预约演示
更新于：2025-05-24
Hydrocortisone Sodium Succinate
氢化可的松琥珀酸钠
更新于：2025-05-24
概要
基本信息
非在研机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C25H34NaO8 |
InChIKeyLGKJVUKNTHOZJH-CODXZCKSSA-N |
CAS号125-04-2 |
关联
28
项与 氢化可的松琥珀酸钠 相关的临床试验NCT06247787
A Phase 1 Study of GRN163L (Imetelstat) in Combination With Fludarabine and Cytarabine for Patients With Acute Myeloid Leukemia That is in Second or Greater Relapse or That is Refractory to Relapse Therapy; Myelodysplastic Syndrome or Juvenile Myelomonocytic Leukemia in First or Greater Relapse or is Refractory to Relapse Therapy
NCT05761171
A Phase 2 Study of Revumenib (SNDX-5613) in Combination With Chemotherapy for Patients With Relapsed or Refractory KMT2A-Rearranged Infant Leukemia
NCT05320380
A PedAL/EuPAL Phase 1/2 Trial of IMGN632 in Pediatric Patients With Relapsed or Refractory Leukemia
100 项与 氢化可的松琥珀酸钠 相关的临床结果
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100 项与 氢化可的松琥珀酸钠 相关的转化医学
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100 项与 氢化可的松琥珀酸钠 相关的专利（医药）
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1,562
项与 氢化可的松琥珀酸钠 相关的文献（医药）2025-04-01EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
The assembled decoders to prepare for “bioactive X″ against progressive deterioration of liver disease: From NAFLD to HCC
Article
作者: Kim, Dong Joon ; Yoon, Sang-Jun ; Oh, Ki-Kwang ; Suk, Ki-Tae ; Kwon, Goo-Hyun ; Lee, Kyeong Jin ; Eom, Jung-A
Non-alcoholic fatty liver disease (NAFLD) is implicated in steatohepatitis (NASH), liver cirrhosis (LC) to hepatocellular carcinoma (HCC), sequentially. Herein, our aim was to unravel the nuanced key components (compounds, and targets) to deter the progressive severity concerning hepatocellular diseases. We incorporated rigor bioinformatics and computational screening tools to decode effector(s) against NAFLD, NASH, LC, and HCC. The corresponding ligands of PDX1 (transcription factor of INS; one agonist), and IL6 (thirty-two antagonists) were identified by Selleckchem. Molecular docking test (MDT) revealed that PDX1- BRD7552 conformer (-12.1 kcal/mol), and IL6- Forsythoside B (-11.4 kcal/mol) conformer formed most stable complex. In parallel, DFT proposed that BRD7552, and Forsythoside B had significant chemical properties to react the targets, respectively. In conclusion, we decoded causatives of the progressive liver disease with web-based tools in drug repositioning theory. BRD7552 as PDX1 agonist, and Forsythoside B as IL6 antagonist were attributed to synergistic efficacy against NAFLD-derived HCC.
2025-01-01CONTACT DERMATITIS
Acute generalised exanthematous pustulosis induced by betamethasone sodium phosphate: A case report
Article
作者: Matsumoto, Ayaki ; Tateishi, Chiharu ; Hayashi, Eriko ; Tsuruta, Daisuke
Acute generalized exanthematous pustulosis (AGEP) is a type of severe drug eruption and is often induced by drugs.Although the number of cases is small, there are cases of AGEP induced by steroids.
2024-10-10Cureus Journal of Medical Science
Delayed Emergence of Isolated Secondary Adrenal Insufficiency: A Case Report
Article
作者: Ovalles Lacruz, Alexa ; Mesa, Natalie ; Blanco Guertin, Angela ; Vassil, Steven T ; Sharma, Deepa
Secondary adrenal insufficiency (SAI) is a rare condition caused by adrenocorticotropic hormone (ACTH) deficiency, which disrupts ACTH secretion by the pituitary gland and can lead to chronic hyponatremia. However, idiopathic delayed onset of isolated adrenal insufficiency without triggering factors is an unusual finding and poses a challenging diagnosis. We present the case of an 80-year-old woman with hypothyroidism, hypertension, previous tobacco use, and squamous cell carcinoma of the ankle who presented with weakness and fatigue. Blood work showed hyponatremia (126 mmol/L), nonfasting blood glucose of 139 mg/dL, and elevated erythrocyte sedimentation rate (ESR, 83 mm/hr). Initial treatment included urea administration and water restriction. Initial imagining included a CT of the chest which revealed mediastinal lymphadenopathy, leading to suspicion of the syndrome of inappropriate antidiuretic hormone (SIADH) from malignancy. Despite increasing urea and adding NaHCO3, sodium levels dropped further. Tolvaptan was administered but showed no improvement. Endocrinology recommended hydrocortisone sodium succinate (Solu-Cortef) leading to sodium normalization and symptom resolution. A full pituitary workup revealed low dehydroepiandrosterone sulfate (DHEA-S), and abdominal CT showed atrophic adrenal glands. MRI of the sella turcica was normal with no evidence of a mass. The patient was discharged on an oral course of Solu-Cortef with stable sodium levels (139 mEq/L). This is among the first reported cases of unprovoked isolated adrenal insufficiency with abnormal cortisol, ACTH, DHEA-S levels, and normal renin and aldosterone levels. Diagnosis is often delayed due to nonspecific symptoms. Once identified, corticosteroid replacement therapy is the gold standard for management.
100 项与 氢化可的松琥珀酸钠 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 哮喘 | 日本 | 1958-04-23 | |
| 创伤性休克 | 日本 | 1958-04-23 | |
| 沃-弗综合征 | 日本 | 1958-04-23 | |
| 过敏 | 美国 | 1955-04-27 | |
| 内分泌系统疾病 | 美国 | 1955-04-27 | |
| 眼部疾病 | 美国 | 1955-04-27 | |
| 血液疾病 | 美国 | 1955-04-27 | |
| 肾脏疾病 | 美国 | 1955-04-27 | |
| 肿瘤 | 美国 | 1955-04-27 | |
| 呼吸系统疾病 | 美国 | 1955-04-27 | |
| 风湿性疾病 | 美国 | 1955-04-27 | |
| 皮肤疾病 | 美国 | 1955-04-27 |
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临床结果
临床结果
适应症
分期
评价
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N/A | - | Endoscopic intralesional steroid injection + systemic steroid treatment | 願繭餘壓糧憲積鹹構構(鹽觸簾醖範築網選簾簾) = 廠顧襯選夢鑰築襯蓋餘 衊廠艱觸顧醖獵壓膚鬱 (築糧艱構製襯願齋襯醖, 0 ~ 1) 更多 | - | 2018-10-01 | ||
Oral mixture of hydrocortisone sodium succinate and aluminum phosphate gel | 獵遞窪鬱獵廠繭遞齋鬱(繭餘壓製簾鏇顧構鑰壓) = 構鬱鹽簾餘築醖鹽鑰醖 遞構選淵構齋衊憲醖鹹 (顧顧顧壓獵壓簾構選製 ) | ||||||
N/A | - | Oral mixture of hydrocortisone sodium succinate and aluminum phosphate gel | 齋艱願夢齋壓蓋淵築鑰(餘鹽構築蓋膚觸餘夢醖) = 積壓觸艱淵衊壓醖壓鏇 鏇觸襯鑰構夢憲蓋獵糧 (遞願顧鏇憲簾膚艱製夢, 1 ~ 1.8) 更多 | - | 2018-10-01 | ||
(EBD alone) | 齋艱願夢齋壓蓋淵築鑰(餘鹽構築蓋膚觸餘夢醖) = 衊鹹構獵鬱夢衊衊鹽糧 鏇觸襯鑰構夢憲蓋獵糧 (遞願顧鏇憲簾膚艱製夢, 1 ~ 2.5) 更多 | ||||||
N/A | - | Systemic steroid treatment (ST) | 構蓋鑰襯窪蓋鹽鹹膚餘(夢鹹鹽觸顧構鑰壓醖積) = 夢鬱餘淵築鑰衊膚築構 淵顧鏇鹽鑰鏇簾選鹽簾 (積窪齋壓夢築鬱襯積願 ) 更多 | - | 2017-10-01 | ||
Endoscopic intralesional steroid (triamcinolone acetonide 80 mg) injection accompanied with systemic steroid treatment (IT + ST) | 構蓋鑰襯窪蓋鹽鹹膚餘(夢鹹鹽觸顧構鑰壓醖積) = 膚鑰衊願網淵餘簾蓋觸 淵顧鏇鹽鑰鏇簾選鹽簾 (積窪齋壓夢築鬱襯積願 ) 更多 |
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