维莫地吉(Vismodegib) - 药物靶点：SMO_在研适应症：转移性基底细胞癌，基底细胞癌，铂耐药性输卵管癌_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Vismodegib (USAN/INN)、维莫德吉、GDC-0449

+ [5]

靶点

SMO

作用机制

SMO拮抗剂(SMO受体拮抗剂)

治疗领域

肿瘤神经系统疾病消化系统疾病+ [4]

在研适应症

转移性基底细胞癌基底细胞癌铂耐药性输卵管癌+ [9]

非在研适应症

晚期乳腺癌晚期胰腺腺癌晚期前列腺癌+ [29]

原研机构

Genentech, Inc.

在研机构

Genentech, Inc.Roche Registration GmbH

Roche Holding AG

非在研机构

Hoffmann-La Roche Ltd.Hoffmann-La Roche, Inc.Roche Pharma AG

+ [1]

最高研发阶段批准上市

首次获批日期

美国 (2012-01-30),

基底细胞癌

最高研发阶段(中国)-

特殊审评临床急需境外新药 (中国)

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结构/序列

分子式C19H14Cl2N2O3S

InChIKeyBPQMGSKTAYIVFO-UHFFFAOYSA-N

CAS号879085-55-9

关联

93

项与维莫地吉相关的临床试验

NCT06616623

/ Recruiting临床1期IIT

A Phase Ib Study of Vismodegib and Atezolizumab in Patients with Advanced Non-Small Cell Lung Cancer (ML43922)

This phase Ib trial tests the safety, side effects, and best dose of the combination of vismodegib and atezolizumab in treating patients with non-small cell lung cancer (NSCLC) that has come back after a period of improvement (recurrent) or has spread from where it first started (primary site) to other places in the body (metastatic). Vismodegib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving a combination of vismodegib and atezolizumab may be safe, tolerable and/or effective than either drug alone in treating patients with recurrent or metastatic NSCLC.

开始日期2024-12-31

申办/合作机构

Ohio State University Comprehensive Cancer Center

[+1]

NCT06344052

/ Recruiting临床2期

A Phase 2 Study to Assess the Efficacy of SP-002 with Vismodegib for the Treatment of Locally Advanced Basal Cell Carcinoma

The goal of this clinical trial is to evaluate the efficacy of using SP-002 in participants with locally advanced Basal cell carcinoma. The main question it aims to answer is what the objective response rate for a basal cell carcinoma tumor is following 1 or 3 cycles of SP-002 treatment given as an add-on to hedgehog pathway inhibitor therapy.
Researchers will compare the objective response rate for treated Basal cell carcinoma tumors between 3 treatment Arms.
* Arm 1 participants will receive daily hedgehog pathway inhibitor, and 3 cycles of SP-002 treatment.
* Arm 2 participants will receive daily hedgehog pathway inhibitor, and 1 cycle of SP-002 treatment.
* Arm 3 participants will receive daily hedgehog pathway inhibitor only.

开始日期2024-04-09

申办/合作机构

Stamford Pharmaceuticals, Inc.

NCT05561634

/ Not yet recruiting临床2期IIT

Evaluation of Radiotherapy After Complete Response to Sonic Hedgehog Pathway Inhibitors in Patients With Locally Advanced Basal Cell Carcinoma: a Prospective Multicenter Study

Locally advanced basal cell carcinoma (BCC) are large BCCs or BCCs located in areas subject to functional and aesthetic risk following surgery or radiotherapy. In these particular situations, surgery and radiotherapy are sometimes not appropriate, and Sonic Hedgehog inhibitors (SHHi) (Vismodegib and Sonidegib) can be proposed. SHHi are effective treatments in laBCC but most CR patients discontinue treatment because of tolerability. Approximately 65% of the population experience a relapse after discontinuation. A few cases of patients treated concomitantly by radiotherapy and vismodegib have been reported in the literature, suggesting that combining vismodegib and concomitant radiotherapy results in an improved overall response compared to a single modality treatment. There is no study evaluating a "consolidation radiotherapy" after complete response to SHHi. We carry out a prospective multicenter study in order to evaluate consolidation radiotherapy in patients with laBCC after achieving complete response with SHHi, with the hypothesis of reducing recurrence after discontinuation of SHHi.

开始日期2023-07-01

申办/合作机构

Centre Hospitalier Universitaire de Lille

[+1]

100 项与维莫地吉相关的临床结果

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100 项与维莫地吉相关的转化医学

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100 项与维莫地吉相关的专利（医药）

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997

项与维莫地吉相关的文献（医药）

2025-01-01·BIOMATERIALS

Bioactive nanocomposite hydrogel enhances postoperative immunotherapy and bone reconstruction for osteosarcoma treatment

Article

作者: Fu, Hao ; Mi, Bobin ; Yan, Chenchen ; Bian, Liming ; Zeng, Ruiyin ; Chu, Xiangyu ; Wang, Ruinan ; Liu, Guohui ; Liu, Tuozhou ; Lin, Jiali ; Xiong, Yuan ; Hu, Liangcong ; Zhang, Kunyu

Osteosarcoma, a malignant bone tumor often characterized by high hedgehog signaling activity, residual tumor cells, and substantial bone defects, poses significant challenges to both treatment response and postsurgical recovery. Here, we developed a nanocomposite hydrogel for the sustained co-delivery of bioactive magnesium ions, anti-PD-L1 antibody (αPD-L1), and hedgehog pathway antagonist vismodegib, to eradicate residual tumor cells while promoting bone regeneration post-surgery. In a mouse model of tibia osteosarcoma, this hydrogel-mediated combination therapy led to remarkable tumor growth inhibition and hence increased animal survival by enhancing the activity of tumor-suppressed CD8⁺ T cells. Meanwhile, the implanted hydrogel improved the microenvironment of osteogenesis through long-term sustained release of Mg²⁺, facilitating bone defect repair by upregulating the expression of osteogenic genes. After 21 days, the expression levels of ALP, COL1, RUNX2, and BGLAP in the Vis-αPD-L1-Gel group were approximately 4.1, 5.1, 5.5, and 3.4 times higher than those of the control, respectively. We believe that this hydrogel-based combination therapy offers a potentially valuable strategy for treating osteosarcoma and addressing the tumor-related complex bone diseases.

2025-01-01·JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Cytoreductive approach with hedgehog inhibitors followed by reflectance confocal microscopy assisted Mohs surgery for morpheiform basal cell carcinoma

Letter

作者: Dika, Emi ; Sgarzani, Rossella ; Campione, Elena ; Rapparini, Luca ; Scotti, Biagio ; Venturi, Federico

The use of hedgehog inhibitors (HHi) as a cytoreductive treatment prior to surgery for locally advanced basal cell carcinoma (laBCC) is emerging, yet optimal timing.To evaluate the effectiveness of combining HHi with videodermatoscopy (VDS) and reflectance confocal microscopy (RCM) in managing a case of laBCC.A 68-yr-old woman with histol. confirmed laBCC on the left zygomatic region, measuring 6 × 7 cm and classified as stage IIIB, initially declined surgery due to aesthetic concerns.She was treated with Vismodegib, a hedgehog inhibitor, resulting in a notable reduction in tumor size over 4 mo.After 12 mo, with stable disease and mild adverse effects, the patient underwent Mohs microg. surgery (MMS) with pre-surgical assessment using VDS and RCM.VDS and RCM provided detailed imaging of the tumor, leading to a successful one-stage MMS with clear margins.The patient was satisfied with the aesthetic and functional outcomes, and no evidence of local recurrence was observed 18 mo post-surgery.Pre-surgical treatment with HHi effectively reduced tumor size, minimizing potential surgical sequelae.The integration of VDS and RCM in MMS enhanced the precision of margin assessment, reducing the number of required stages.This approach may be particularly beneficial for managing laBCC in critical areas, with the potential for further improvements using advanced technologies like LC-OCT.

2024-12-01·REPRODUCTIVE TOXICOLOGY

Efcab7 deletion sensitizes mice to the teratogenic effects of gastrulation-stage alcohol exposure

Article

作者: Fish, Eric W. ; Fish, Eric W ; Boschen, Karen E ; Boschen, Karen E. ; Parnell, Scott E. ; Parnell, Scott E

Alcohol exposure during the gastrulation stage of development can disrupt Sonic hedgehog (Shh) signaling and cause eye, craniofacial, and brain defects. One of the genes that regulates Shh signaling is Efcab7, which encodes a protein that facilitates the actions of Smoothened (Smo), a critical component of the Shh pathway. Previous work from our lab has demonstrated that Efcab7 is differentially expressed between two sub-strains of C57BL/6 mice that differ in their sensitivity to gastrulation-stage alcohol exposure. The more alcohol-sensitive C57BL/6 J mice express lower levels of Efcab7 during gastrulation than do the less alcohol-sensitive C57BL/6NHsd mice. The current study examined whether partial or full Efcab7 deletions render mice more sensitive to gastrulation-stage alcohol exposure and affect the sensitivity to other modulators of Shh signaling that cause craniofacial malformations. Efcab7^+/- dams were mated with Efcab7^+/- sires to produce Efcab7^+/+, Efcab7^+/-, and Efcab7^-/- fetuses. On gestational day 7 (GD 7), they received either alcohol (two doses of 2.9 g/kg, i.p., given 4 hours apart), the Smo antagonist vismodegib (40 mg/kg, or vehicle, p.o.), the Smo agonist SAG (20 mg/kg) or the appropriate vehicles. GD 17 fetuses were collected and examined for ocular and craniofacial dysmorphology. As compared to Efcab7^+/+ fetuses, Efcab7^-/- fetuses exposed to alcohol or vismodegib treatment had more severe ocular and craniofacial malformations. In contrast, Efcab7^-/- fetuses had less severe malformations induced by SAG. These results confirm that Efcab7 can modify responses to Shh agonists and antagonists and further identify Efcab7 as a gene important for the sensitivity to gastrulation-stage alcohol exposure.

94

项与维莫地吉相关的新闻（医药）

2025-01-17

·stamfordpharmaceuticals.com

Stamford announces positive results from Phase 2 Study of SP-002 in combination with 4-weeks of vismodegib in multi-lesional Basal Cell Carcinoma patients

January 17, 2025 Stamford has announced positive results for its ASN-002-003 multi-lesional clinical trial (NCT 04416516. Protocol No ASN-002-003) evaluating SP-002, an Adenovirus-5 replication deficient vector encoding human Interferon- in combination with vismodegib (a Hedgehog Pathway Inhibitor) in subjects presenting with multiple BCCs. “We are very pleased with these positive results from the Phase 2 study demonstrating the safety and efficacy of our gene therapy for patients with multiple nodular and superficial BCCs. We are particularly excited that the histopathologic criteria, which would allow responsive patients to be identified at screening and used for patient selection. This histopathologic criterion was first noted in the ASN-002-001 clinical study and has now been successfully reproduced in ASN-002-003. We believe this enables us to develop a useful treatment option for patients with nodular BCC and addresses the important need for a non-surgical option for those with BCCs in the H-zone or for those who are not ideal candidates for surgery.” Dr Clement Leong (PhD), CEO of Stamford Pharmaceuticals Press Release: Stamford announces positive results from Phase 2 Study of SP-002 in combination with 4-weeks of vismodegib in multi-lesional Basal Cell Carcinoma patients

临床2期基因疗法临床结果

2024-12-02

·蒲公英Ouryao

最新粤港澳大湾区内地九市临床急需进口港澳药品医疗器械目录

转自：广东省药监局编辑：水晶 12月2日，广东省药监局网省消息，广东省药监局和广东省卫健委发布粤港澳大湾区内地九市临床急需进口港澳药品医疗器械目录（2024年）的通告。《通告》指出，本批目录收录34个上市药品及37个医疗器械。对已列入目录的药械产品，将于2024年12月1日起按照《条例》第九条进行管理。 34个药品：卡那奴单抗、维莫德吉胶囊、盐酸维那卡兰注射液、阿仑珠单抗、罗氟司特片、氨己烯酸薄膜衣片、卡博替尼薄膜衣片、阿培利司薄膜衣片、厄达替尼片、注射用羟钴胺素、布西珠单抗、伊匹木单抗注射液、巴氯芬注射液、艾沙妥昔单抗注射用浓缩液、肾上腺素注射液（预充笔）、莱博雷生片、瑞玛奈珠单抗、硫酸瑞美吉泮口崩片、注射用坦昔妥单抗、二十碳五烯酸乙酯软胶囊、阿扎胞苷片、曲美木单抗、注射用芦比替定、阿司福酶α注射液、阿伏利尤单抗、特泽利尤单抗、磷酸芦可替尼乳膏、罗莫佐单抗、重组人促卵泡素α/促黄体素α注射液、注射用重组人促卵泡素α/促黄体素α、艾普奈珠单抗、伊曲莫德片、依洛硫酸酯酶α注射液、维替索妥尤单抗。根据《广东省粤港澳大湾区内地九市进口港澳药品医疗器械管理条例》（以下简称《条例》）中对急需港澳药械实施目录管理的要求，广东省药品监督管理局、广东省卫生健康委员会经研究决定发布广东省粤港澳大湾区内地九市临床急需港澳药品医疗器械目录（2024年）。本批目录将按《国家药品监督管理局国家卫生健康委员会关于临床急需境外新药审评审批相关事宜的公告》（2018年第79号）发布并符合《条例》要求的港澳已上市药品及《条例》实施前已批准的共71个药品及医疗器械收录。对已列入目录的药械产品，将于2024年12月1日起按照《条例》第九条进行管理。特此通告。附件：1.广东省粤港澳大湾区内地九市临床急需进口港澳药品目录（2024年） 2.广东省粤港澳大湾区内地九市临床急需进口港澳医疗器械目录（2024年）广东省药品监督管理局广东省卫生健康委员会 2024年11月29日

2024-11-28

·今日头条

【Nature子刊】肿瘤边界的免疫学：中山大学张荣欣团队解析结直肠癌治疗的新机制

【导读】错配修复（MMR）缺陷（dMMR）而非MMR缺陷（pMMR）的结直肠癌（CRC）患者，往往能从免疫检查点阻断（ICB）疗法中获益。为了剖析这些不同治疗反应背后的肿瘤微环境（TME），团队整合了空间增强分辨率omics-测序（Stereo-seq）、单细胞RNA测序和多路复用成像分析，绘制了未经治疗和接受过ICB治疗的CRC患者肿瘤的高清空间图。 2024年11月26日，中山大学肿瘤防治中心结直肠科张荣欣教授团队在期刊《Nature Communications》上发表了题为“Spatially organized tumor-stroma boundary determines the efficacy of immunotherapy in colorectal cancer patients”的研究论文。研究结果表明，肿瘤-基质边界的空间组织和免疫状态是dMMR和pMMR CRC的一个显著特征，与ICB反应有关。这项研究指出了肿瘤的分子和细胞空间结构在ICB反应中的重要性，提出了重新规划肿瘤-基质边界，以提高大多数CRCs免疫疗法敏感性的可能性。 https://www-nature-com.libproxy1.nus.edu.sg/articles/s41467-024-54710-3 关于结直肠癌 01 免疫检查点阻断（ICB）疗法重新定义了结直肠癌（CRC）患者的治疗。一般来说，DNA错配修复（MMR）缺陷/微卫星不稳定性高（dMMR/MSI-hi）的结直肠癌患者突变负荷较高，往往对ICB疗法敏感，而MMR强化（pMMR）的患者突变负荷通常较低，大多无应答。团队最近报告了在dMMR队列中，抗程序死亡1（PD1）单克隆抗体（mAb，sintilimab）的总体反应率为93.75%（15/16）（12例为完全反应），这有可能使这些患者免于根治性手术。在这项研究中，团队通过分析25例CRC患者的肿瘤标本，其中包括未经治疗的dMMR、pMMR和抗PD1治疗的dMMR患者，应答者（完全应答 (CR)/PR）和非应答者（疾病稳定，SD），生成了CRC空间转录组图谱，并发现了一个300微米（μm）的边界区域，该区域调控免疫细胞流入肿瘤中心区域（>150μm）。在这种肿瘤-基质边界的微观结构中，肿瘤细胞、成纤维细胞、巨噬细胞/树突状细胞（DC）和T细胞亚群之间的相互作用，与dMMR和pMMR CRCs患者不同的免疫状态有关，这可能与他们不同的ICB反应有关。 CXCL14CAFs可能有助于ICB非应答者TME中的有序基质结构和T细胞排异 02 CXCL14CAF可能通过重塑细胞外基质的组织和结构来促进结构屏障的形成，从而导致ICB非应答者的T细胞专属TME。通过使用有转录组学和临床数据的独立ICB治疗的CRC患者队列（GSE205506），团队进一步观察到，与应答者相比，ICB非应答者的CAF中CXCL14表达量和ECM组织特征得分显著更高。在肾细胞癌（RCC，SCP1288）和黑色素瘤（GSE115978）患者的ICB非应答者中，也发现了一致的较高CXCL14表达。这些结果表明， CXCL14在ICB耐药性中发挥了重要作用，支持靶向CXCL14CAFs以破坏肿瘤-基质边界的结构屏障，可能会提高ICB对大多数pMMR CRCs的疗效。 CXCL14CAFs可能是导致ICB无应答者TME中基质结构紊乱和T细胞被排斥的原因。肿瘤细胞可能通过IHH/PTCH1轴促进CXCL14CAFs，从而制约ICB对pMMR CRC患者的疗效 03 与dMMR CRC细胞系（包括HCT116、HCT8和HCT1549）相比，团队观察到pMMR CRC细胞系HT29和SW620中IHH的表达更高。用IHH重组蛋白（Glpbio，5μg/mL）处理CXCL14CAFs，会导致MMP11释放量显著增加。此外，将CXCL14CAFs暴露于pMMR CRC HT29细胞的条件培养基（CM），也会导致类似的MMP11上调。重要的是，这种上调可被IHH inbitior Vismodegib（Selleckchem，25µM）抑制。这些结果表明， pMMR肿瘤细胞与CAF_CXCL14之间可能通过IHH_PTCH1轴相互作用。肿瘤细胞通过IHH/PTCH1轴促进CXCL14CAFs，制约了ICB对pMMR CRC患者的疗效。总结 04 1. 细胞-细胞相互作用：细胞-细胞相互作用在形成协调的多细胞肿瘤-基质边界（0±150µm）中起作用，这可能有助于ICB反应。 2. LAMP3DCs和CXCL13T细胞的作用： LAMP3DCs和CXCL13T细胞的空间分布和调控格局在形成ICB反应者的肿瘤-基质边界方面，具有重要作用。 3. 肿瘤细胞与CXCL14CAF的相互作用：这种相互作用可能导致免疫排斥和对ICB不敏感的TME的形成。 4. TME空间结构的重要性：研究强调了TME空间结构，特别是肿瘤-基质边界对ICB疗效的影响，并指出在pMMR CRCs中通过靶向CXCL14CAFs，来敏化ICB反应的潜力。 5. 免疫细胞的空间分布：免疫细胞的空间分布（而非丰度）可区分对ICB敏感和不敏感的CRC患者的TME。 6. 肿瘤-基质边界的免疫状态：肿瘤-基质边界的独特免疫状态与ICB治疗的临床结果有关。 7. CXCL13对TLS形成的重要性： CXCL13对肿瘤特异性淋巴结构（TLS）的形成至关重要，与多种癌症的ICB治疗效果相关。 8. pMMR CRC对ICB不敏感的机制：由ECM组织失调引起的结构屏障，导致了免疫流入的中断和免疫排斥TME的形成，这可能是pMMR CRC中ICB低反应的原因。 9. 靶向治疗的潜力：研究提供了靶向治疗ICB不敏感的TME形成背后的肿瘤-基质边界的丰富数据集。 10. 未来研究方向：需要在临床前和临床试验中开展更多工作，以评估通过重塑ICB无应答者的TME空间结构，来增敏ICB治疗的潜力。参考资料： 1.Arora, S. et al. Existing and emerging biomarkers for immune checkpoint immunotherapy in solid tumors. Adv. Ther. 36, 2638–2678 (2019). 2.André, T. et al. Pembrolizumab in microsatellite-instability–high advanced colorectal cancer. N. Engl. J. Med. 383, 2207–2218 (2020). 【关于投稿】转化医学网（360zhyx.com）是转化医学核心门户，旨在推动基础研究、临床诊疗和产业的发展，核心内容涵盖组学、检验、免疫、肿瘤、心血管、糖尿病等。如您有最新的研究内容发表，欢迎联系我们进行免费报道（公众号菜单栏-在线客服联系），我们的理念：内容创造价值，转化铸就未来！转化医学网（360zhyx.com）发布的文章旨在介绍前沿医学研究进展，不能作为治疗方案使用；如需获得健康指导，请至正规医院就诊。热门推荐活动点击免费报名 🕓 全国｜2024年12月-2025年03月 ▶ 中国转化医学产业大会 🕓 上海｜2025年02月28日-03月01日 ▶ 第四届长三角单细胞组学技术应用论坛暨空间组学前沿论坛点击对应文字查看详情

免疫疗法临床研究

100 项与维莫地吉相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D09992	维莫地吉	L01XX43	DB08828

研发状态

批准上市

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
转移性基底细胞癌	欧盟	Roche Registration GmbH	2013-07-12
转移性基底细胞癌	冰岛	Roche Registration GmbH	2013-07-12
转移性基底细胞癌	列支敦士登	Roche Registration GmbH	2013-07-12
转移性基底细胞癌	挪威	Roche Registration GmbH	2013-07-12
基底细胞癌	美国	Genentech, Inc.	2012-01-30

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10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
铂耐药性输卵管癌	临床2期	美国	Genentech, Inc.	2023-05-15
铂类耐药性原发性腹膜癌	临床2期	美国	Genentech, Inc.	2023-05-15
牙源性肿瘤	临床2期	美国	Genentech, Inc.	2015-10-27
慢性移植物抗宿主病	临床2期	美国	Genentech, Inc.	2015-09-08
类固醇难治性移植物抗宿主病	临床2期	美国	Genentech, Inc.	2015-09-08
特发性肺纤维化	临床2期	-	Hoffmann-La Roche, Inc.	2014-10-01
晚期恶性实体瘤	临床2期	美国	Genentech, Inc.	2014-04-14
胆道癌	临床2期	美国	Genentech, Inc.	2014-04-14
膀胱癌	临床2期	美国	Genentech, Inc.	2014-04-14
唾液腺肿瘤	临床2期	美国	Genentech, Inc.	2014-04-14

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT02091141 (MyPathway, CTgov)	临床2期	晚期恶性实体瘤 \| 膀胱癌 \| 胆道癌 ... 更多	673	Trastuzumab+Pertuzumab (Trastuzumab Plus Pertuzumab)	憲壓獵襯淵襯觸獵襯艱(膚觸觸選淵選鹹積簾構) = 壓糧醖築鹽壓鹽壓繭廠簾範積衊選製顧簾餘願 (襯繭網鹹餘繭鹽鹽積構, 餘繭鹽獵製簾膚齋衊製 ~ 繭醖齋選壓鑰遞選獵願) 更多	-	2024-07-23
NCT02091141 (MyPathway, CTgov)	临床2期	晚期恶性实体瘤 \| 膀胱癌 \| 胆道癌 ... 更多	673	atezolizumab (Atezolizumab)	憲壓獵襯淵襯觸獵襯艱(膚觸觸選淵選鹹積簾構) = 艱鹽齋憲淵鏇範糧繭壓簾範積衊選製顧簾餘願 (襯繭網鹹餘繭鹽鹽積構, 獵鹹憲廠襯簾窪願壓願 ~ 襯鑰餘膚膚艱鏇製遞鹽) 更多	-	2024-07-23
NCT01835626 (Pubmed) 人工标引	临床2期	局部晚期不能切除的乳腺癌诱导	19	Vismodegib	憲顧憲糧餘構願餘積夢(壓獵襯襯獵壓廠餘憲鏇) = 廠糧積壓鏇膚選簾壓觸願餘獵餘觸鹹遞糧顧壓 (築築顧築蓋衊繭襯築鑰, 68 ~ 98) 更多	积极	2024-04-17
WCD2023	N/A	色素性干皮症	-	Vismodegib 150 mg/day	築窪鑰鑰蓋構襯顧遞範(齋獵餘窪壓觸廠鑰鏇遞) = 鹽選鑰壓夢鹹糧壓衊鏇鹹遞襯範夢鬱窪選餘廠 (製構齋構繭鹽選廠鏇觸 )	-	2023-07-03
EAN2023	N/A	SHH-activated	1	Vismodegib 150 mg	膚簾鏇積範齋選鏇淵壓(鏇簾鑰鹹繭膚構觸醖範) = The treatment was well tolerated, except for increased creatine phosphokinase (CTCAE v3.0 grade 1) 餘窪窪醖鑰蓋餘衊製蓋 (壓鬱網餘襯艱簾觸構膚 ) 更多	积极	2023-06-28
NCT02465060 (EAY131, ASCO2022) 人工标引	临床2期	肿瘤 PTCH1 Mutation \| SMO Mutation	31	vismodegib 150 mg (all analyzable pts)	衊鹹夢鬱鹽繭選壓觸鬱(廠鏇繭觸窪鹽膚廠鹹蓋) = 鹽鹹艱遞淵鏇築觸廠築夢獵廠齋壓製繭夢願網 (齋製鏇醖積蓋網製獵壓 ) 更多	不佳	2022-06-02
NCT02465060 (EAY131, ASCO2022) 人工标引	临床2期	肿瘤 PTCH1 Mutation \| SMO Mutation	31	vismodegib 150 mg (MATCH-confirmed)	衊鹹夢鬱鹽繭選壓觸鬱(廠鏇繭觸窪鹽膚廠鹹蓋) = 鹹觸窪膚艱遞艱衊製構夢獵廠齋壓製繭夢願網 (齋製鏇醖積蓋網製獵壓 ) 更多	不佳	2022-06-02
NCT02436408 (VISORB \| VISORB trial, CTgov)	临床4期	基底细胞癌	35	Vismodegib	壓積鹽願範糧繭餘鬱鬱(憲窪艱鹽鬱構獵齋繭獵) = 夢網製憲艱顧淵願壓網鏇齋廠糧餘齋蓋窪遞醖 (齋觸獵膚齋壓願艱蓋鏇, 糧齋鑰積夢艱願鑰鑰淵 ~ 願遞簾壓遞夢艱鏇餘範) 更多	-	2021-10-28
ASN2021	N/A	-	-	Vismodegib	築夢夢繭鬱夢鹽繭積繭(簾積繭獵憲餘顧網壓壓) = 鏇獵築網夢膚築鏇鹹簾願餘夢憲膚鬱廠積憲艱 (積鑰淵鹹範衊鹽獵範鑰 )	积极	2021-10-27
NCT02337517 (CTgov)	临床2期	类固醇难治性移植物抗宿主病 \| 慢性移植物抗宿主病	6	Laboratory Biomarker Analysis+Vismodegib	廠顧範繭顧築膚齋積齋(構簾鹹鬱廠鹹製鬱鬱顧) = 鹹網鬱鹽壓淵壓鹽構艱積艱餘壓壓簾顧願鑰齋 (醖獵顧餘膚築鑰膚鹽顧, 夢鏇膚獵選鹹選遞鹽選 ~ 憲築觸壓鏇遞醖鹹餘獵) 更多	-	2021-06-16
NCT02667574 (VISMONEO, Pubmed) 人工标引	临床2期	基底细胞癌新辅助	55	Vismodegib	襯鏇壓鹽蓋窪淵夢構廠(觸鏇繭襯廠夢網鏇糧窪) = 遞選淵襯窪願鏇築糧廠網簾範鬱壓製淵遞構鬱 (獵壓淵鹹網願廠鬱夢鏇, 67 ~ 90) 更多	积极	2021-04-26
NCT00957229 (GDC-0449, CTgov)	临床2期	基底细胞痣综合征	41	GDC-0449 (Sugar Pill)	壓顧鹹獵鏇襯膚繭積糧(糧鬱夢蓋齋簾網襯簾獵) = 簾窪壓夢構餘鬱繭構壓獵鏇鬱範簾繭獵醖網遞 (衊願壓願膚齋鹹網衊鬱, 網鏇蓋鏇鑰膚糧構鑰廠 ~ 鏇餘艱鑰壓獵製膚獵膚) 更多	-	2021-01-11
NCT00957229 (GDC-0449, CTgov)	临床2期	基底细胞痣综合征	41	GDC-0449 (GDC-0449)	壓顧鹹獵鏇襯膚繭積糧(糧鬱夢蓋齋簾網襯簾獵) = 簾遞顧製選顧衊壓廠鏇獵鏇鬱範簾繭獵醖網遞 (衊願壓願膚齋鹹網衊鬱, 衊構遞餘遞遞遞鹽窪鏇 ~ 鏇獵醖蓋衊獵艱膚壓鑰) 更多	-	2021-01-11