Meprednisone

Recently, new two-dimensional (2D) materials have emerged and are used for various engineering applications. One such new 2D material is beta (β-)phosphoborophane. Initially, we ensured the structural and dynamic stability of β-phosphoborophane. The semiconducting behavior of β-phosphoborophane with an energy band of 1.252 eV reveals that it is a suitable material for chemical nanosensors. We used β-phosphoborophane as adsorbing material for some of the molecules emitted from cosmetics such as hydroxycitronellal and alpha isomethyl ionone. The adsorption of target molecules changes the energy band gap of β-phosphoborophane, inferred based on the results of band structure and projected density of states. Furthermore, the changes in the electronic properties of β-phosphoborophane upon adsorption of target molecules are observed with regard to charge transfer and electron density difference results. The chemo-resistive nature of β-phosphoborophane is revealed from the relative energy gap changes owing to hydroxycitronellal and alpha isomethyl ionone adsorption.

The structural stability, dynamical firmness, electronic properties, and interaction behavior of hydroxycitronellal and alpha isomethyl ionone on β-phosphoborophane are explored within the framework of the DFT method. The hybrid GGA/B3LYP functional is used for optimizing the base material β-phosphoborophane. All the calculation in the research study is carried out by the QuantumATK simulation package. The result of the proposed work supports that β-phosphoborophane can be a suitable sensing material for hydroxycitronellal and alpha isomethyl ionone, which are found in cosmetics.

Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling side effect of cancer chemotherapy that can often limit treatment options for cancer patients or have life-long neurodegenerative consequences that reduce the patient’s quality of life. CIPN is caused by the detrimental actions of various chemotherapeutic agents on peripheral axons. Currently, there are no approved preventative measures or treatment options for CIPN, highlighting the need for the discovery of novel therapeutics and improving our understanding of disease mechanisms. In this study, we utilized human-induced pluripotent stem cell (hiPSC)-derived motor neurons as a platform to mimic axonal damage after treatment with vincristine, a chemotherapeutic used for the treatment of breast cancers, osteosarcomas, and leukemia. We screened a total of 1902 small molecules for neuroprotective properties in rescuing vincristine-induced axon growth deficits. From our primary screen, we identified 38 hit compounds that were subjected to secondary dose response screens. Six compounds showed favorable pharmacological profiles – AZD7762, A-674563, Blebbistatin, Glesatinib, KW-2449, and Pelitinib, all novel neuroprotectants against vincristine toxicity to neurons. In addition, four of these six compounds also showed efficacy against vincristine-induced growth arrest in human iPSC-derived sensory neurons. In this study, we utilized high-throughput screening of a large library of compounds in a therapeutically relevant assay. We identified several novel compounds that are efficacious in protecting different neuronal subtypes from the toxicity induced by a common chemotherapeutic agent, vincristine which could have therapeutic potential in the clinic.