预约演示
更新于：2025-07-20
Quinapril Hydrochloride
盐酸喹那普利
更新于：2025-07-20
概要
基本信息
原研机构 |
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C25H31ClN2O5 |
InChIKeyIBBLRJGOOANPTQ-JKVLGAQCSA-N |
CAS号82586-55-8 |
关联
16
项与 盐酸喹那普利 相关的临床试验NCT05713396
Long - Term Effect of Quinapril or Losartan or Their Combination on Diabetic Autonomic Neuropathy and Left Ventricular Function Over a Period of 4 Years. A Radionuclide Ventriculography Study.
NCT01669434
Chronic Angiotensin Converting Enzyme Inhibitors in Intermediate Risk Surgery: A Randomized, Single-Blinded Study
CTR20132627
盐酸喹那普利片在健康男性受试者中的单次剂量、随机、开放生物等效性研究
100 项与 盐酸喹那普利 相关的临床结果
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100 项与 盐酸喹那普利 相关的转化医学
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100 项与 盐酸喹那普利 相关的专利（医药）
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1,389
项与 盐酸喹那普利 相关的文献（医药）2025-10-01COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
Effects of re-enter water on antioxidant, immune, intestinal flora and metabolome of Chinese mitten crab (Eriocheir sinensis) after high temperature air exposure
Article
作者: Wang, Shihui ; Luo, Liang ; Yang, Yuhong ; Zhao, Zhigang ; Li, Zhiqiang ; Guo, Kun ; Deng, Xiangyi ; Zhang, Rui
Both air exposure stress and heat stress can cause stress responses of Eriocheir sinensis and affect its normal life activities. The objective of this research was to investigate the impact of re-enter water treatment on immunoenzyme activity, immune-related gene expression, hemolymph parameters, intestinal microbiota composition, and metabolomic profiles in Eriocheir sinensis after being subjected to high-temperature air exposure. The findings indicated that the re-enter water effectively mitigated the negative impacts of high-temperature air exposure on both antioxidant and immune capacities. Following treatment with high-temperature air, levels of acid phosphatase (ACP), alkaline phosphatase (AKP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were significantly elevated compared to their baseline values (P < 0.05), followed by a decline as re-enter water started with recovery to baseline levels detected at 24 h after re-enter water. Additionally, the levels of heat shock proteins HSP90 and HSP70 exhibited a notable rise after being subjected to high-temperature air. Nevertheless, after 24 h of soaking treatment, these levels reverted to values similar to those recorded initially. However, after re-enter water treatment, the changes in intestinal microbial composition and metabolic level caused by high temperature air exposure were not effectively improved. The analysis of intestinal microbiota revealed that the relative abundance of Bacteroidetes in the recovery group was significantly lower compared to the initial group, whereas the relative abundances of Proteobacteria and Firmicutes were found to be higher than those in the initial group. Concurrently, metabolomics analysis indicated a significant increase in palmitic acid metabolism levels within the high-temperature air group (P < 0.05), while glycine content showed a notable decrease (P < 0.05), and the metabolic changes caused by high temperature air exposure was still not fully recovered after re-enter water.
2025-06-01INTERNATIONAL JOURNAL OF CARDIOLOGY
An updated review on therapeutic strategies in coronary microvascular dysfunction
Review
作者: Khandkar, Chinmay ; Yong, Andy ; Ravindran, Jayant ; Rehan, Rajan
Coronary microvascular dysfunction (CMD) is well-known cause of angina, yet treatment options remain limited. This systematic review and meta-analysis examines the current literature and provides a contemporary evaluation of treatments using a stringent definition for CMD with accurate methods of microvascular assessment in accordance with recent consensus guidelines. Methods and Results: A search strategy was conducted independently by two authors (CK and RR). Studies were required to be prospective trials in adult patients with documented CMD by IC doppler wire, thermodilution techniques, or perfusion imaging via PET/MRI. CMD was defined as either coronary flow reserve (CFR)/myocardial perfusion reserve (MPR) < 2.5, and/or index of microvascular resistance (IMR) > 25. Methodological quality of studies was assessed via the Cochrane Risk of Bias tool. The primary and secondary endpoints were change in CFR/MPR/IMR and change in Seattle Angina Questionnaire (SAQ) scores respectively. Two-sided p-values were used and considered significant if p < 0.05. A total of 11,360 records were identified, from which 14 were included in this review covering 9 different treatments. Two treatments (quinapril and ranolazine) showed significant improvement in both CFR and angina. Three ranolazine trials were pooled in meta-analysis. The standardised mean difference showed a weak positive effect (0.24) with wide intervals (-0.21 to 0.26) which was not statistically significant (p = 0.20). We subsequently reviewed all treatments as mentioned in recent European consensus statements. Conclusions: The overall quality of evidence surrounding treatments for CMD is of "low", with lack of robust data highlighting the dire need for higher quality trials in this area.
2025-04-01JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
DFT analysis for structure, vibrational assignments, and molecular properties of medicinally important isoquinoline
作者: Mir, M. Amin
2-Benzanine, also recognized as isoquinoline or benzo pyridine, acts as a weak tertiary base with diverse biol. and pharmacol. effects.These include potential activities against Parkinson's disease, antimalarial, anti-HIV, insect growth, anticancer, antibiotic, antileukemic properties, and the ability to serve as a chiral ligand scaffold.In this study, the B3LYP technique and the basis set 6-311++G(d, p) were employed for both computational and exptl. examinations of isoquinoline using d. functional theory (DFT).The findings revealed that isoquinoline possesses a dipole moment of 2.004 D and rotational constants (GHz) of 3.101, 1.22, and 0.875.Various tests, including IR, UV-visible, HNMR, and binding energies, corroborated the exptl. results.Analyzing the computed energy difference between the HOMO at -5.581 eV and the LUMO at 1.801 eV indicated the stability of isoquinoline, with an energy gap of 3.78 eV.The electron polarizability and chem. hardness values were found to be 1.89 and 0.529, resp.Drug-likeness tests suggest that isoquinoline could function as an antibiotic, given its similarity in effects to other compounds such as isoquinoline, quinolone, debrisoquine, palmatine, columbamine, and jatropine.
100 项与 盐酸喹那普利 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 心脏衰竭 | 美国 | 1991-11-19 | |
| 高血压 | 美国 | 1991-11-19 |
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临床结果
临床结果
适应症
分期
评价
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N/A | EGR1 | STAT3 | PRR ... 更多 | 12 | (Control (CTL)) | 夢廠艱齋獵鑰襯繭衊積(蓋餘醖壓憲簾顧蓋積夢) = 膚鹽構簾繭遞繭觸顧艱 憲願餘鬱願選襯範餘淵 (淵醖憲膚製憲窪窪憲淵 ) | 积极 | 2021-04-01 | |
(Diabetic (DM)) | 夢廠艱齋獵鑰襯繭衊積(蓋餘醖壓憲簾顧蓋積夢) = 顧鬱製簾選襯鑰網範齋 憲願餘鬱願選襯範餘淵 (淵醖憲膚製憲窪窪憲淵 ) | ||||||
临床4期 | 291 | 範壓網鹽鑰齋襯網範蓋 = 醖構願憲遞鑰鹽夢鹽餘 憲鹹壓窪醖齋鬱選憲簾 (鹹襯鹹網鬱範蓋齋築鏇, 糧遞簾鑰膚獵願衊願蓋 ~ 憲遞繭願淵艱廠鬱築夢) 更多 | - | 2017-12-11 | |||
(ACEI Continuation) | 範壓網鹽鑰齋襯網範蓋 = 糧顧簾願廠構鏇觸鏇蓋 憲鹹壓窪醖齋鬱選憲簾 (鹹襯鹹網鬱範蓋齋築鏇, 糧襯醖醖齋築鏇醖窪餘 ~ 構築獵鑰醖構獵鹹窪糧) 更多 | ||||||
N/A | - | 憲鹹鏇獵鑰網襯廠窪選(鹽淵鬱淵繭鬱遞膚鹽餘) = 淵簾構築範顧遞淵夢積 憲顧蓋蓋鹽顧壓艱鹹艱 (膚膚願築鹹襯遞鑰簾選 ) | 积极 | 2013-09-25 | |||
N/A | 66 | 糧壓鑰範艱醖獵範鬱衊(觸廠襯鏇鑰艱憲鹹遞膚) = 顧蓋鬱淵餘遞壓窪鬱顧 網壓襯鹹鑰夢顧構範衊 (網鏇鹹構壓鑰製餘遞顧 ) 更多 | 积极 | 2010-06-01 | |||
糧壓鑰範艱醖獵範鬱衊(觸廠襯鏇鑰艱憲鹹遞膚) = 淵鏇淵壓艱顧衊獵觸夢 網壓襯鹹鑰夢顧構範衊 (網鏇鹹構壓鑰製餘遞顧 ) 更多 |
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