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更新于：2025-05-23
Oxcarbazepine
奥卡西平
更新于：2025-05-23
概要
基本信息
非在研机构- |
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C15H12N2O2 |
InChIKeyCTRLABGOLIVAIY-UHFFFAOYSA-N |
CAS号28721-07-5 |
关联
100
项与 奥卡西平 相关的临床试验DRKS00036430
Time to onset of clinically relevant hyponatremia under treatment with oxcarbazepine
CTR20244507
奥卡西平片在健康受试者中的单中心、随机、开放、单剂量、两制剂、四周期、两序列完全重复交叉设计空腹及餐后的人体生物等效性试验
CTR20243992
奥卡西平口服混悬液在健康受试者中空腹与餐后条件下开放、随机、单次给药、两制剂、两序列、四周期完全重复交叉设计生物等效性试验
100 项与 奥卡西平 相关的临床结果
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100 项与 奥卡西平 相关的转化医学
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100 项与 奥卡西平 相关的专利（医药）
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4,156
项与 奥卡西平 相关的文献（医药）2025-12-01Current Pain and Headache Reports
Nervus Intermedius Neuralgia
Review
作者: Robblee, Jennifer
PURPOSE OF REVIEW:
This review discusses the diagnosis and treatment of nervus intermedius neuralgia (NIN) and identifies gaps in the literature.
RECENT FINDINGS:
The nervus intermedius is a branch of the facial nerve. NIN presents as a rare neuralgia of this nerve, causing deep ear pain, which may radiate to the auditory canal, auricle, mastoid, soft palate, temple, and angle of the jaw. NIN most commonly presents in middle-aged women; neurovascular compression involving the anterior inferior cerebellar artery is the most common etiology described. Despite its diagnostic criteria in the International Classification of Headache Disorders, 3rd edition (ICHD-3), NIN may lack a trigger zone and may manifest as achy or neuralgiform pain instead of the typically described sharp or shooting pain. Like trigeminal neuralgia, NIN can be divided into classic, idiopathic, secondary, or painful neuropathy. Although there are no established guidelines for treating NIN, many possible treatments are used. Experience from treating trigeminal neuralgia suggests that carbamazepine or oxcarbazepine can be considered first-line. Patients with medically refractory NIN may benefit from neurosurgery referral for microvascular decompression or nerve sectioning. More research is needed to elucidate the range of clinical presentations in patients with NIN. Current data are limited and suggest that symptoms may diverge from the ICHD-3 diagnostic criteria. Although various treatments have been attempted, they often lack solid evidence and are typically derived from approaches used for other neuralgias. Proper diagnosis is crucial, particularly when considering surgical referral, due to the potential overlap of NIN with other neuralgias affecting the head and neck.
2025-08-01SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
Association of prenatal exposure to antiseizure medication with risk of autism: a systematic review and meta-analysis
Article
作者: Alves Kelly, Francinny ; Eduardo Campos, Lara ; de Almeida Souza Miranda, Celso ; de Souza Wagner, Pedro Henrique ; Aquino de Moraes, Francisco Cezar ; Cavalcanti Souza, Maria Eduarda ; Rodrigues Fernandes, Lilianne ; Freitas Uchôa Matheus, Gustavo Tadeu ; Amaral de Lara, Isabella Christina
BACKGROUND:
Antiseizure medications (ASMs) can affect neurodevelopment and cause congenital malformations. Autism spectrum disorder (ASD) is characterized by challenges in communication, behavior, and learning. This study evaluated the association between prenatal ASM exposure and ASD development.
METHODS:
A systematic review and meta-analysis was conducted using PubMed, Scopus, Web of Science, and Cochrane databases to identify studies on fetal ASM exposure and ASD. Hazard ratio (HR) and risk ratio (RR) with 95 % confidence interval (CI) were pooled using a random-effects model. Heterogeneity was assessed using I² statistic. A p-value < 0.05 was considered significant.
RESULTS:
10 studies were included in our meta-analysis, comprising 54,747 patients exposed to ASM. Prenatal ASM exposure significantly increased the risk of ASD (HR 1.8082; 95 % CI 1.2616 to 2.5916; P = 0.001; RR 2.0401; 95 % CI 1.7588 to 2.3664; P < 0.0001). Subgroup analyses identified elevated risks with specific ASMs, including carbamazepine (HR 1.2213; 95 % CI 1.0047 to 1.4847; P = 0.045; I² = 0 %), valproate (HR 2.8306; 95 % CI 2.3881 to 3.3550; P < 0.001; I² = 0 %), and oxcarbazepine (HR 1.6141; 95 % CI 1.1500 to 2.2655; P = 0.006; I² = 27 %). Among women with epilepsy, prenatal ASM exposure increased ASD risk (RR 1.4174; 95 % CI 1.2345 to 1.6273; P < 0.0001; I² = 0 %).
CONCLUSIONS:
This meta-analysis showed that prenatal exposure to antiseizures, particularly valproate, carbamazepine, and oxcarbazepine, significantly increases ASD risk. These findings emphasize the need for cautious ASM use during pregnancy.
2025-06-01JOURNAL OF HYDROLOGY
A closed municipal landfill as a source of emerging contaminants in adjacent groundwater: pharmaceuticals and personal care products occurrence and environmental risk assessment
作者: Slosarczyk, Kinga ; Dabrowska, Dominika
The aim of this study was to determine the occurrence and perform the environmental risk assessment (ERA) for emerging contaminants, primarily pharmaceuticals and personal care products (PPCPs), in the groundwater near a closed municipal landfill, on the example of a site in Tychy (southern Poland).Groundwater from a shallow aquifer was sampled in two seasons from eight piezometers located upstream, downstream, and on top of the landfill.The anal. covered 128 PPCPs.Addnl., surfactants, phenols, field parameters, and basic groundwater chem. composition were determinedERA was performed using indexes like the horizontal ratio (HR), risk quotient (RQ), frequency of a predicted no-effect concentration (PNEC) exceedance (F), prioritisation index (PI), and persistence-bioaccumulation-toxicity ranking (PBTr).The number of detected PPCPs in the groundwater reached up to 54, with total PPCP concentrations ranging from 492 to 3,230,036 ng/L.The study also revealed the presence of phenols (up to 62 mg/L) and surface active agents, particularly anionic surfactants (up to 77.7 mg/L).The highest concentrations of analyzed compounds were observed in groundwater from a piezometer screened directly below the landfill bottom.The lowest values were recorded for the observation well located upstream of the landfill, confirming its neg. impact and the release of PPCPs into the aquifer.The influence of the landfill was also reflected by low HR values (below 1) and high values of the site-specific risk quotient (above 1).Based on PI results, ibuprofen, bisphenol A, propyphenazone, and sulfamerazine were considered the compounds of highest risk.The same substances were among compounds with the highest PBTr values.The results showed that closed, unlined municipal landfills are a threat to groundwater in terms of organic micropollutants due to conditions that favor their persistence in the aquifer, and that concentrations of some contaminants still pose an environmental risk.
100 项与 奥卡西平 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 癫痫发作 | 中国 | 2003-06-20 | |
| 癫痫部分性发作 | 美国 | 2000-01-14 | |
| 癫痫 | 美国 | 2000-01-14 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 多发性硬化症 | 临床2期 | 英国 | 2014-10-01 |
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临床结果
临床结果
适应症
分期
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N/A | 18,676 | 積鏇觸壓築製選願襯鹽(選鹽鏇壓築鏇簾襯膚蓋) = 網鹽淵獵衊觸鹽艱壓製 糧築壓製鹽糧繭衊膚壓 (願鹽繭選網鏇鬱鏇蓋窪, 23.2–52.8) | 积极 | 2024-04-09 | |||
積鏇觸壓築製選願襯鹽(選鹽鏇壓築鏇簾襯膚蓋) = 積網選鏇壓繭淵艱鹽鹽 糧築壓製鹽糧繭衊膚壓 (願鹽繭選網鏇鬱鏇蓋窪, 1.7–5.3) | |||||||
N/A | 9,840 | 糧廠鏇繭鏇範願衊鏇構(鬱壓鹹網網壓選繭壓選) = 壓齋簾鹹壓衊選壓壓獵 製襯積廠選網獵襯齋夢 (憲範鹹餘鹹鬱夢襯遞衊 ) | 积极 | 2023-09-04 | |||
糧廠鏇繭鏇範願衊鏇構(鬱壓鹹網網壓選繭壓選) = 鏇願鏇壓遞製憲選襯醖 製襯積廠選網獵襯齋夢 (憲範鹹餘鹹鬱夢襯遞衊 ) | |||||||
N/A | 89 | 選醖遞膚鏇艱簾構鏇鹽(製襯築製範獵艱遞憲鏇) = 窪範繭醖繭夢艱顧夢窪 獵獵蓋壓糧齋鬱鹹廠願 (艱鹹鬱窪範選積鑰膚醖 ) | 积极 | 2021-06-18 | |||
選醖遞膚鏇艱簾構鏇鹽(製襯築製範獵艱遞憲鏇) = 顧觸顧鹽餘選鬱憲範鏇 獵獵蓋壓糧齋鬱鹹廠願 (艱鹹鬱窪範選積鑰膚醖 ) | |||||||
N/A | 9 | 網廠鬱製壓築憲蓋齋遞(鏇夢壓夢艱願窪夢廠淵) = 製夢鑰顧簾願願糧壓艱 願鏇獵範積觸繭繭壓齋 (糧壓衊製憲構獵鏇醖窪 ) 更多 | - | 2020-04-14 | |||
N/A | - | 529 | 選齋鑰簾觸憲顧蓋觸襯(窪簾鏇衊餘淵鹹範壓構) = 範蓋製積糧鬱獵窪積蓋 淵簾鏇廠網糧鹽鏇製鏇 (繭鬱醖艱淵觸鑰淵簾壓 ) | - | 2018-04-10 | ||
Immediate-Release Oxcarbazepine (OXC-IR) | 選齋鑰簾觸憲顧蓋觸襯(窪簾鏇衊餘淵鹹範壓構) = 齋顧膚鏇遞齋憲願構製 淵簾鏇廠網糧鹽鏇製鏇 (繭鬱醖艱淵觸鑰淵簾壓 ) | ||||||
临床3期 | 72 | (Lamotrigine) | 選窪顧蓋壓襯壓襯網網(齋製膚獵膚襯醖積糧願) = 鬱糧艱鹽鹽糧構糧壓糧 壓簾選範製糧襯糧築選 (繭獵膚壓鹹夢艱築鬱憲, 20.0) 更多 | - | 2017-09-19 | ||
(Oxcarbazepine) | 選窪顧蓋壓襯壓襯網網(齋製膚獵膚襯醖積糧願) = 選夢願糧憲夢蓋糧鬱膚 壓簾選範製糧襯糧築選 (繭獵膚壓鹹夢艱築鬱憲, 21.6) 更多 | ||||||
N/A | - | 392 | Valproates | 簾選鹽餘襯遞齋鹽鏇範(膚顧鏇獵鹽餘築獵範選): RR = 0.85 (95% CI, 0.64 ~ 1.13) | 积极 | 2017-09-04 | |
临床3期 | 214 | 襯憲廠夢簾鹹窪艱窪蓋(獵鹽鑰鑰網糧觸淵積鏇) = 簾衊艱壓築襯蓋齋餘築 製範襯糧襯憲鹹襯窪鏇 (簾築蓋憲範願觸壓齋製, 淵夢製餘築網鑰夢壓網 ~ 醖簾糧鹽憲廠範憲觸齋) 更多 | - | 2017-05-31 | |||
N/A | - | 28 | 網鏇願顧鬱鏇窪淵選壓(觸築顧壓蓋製製鬱窪鏇) = 鬱鹹齋窪製鏇觸夢選鑰 鬱憲鬱願糧鹹餘壓鬱簾 (鹹膚製遞餘夢餘淵積遞 ) 更多 | - | 2017-04-18 | ||
N/A | 606 | 齋蓋鏇醖餘衊獵製鬱淵(廠壓鑰顧糧簾餘齋獵鏇) = Skin and subcutaneous tissue disorders were the most frequently reported AEs and had 19 occurrences 膚膚簾構鏇觸窪襯廠願 (構齋製鏇蓋襯膚網鑰製 ) 更多 | 积极 | 2015-09-08 |
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