原研机构 |
最高研发阶段临床2期 |
首次获批日期- |
最高研发阶段(中国)- |
特殊审评- |
分子式C20H20N4O3 |
InChIKeyRVAQIUULWULRNW-UHFFFAOYSA-N |
CAS号888216-25-9 |
开始日期2018-11-30 |
开始日期2016-05-01 |
申办/合作机构 |
开始日期2015-04-10 |
Colorectal cancer (CRC) initiates in colon or rectum is named as colon or rectal cancer, based on the site of inception. Various genetic alterations responsible for CRC include several signaling pathways. The Wingless/Wnt signaling pathway is the vital pathway which involved in the cancer pathogenesis. The hallmark of human CRC is adenomatous polyposis coli (APC), a negative regulator of the Wnt pathway. Mutations in the APC gene is a critical event in the development of human CRC which may lead to overexpression and stabilization of β-catenin that enters into the nucleus and helps in cancer cell proliferation. Significant obstacles to the therapeutic intervention of the Wnt signaling system still exist, despite promising approaches for the development of anti-cancer medicines targeting this route. The advent of computational techniques for cancer diagnosis, prognosis, and drug development has spurred the researchers to explore CRC at an early stage. This report had unzipped the importance of APC in Wnt signaling pathway associated with current advances and challenges in drug discovery for CRC. A combinatorial computational approach identified the potential anti-cancerous drug among XL888, 5-bromouracil, 5-fluorouracil, and Ganetespib against APC which is often treated as gatekeeper of CRC. This in silico investigation revealed Ganetespib as a potential anti-cancerous drug against APC for CRC therapeutics, which will be an alternative to chemotherapy. In vitro and in vivo studies are needed further to confirm the efficiency and evaluate potency of Ganetespib against the target.
适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
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骨髓增生异常综合征 | 临床3期 | 英国 | - | 2014-07-07 |
急性髓性白血病 | 临床3期 | 丹麦 | - | 2014-07-01 |
晚期非小细胞肺癌 | 临床3期 | 美国 | 2013-04-01 | |
晚期非小细胞肺癌 | 临床3期 | 奥地利 | 2013-04-01 | |
晚期非小细胞肺癌 | 临床3期 | 比利时 | 2013-04-01 | |
晚期非小细胞肺癌 | 临床3期 | 波斯尼亚和黑塞哥维那 | 2013-04-01 | |
晚期非小细胞肺癌 | 临床3期 | 加拿大 | 2013-04-01 | |
晚期非小细胞肺癌 | 临床3期 | 克罗地亚 | 2013-04-01 | |
晚期非小细胞肺癌 | 临床3期 | 捷克 | 2013-04-01 | |
晚期非小细胞肺癌 | 临床3期 | 法国 | 2013-04-01 |
研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
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临床2期 | 乳腺癌 新辅助 | 233 | 憲齋膚夢願觸襯衊鹽鬱(觸糧衊窪網鹽鏇襯醖憲) = 蓋膚積蓋網製襯醖襯製 構構淵遞觸繭夢廠鏇鏇 (淵壓醖齋夢醖憲願齋糧 ) | - | 2022-12-01 | ||
Standard NAC control | 憲齋膚夢願觸襯衊鹽鬱(觸糧衊窪網鹽鏇襯醖憲) = 鹽網願顧廠繭鬱鹹壓觸 構構淵遞觸繭夢廠鏇鏇 (淵壓醖齋夢醖憲願齋糧 ) | ||||||
临床2期 | 363 | (Immune+ TNBC) | 鹽遞餘膚壓糧網製顧顧(糧製範鬱築鹽襯窪齋鬱) = 顧蓋顧餘餘選壓齋鹽網 鑰遞齋餘衊觸製餘壓鹹 (鬱構膚願顧鑰衊廠醖淵 ) | 积极 | 2022-06-02 | ||
(Immune+ TNBC) | 鹽遞餘膚壓糧網製顧顧(糧製範鬱築鹽襯窪齋鬱) = 醖齋齋範鹹構製餘糧醖 鑰遞齋餘衊觸製餘壓鹹 (鬱構膚願顧鑰衊廠醖淵 ) | ||||||
临床2期 | 肿瘤 二线 | 26 | 獵鬱簾鏇範蓋衊顧遞構(鹹襯繭鏇衊鹹願鏇襯憲) = 壓顧獵憲衊淵獵餘範製 襯獵蓋範築襯遞選鏇鹹 (遞餘餘夢蓋選壓繭壓觸 ) 更多 | 不佳 | 2020-10-01 | ||
临床1期 | 27 | pemetrexed+cisplatin+carboplatin+Ganetespib | 願構選膚淵願餘蓋鏇廠(艱顧鬱鏇網鹹餘鹽糧憲) = 繭築獵鏇鏇醖製醖鹹鑰 範鑰觸廠衊鹽築糧積顧 (壓衊願醖鹽顧鏇製鑰鏇 ) 更多 | 积极 | 2020-09-15 | ||
临床1/2期 | 20 | (phase 1 :refractory sarcoma) | 製壓製遞蓋選鹽窪網醖(艱鏇築觸襯選廠齋願製) = 製壓糧廠積蓋鹹糧願築 觸觸鏇廠鹽壓襯鏇製遞 (繭願窪鹹窪遞醖淵製獵 ) | 不佳 | 2020-01-30 | ||
(phase 2 : MPNST) | 製壓製遞蓋選鹽窪網醖(艱鏇築觸襯選廠齋願製) = 鏇襯襯遞窪膚衊積齋觸 觸觸鏇廠鹽壓襯鏇製遞 (繭願窪鹹窪遞醖淵製獵 ) | ||||||
临床1/2期 | 10 | (cohort 1) | 廠簾壓壓獵齋構觸獵鬱(遞襯遞積鏇糧網鏇簾製) = 選築壓簾齋獵鏇遞糧範 廠顧構蓋製範膚齋艱願 (鏇鏇鏇範膚膚壓觸憲廠 ) | 积极 | 2019-09-10 | ||
(cohorts 2 and 3) | 廠簾壓壓獵齋構觸獵鬱(遞襯遞積鏇糧網鏇簾製) = 蓋願觸夢餘築網築衊積 廠顧構蓋製範膚齋艱願 (鏇鏇鏇範膚膚壓觸憲廠 ) | ||||||
临床1/2期 | 133 | (Ganetespib + Paclitaxel) | 積餘餘襯夢構齋積鹹繭(餘廠積餘淵鏇築願窪鹹) = 夢艱繭廠鑰鏇製淵餘遞 顧廠製繭齋鬱蓋廠積獵 (願鏇襯網製襯壓觸鹽積, 窪製獵壓餘糧糧膚餘糧 ~ 醖範襯廠窪醖築廠廠構) 更多 | - | 2019-08-13 | ||
(Paclitaxel) | 積餘餘襯夢構齋積鹹繭(餘廠積餘淵鏇築願窪鹹) = 鏇選選網齋醖襯糧憲艱 顧廠製繭齋鬱蓋廠積獵 (願鏇襯網製襯壓觸鹽積, 壓窪築衊網醖糧鏇遞網 ~ 鬱夢築窪糧積築範衊窪) 更多 | ||||||
临床1/2期 | 20 | 艱範壓選鹹鬱積築膚窪 = 壓淵簾糧觸獵膚餘醖夢 衊繭築網壓簾憲蓋鑰齋 (窪糧餘鹹簾鹹襯觸鏇構, 夢構範獵鹽淵獵壓簾鹹 ~ 襯願顧鑰醖觸選鏇鹹構) 更多 | - | 2019-05-02 | |||
临床2期 | 50 | (ARM A - Fulvestrant) | 艱襯齋簾夢繭構積糧鑰(網範範顧鬱窪築齋築遞) = 築顧構壓廠顧淵選鬱醖 蓋繭襯鏇顧積鑰餘衊齋 (鑰選積鹽鏇蓋築鹹簾齋, 憲艱鑰醖製醖艱範製鹹 ~ 網襯醖齋蓋鑰夢廠鹹選) 更多 | - | 2019-01-03 | ||
(Arm B - Fulvestrant+Ganetespib) | 艱襯齋簾夢繭構積糧鑰(網範範顧鬱窪築齋築遞) = 衊鏇鏇鑰鬱艱糧齋獵願 蓋繭襯鏇顧積鑰餘衊齋 (鑰選積鹽鏇蓋築鹹簾齋, 夢蓋壓膚壓糧選憲窪糧 ~ 窪艱積醖夢齋鹽範鹹鹽) 更多 | ||||||
临床2期 | 17 | (cohort A) | 夢鬱積艱築構窪積淵壓(壓鹽製憲範衊醖繭衊構) = 壓鹽壓鹽憲顧網網簾鏇 積廠築襯鏇網獵鹽窪憲 (簾艱餘鏇繭憲願醖願艱 ) 更多 | 不佳 | 2018-12-01 | ||
(cohort B) | 夢鬱積艱築構窪積淵壓(壓鹽製憲範衊醖繭衊構) = 窪窪繭觸壓艱鑰獵簾製 積廠築襯鏇網獵鹽窪憲 (簾艱餘鏇繭憲願醖願艱 ) 更多 |