Trastuzumab biosimilar(Shanghai Henlius Biotech, Inc.)

2025年3月24日，复宏汉霖（2696.HK）发布2024年度业绩，于业绩期内实现营业收入约人民币57.244亿元，较去年同期增长约6.1%，净利润达8.205亿元，同比增长50.3%，净利润率达14.3%，同比增长41.6%。这是继2023年首次取得全年盈利之后，公司连续第二年实现全年盈利。核心产品商业化销售的持续扩大成为业绩盈利的重要驱动力，产品销售收入合计约人民币49.335亿元，同比增长8.3%。此外，公司全年研发投入达到人民币18.405亿元，同比增长28.4%。 公司加速创新管线突破并高效拓展全球布局，释放更多增长潜力，推动公司可持续高质量发展。截至目前，复宏汉霖已有6款产品在中国获批上市，4款产品在国际获批上市，触达50多个国家和地区，广泛覆盖亚洲、欧洲、拉丁美洲、北美洲和大洋洲，惠及全球超75万患者。业绩期内，公司在全球范围内完成25项上市注册申请递交，并获得17项批准，覆盖中国、美国、欧盟、加拿大、印尼等多个国家和地区，加速产品全球化进程。同时，公司秉持差异化的创新研发策略，构建了约50个分子的多元化管线，覆盖单抗、多抗、抗体偶联药物（ADC）、融合蛋白等丰富的药物形式，并持续深化AI等前沿技术和平台赋能，破解临床之需并促进创新成果转化落地。 复宏汉霖董事长张文杰先生表示：“ 公司持续实现全年盈利增长，充分验证了我们在战略布局和商业运营效率上的不断提升，为可持续发展奠定了坚实基础。秉持‘以患者为中心’的理念，复宏汉霖将继续聚焦临床未尽之需，充分发挥一体化平台优势，进一步优化精益运营管理体系，助力公司迈向更高质量发展。” 复宏汉霖执行董事、首席执行官朱俊博士表示：“ 过去一年里，我们锚定创新和国际化两大抓手，全面加速海外市场拓展，成为中国生物医药企业出海领导者，同时打造多元化创新管线，并积极拥抱前沿技术，不断激发创新活力，释放持续增长动能。面向未来，我们将继续以创新为引领，在国际化征程上阔步前行，为全球患者提供更多高品质治疗方案。” 连续盈利聚势增长，全球拓局致远新篇 2024年，公司继续深耕乳腺癌、肺癌、消化道肿瘤等高发癌种领域，核心产品营收保持稳健增长，推动连续盈利目标。业绩期内，公司6款产品销售收入合计约人民币49.335亿元，同比增长8.3%，其中，公司自建商业化团队推广的汉曲优®（曲妥珠单抗，美国商品名：HERCESSI™，欧洲商品名：Zercepac®）、H药 汉斯状®（斯鲁利单抗，欧洲商品名：Hetronifly®）、汉贝泰®（贝伐珠单抗）和汉奈佳®（奈拉替尼）于2024全年分别实现销售收入约人民币28.100亿元、13.126亿元、1.971亿元和0.453亿元。此外，基于与合作伙伴的约定，公司就汉利康®（利妥昔单抗）实现销售及授权许可收入约人民币5.504亿元，汉达远®（阿达木单抗）实现销售收入0.401亿元。 公司乳腺癌领域重磅产品汉曲优®继续保持良好增长。2024年，该产品全球销售额收入约人民币28.100亿元，其中，国内销售额约人民币26.924亿元，海外销售收入约1.176亿元，同比增长27.0%。汉曲优®是在中美欧三地获批的国产单抗生物类似药，也是获批上市国家和地区最多的国产单抗生物类似药。2024年，该产品在菲律宾、巴西、美国、加拿大等多地获批上市，并成功发货至沙特和美国，其商业化供货网络已覆盖中国、东南亚、北美、欧洲、中东及拉丁美洲等地区。截至目前，汉曲优®已在50多个国家和地区获批上市，包括美国、英国、加拿大、法国、德国、瑞士、澳大利亚等，并进入中国、英国、法国、德国等多个国家的医保目录，惠及超过24万名患者。2024年，公司乳腺癌产品矩阵再添“利器”。2024年8月，复宏汉霖与甫康药业达成小分子抗肿瘤药物汉奈佳®的商业化合作。该款产品主要用于HER2阳性早期乳腺癌的强化辅助治疗，可与汉曲优®实现序贯治疗，有望降低HER2阳性早期乳腺癌患者术后5年和10年复发风险，为患者提供了全新的治疗选择。 聚焦肺癌和消化道肿瘤，H药 汉斯状®以突破性疗效和差异化优势，获得广泛认可，已在中国、欧洲和东南亚等30多个国家和地区获批上市，惠及超过10万名患者。2024年，H药实现全球销售收入约13.126亿元，同比增长17.2%，其中，国内销售额约人民币13.089亿元。H药是全球首个获批用于一线治疗小细胞肺癌的抗PD-1单抗。2024年12月，该产品获批非鳞状非小细胞肺癌（nsNSCLC）新适应症，这是继鳞状非小细胞肺癌（sqNSCLC)、广泛期小细胞肺癌（ES-SCLC)后，该产品在肺癌领域获批的第三项适应症。此外，H药已成功纳入中国118个省/城市级惠民保，市场竞争力和影响力不断提升。海外拓展方面，公司持续携手Intas、KGbio和复星医药等合作伙伴全力推动H药的全球化进程，覆盖美国、欧洲、东南亚、中东和北非等100多个国家和地区。2024年第一季度，公司高效完成H药首批海外发货，标志着H药成为首个登陆东南亚国家的国产抗PD-1单抗，为全球更多病患带来新的治疗选择。2025年2月，H药于欧盟获批上市，用于一线治疗广泛期小细胞肺癌，成为首个且目前唯一在欧盟获批上市用于ES-SCLC治疗的抗PD-1单抗，进一步惠及全球更多患者。 2024年，公司持续践行为全球患者提供可负担的创新产品的使命，于国际市场取得令人瞩目的卓越成绩，成功实现国际化闭环1.0。继汉曲优®和汉斯状®之后，中国首款生物类似药汉利康®在秘鲁等多个拉丁美洲国家获批上市，汉贝泰®也首次于玻利维亚获批上市，成为复宏汉霖第四款海外获批自研产品。此外，公司在研地舒单抗生物类似药HLX14的上市申请已在欧盟和美国获受理，在研帕妥珠单抗生物类似药HLX11的上市申请也在中国和美国获受理，为全球化发展注入新动能。2024年以来，公司商业合作再添新成果，分别就汉曲优®与Getz以及就5款生物药与Abbott进一步扩大在新兴市场的合作，并与Dr. Reddy’s就在研达雷妥尤单抗生物类似药HLX15达成欧美授权合作，加速推进公司产品进入全球市场。同时，公司还与Sermonix就临床阶段在研新型乳腺癌内分泌疗法HLX78（拉索昔芬）达成亚洲区域合作，与Palleon签署合作与许可协议，探索推进糖编辑疗法，进一步完善夯实自身管线布局。此外，公司与SVAX达成战略合作，于沙特设立合资公司，共同提升先进生物药在中东北非土耳其地区的可及性。 深化创新管线布局，破解临床未尽之需 2024年，复宏汉霖聚焦未被满足的临床需求，在以抗体技术为核心的创新领域持续推进，致力于加速更多潜在“First-in-Class”和“Best-in-Class”分子进入临床开发阶段。公司持续搭建并优化抗体偶联药物（ADC）技术平台和T细胞衔接器（T Cell Engager, TCE）技术平台，并充分运用以AI为代表的前沿技术，为创新研发提供有力支持。 临床开发方面，公司积极推进H药 汉斯状®、HLX22（抗HER2单抗）、HLX43（PD-L1 ADC）等创新产品的临床开发。H药联合贝伐珠单抗联合化疗用于一线治疗转移性结直肠癌（mCRC）患者的国际多中心临床研究（ASTRUM-015）进入III期研究阶段，并于中国、印度尼西亚和日本完成首例受试者给药，H药 汉斯状®有望成为全球首个治疗non-MSI-H mCRC的抗PD-1单抗。此外，H药联合化疗同步放疗一线治疗局限期小细胞肺癌（LS-SCLC）的国际多中心III期临床试验和H药联合化疗用于新辅助/辅助治疗胃癌III期临床研究正在积极推进，公司还在美国积极推进一项H药对比一线标准治疗阿替利珠单抗用于ES-SCLC的头对头桥接试验，以支持H药更多适应症在全球的申报上市。靶向HER2创新型单抗HLX22在HER2阳性晚期胃癌中的 III期临床试验亦相继获中国药监局（NMPA）、美国食药监局（FDA）、日本药品医疗器械综合机构（PMDA）、澳大利亚药品管理局（TGA）等许可，并完成全球首例受试者给药。2025年3月，HLX22获美国FDA孤儿药资格认定，用于治疗胃癌。同时，公司还启动了HLX22联合曲妥珠单抗和化疗/联合德曲妥珠单抗的II期临床试验，进一步探索以HLX22为基石的HER2靶向疗法在多项实体瘤中的治疗潜力。作为全球第二款、国内首款进入临床阶段的PD-L1 ADC，HLX43在实体瘤中开展的II期临床研究已完成首例受试者给药。此外，HLX43联用H药的ADC免疫联合疗法也已获批开展晚期/转移性实体瘤患者的Ib/II期临床试验，有望发挥ADC+IO协同增效的抗肿瘤作用。 与此同时，公司持续优化生产运营与质量管理体系，为未来发展筑牢根基。截至目前，公司已建成48,000升商业化产能，稳定供货中国、东南亚、北美、欧洲、中东及拉丁美洲等地区。随着松江基地（二）项目的推进竣工验收，公司将进一步强化产能布局，为未来发展提供更强支撑。质量管理方面，公司商业化生产基地及配套体系已通过近百项各国药监机构及国际合作伙伴的核查或审计，获得中国、欧盟、美国、印尼及巴西等多个PIC/S成员国的GMP认证。此外，松江基地还通过ISO 14001环境管理体系和ISO 45001职业健康安全管理体系双认证，标志着其在环境可持续管理及员工健康安全管理方面达到国际先进水平，为公司全球化生产与供应体系再添权威认证。 展望未来，复宏汉霖将继续秉持“以患者为中心”的理念，以创新为基石，以全球化为驱动，持续提升商业化运营能力、并强化产能建设，为全球患者提供更多可及、可负担的优质治疗方案，继续向着成为具有全球竞争力的生物制药企业稳步迈进。 关于复宏汉霖 复宏汉霖（2696.HK）是一家国际化的创新生物制药公司，致力于为全球患者提供可负担的高品质生物药，产品覆盖肿瘤、自身免疫疾病、眼科疾病等领域，已有6款产品在中国获批上市，4款产品在国际获批上市，4个上市申请分别获中国药监局、美国FDA和欧盟EMA受理。自2010年成立以来，复宏汉霖已建成一体化生物制药平台，高效及创新的自主核心能力贯穿研发、生产及商业运营全产业链。公司已建立完善高效的全球创新中心，按照国际药品生产质量管理规范（GMP）标准进行生产和质量管控，不断夯实一体化综合生产平台，其中，公司商业化生产基地已相继获得中国、欧盟和美国GMP认证。 复宏汉霖前瞻性布局了一个多元化、高质量的产品管线，涵盖约50个分子，并全面推进基于自有抗PD-1单抗H药汉斯状®的肿瘤免疫联合疗法。截至目前，公司已获批上市产品包括国内首个生物类似药汉利康®（利妥昔单抗）、自主研发的中美欧三地获批单抗生物类似药汉曲优®（曲妥珠单抗，美国商品名：HERCESSI™，欧洲商品名：Zercepac®）、汉达远®（阿达木单抗）、汉贝泰®（贝伐珠单抗）、全球首个获批一线治疗小细胞肺癌的抗PD-1单抗汉斯状®（斯鲁利单抗，欧洲商品名：Hetronifly®）以及汉奈佳®（奈拉替尼）。公司亦同步就19个产品在全球范围内开展30多项临床试验，对外授权全面覆盖欧美主流生物药市场和众多新兴市场。

SHANGHAI, March 24, 2025 /PRNewswire/ -- Henlius (2696.HK) announced its 2024 annual results. During the reporting period, Henlius' total revenue reached approximately RMB5.7244 billion, representing an increase of 6.1% YoY. The net profit reached RMB820.5 million, a 50.3% YoY growth, with a net profit margin of 14.3%, up by 41.6% YoY. This marks Henlius' second consecutive year of full-year profitability following its first profitable year in 2023. The increasing commercial sales of core products have been a key driver of profitability, with total product sales revenue reaching approximately RMB4.9335 billion, an increase of 8.3% YoY. Additionally, the company's annual R&D expenditure reached RMB1.8405 billion, representing an increase of 28.4% YoY. Henlius has accelerated breakthroughs in its innovation pipeline and efficiently expanded its global footprint, unlocking further growth potential and driving sustainable, high-quality development. Up to date, Henlius has secured approvals for 6 products in China and 4 internationally, reaching over 50 countries and regions across Asia, Europe, Latin America, North America, and Oceania, benefiting over 750,000 patients worldwide. During the reporting period, the company completed 25 marketing applications and secured 17 approvals around the world, covering key markets such as China, the United States (U.S.), the European Union (EU), Canada and Indonesia, accelerating its global expansion. Additionally, Henlius has maintained a differentiated innovation strategy, building a pipeline of about 50 molecules, including monoclonal antibodies (mAbs), polyclonal antibodies (pAbs), antibody-drug conjugates (ADCs), and fusion proteins. The company leverages cutting-edge technologies such as AI to address unmet clinical needs and enhance the translation of innovative achievements. Mr. Wenjie Zhang, Chairman of Henlius, said: "Henlius has consistently achieved year-round profit growth, which fully validates our continuous improvement in strategic planning and business operational efficiency, laying a solid foundation for sustainable development. Adhering to patient-centricity, Henlius will continue to focus on unmet clinical needs, fully leverage the advantages of its integrated platform, further optimize the lean operation management system, and drive the company towards higher quality development." Dr. Jason Zhu, Executive Director and Chief Executive Officer of Henlius, said: "Over the past year, we have anchored our strategy in innovation and globalization, accelerating overseas market expansion and solidifying our position as a leader among Chinese biopharmaceutical companies going global. By building a diversified innovation pipeline and embracing cutting-edge technologies, we have consistently fuelled innovation and unlocked sustainable growth momentum. Moving forward, we will continue to be driven by innovation, advancing our global journey to deliver more high-quality treatment options for patients worldwide." Harnessing Momentum through Profitability, Charting New Horizons in Global Expansion In 2024, Henlius continued to deepen its focus on high-incidence cancer areas such as breast cancer, lung cancer, and gastrointestinal tumours, with core products driving steady revenue growth and achieving the goal of sustained profitability. During the reporting period, Henlius' 6 products recorded total sales revenue of RMB4.9335 billion, up by 8.3% YoY. Among these, HANQUYOU (trastuzumab, trade name: HERCESSI™ in the U.S., Zercepac® in Europe), HANSIZHUANG (serplulimab, trade name: Hetronifly® in Europe), HANBEITAI (bevacizumab) and HANNAIJIA (neratinib), achieved sales revenues of RMB2.8100 billion, RMB1.3126 billion, RMB197.1 million and RMB45.3 million, respectively in 2024. Additionally, based on agreements with partners, the company received total revenues of RMB550.4 million and RMB40.1 million for HANLIKANG (rituximab) and HANDAYUAN (adalimumab), respectively. The company's core product on breast cancer, HANQUYOU, maintained robust growth. In 2024, the global sales revenue of HANQUYOU was approximately RMB2.8100 billion, with domestic sales of RMB2.6924 billion and overseas sales revenue of RMB117.6 million up by 27.0% YoY. HANQUYOU is a China-developed monoclonal antibody biosimilar receiving approvals in China, the U.S., and Europe, making it the most widely approved Chinese mAb biosimilar across multiple countries and regions. In 2024, the product received approvals for marketing in countries and regions including the Philippines, Brazil, the U.S., and Canada, with successful shipments made to Saudi Arabia and the U.S. Its commercial supply network now covers countries and regions such as China, Southeast Asia, North America, Europe, the Middle East, and Latin America. To date, HANQUYOU has gained marketing approvals in over 50 countries and regions, including the U.S., the U.K., Canada, France, Germany, Switzerland and has been included in the national medical insurance catalogues of countries such as China, the UK, France, and Germany, benefiting over 240,000 patients globally. Additionally, in August 2024, Henlius entered into a strategic cooperation with Convalife Pharmaceuticals for HANNAIJIA (neratinib), an oral small molecule anti-tumour drug, further enriching its breast cancer treatment portfolio. Neratinib is used for extended adjuvant therapy in early-stage HER2-positive breast cancer and can be used sequentially with HANQUYOU to further reduce the risk of recurrence for patients with early-stage HER2-positive breast cancer within 5 and 10 years after surgery, providing a new treatment option for patients. Focusing on lung cancer and gastrointestinal tumours, HANSIZHUANG, recognized for its breakthrough efficacy and differentiated advantages, has been approved for marketing in over 30 countries and regions, including China, Europe and Southeast Asia, benefiting more than 100,000 patients. In 2024, HANSIZHUANG recorded a total sales revenue of RMB1.3126 billion, representing an increase of 17.2% YoY, with domestic sales of RMB1.3089 billion. HANSIZHUANG is the world's first anti-PD-1 mAb approved for the first-line treatment of small cell lung cancer. In December 2024, it was approved for the treatment of non-squamous non-small cell lung cancer (nsNSCLC), marking its third approved indication in lung cancer following squamous NSCLC and extensive-stage small cell lung cancer (ES-SCLC). Furthermore, HANSIZHUANG has been included in 118 provincial/city-level commercial medical insurance programs across China, further strengthening its market competitiveness. In terms of overseas expansion, the company continues to collaborate with partners including Intas, KGbio, and Fosun Pharma to promote the globalization of HANSIZHUANG. To date, HANSIZHUANG has been licensed out to more than 100 countries and regions including the U.S., Europe, Southeast Asia, the Middle East, and North Africa. In the first quarter of 2024, the company efficiently completed the first shipment of HANSIZHUANG overseas, marking its entry as the first domestically produced anti-PD-1 mAb in Southeast Asian countries, offering new treatment options to patients worldwide. In February 2025, it was approved in the EU for the first-line ES-SCLC treatment, becoming the first and currently the only anti-PD-1 mAb in the EU for this indication, further benefiting more patients worldwide. In 2024, as part of its commitment to provide affordable and high-quality biomedicines for patients worldwide, Henlius has achieved remarkable success in the international market, and successfully realized the "Closed-loop Internationalization 1.0". Following HANQUYOU and HANSIZHUANG, China's first biosimilar, HANLIKANG, was approved for marketing in several Latin American countries including Peru, while HANBEITAI received its first approval in Bolivia, becoming Henlius' fourth product approved overseas. Moreover, the marketing applications for HLX14 (denosumab biosimilar) have been accepted in both the EU and the U.S., and the marketing applications for HLX11 (pertuzumab biosimilar) have also been accepted in China and the U.S., infusing new momentum into the company's global development. In 2024, the company achieved new milestones in business collaborations. Henlius has expanded its collaborations in emerging markets with Getz for HANQUYOU and with Abbott for five biopharmaceuticals. It has also entered into an out-licensing partnership with Dr. Reddy's for HLX15, a biosimilar of daratumumab, accelerating the global expansion of the product. Besides, the company partnered with Sermonix on HLX78 (lasofoxifene), an investigational novel endocrine therapy for breast cancer, for the Asian region, and collaborated with Palleon to advance glycan-editing therapies, further enhancing its pipeline. Additionally, the company established a strategic partnership with SVAX to set up a joint venture in Saudi Arabia, enhancing the accessibility of advanced biologics across the Middle East, North Africa, and Türkiye (MENAT) countries. Deepening Innovation Pipeline to Address Unmet Clinical Needs In 2024, Henlius focused on unmet clinical needs, driving innovation in antibody technology to accelerate the development of potential "First-in-Class" and "Best-in-Class" molecules into clinical stages. The company optimized its ADC and T cell Engager (TCE) platforms, leveraging advanced technologies such as AI to enhance R&D capabilities. In clinical development, Henlius actively progressed the development of HANSIZHUANG, HLX22 (anti-HER2 mAb), HLX43 (PD-L1 ADC) and other products. The company has initiated a range of clinical trials to support global regulatory submissions for a wide variety of indications for HANSIZHUANG. The phase 3 stage of the international multi-centre clinical trial (ASTRUM-015) of serplulimab in combination with bevacizumab and chemotherapy in first-line treatment of metastatic colorectal cancer (mCRC) has dosed the first patients in China, Indonesia and Japan, potentially making it the first anti-PD-1 mAb in non-MSI-H mCRC worldwide. The company is actively advancing an international multi-centre phase 3 clinical trial of HANSIZHUANG plus chemotherapy and concurrent radiotherapy in patients with limited-stage small cell lung cancer (LS-SCLC) and a phase 3 clinical trial of HANSIZHUANG plus chemotherapy as neoadjuvant/adjuvant therapy for gastric cancer (GC). Henlius is also conducting a bridging head-to-head trial in the U.S. to compare HANSIZHUANG with standard of care atezolizumab (anti-PD-L1 mAb) for the first-line treatment of ES-SCLC. HLX22, targeting HER2-positive advanced gastric cancer, received Phase 3 clinical trial approvals from China NMPA, U.S. FDA, Japan PMDA, Australia TGA etc., and this international study has been initiated in multiple countries and regions worldwide and has completed its first patient dosing globally. In March 2025, the U.S. FDA granted orphan drug designation (ODD) to HLX22 for the treatment of gastric cancer. A phase 2 trial is also evaluating the potential of HLX22 in other HER2-expressing solid tumours in combination with trastuzumab and chemotherapy or in combination with trastuzumab deruxtecan (T-DXd). HLX43, the world's second and China's first clinical-stage PD-L1 ADC, has completed its first phase 2 clinical trial dosing in solid tumours. In addition, a phase 1b/2 trial of HLX43 in combination with the anti-PD-1 mAb serplulimab has been approved in China, aiming to exploit the synergistic effects of ADC and immunotherapy in advanced/metastatic solid tumours. Meanwhile, the company continues to optimize its production operations and quality management system, strengthening its foundation for future development. To date, it has established a total commercial capacity of 48,000 litres, ensuring stable supply to countries and regions including China, Southeast Asia, North America, Europe, the Middle East, and Latin America. The completion of the Songjiang Second Plant will further enhance its production capabilities. In terms of quality management, the company's manufacturing facilities and production lines have successfully passed nearly a hundred inspections or audits conducted by various regulatory authorities and international business partners. It has obtained GMP certifications from China, the EU, the U.S. and multiple PIC/S member countries, including Indonesia and Brazil. Additionally, the Songjiang Facility has received ISO 14001 and ISO 45001 dual certifications, demonstrating its international leadership in environmental sustainability and employee health and safety, further strengthening its company's global production and supply capabilities. Looking forward, Henlius will continue to adhere to its patient-centricity, driven by innovation and globalization, to enhance commercial operations, strengthen production capacity and provide more accessible and affordable high-quality treatment options for patients worldwide, steadily advancing toward becoming a globally competitive biopharmaceutical company. About Henlius Henlius (2696.HK) is a global biopharmaceutical company with the vision to offer high-quality, affordable and innovative biologic medicines for patients worldwide with a focus on oncology, autoimmune diseases and ophthalmic diseases. Up to date, 6 products have been launched in China, 4 have been approved for marketing in overseas markets, and 4 marketing applications have been accepted for review in China, the U.S. and the EU, respectively. Since its inception in 2010, Henlius has built an integrated biopharmaceutical platform with core capabilities of high-efficiency and innovation embedded throughout the whole product life cycle including R&D, manufacturing and commercialization. It has established global innovation centre and Shanghai-based commercial manufacturing facilities certificated by China, the EU and U.S. GMP. Henlius has pro-actively built a diversified and high-quality product pipeline covering about 50 molecules and has continued to explore immuno-oncology combination therapies with proprietary HANSIZHUANG (anti-PD-1 mAb) as the backbone. To date, the company's launched products include HANLIKANG (rituximab), the first China-developed biosimilar, HANQUYOU (trastuzumab, trade name: HERCESSI™ in the U.S., Zercepac® in Europe), a China-developed mAb biosimilar approved in China, Europe and U.S., HANDAYUAN (adalimumab), HANBEITAI (bevacizumab), HANSIZHUANG (serplulimab, trade name: Hetronifly® in Europe), the world's first anti-PD-1 mAb for the first-line treatment of SCLC, and HANNAIJIA (neratinib). What's more, Henlius has conducted over 30 clinical studies for 19 products, expanding its presence in major markets as well as emerging markets. SOURCE Henlius WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED