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更新于：2025-07-05
Quinapril Hydrochloride
盐酸喹那普利
更新于：2025-07-05
概要
基本信息
原研机构 |
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C25H31ClN2O5 |
InChIKeyIBBLRJGOOANPTQ-JKVLGAQCSA-N |
CAS号82586-55-8 |
关联
16
项与 盐酸喹那普利 相关的临床试验NCT05713396
Long - Term Effect of Quinapril or Losartan or Their Combination on Diabetic Autonomic Neuropathy and Left Ventricular Function Over a Period of 4 Years. A Radionuclide Ventriculography Study.
NCT01669434
Chronic Angiotensin Converting Enzyme Inhibitors in Intermediate Risk Surgery: A Randomized, Single-Blinded Study
CTR20132627
盐酸喹那普利片在健康男性受试者中的单次剂量、随机、开放生物等效性研究
100 项与 盐酸喹那普利 相关的临床结果
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100 项与 盐酸喹那普利 相关的转化医学
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100 项与 盐酸喹那普利 相关的专利（医药）
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1,384
项与 盐酸喹那普利 相关的文献（医药）2025-06-01INTERNATIONAL JOURNAL OF CARDIOLOGY
An updated review on therapeutic strategies in coronary microvascular dysfunction
Review
作者: Khandkar, Chinmay ; Yong, Andy ; Ravindran, Jayant ; Rehan, Rajan
Coronary microvascular dysfunction (CMD) is well-known cause of angina, yet treatment options remain limited. This systematic review and meta-analysis examines the current literature and provides a contemporary evaluation of treatments using a stringent definition for CMD with accurate methods of microvascular assessment in accordance with recent consensus guidelines. Methods and Results: A search strategy was conducted independently by two authors (CK and RR). Studies were required to be prospective trials in adult patients with documented CMD by IC doppler wire, thermodilution techniques, or perfusion imaging via PET/MRI. CMD was defined as either coronary flow reserve (CFR)/myocardial perfusion reserve (MPR) < 2.5, and/or index of microvascular resistance (IMR) > 25. Methodological quality of studies was assessed via the Cochrane Risk of Bias tool. The primary and secondary endpoints were change in CFR/MPR/IMR and change in Seattle Angina Questionnaire (SAQ) scores respectively. Two-sided p-values were used and considered significant if p < 0.05. A total of 11,360 records were identified, from which 14 were included in this review covering 9 different treatments. Two treatments (quinapril and ranolazine) showed significant improvement in both CFR and angina. Three ranolazine trials were pooled in meta-analysis. The standardised mean difference showed a weak positive effect (0.24) with wide intervals (-0.21 to 0.26) which was not statistically significant (p = 0.20). We subsequently reviewed all treatments as mentioned in recent European consensus statements. Conclusions: The overall quality of evidence surrounding treatments for CMD is of "low", with lack of robust data highlighting the dire need for higher quality trials in this area.
2025-04-01JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
DFT analysis for structure, vibrational assignments, and molecular properties of medicinally important isoquinoline
作者: Mir, M. Amin
2-Benzanine, also recognized as isoquinoline or benzo pyridine, acts as a weak tertiary base with diverse biol. and pharmacol. effects.These include potential activities against Parkinson's disease, antimalarial, anti-HIV, insect growth, anticancer, antibiotic, antileukemic properties, and the ability to serve as a chiral ligand scaffold.In this study, the B3LYP technique and the basis set 6-311++G(d, p) were employed for both computational and exptl. examinations of isoquinoline using d. functional theory (DFT).The findings revealed that isoquinoline possesses a dipole moment of 2.004 D and rotational constants (GHz) of 3.101, 1.22, and 0.875.Various tests, including IR, UV-visible, HNMR, and binding energies, corroborated the exptl. results.Analyzing the computed energy difference between the HOMO at -5.581 eV and the LUMO at 1.801 eV indicated the stability of isoquinoline, with an energy gap of 3.78 eV.The electron polarizability and chem. hardness values were found to be 1.89 and 0.529, resp.Drug-likeness tests suggest that isoquinoline could function as an antibiotic, given its similarity in effects to other compounds such as isoquinoline, quinolone, debrisoquine, palmatine, columbamine, and jatropine.
2025-03-01JOURNAL OF FOOD COMPOSITION AND ANALYSIS
Heavy metal accumulation, yield and health risk assessment of wheat crop grown in contaminated soil amended with bioash for sustainable agriculture
作者: Kumar, Umesh ; Sharma, Rajesh Kumar ; Kumar, Indrajeet ; Singh, Prince Kumar
Prolonged use of wastewater irrigation in peri-urban agriculture has increased levels of heavy metals (HMs) in soil, raising concerns regarding both food safety and human health.To address this issue, the effectiveness of agro-waste derived bioashes (ADB), specifically rice husk ash (RHA) and sugarcane bagasse ash (SBA), was investigated as soil amendment materials to immobilize HMs in soil and reduce their accumulation in crops.The aim of the present study was to evaluate the effects of RHA and SBA on HM uptake, growth, yield, nutrient quality, and seed metabolite profiles of wheat (Triticum aestivum L. cv. HUW 234) crop grown in HM contaminated soils, along with associated health risks.Results revealed that SBA significantly and effectively reduced Cr, Ni, Cu, Zn, and Cd accumulation in wheat seeds (13.5%, 33.8%, 17.6%, 7.8%, and 10.0%, resp.), more compared to RHA (6.8%, 16.9%, 8.8%, 3.9%, and 5.0%) with maximum accumulation in roots followed by shoots and least in seeds.Health risk assessments showed that the estimated daily intake (EDI) of HMs was found highest for Zn and lowest for Cd in both the children and adults consuming wheat seeds, with hazard quotient values above a unit for all the HMs.The present study concludes that SBA could be effectively used as a superior soil amendment to reduce HM toxicity in soil-wheat system, associated human health risks and to promote sustainable agriculture in peri-urban areas.
100 项与 盐酸喹那普利 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 心脏衰竭 | 美国 | 1991-11-19 | |
| 高血压 | 美国 | 1991-11-19 |
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临床结果
临床结果
适应症
分期
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N/A | EGR1 | STAT3 | PRR ... 更多 | 12 | (Control (CTL)) | 獵鏇鹽襯窪糧獵衊選積(遞製壓淵憲鹽製蓋製鏇) = 繭襯鬱蓋顧網願網鏇齋 壓觸鹹築選選壓鏇鹹鑰 (廠網膚衊壓積鑰淵鬱廠 ) | 积极 | 2021-04-01 | |
(Diabetic (DM)) | 獵鏇鹽襯窪糧獵衊選積(遞製壓淵憲鹽製蓋製鏇) = 醖壓憲糧醖齋衊構淵鏇 壓觸鹹築選選壓鏇鹹鑰 (廠網膚衊壓積鑰淵鬱廠 ) | ||||||
临床4期 | 291 | 廠壓鏇蓋窪顧衊餘醖構 = 夢簾獵鬱鬱鬱鏇構選糧 觸鏇蓋顧範製膚淵鹽製 (鏇齋積鏇鬱積鑰窪鬱襯, 顧遞簾願鬱廠壓蓋蓋繭 ~ 淵窪繭蓋餘糧鬱鹽選壓) 更多 | - | 2017-12-11 | |||
(ACEI Continuation) | 廠壓鏇蓋窪顧衊餘醖構 = 夢齋簾餘顧襯觸鏇積艱 觸鏇蓋顧範製膚淵鹽製 (鏇齋積鏇鬱積鑰窪鬱襯, 獵夢鑰窪壓鹽醖鏇觸糧 ~ 築顧顧憲獵鹽夢鹹獵鏇) 更多 | ||||||
N/A | - | 製鬱網遞蓋鬱餘鏇醖壓(範鹽憲蓋選蓋壓夢鏇繭) = 鏇蓋窪窪構築淵壓壓蓋 觸鑰鹽顧築觸淵淵餘構 (艱壓鑰製鑰膚製鏇齋壓 ) | 积极 | 2013-09-25 | |||
N/A | 66 | 醖積餘齋齋鬱糧獵觸鏇(願獵遞鏇遞築鹽積窪構) = 膚淵積壓糧餘夢廠顧艱 遞蓋膚糧醖窪顧簾築製 (餘餘廠蓋廠廠製鹹範夢 ) 更多 | 积极 | 2010-06-01 | |||
醖積餘齋齋鬱糧獵觸鏇(願獵遞鏇遞築鹽積窪構) = 簾齋壓網膚鏇蓋憲鹹製 遞蓋膚糧醖窪顧簾築製 (餘餘廠蓋廠廠製鹹範夢 ) 更多 |
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