eFFECTOR Therapeutics said Thursday it will halt development of tomivosertib in lung cancer after the MNK inhibitor failed to significantly improve survival. Shares of the selective translation regulator inhibitor (STRI) developer plummeted 82%.
The tomivosertib arm achieved a median progression free survival (PFS) of 13 weeks, which was not statistically significant compared with the PFS of 11.7 weeks seen by the comparator arm.
Additionally, eFFECTOR said that there is “no trend favouring tomivosertib” in regards to overall survival (OS). The oral small molecule also had a worse safety profile, with 67% Grade 3 or higher treatment emergent adverse events compared with 37% in the Keytruda plus placebo group.
While chief executive Steve Worland confirmed that “tomivosertib won’t be moving forward in frontline NSCLC,” he added that an investigator-sponsored trial in acute myeloid leukaemia (AML) “will continue unchanged.”