更新于：2024-11-18
Amlodipine Besylate/Olmesartan Medoxomil
奥美沙坦酯氨氯地平
更新于：2024-11-18
概要
基本信息
药物类型 小分子化药 |
别名 Azor、Ol-Vamlo、Olmersartan medoxomil/amlodipine besilate + [6] |
作用机制 AT1R拮抗剂(血管紧张素II-1型受体拮抗剂)、VDCCs阻滞剂(电压门控性钙通道复合体阻滞剂) |
治疗领域 |
非在研适应症- |
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (2007-09-26), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C29H30N6O6 |
InChIKeyUQGKUQLKSCSZGY-UHFFFAOYSA-N |
CAS号144689-63-4 |
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关联
44
项与 奥美沙坦酯氨氯地平 相关的临床试验奥美沙坦酯左氨氯地平片(20mg/2.5mg)用于奥美沙坦酯片(20mg)或苯磺酸氨氯地平片(5mg)单药治疗4周血压不能有效控制的原发性轻、中度高血压患者的有效性和安全性的随机、双盲双模拟、多中心Ⅲ期临床研究
健康成年受试者空腹和餐后单次口服奥美沙坦酯氨氯地平片的随机、开放、单剂量、两序列、两制剂、两周期、双交叉设计的生物等效性试验
山西德元堂药业有限公司研制的奥美沙坦酯氨氯地平片（规格：40 mg/10 mg）与持证商为Daiichi Sankyo，生产企业为Daiichi Sankyo Europe GmbH的奥美沙坦酯氨氯地平片（规格：40 mg/10 mg；商品名：Sevikar®）在中国健康受试者中进行的单中心、随机、开放、两制剂、空腹/餐后、单次给药、两周期、双交叉设计的生物等效性研究
100 项与 奥美沙坦酯氨氯地平 相关的临床结果
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100 项与 奥美沙坦酯氨氯地平 相关的转化医学
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100 项与 奥美沙坦酯氨氯地平 相关的专利（医药）
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22
项与 奥美沙坦酯氨氯地平 相关的文献（医药）2023-12-12ACS nano
Azo Reductase Activated Magnetic Resonance Tuning Probe with “Switch-On” Property for Specific and Sensitive Tumor Imaging in Vivo
Article
作者: Song, Yang ; Tan, Weihong ; Li, Linyao ; Zhu, Xiaokang ; Li, Yu ; Song, Erqun ; Deng, Siyu ; Gu, Peilin
Cancer remains a threat to human health. However, if tumors can be detected in the early stage, then the effectiveness of cancer treatment could be significantly improved. Therefore, it is worthwhile to develop more sensitive and accurate cancer diagnostic methods. Herein, we demonstrated an azo reductase (AzoR)-activated magnetic resonance tuning (MRET) probe with a "switch-on" property for specific and sensitive tumor imaging in vivo. Specifically, Gd-labeled DNA1 (DNA1-Gd) and cyclodextrin-coated magnetic nanoparticles (MNP-CD) were employed as enhancer and quencher of MRET, respectively, while DNA2, an azobenzene (Azo) group-modified aptamer (AS1411), served as a linker between enhancer and quencher to construct the MRET probe of MNP@DNA(1-2)-Gd. In tumor tissues with high-level AzoR, the T1-weighted magnetic resonance signal of the MRET probe could be restored by intelligently regulating the switch from "OFF" to "ON" after activation with AzoR, thus accurately indicating the location of the tumor accurately. Moreover, the tumor with a 4 times smaller size than that of the normal tumor model could be imaged based on the proposed MRET probe. The as-proposed MRET-based magnetic resonance imaging strategy not only achieves tumor imaging accurately but also shows promise for early diagnosis of tumors, which might improve patients' survival rates and provide an opportunity for image-guided biomedical applications in the future.
2023-12-01Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
The enhancement effect of small molecule Lyb24 reveals AzoR as a novel target of polymyxin B
Article
作者: Huang, Wei ; Hu, Chunxia ; Wang, Xiao ; Zhou, Guibao ; Cheng, Shumin ; Liu, Shiyi ; Zou, Quanming ; Sun, Longqin ; Zhang, Jinyong ; Cui, Ruiqin ; Li, Jingli ; Liu, Jianhua ; Zhao, Yan ; Huang, Ying ; Zeng, Huan
Given the important role of polymyxin B (PB) in the treatment of drug-resistant Gram-negative bacterial infections, the emergence of PB resistance poses a serious threat to public health. Adjuvant development is a supplementary strategy that can compensate for the lack of novel antibiotics by protecting PB. In this study, we found a small molecule named Lyb24 that showed weak antibacterial activity (minimum inhibitory concentration ≥ 10 μg/ml) but potentiated and revitalized the efficacy of PB against Gram-negative pathogens, including mcr-1- and mgrB-deletion-mediated PB-resistant strains. Our results showed that Lyb24 inhibits the translational levels of genes associated with the modification of lipid A. In addition, Lyb24 increases the permeability, disrupts the integrity and induces the depolarization of the membrane. We further found that both Lyb24 and PB could directly bind to AzoR and inhibit its activity. Structural analysis showed that Lyb24 binds to the isoalloxazine ring of flavin mononucleotide (FMN) through pi-pi stacking and loop η4 of AzoR. A pneumonia model was used to confirm that the activity against clinical PB-resistant Klebsiella pneumoniae was enhanced due to Lyb24 on PB. In conclusion, we provide a potential therapeutic regimen by combining Lyb24 and PB to treat Gram-negative-resistant bacterial infections. Our findings not only explain the synergistic effect of Lyb24, but also expand our knowledge on the mechanism of action of PB.
2022-07-01Biophysical chemistry
Sulphonated azo dye decolorization by Alcaligenes faecalis subsp. phenolicus MB207: Insights from laboratory and computational analysis
Article
作者: Yasmin, Azra ; Basharat, Zarrin
Microbial decolorization of azo dyes, mediated by an enzymatic mechanism is an intricate cost-effective, and eco-friendly treatment method of genotoxic azo pollutants. Scientists are on the constant lookout for microbes, enzymes, and mechanisms that could aid remediation of the environment at a fast pace. Alcaligenes faecalis subsp. phenolicus MB207 is one such bacteria, consisting of azoreductase (AzoR) and laccase/multicopper oxidase enzyme responsible for sulphonated mono-azo dye (Methyl orange) and di-azo dye (Congo red) degradation. AzoR degrades dyes by a ping-pong setup while multicopper oxidase achieves this through a non-specified radical approach. We have coupled experimental analysis with bioinformatics for deciphering intricacies of this procedure in tiny scale enzymatic machines of this biotope. The degradation assays were followed by molecular docking of the enzyme-substrate complexes. Key anchoring bonds were detected and mapped H-bonding, electron exchange, ionic interactions, as well as hydrophobic interactions, provided insights into dye-enzyme and NADH-enzyme binding. This study establishes a foundation of the molecular basis of dye interaction with azoR and multicopper oxidase in A. facealis subsp. phenolicus MB207.
100 项与 奥美沙坦酯氨氯地平 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 原发性高血压 | 中国 | 2018-07-12 | |
| 高血压 | 美国 | 2007-09-26 |
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临床结果
临床结果
适应症
分期
评价
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临床3期 | 2,204 | Olmesartan(OLM) (Olmesartan(OLM) 40 Mg-Amlodipine(AML) 10 mg) | 窪繭衊廠膚鬱壓鏇膚膚(膚糧觸淵鬱積繭醖糧糧) = 膚顧築製築繭範膚憲襯 膚鬱繭鹽窪淵願製餘夢 (餘鬱繭網廠願鏇繭餘壓, 衊窪齋築顧襯淵鏇繭襯 ~ 簾艱齋顧範選窪壓憲窪) 更多 | - | 2011-11-22 | ||
OLM 40+AML (OLM 40-AML 10-Hydrochlorothiazide (HCTZ) 12.5) | 窪繭衊廠膚鬱壓鏇膚膚(膚糧觸淵鬱積繭醖糧糧) = 膚鬱鑰糧製範夢選夢醖 膚鬱繭鹽窪淵願製餘夢 (餘鬱繭網廠願鏇繭餘壓, 衊蓋餘築艱鬱糧鬱獵構 ~ 淵鬱範廠範鬱醖衊選壓) 更多 |
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