Nov. 13, 2024 -- Creative Medical Technology Holdings, Inc. (NASDAQ: CELZ), a biotechnology leader in regenerative medicine, is pleased to announce the successful completion of an independent interim safety review by the Data Safety Monitoring Board (DSMB) for its ADAPT clinical trial. The trial evaluated CELZ-201, a novel therapeutic perinatal tissue derived cell product, designed to treat chronic lower back pain associated with degenerative disc disease. The DSMB reviewed safety data from th

Phase 2 trial initiation in patients with sleep /wake disorders results in milestone payment of US$3.5 million to Nxera 13 November 2024 – Nxera Pharma Co., Ltd. (“Nxera” or “the Company”; TSE 4565) – formerly known as Sosei Group or Sosei Heptares – notes that Centessa Pharmaceuticals has initiated a Phase 2 trial of ORX750, an investigational, orally administered, highly potent and selective orexin receptor 2 (OX2R) agonist for the treatment of narcolepsy type 1 (NT1), narcolepsy type 2 (NT2),

Nov. 14, 2024 -- Alumis Inc. (Nasdaq: ALMS), a clinical stage biopharmaceutical company developing oral therapies using a precision approach to optimize clinical outcomes and significantly improve the lives of patients with immune-mediated diseases, today announced the company will give two data presentations at ACR Convergence 2024, the annual meeting of the American College of Rheumatology (ACR), being held November 14–19, 2024, in Washington, D.C. Data to be presented at ACR show that treat

11月15日，英派药业宣布已于近日完成2.5亿元人民币D++轮融资，本轮融资由全球知名产业投资机构和知名保险基金共同投资。舟渡资本担任本轮融资的独家财务顾问。根据新闻稿，本轮融资将支持英派药业核心产品塞纳帕利（senaparib）的商业化，及包含PARP1选择性抑制剂在内的多个化合物的全球临床开发，同时用于加速多个早期项目的研发。 英派药业致力于研发靶向抗癌创新药，专注于合成致死作用机制。该公司以DNA损伤修复通路（DDR）自主研发产品为基础，构建了覆盖全面的DDR产品管线之一，并且正在逐步拓展到更多的全新的合成致死靶点。今年4月，该公司宣布完成4亿元人民币D+轮融资，由高特佳投资和熙诚金睿共同领投，扬州国金投资和顾屿南歌参与，原股东礼来亚洲基金与厦门建发新兴投资本轮持续加码。 英派药业的研发管线包括PARP抑制剂（senaparib/IMP4297）、Wee1抑制剂（IMP7068）、ATR抑制剂（IMP9064）、PARP1选择性抑制剂（IMP1734，与美国Eikon Therapeutics合作开发）以及多个其他DDR靶点抑制剂。其中PARP抑制剂塞纳帕利在全球范围包含中国

– Long-term follow-up data highlight further reductions in tumor size, increase in ORR with additional CRs, sustained improvement in desmoid tumor symptoms, and consistent safety profile, now with a median duration of therapy of approximately 3 years – Nov. 07, 2024 -- SpringWorks Therapeutics, Inc. (Nasdaq: SWTX), a commercial-stage biopharmaceutical company focused on severe rare diseases and cancer, today announced that long-term efficacy and safety data from the Phase 3 DeFi trial of niroga

2024年11月15日，三生制药今日宣布，旗下沈阳三生制药有限责任公司与上海恩凯细胞技术有限公司（下称：恩凯赛药）就NK细胞技术达成战略合作。 本次协议的签署标志着三生制药与恩凯赛药在NK细胞治疗领域的合作迎来新的里程碑。双方将通过整合优势技术和资源，共同推进授权技术及相关产品的研发、临床研究、上市注册及商业化等。 恩凯赛药创始人田志刚院士表示：“恩凯赛药是一家面向全球，处于临床阶段，专注于原创研发的生物技术企业。我们非常期待能与三生制药携手合作，使先进细胞疗法更多的服务于所需人群。充分开发NK细胞生产平台技术的价值新路径，加速实现NK细胞前沿技术及其应用的落地。” 三生制药董事长兼首席执行官娄竞博士表示：“在‘让创新生物药触手可及’的使命驱动之下，近年来，三生制药在大力推动自有管线开发的同时，着眼全球临床需求迫切的疾病领域，聚焦前沿医疗科技研究，致力于发掘优质合作标的和伙伴，从而推动创新生物药及疗法的开发，为患者造福。我们期待通过本次合作，能够推动创新NK细胞疗法的研发、上市和商业化进程，帮助更多患者享受到民族创新药和创新疗法的治疗获益，为‘健康中国’建设作出贡献。” NK细胞生

“11月1日，艾伯维 和 EvolveImmune Therapeutics 宣布合作和选择许可协议，以开发下一代癌症生物治疗药物，合作将 艾伯维 的肿瘤学专业知识与 EvolveImmune 专有的 EVOLVE T 细胞接合器平台相结合，开发用于癌症的新型多特异性治疗性抗体 根据协议条款，EvolveImmune 将从 艾伯维 获得总计 6500 万美元的前期费用和股权投资，并有资格获得高达 14 亿美元的总计期权费用和里程碑，以及净销售额的分级特许权使用费。” 艾伯维（纽约证券交易所代码：ABBV）和 EvolveImmune Therapeutics（一家开发下一代生物治疗药物以克服癌细胞对当前免疫疗法耐药性的治疗挑战）在11月1日宣布达成合作和选择许可协议，为肿瘤学中的多个靶点开发多特异性生物制剂。该发现合作伙伴关系将利用 EvolveImmune 的 T 细胞接合器平台开发基于抗体的新型实体和血液系统恶性肿瘤疗法。 EvolveImmune 专有的 EVOLVE 平台旨在提供有效、选择性和集成的 T 细胞共刺激，以扩增和维持 T 细胞的肿瘤杀伤能力。该方法旨在绕过低肿

Preliminary data demonstrate durable and dose-dependent T cell responses targeting KRAS mutations and induced responses to patient-specific neoantigens Correlation observed between disease-free survival (“DFS”) and T cell response ELI-002 Phase 1 safety and tolerability profile remains favorable ELI-002 Phase 2 interim event-driven DFS analysis expected in H1 2025 Nov. 07, 2024 -- Elicio Therapeutics, Inc. (Nasdaq: ELTX, “Elicio Therapeutics” or “Elicio”), a clinical-stage biotechnology compan

BDC-4182 demonstrated compelling anti-tumor activity and an acceptable safety profile in preclinical studies BDC-4182 outperformed cytotoxic claudin 18.2 ADCs in syngeneic model Learnings from BDC-1001 data suggest Boltbody™ ISACs with enhanced immune activation could offer greater efficacy, warranting further testing Nov. 07, 2024 -- Bolt Biotherapeutics (Nasdaq: BOLT), a clinical-stage biopharmaceutical company developing novel immunotherapies for the treatment of cancer, today presented upda

MB-108 (HSV-1 oncolytic virus) is active and well tolerated in patients with recurrent glioblastoma in ongoing Phase 1 clinical trial Preclinical data support a novel combination of MB-108 (HSV-1 oncolytic virus) and MB-101 (IL13Rα2‐targeted CAR-T cell therapy) to optimize clinical results Nov. 07, 2024 -- Mustang Bio, Inc. (“Mustang” or the “Company”) (Nasdaq: MBIO), a clinical-stage biopharmaceutical company focused on translating today’s medical breakthroughs in cell therapies into potential