预约演示
更新于：2025-05-16
Benoxinate Hydrochloride
盐酸奥布卡因
更新于：2025-05-16
概要
基本信息
非在研机构- |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 日本 (1966-06-07), |
最高研发阶段(中国)批准上市 |
特殊审评- |
登录后查看时间轴
结构/序列
分子式C17H29ClN2O3 |
InChIKeyPRGUDWLMFLCODA-UHFFFAOYSA-N |
CAS号5987-82-6 |
关联
11
项与 盐酸奥布卡因 相关的临床试验ChiCTR2500097357
Observation on the psychological nursing and effect of hydrochloric Oxybuprocaine in patients undergoing refractive surgery
NCT05733741
Preservative-free Topical Anesthetics for the Management of Postoperative Pain Following Photorefractive Keratectomy
NCT05666362
Hemodynamic Response Of Premature Brain To Pain During Retinopathy Of Prematurity Screening: A Randomized Controlled Trial
100 项与 盐酸奥布卡因 相关的临床结果
登录后查看更多信息
100 项与 盐酸奥布卡因 相关的转化医学
登录后查看更多信息
100 项与 盐酸奥布卡因 相关的专利（医药）
登录后查看更多信息
563
项与 盐酸奥布卡因 相关的文献（医药）2025-12-31ANNALS OF MEDICINE
Optimizing injection accuracy for Baxter’s nerve entrapment: an ultrasonography-guided approach based on anatomical surface landmarks
Article
作者: Choi, Jung-woo ; Shin, Mi Young ; Nam, Yong-Seok ; Kim, Sang-Hyun ; Kim, Jun-Ho ; Kim, In-Beom ; Lee, Hyung-Jin
INTRODUCTION:
The clinical feasibility and applicability of surface landmarks for Baxter nerve entrapment to proximal and distal sites is unclear. This study provides anatomical guidelines for optimal transducer placement using two specific landmarks, the most inferior tip of the medial malleolus (A) and the most protruding posterior tip of the calcaneus (B), to enhance the diagnostic and therapeutic injection efficacy for proximal and distal entrapment sites.
MATERIALS AND METHODS:
Eighty-six feet from 45 fresh cadavers (25 male and 20 female) were dissected to determine Baxter's nerve (BN) localization. With A and B as key landmarks, distances (OB, OBN, BBN, and BNx) were measured to accurately localize the nerve. The OB distance was divided into four equal-length quadrants or zones. Twenty feet from 10 fresh cadavers (5 males and 5 females) underwent ultrasonography-guided injection using in-plane and out-of-plane techniques. Two practitioners marked the landmarks to ensure reproducibility and an experienced anesthesiologist administered the injections. The spread of the injected dye was assessed, and statistical analyses were conducted.
RESULTS:
Average OB, OBN, BBN, and BNx distances were 50.55 ± 5.83 mm, 7.19 ± 5.85 mm, 43.77 ± 5.31 mm, and 12.13 ± 5.75 mm, respectively. Significant sex-related differences (O to B; B to BN) and notable disparities between the distances on the right and left sides (O to BN; BN to X-axis) were observed. Most of the BN (81.4%) was located in zone 1, representing 25% of the OB length. For entrapment site 1, the in-plane technique achieved a 100% success rate whereas the out-of-plane method achieved an 80% success rate. For entrapment site 2, the out-of-plane approach (90% success) outperformed the in-plane approach (20% success).
CONCLUSION:
Using two specific landmarks provides reliable guidelines for optimal transducer placement during injections targeting compressive neuropathy at proximal and distal entrapment sites.
2025-01-01Journal of Studies on Alcohol and Drugs
Trends of Buprenorphine Prescribing for Opioid Dependence Before and During the Early and Later Part of the COVID-19 Pandemic: A Study From a Large, Publicly Funded Opioid Agonist Treatment Service in India
Article
作者: Naik, Shalini S. ; Basu, Debasish ; Mattoo, Surendra K. ; Kaur, Simranjit ; Subodh, B. N. ; Ghosh, Abhishek
OBJECTIVE:
The COVID-19 pandemic has affected the availability of and access to medications for opioid dependence (OD). We examined the monthly trends in new buprenorphine/naloxone (BNX) treatment episodes, number of clinical visits for BNX, BNX dispensed per person, and BNX prescription over 56 months, which included the pre-pandemic period and the early and later parts of the pandemic (January 2017 to August 2022).
METHOD:
Research data were collected from the pharmacy database of a large publicly funded treatment center in India. A flexible, low-threshold service was adopted in April 2020 in response to the lockdown implemented on March 25, 2020. Change point analyses were performed to examine monthly trends visually and statistically. We used autoregressive integrated moving averages to forecast trends from April to August 2020 and March to August 2022, using January 2017 to March 2020 and March 2020 to February 2022 as training data sets.
RESULTS:
A total of 993 patients were started on BNX treatment; 40,452 BNX clinic attendances were made; 1,401,393 BNX tablets were dispensed; and 6,795 new patients with OD were registered. The observed data for clinic attendance for BNX was significantly lower than the projected estimates in April to August 2020; however, observed new treatment episodes and monthly BNX prescriptions were within the 95% projected estimates; BNX dispensed per person was significantly more than the projected estimate. In contrast, observed BNX prescription trends surpassed the upper limit of the 95% confidence interval in March to August 2022.
CONCLUSIONS:
A low-threshold and flexible-treatment service could mitigate the unintended consequences of pandemic-induced restrictions.
2024-12-01INTERNATIONAL JOURNAL OF PHARMACEUTICS
Spring and parachute approach for piroxicam dissolution; its phenomenological model on the thermodynamics of irreversible processes
Article
作者: Goto, Satoru ; Tsunoda, Chihiro ; Moritake, Kota ; Tsuchida, Tomohiro ; Kataoka, Hikaru ; Fujita, Momoko
Even though the spring and parachute approach for poorly water-soluble drug candidates effectively improves their dissolution curves with eutectic mixtures, deep eutectic solvents, solid dispersion polymers, and solid solutions, we cannot consider that its enabling factor in these pharmaceutical modifications was enough to be clarified. Based on our previous study that oxybuprocaine acts as a role of parachute generator for piroxicam, the present study explored a small-molecule parachute generator and found that propranolol, a β-adrenergic-blocking drug, has a parachute effect on the supersaturated state of piroxicam. In addition, changing the concentration of tetracaine and dibucaine to 10 mM and 2.5 mM also showed a parachute effect. These parachute generators control piroxicam's dissolved state kinetically by making the supersaturated state of piroxicam a steady state. However, as the piroxicam anhydrous crystals diminished and the piroxicam monohydrate crystals grew due to Ostwald ripening, it led to attenuating the supersaturated state. This finding advances the elucidation of the mechanism of the parachute effect of polymers.
100 项与 盐酸奥布卡因 相关的药物交易
登录后查看更多信息
研发状态
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 多泪 | 日本 | 1972-12-26 | |
| 麻醉 | 日本 | 1966-06-07 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 114 | Small incision lenticule extraction+Proxymetacaine 0.5%+Oxybuprocaine 0.4%+Tobramycin and dexamethasone+Ofloxacin | 鏇築網蓋糧鏇廠蓋繭鏇(鹽艱蓋廠構遞蓋襯構窪) = 觸製繭鬱淵憲鑰遞憲糧 製壓鏇鹹壓壓鬱艱鹹鹽 (遞糧簾獵觸觸繭淵鑰鏇, 0.48) 更多 | - | 2024-04-23 | ||
N/A | - | 42 | 鑰顧鑰簾觸餘淵積積鏇(壓衊遞鹽淵築選鹹簾鏇): P-Value = 0.029 更多 | 积极 | 2021-09-01 | ||
N/A | - | 67 | 夢齋膚願鏇製膚構廠艱(簾窪顧壓鬱獵鹹鹽憲繭) = 鑰窪齋膚遞鬱廠簾膚窪 繭襯簾觸願餘窪襯醖繭 (艱鬱壓鑰蓋觸膚蓋範憲 ) 更多 | 积极 | 2011-02-01 | ||
夢齋膚願鏇製膚構廠艱(簾窪顧壓鬱獵鹹鹽憲繭) = 鹽顧鹹憲鹹選壓遞獵蓋 繭襯簾觸願餘窪襯醖繭 (艱鬱壓鑰蓋觸膚蓋範憲 ) 更多 | |||||||
N/A | 50 | Tetracaine/Oxybuprocaine | 齋壓廠願積蓋積蓋壓衊(襯觸顧積製憲製鏇顧獵) = 醖淵觸選窪網鑰製餘範 製齋淵鏇襯簾壓網積鹽 (製艱憲壓鬱餘淵衊簾齋 ) | 积极 | 2006-05-01 | ||
齋壓廠願積蓋積蓋壓衊(襯觸顧積製憲製鏇顧獵) = 鏇夢憲艱蓋膚網蓋鹽糧 製齋淵鏇襯簾壓網積鹽 (製艱憲壓鬱餘淵衊簾齋 ) |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
Eureka LS:
全新生物医药AI Agent 覆盖科研全链路，让突破性发现快人一步
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用