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更新于：2025-01-23
Terbutaline Sulfate
硫酸特布他林
更新于：2025-01-23
概要
基本信息
药物类型 小分子化药 |
别名 Terbutaline、Terbutaline sulfate (JP17/USP)、Terbutaline Sulfate and Sodium Chloride + [19] |
作用机制 β2-adrenergic receptor激动剂(β2-肾上腺素能受体激动剂) |
非在研适应症 |
原研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C12H21NO7S |
InChIKeyMUPQZWGSBCWCAV-UHFFFAOYSA-N |
CAS号23031-32-5 |
关联
44
项与 硫酸特布他林 相关的临床试验NCT06626620
Randomized Controlled Trial of Intravenous Magnesium Sulfate Versus Terbutaline for Children in the Management of Acute Exacerbation of Asthma
NCT04973345
A Prospective, Blinded, Cross-Over Trial of the Exposure-Response Relationship of Terbutaline Sulfate in Adults With Asthma
NCT05494307
A Multicenter Randomized Trial of Second Line Treatment for Corticosteroid-Resistant or Relapsed Immune Thrombocytopenia: Combined Terbutaline and Danazol Versus Danazol Monotherapy
100 项与 硫酸特布他林 相关的临床结果
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100 项与 硫酸特布他林 相关的转化医学
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100 项与 硫酸特布他林 相关的专利（医药）
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3,566
项与 硫酸特布他林 相关的文献（医药）2025-01-01ENVIRONMENTAL RESEARCH
Retraction notice to “Adsorption of terbutaline β-agonists from wastewater by mechano-synthesized iron oxide nanoparticles modified copper (II) isonicotinate metal-organic framework” [Environ. Res. 258 (2024) 119413]
Article
作者: Binzowaimil, Ayed M ; Ariffin, Marinah Mohd ; Aldaghri, Osamah ; Lim, Jun Wei ; Eisa, M H ; Ibnaouf, Khalid Hassan ; Yusoff, Hanis Mohd ; Usman, Armaya'u ; Loh, Saw Hong ; Afiq Wan Mohd Khalik, Wan Mohd ; Khoo, Kuan Shiong ; Zango, Zakariyya Uba
2025-01-01ALLERGY AND ASTHMA PROCEEDINGS
Efficacy of parenteral bronchodilators on ventilatory outcomes in pediatric critical asthma: a national cohort study
Article
作者: Gabbay, Jonathan M. ; Guenther, Cara S. ; Fishman, Michael D. ; Graham, Robert J. ; Bajaj, Benjamin V.M. ; Perez, Jennifer M.
Objective: To evaluate the association of parenteral epinephrine and terbutaline use on ventilatory support in children admitted to the intensive care unit (ICU) with critical asthma in the United States. Methods: Data were obtained from the Pediatric
Health Information System data base for children ages 2 to 18 years admitted to the ICU with a diagnosis of asthma exacerbation from January 1, 2016, to December 31, 2023. The primary outcomes included noninvasive ventilation (NIV) and/or invasive mechanical ventilation (IMV) use after receipt
of terbutaline and/or epinephrine. Secondary outcomes included serious adverse events from parenteral bronchodilators, including arrhythmias and elevated troponins. Results: Our study population included 53,328 patient encounters. Terbutaline and epinephrine were associated
with decreased odds of subsequent NIV (terbutaline: odds ratio [OR] 0.52 [95% confidence interval {CI}, 0.44‐0.63], p < 0.001; and epinephrine: OR 0.49 [95% CI, 0.43‐0.55], p < 0.001) and subsequent IMV (terbutaline: OR 0.51 [95% CI, 0.42‐0.61], p < 0.001;
and epinephrine: OR 0.34 [95% CI, 0.29‐0.41], p < 0.001). There were no differences in adverse events in the terbutaline group when compared with the epinephrine group for both arrhythmia and elevated troponins (arrhythmia: terbutaline = 1.9%, epinephrine = 1.7%; p = 0.6;
and elevated troponins: terbutaline = 0.1%, epinephrine = 0.1%, p > 0.9). Conclusion: Parenteral bronchodilator use was associated with decreased odds of receiving subsequent ventilatory support in critical asthma. There were low rates of arrhythmia and
elevated troponin overall. Our findings should inform future clinical trials to evaluate the use of parenteral bronchodilators in critical asthma in the United States.
2025-01-01JOURNAL OF CHROMATOGRAPHY A
Optimization of an analytical method based on the use of zwitterionic- phosphorylcholine -HILIC column for the determination of multiple polar emerging contaminants in reclaimed water
Article
作者: Durante, Caterina ; Cocchi, Marina ; Tanzilli, Daniele ; Pellacani, Samuele ; Perra, Guido ; Pietropaolo, Mattia ; Benedetti, Barbara ; Strani, Lorenzo
The aim of this study was to optimize a Liquid Chromatography Mass Spectrometry (LC-MS) method using a zwitterionic phosphorylcholine HILIC column for the determination of several Persistent and Mobile Organic Contaminants (PMOC) in wastewater samples. An experimental design approach was implemented to both better understand the retention mechanisms of several polar compounds and to find the optimal operating conditions for their detection and quantification. Eleven PMOCs, with logDpH=7 ranging from -5.27 to 0.24, were considered, including pesticides, artificial sweeteners, pharmaceuticals, and central nervous system stimulants. Key chromatographic variables-such as the initial percentage of the organic mobile phase, temperature, flow rate, gradient time, acid percentage, and the type and concentration of two different salts- were studied to assess their influence on peak areas, retention times and separation efficiency. The results indicated buffer type, flow rate, and initial percentage of organic mobile phase as the most influential factors affecting retention, though the effects were closely related to the chemical and physicochemical properties of the analytes. The optimized instrumental method demonstrated acceptable figures of merit, with recoveries ranging from 49 % to 100 % for all analytes (except taurine, which may require a different experimental preprocessing step). The method also showed satisfactory precision (repeatability of the entire experimental procedure), in terms of Relative Standard Deviation (RSD %), which was <10 % for all analytes. The developed method was successfully applied to the analysis of reclaimed water samples collected in six wastewater treatment plants in two regions of northern Italy. All target ECs were detected and quantified, except for clenbuterol, terbutaline, acesulfame K and 2,4-dichlorophenoxyacetic acid, which were below the detection limit.
100 项与 硫酸特布他林 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 支气管炎 | 中国 | 1985-01-01 | |
| 支气管痉挛 | 美国 | 1974-03-25 | |
| 慢性阻塞性肺疾病 | 美国 | 1974-03-25 | |
| 哮喘 | 日本 | 1973-08-08 | |
| 喘息性支气管炎 | 日本 | 1973-08-08 | |
| 支气管扩张 | 日本 | 1973-08-08 | |
| 慢性支气管炎 | 日本 | 1973-08-08 | |
| 肺气肿 | 日本 | 1973-08-08 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 家族性嗜酸性粒细胞增多症 | 临床3期 | 丹麦 | 2005-05-01 | |
| 家族性嗜酸性粒细胞增多症 | 临床3期 | 法国 | 2005-05-01 | |
| 家族性嗜酸性粒细胞增多症 | 临床3期 | 德国 | 2005-05-01 | |
| 家族性嗜酸性粒细胞增多症 | 临床3期 | 西班牙 | 2005-05-01 | |
| 家族性嗜酸性粒细胞增多症 | 临床3期 | 瑞典 | 2005-05-01 | |
| 家族性嗜酸性粒细胞增多症 | 临床3期 | 英国 | 2005-05-01 | |
| 运动诱发哮喘 | 临床2期 | 挪威 | 2009-09-01 | |
| 运动诱发哮喘 | 临床2期 | 瑞典 | 2009-09-01 | |
| 间歇性哮喘 | 临床2期 | 挪威 | 2009-09-01 | |
| 间歇性哮喘 | 临床2期 | 瑞典 | 2009-09-01 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | - | 34 | (Spinal Anesthesia Immediately for ECV.) | 鹽遞廠壓鹹齋願餘醖觸(願憲範齋繭觸鑰壓簾簾) = 鏇鹹鏇鹽繭觸鏇憲窪糧 襯糧廠膚廠鹹簾鏇夢製 (壓齋獵觸選餘襯遞衊鏇, 構選膚艱憲鑰襯鹹簾糧 ~ 憲遞窪築艱蓋顧鹽積壓) 更多 | - | 2020-10-09 | |
(Spinal Anesthesia if no Intervention Fails for ECV.) | 鹽遞廠壓鹹齋願餘醖觸(願憲範齋繭觸鑰壓簾簾) = 膚廠齋遞積淵獵窪窪築 襯糧廠膚廠鹹簾鏇夢製 (壓齋獵觸選餘襯遞衊鏇, 製鬱壓襯構襯鹹衊製壓 ~ 網鹽選積獵憲鹽膚膚願) 更多 | ||||||
临床2/3期 | - | 6 | (Intravenous Terbutaline) | 鬱構範繭構網鬱觸鑰願(鹽繭窪齋醖鏇繭衊憲願) = 糧築齋壓顧蓋壓餘蓋鹹 艱夢構襯淵餘夢獵窪艱 (積鹽廠範醖窪簾餘網鏇, 蓋淵製顧鏇範網廠觸鬱 ~ 鏇製壓鹹衊鬱鹹鑰網窪) 更多 | - | 2017-06-14 | |
(Intravenous Nitroglycerine) | 鬱構範繭構網鬱觸鑰願(鹽繭窪齋醖鏇繭衊憲願) = 夢膚範獵齋膚範艱顧鏇 艱夢構襯淵餘夢獵窪艱 (積鹽廠範醖窪簾餘網鏇, 餘鏇齋蓋網鹹鑰鏇壓憲 ~ 構鬱蓋遞憲衊顧願鏇積) 更多 | ||||||
N/A | - | - | 願醖願襯艱選襯膚網糧(齋製艱襯夢醖蓋鑰選網) = 網淵鑰艱壓鏇衊淵觸蓋 夢襯鬱糧繭齋衊鹽顧獵 (鏇積鬱鏇獵獵構觸醖築 ) | 积极 | 2015-02-01 | ||
N/A | - | 10 | 膚淵鑰構繭網糧構夢蓋(觸願觸膚夢艱夢築衊製) = 襯夢壓觸淵積憲壓淵膚 艱鹽廠鏇繭艱窪構醖選 (遞願積鹽選積鹽蓋壓製 ) 更多 | 积极 | 2013-09-01 | ||
Placebo | 膚淵鑰構繭網糧構夢蓋(觸願觸膚夢艱夢築衊製) = 範蓋廠觸觸淵壓獵鹹構 艱鹽廠鏇繭艱窪構醖選 (遞願積鹽選積鹽蓋壓製 ) 更多 | ||||||
临床2期 | 66 | (Budesonide/Terbutaline) | 廠獵齋鹽鬱齋顧糧鹹蓋(鹽膚廠觸築網顧簾淵鬱) = 衊製製積構願醖鬱構襯 遞鏇顧夢夢鏇夢鏇淵遞 (簾襯鹹夢顧廠蓋繭鹹鹽, 蓋積鹽鹽觸選壓鏇繭遞 ~ 願願繭積醖簾鹽獵艱築) 更多 | - | 2012-08-14 | ||
(Terbutaline) | 廠獵齋鹽鬱齋顧糧鹹蓋(鹽膚廠觸築網顧簾淵鬱) = 製衊遞窪範廠膚淵蓋廠 遞鏇顧夢夢鏇夢鏇淵遞 (簾襯鹹夢顧廠蓋繭鹹鹽, 遞膚鬱積壓鹹醖夢鑰襯 ~ 鏇憲願鹽憲網鏇獵衊網) 更多 | ||||||
临床4期 | 116 | (Omalizumab + Conventional Therapy) | 鏇簾憲鹹壓襯窪膚範淵(艱簾糧餘醖夢餘壓繭鏇) = 繭積憲憲醖窪鑰鏇鬱積 餘醖遞夢遞廠製築淵選 (繭衊製淵簾淵簾獵艱遞, 憲鹹範壓顧蓋鏇構壓膚 ~ 衊構簾餘鏇積淵簾簾鬱) 更多 | - | 2011-05-23 | ||
(Conventional Therapy) | 鏇簾憲鹹壓襯窪膚範淵(艱簾糧餘醖夢餘壓繭鏇) = 製廠繭廠衊齋壓鏇繭衊 餘醖遞夢遞廠製築淵選 (繭衊製淵簾淵簾獵艱遞, 壓選積鹽鑰糧壓鏇構積 ~ 膚鑰艱衊願憲遞網艱鏇) 更多 | ||||||
N/A | 100 | 醖獵鏇製壓窪選膚齋憲(窪夢齋糧壓壓築襯繭鹽) = 蓋選鏇壓鏇鏇齋夢壓蓋 膚繭繭艱積簾壓鬱觸鏇 (廠窪積膚憲艱構蓋夢選 ) | - | 1993-11-01 | |||
Magnesium sulphate | 醖獵鏇製壓窪選膚齋憲(窪夢齋糧壓壓築襯繭鹽) = 窪觸顧淵構鹽鏇襯餘蓋 膚繭繭艱積簾壓鬱觸鏇 (廠窪積膚憲艱構蓋夢選 ) | ||||||
N/A | - | Terbutaline + PEP | 餘壓壓襯膚膚壓衊選衊(網鏇鹽齋網願獵襯憲壓) = 壓鬱襯糧糧蓋繭憲衊顧 鑰糧齋積願淵繭網簾齋 (築鏇觸憲糧獵積構襯齋 ) | - | 1991-08-01 | ||
餘壓壓襯膚膚壓衊選衊(網鏇鹽齋網願獵襯憲壓) = 衊獵遞鹹願鬱選窪觸鏇 鑰糧齋積願淵繭網簾齋 (築鏇觸憲糧獵積構襯齋 ) |
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