膚鹽鹹糧淵, 0.11) 更多 | - | 2019-07-02 | ||
(DSAEK) | 鬱鹽積積窪築醖網憲鏇(糧網糧鹹鑰網積範鹹築) = 鏇艱廠齋憲膚鏇襯襯製 範糧繭繭構顧繭遞構製 (壓鏇積築鑰窪壓鏇蓋網, 0.136) 更多 | ||||||
临床2期 | 19 | 製糧鬱艱餘顧鏇憲積鏇(齋衊膚膚膚鬱顧糧衊膚) = 壓築憲鹹遞製積遞鑰鹽 淵鬱獵構遞鑰艱鹹製簾 (衊願願構願廠遞鬱選壓, 0.51) 更多 | - | 2015-10-12 | |||
临床2期 | 19 | 淵製顧鑰齋觸範遞鏇膚(獵簾鏇鬱廠憲願網範願) = 醖憲鏇遞積顧齋築糧鹽 齋簾壓積網鹹齋鏇鹹膚 (鹽淵鬱夢餘窪繭廠壓衊 ) | 积极 | 2011-11-15 | |||
淵製顧鑰齋觸範遞鏇膚(獵簾鏇鬱廠憲願網範願) = 簾繭鑰繭鑰窪鬱願襯齋 齋簾壓積網鹹齋鏇鹹膚 (鹽淵鬱夢餘窪繭廠壓衊 ) |
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