维生素C(Ascorbic Acid) - 在研适应症：维生素缺乏，抗坏血酸缺乏，铁过剩_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Ascorbate、Ascorbic Acid、Ascorbic acid (JP17/USP/INN)

+ [55]

靶点-

作用机制

维生素C补充剂

治疗领域

心血管疾病内分泌与代谢疾病血液及淋巴系统疾病+ [11]

在研适应症

维生素缺乏抗坏血酸缺乏铁过剩+ [24]

非在研适应症

急性髓性白血病喂食及进食障碍牙龈炎+ [6]

原研机构

宜昌人福药业有限责任公司

在研机构

沈阳华泰药物研究有限公司

宜昌人福药业有限责任公司

University of Calcutta

+ [33]

非在研机构

The Case Comprehensive Cancer CenterEMS SA (Brazil)

諾金有限公司

+ [1]

最高研发阶段批准上市

首次获批日期

中国 (1981-01-01),

铁过剩高铁血红蛋白血症坏血病

最高研发阶段(中国)批准上市

特殊审评孤儿药 (欧盟)、孤儿药 (美国)

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结构

分子式C6H8O6

InChIKeyCIWBSHSKHKDKBQ-JLAZNSOCSA-N

CAS号50-81-7

关联

768

项与维生素C 相关的临床试验

CTRI/2024/07/070297 / Not yet recruiting临床3期IIT

Evaluation of gingival depigmentation using microneedling procedure with vitamin-c and electrosurgery: A split mouth randomized controlled trial. - NIL

开始日期2025-01-01

申办/合作机构-

NCT04756063 / Recruiting临床4期

Parenteral Ascorbic Acid Repletion in TransplantatIon (PARTI): a Randomized, Double-Blinded, Placebo-Controlled Trial

A single-center, randomized, double-blinded placebo-controlled trial is proposed to investigate administration of supraphysiologic doses of ascorbic acid (vitamin C, AA) to patients undergoing liver transplantation. Participants randomized to the intervention group will receive intravenous (IV) AA 1500 mg every 6 hours for 48 hours. Participants randomized to the control group will receive a saline placebo. The primary study outcome will be a change in the Sequential Organ Failure Assessment (SOFA) score from baseline to three days after the first dose of drug (dSOFA3). Secondary outcomes will include total vasopressor dose in norepinephrine equivalents, 30-day and 1-year mortality, and serum AA levels.

开始日期2025-01-01

申办/合作机构

University of Wisconsin Madison

NCT06710899 / Not yet recruiting早期临床1期

Does Vitamin C Improve the Efficacy of Methenamine Hippurate (Hiprex®) in Prophylaxis of Recurrent Urinary Tract Infections? A Proof of Concept Study

A single centre proof of concept study to assess whether Vitamin C improves the efficacy of Methenamine Hippurate (Hiprex®) in the prophylaxis of recurrent urinary tract infections (rUTIs) in women

开始日期2025-01-01

申办/合作机构

University Hospitals of North Midlands NHS Trust

100 项与维生素C 相关的临床结果

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100 项与维生素C 相关的转化医学

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100 项与维生素C 相关的专利（医药）

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51,701

项与维生素C 相关的文献（医药）

2025-04-01·TALANTA

Determination of melatonin by potentiometric stripping analysis using sensor based on boron-doped diamond electrodes

Article

作者: Michniak, P ; Marton, M ; Rehacek, V ; Hojova, L ; Vojs, M ; Stanova, A Vojs ; Hotovy, I

A three-electrode screen-printed sensor with heavily doped microcrystalline boron-doped diamond electrodes grown by chemical vapor deposition on alumina substrates was used to determine the concentration of melatonin by constant current potentiometric stripping analysis. This paper provides a detailed examination of the irreversible oxidation behavior of melatonin by cyclic voltammetry at a boron-doped diamond electrode. The relationship between the current response and the square root of the scan rate confirmed a diffusion-controlled oxidation process. The research highlights the strong effect of electrode pretreatment on electrode properties, demonstrating its influence on electrochemical activity and electron-transfer kinetics. After the electrodes were cathodically pretreated, the melatonin responses increased more than four times compared to the anodically pretreated electrodes. Optimum results were obtained in constant current potentiometric stripping analysis at pH value of 3.0 using the Britton-Robinson buffer solution as an electrolyte. Further optimization of the accumulation potential/time, and stripping current led to improved melatonin detection sensitivity, achieving a significantly lower limit of detection of 14.6 μg L^-1 compared to square wave voltammetry (110 μg L^-1). Interference studies assessed the impact of selected organic compounds on melatonin determination. While some compounds like dopamine, l-ascorbic acid, and uric acid showed minimal interference, l-tryptophan and serotonin significantly influenced melatonin responses. The sensor was successfully applied to determine of melatonin in a commercial pharmaceutical supplement. A satisfactory result was obtained by constant current potentiometric stripping analysis as the recovery reached 100.75 % compared to the reference value obtained by the LC-HRMS method. The proposed method, due to the excellent properties of the boron-doped diamond electrode and constant current potentiometric stripping analysis, provides a fast measurement procedure of melatonin with high sensitivity (compared to square wave voltammetry) at a stable background signal. Moreover, the method is insensitive to dissolved oxygen in the electrolyte and only the stripping current of the potentiometric stripping analysis needs to be optimized.

2025-04-01·FOOD MICROBIOLOGY

Co-culture fermentation of Debaryomyces hansenii and Bacillus atrophaeus alleviates quality deterioration of litchi fruit by ameliorating microbial community diversity and composition

Article

作者: Shao, Yuanzhi ; Hu, Yuxin ; Wang, Xin ; Li, Zhen ; Li, Rui ; Wang, Yu ; Li, Wen

Microbial communities, both on the surface and within fruit, play a crucial role in reducing postharvest diseases and maintaining fruit quality. This study investigated the effects of co-culture fermentation supernatant of Debaryomyces hansenii (Y) and Bacillus atrophaeus (T) on disease control and quality preservation of postharvest litchi fruit, while exploring the underlying mechanisms through microbiome profiling. The results indicated that Y + T treatment not only reduced decay percentage, weight loss, and pH increase but also preserved the pericarp cell integrity and reduced the lignin accumulation. Additionally, it delayed changes in firmness, chroma value, anthocyanin content, and the contents of soluble sugar, protein, and vitamin C during storage. High-throughput sequencing revealed significant differences in the diversity and richness of bacterial and fungal species between the control and Y + T-treated fruit. The Y + T treatment maintained microbial diversity, promoted the growth and metabolism of potentially beneficial genera (e.g., Cyanobacteria, Bacillus, Paenibacillus, Hanseniaspora, Pichia), and suppressed pathogenic genera (e.g., Xylaria, Lasiodiplodia, Gibberella, Fusarium). These changes contributed to promote disease resistance and improve postharvest quality of litchi fruit. This study provides valuable insights into how microbial antagonists can regulate postharvest diseases and sets the groundwork for developing beneficial microbial consortia to enhance the postharvest safety and commercial value of litchi fruit.

2025-03-01·ANALYTICAL BIOCHEMISTRY

Electrochemical determination of ascorbic acid using sensitive and disposable methylene blue modified pencil graphite electrode

Article

作者: Aishwarya, K G ; Nayaka, Y Arthoba ; Sahana, H R ; Pradeepa, E

In the present work, a convenient, efficient and disposable electrochemical sensor has been developed by electropolymerizing methylene blue (PMB) on the surface of a pencil graphite electrode (PGE), which facilitates the electrochemical analysis of an antioxidant l-Ascorbic Acid (AA). The structural characteristics of both the methylene blue modified pencil graphite electrode (PMB/PGE) and the bare pencil graphite electrode (BPGE) have been examined using scanning electron microscopy (SEM) in conjunction with energy-dispersive X-ray analysis (EDX). Additionally, the charge transfer behavior has been evaluated using the electron impedance spectroscopy (EIS). The voltammetric response of AA has been examined using different methods, such as differential pulse voltammetry (DPV) and linear sweep voltammetry (LSV). This exploration has been carried out in 0.1 M phosphate buffer solution (PBS) of physiological pH 7.0. The electrochemical sensor PMB/PGE proposed in this study exhibited an improved peak current and a slight negative shift in peak potential for AA compared to bare electrode. The enhancement in peak current at the modified electrode has been attributed to the electrocatalytic characteristics of the modifiers. The limit of detection (LOD) for AA has been determined using the differential pulse voltammetry (DPV), with concentrations ranging from 1.0 μM to 12.0 μM. The calculated LOD value has been found to be 0.15 μM. The selectivity and practicality of the modified electrode has been assessed through the real sample analysis and demonstrating its capability to detect AA in the presence of paracetamol (PA) resulting in satisfactory recovery results. Hence the proposed sensor could be successfully validated for the determination of AA in pharmaceutical sample.

350

项与维生素C 相关的新闻（医药）

2024-12-15

·思齐俱乐部

两大医药巨头，重磅合作

【导读】石药集团与百济神州达成相关药品的独家授权协议石药集团12月13日早间公告，已与百济神州就集团的新型甲硫氨酸腺苷转移酶2A（MAT2A）抑制剂（SYH2039），以及后续开发的由该化合物组成或含有该化合物的任何药品在全球的开发、制造及商业化订立独家授权协议。根据协议，石药集团将收取总计1.5亿美元的预付款，并有权收取最高1.35亿美元的潜在开发里程碑付款及最高15.5亿美元的潜在销售里程碑付款，以及根据该产品的年度销售净额计算的分层销售提成。除去分层销售提成，上述合作总金额最高达18.35亿美元，按最新汇率计算，约合133亿元人民币。 SYH2039是石药集团通过AI驱动的小分子药物设计平台获得的临床候选药物，有潜力成为一款同类最优(best-in-class)的抗肿瘤药物。该平台通过AI技术分析靶标蛋白与化合物分子的结合模式，对分子成药性进行针对性优化设计，最终筛选得到高活性、高选择性的小分子MAT2A抑制剂。目前，SYH2039已经在中国开展I期临床研究，初步资料展现出了良好的安全性、PK行为和PK-PD标记物相关性。 2024年前三季度，石药集团收入同比下跌4.9%至226.86亿元人民币，净利润同比下跌15.9%至37.78亿元人民币；其中，第三季度收入与股东净利润分别同比下滑17.8%与51.5%。中泰国际认为，2024年石药集团的成药业务收入将同比下降7%，2025年-2026年为缓步回升。其理由包括：首先，虽然公司表示2024年获批的肿瘤新药伊立替康、两性霉素B脂质体、奥玛珠单抗上市以来销售表现较好，但通常新药从上市到上量略需时间，而且津优力与多美素集采为2024年3月起在各地陆续执行，因此集采降价对四季度与2025年收入仍将产生影响。其次，恩必普与玄宁上市已近20年，在医保控费趋紧及市场竞争加剧的情况下，短期内销售收入大幅回升的可能性不高。此外，根据第三季度情况，预计由于维生素C需求下滑及咖啡因价格下降等原因，2024年全年原料产品与功能食品及其它板块的收入将略逊预期，短期内难以大幅回升。截至记者发稿，石药集团股价为4.79港元，跌幅为4.39%，最新市值为557亿港元；百济神州港股股价为108.4港元，微跌0.28%，最新市值为1578亿港元。来源：中国基金报作者：卢鸰商务合作 130 6172 3098 zakk.cui@siqibest.com 点击阅读原文了解更多

引进/卖出财报临床1期

2024-12-13

·生物谷

你喝对果汁了吗？Food Sci. Hum. Wellness揭秘不同加工程度的果汁对健康的影响

在当今社会，随着人们健康意识的逐步提高，对饮食的关注已不再仅仅局限于满足味蕾的享受，而是进一步深入到对营养与健康影响的考量。果汁和饮料作为日常饮品的重要组成部分，频繁出现在我们的餐桌、办公场所和休闲时刻。无论是早餐桌上的一杯鲜榨橙汁，还是下午茶时的一瓶果味饮料，它们凭借丰富多样的口味和便捷的饮用方式，融入了我们的生活节奏。然而，在这看似平常的消费背后，却隐藏着一个备受关注且争议不断的话题——不同加工程度的果汁饮料（FJBs）究竟会对我们的健康产生怎样的影响？近日，一项发表在Food Sci. Hum. Wellness的题为Health effects of fruit juices and beverages with varying degrees of processing的研究，通过整合多种分类系统明确了FJBs的加工类别，对比各国膳食指南态度，并综合临床研究、流行病学调查及动物实验，对果汁饮料（FJBs）对健康的影响进行了深入剖析。结果表明，FJBs对体重、心血管等健康方面的影响较为复杂，与加工度等诸多因素有关。例如，加工会影响营养素含量，添加剂、消费者偏好等因素也发挥着作用，而且不同加工方法的果汁在健康效益上存在差异，这为指导FJBs的消费和研究提供了重要参考。一、果汁饮料（FJBs）的加工分类与膳食指南态度 1. 加工分类研究通过整合NOVA、UNC、IFIC和IARC四种分类系统，将FJBs精准地划分为低（最低限度）、中、高三个主要类别。在NOVA系统中，果汁饮料和水果味饮料因含有多种添加剂和复杂成分被归为超加工食品；100%果汁通常属于中度加工范畴；新兴的非热加工NFC果汁则最大限度地保留了水果的原始特性，接近最低限度加工。这种分类为后续深入探讨FJBs的健康影响构建了重要的框架。图1. 根据4种不同的食品加工分类系统对不同类型的FJB进行分类 2. 膳食指南态度各国膳食指南对FJBs的态度存在显著差异。部分国家，如荷兰、加拿大等，将果汁视为有害或等同于含糖饮料（SSBs），建议民众减少摄入；英国、南非、芬兰、中国和美国等国则对100%果汁和水果饮料的推荐摄入量加以区分；还有些国家并未明确区分或提及。与此同时，各国普遍倡导减少SSBs的消费，但仅有少数国家在膳食指南中关注到超加工食品（UPFs），这凸显出UPFs对健康的影响尚未受到广泛重视。图2. 世界各国膳食指南中对100% FJB的描述二、果汁饮料（FJBs）的健康影响研究及影响因素分析 1. 临床研究与流行病学调查在体重管理方面，对于儿童青少年群体而言，100%果汁与肥胖并无直接的因果关系，但在特定年龄段（如2-4岁）可能会产生影响，在成年人中，其与体重增加的关系尚不明确，而SSBs已被证实对健康有害，且与肥胖密切相关。在心血管健康方面，含糖饮料（SSBs）导致心血管疾病的风险确凿无疑，100%果汁能否替代水果预防心血管疾病则存在争议。在糖尿病风险层面，SSBs会显著增加2型糖尿病（T2DM）的发病风险，100%果汁虽有一定关联，但证据质量参差不齐。在痛风和高尿酸血症方面，SSBs与痛风发作紧密相关，100%果汁则因品种不同对痛风的影响各异。在心理健康方面，SSBs与心理健康问题相关，FJBs的影响尚不清晰。在口腔健康方面，过量摄入FJBs均有害，且加工果汁比鲜榨果汁更易引发龋齿。 2. 体内动物研究体内动物研究结果显示，在涉及多种水果品种（如红火龙果、西番莲、柑橘、葡萄、苹果等）及众多疾病种类（肥胖、糖尿病、心血管疾病、骨骼健康等）的实验中，发现果汁或饮料消费与疾病风险存在显著的剂量依赖关系。即高剂量摄入往往会带来更显著的健康影响，适量摄入的影响相对较小，甚至可能有益。这为深入理解FJBs对人体健康影响的机制提供了关键线索。 3. 影响因素分析在总能量摄入和膳食模式方面，100%果汁虽会增加能量摄入，但有助于实现水果摄入目标，且其消费者大多具有较好的膳食模式，而SSBs则与不良饮食行为紧密关联。在营养素层面，加工会改变糖的形式，人体对液体糖和固体糖的代谢不同，100%果汁血糖生成指数相对较低；膳食纤维在加工过程中容易减少，非热加工果汁保留得较多，这与饱腹感相关；多酚受水果品种和加工的影响较大，非热加工NFC果汁能更好地保留其有益功效；维生素C容易在加工过程中受损，非热加工的情况稍好；类胡萝卜素在加工后其含量和生物利用度会发生改变。添加剂包括添加糖、食品添加剂和强化成分，添加糖过量有害，人工甜味剂有潜在不良影响，食品添加剂的安全性存在争议，强化成分可增加营养价值。此外，消费者偏好会影响饮料的选择，包装饮料容易使消费者“上瘾”，引导消费者树立正确观念对促进健康饮食至关重要。图3. FJBs的不同致病作用及其影响因素三、加工方法对果汁健康效益的影响加工方法对果汁健康效益的影响十分显著。热加工虽然能够有效延长果汁的保质期，杀灭微生物，但会导致果汁中的营养素降解，生物活性丧失。相比之下，非热加工技术在保留果汁营养成分方面具有明显优势，能更好地保持果汁的营养品质和口感。NFC果汁与FC果汁的加工过程差异较大，FC果汁在浓缩还原步骤中会破坏天然生物活性物质，使糖分浓缩，健康风险增加；而NFC果汁更接近新鲜水果的状态，非热加工的NFC果汁更是能够最大程度地保留营养和风味，为消费者提供更健康的选择。总体而言，本研究对果汁饮料（FJBs）进行了深入剖析，明确了其加工类别，梳理了各国膳食指南态度。FJBs对健康的影响较为复杂，加工方式会影响营养保留，热加工可能降低营养，非热加工（如NFC果汁）则营养保留良好；营养素受水果品种和加工的双重影响；添加剂和消费者偏好也在其中发挥作用。消费者在选择时，应查看标签，选择加工工艺先进、添加剂合理的产品，如非热加工或简单加工的100%果汁，关注糖分和添加剂情况，控制儿童青少年的摄入量，并合理搭配食物，以此做出健康的选择。参考文献： Zhang X ,Liao X ,Wang Y , et al. Health effects of fruit juices and beverages with varying degrees of processing. Food Science and Human Wellness,2024,13(05):2456-2479. 本文仅用于学术分享，转载请注明出处。若有侵权，请联系微信：bioonSir 删除或修改！点击下方「阅读原文」，前往生物谷官网查询更多生物相关资讯~

2024-12-11

·PRNewswire

Elume Offers Fuss-Free Skincare Solutions for All Skin Tones

The Indian Skincare Brand Is Empowering Women Around the World With Simple, Pleasant, Effective Skincare Solutions FORT LAUDERDALE, Fla., Dec. 11, 2024 /PRNewswire/ -- Elume is a forward-thinking skincare company that is empowering women through simple, streamlined, and effective skincare solutions for all skin tones. The breakout Indian brand's inclusive emphasis comes from its focus on its Asian-first philosophy and its desire to meet the unique needs of the Asian consumer. Elume has created its popular and diverse skincare range through a combination of simple choices and thorough education. The company focuses on reducing overwhelm through easily accessible information and positive experiences. "Our goal is to create pleasant, fuss-free experiences for everyone, no matter their skin tone or skincare needs," said Elume co-founder Pavneet. "Élume is more than a skincare brand; it's a celebration of diversity and natural beauty. Our products, enriched with potent ingredients like Vitamin C and Niacinamide, are crafted to meet the unique needs of people with melanated skin, ensuring they receive the care and nourishment their skin deserves." As a way to make the skincare journey easier, Elume has put a heavy emphasis on transparency throughout its business activity. Formulas are easy to find and presented in concise yet comprehensive formats. This makes it easier for customers to make the best choice based on their unique skin needs. In addition, the company has an entire page devoted to ingredient descriptions to further promote education and wise purchase decisions. There is also a clear dual focus on prevention and treatment. Some products help maintain healthy skin, while others address specific concerns and conditions. One of the best examples of Elume's comprehensive and effective approach to global skincare is its Vitamin C+ range. The popular product line includes a cleanser, toner, serum, and moisturizer, all with clear descriptions and applications. The collection is celebrated for brightening and revitalizing the skin and the ability to consistently deliver exceptional results based on clearly communicated expectations. The brand has similar products formulated for skin radiance, acne, hyperpigmentation, and aging skin. Elume is more than a skincare brand. On the surface, its products offer a proactive approach to skincare, ensuring long-term skin wellness and vitality. But it goes further. The company is also committed to exceptional service as it cares for consumers and gives them the confidence to care for their bodies without the need to cover up or alter them. About Elume Elume is a brand from Skin Habits Pvt. Ltd. and was launched in 2021 in the heart of North India, Chandigarh. The company operates with family values and an emphasis on a better tomorrow. This primarily focuses on leaving behind old, harmful ideologies that have resonated for generations. The Elume team has over 20 years of expertise in skincare and embraces an Asian-first philosophy founded on meticulous research in the areas of melanated skin, tropical weather, and a fast-paced lifestyle. Its products are dermatologically tested, PETA-approved cruelty-free, and manufactured at a WHO GMP-certified factory. Learn more at elume.in. Arvin Mondal Director, International Business Development M: +91 991 590 0348 E: [email protected] SOURCE Elume WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

100 项与维生素C 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D00018	维生素C	G01AD03 S01XA15	DB00126

研发状态

批准上市

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
维生素缺乏	日本	NISSIN Pharmaceutical Co., Ltd.	1990-05-15
抗坏血酸缺乏	日本	neo CritiCare Phama Co., Ltd.	1985-09-09
铁过剩	中国	宜昌人福药业有限责任公司	1981-01-01
高铁血红蛋白血症	中国	宜昌人福药业有限责任公司	1981-01-01
坏血病	中国	宜昌人福药业有限责任公司	1981-01-01

未上市

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
营养和代谢疾病	临床3期	美国	Beth Israel Deaconess Medical Center, Inc.	2018-02-09
脓毒性休克	临床3期	美国	Beth Israel Deaconess Medical Center, Inc.	2018-02-09
喂食及进食障碍	临床3期	巴西	EMS SA (Brazil)	2011-10-01
牙龈炎	临床3期	日本	Lion Corp.	2006-09-01
腺癌	临床2期	美国	McGuff Pharmaceuticals, Inc.	2018-11-28
胰腺继发性恶性肿瘤	临床2期	美国	McGuff Pharmaceuticals, Inc.	2018-11-28
急性髓性白血病	临床2期	美国	The Case Comprehensive Cancer Center	2018-03-16
骨髓增生异常综合征	临床2期	美国	The Case Comprehensive Cancer Center	2018-03-16
骨髓增生性疾病	临床2期	美国	The Case Comprehensive Cancer Center	2018-03-16
大肠腺癌	临床2期	美国	Weill Medical College of Cornell University	2017-03-29

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临床结果

适应症

分期

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ASH2024	N/A	慢性粒单核细胞白血病	-	High dose ascorbate	鬱構艱糧選夢齋獵齋遞(艱蓋獵壓構醖願艱遞遞) = increased total 5hmC levels 簾積壓醖廠觸鬱醖淵夢 (鹽餘選窪夢鏇繭衊鑰襯 ) 更多	-	2024-12-07
Pubmed \| Redox Biol	N/A	胰腺癌	-	Gemcitabine and nab-paclitaxel only	顧壓簾艱製夢艱憲廠蓋(窪壓餘淵鬱鏇窪積鏇積) = 夢願遞齋齋膚窪壓構齋觸膚顧醖遞廠鬱範憲廠 (構夢鹽觸選簾衊淵廠艱 ) 更多	-	2024-11-01
				Gemcitabine and nab-paclitaxel + Pharmacological ascorbate (P-AscH<sup>-</sup>)	顧壓簾艱製夢艱憲廠蓋(窪壓餘淵鬱鏇窪積鏇積) = 襯廠鑰襯繭鹽築積鏇鬱觸膚顧醖遞廠鬱範憲廠 (構夢鹽觸選簾衊淵廠艱 ) 更多
UEGW	N/A	肠道准备	540	Elobixibat plus sodium picosulfate with magnesium citrate	築鏇願糧齋築獵鹹鹹壓(糧構鹹鬱簾艱鹽窪選選): difference = -1.5 (95% CI, -4.8 ~ 1.6) 更多	积极	2024-10-13
				Split-dose 2-L polyethylene glycol with ascorbic acid
NCT04291508 (ASTER, CTgov)	临床2期	呼吸衰竭 \| 危重病 \| 脓毒症 ... 更多	488	Intravenous Acetaminophen (room temperature) (IV Acetaminophen-Active)	憲顧築窪鑰網網鬱壓壓(艱範構齋襯鏇齋願遞淵) = 鏇夢窪鹽壓積獵糧淵鬱積鏇築淵網繭廠齋鏇壓 (鹹糧艱觸顧憲築醖鑰膚, 窪蓋夢餘餘構醖淵遞製 ~ 糧襯製鏇願築願鏇遞獵) 更多	-	2024-09-27
				Intravenous Vitamin C (refrigerated) (IV Vitamin C-Active)	憲顧築窪鑰網網鬱壓壓(艱範構齋襯鏇齋願遞淵) = 憲鹽積鹹觸艱夢繭憲鬱積鏇築淵網繭廠齋鏇壓 (鹹糧艱觸顧憲築醖鑰膚, 獵醖淵襯鹽願鹽鹹襯鏇 ~ 廠構鑰蓋廠鹽鹹積選夢) 更多
ESMO_ASIA2024	N/A	粘膜炎	60	Vitamin C and Zinc injections	夢製製衊積範築鹽築夢(蓋選鏇壓夢製艱願鬱鹽) = 醖壓選壓憲網製鹹蓋網艱築築膚醖衊壓顧襯艱 (鹽廠壓艱簾範鑰構構願 ) 更多	积极	2024-09-14
				vitamin C (Standard care)	夢製製衊積範築鹽築夢(蓋選鏇壓夢製艱願鬱鹽) = 齋選廠觸餘窪壓積醖餘艱築築膚醖衊壓顧襯艱 (鹽廠壓艱簾範鑰構構願 ) 更多
EULAR2024	N/A	肌腱病	72	Dietary supplement (chondroitin sulfate, type I collagen, vitamin C, manganese) + corticosteroid injection	鬱繭顧艱餘淵醖膚選襯(遞淵憲簾顧衊夢糧築繭) = 100% in the diacerein group and 0% in the study group 築夢廠膚蓋觸鏇獵簾範 (鑰淵鹹壓夢餘積齋鹽衊 ) 更多	积极	2024-06-05
				Diacerein + corticosteroid injection
ATS2024	N/A	脓毒症 \| 脓毒性休克	-	Hydrocortisone, Ascorbic Acid, and Thiamine (HAT) Therapy	製網網壓淵構構觸壓襯(簾蓋觸壓製製簾獵醖網) = The use of HAT therapy did not increase incidence of gastrointestinal bleeding compared to placebo/SoC 壓製蓋顧繭襯淵選醖襯 (餘糧蓋衊憲壓糧憲鑰廠 ) 更多	-	2024-05-19
NCT04344184 (CTgov)	临床2期	肾脏疾病 \| 急性肺损伤 \| 新型冠状病毒感染	47	L-ascorbic acid (Infusion)	蓋築衊顧醖構積齋憲憲(窪鑰觸遞蓋製積憲簾鑰) = 選積遞獵憲鏇襯遞選鬱膚鏇製鹹廠構顧願鹽膚 (繭壓構廠襯顧夢築願選, 願範願壓鏇餘衊選鏇範 ~ 蓋糧廠衊網範窪壓齋範) 更多	-	2024-04-04
				Placebo (Placebo)	蓋築衊顧醖構積齋憲憲(窪鑰觸遞蓋製積憲簾鑰) = 構醖遞衊淵鹽糧繭糧鏇膚鏇製鹹廠構顧願鹽膚 (繭壓構廠襯顧夢築願選, 壓齋鹹壓顧壓鑰醖鹹膚 ~ 積憲襯顧繭選網選選鏇) 更多
NCT03433781 (CTgov)	临床1/2期	骨髓增生异常综合征	4	vitamin C (Vitamin C 50 g)	選膚遞繭憲鏇積餘鑰積(淵壓選鹹衊醖積範願膚) = 簾鏇壓膚遞顧蓋夢繭齋範範壓糧鏇夢願網顧鏇 (構壓夢範構觸壓範鹹範, 壓遞觸遞積鑰糧網鹽淵 ~ 餘鏇遞繭鹽鬱齋鹽簾膚) 更多	-	2024-03-27
				vitamin C (Vitamin C 75 g)	選膚遞繭憲鏇積餘鑰積(淵壓選鹹衊醖積範願膚) = 築觸構製糧繭築鏇壓鏇範範壓糧鏇夢願網顧鏇 (構壓夢範構觸壓範鹹範, 鬱繭範築蓋遞繭觸廠廠 ~ 鏇獵顧醖製鬱艱衊觸簾) 更多
NCT04046094 (CTgov)	临床1/2期	膀胱癌	12	Ascorbic Acid	艱獵築選壓構壓築廠獵(積鬱構繭膚構顧積構醖) = 簾獵網範蓋築構膚觸鹹窪願襯艱構網窪獵鹽鹽 (鑰廠襯窪遞餘繭衊製憲, 構艱醖觸願願網壓鏇廠 ~ 糧遞窪鑰繭繭淵鏇廠窪) 更多	-	2024-03-04