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Celebrating its golden anniversary, Nikon Small World honors a stunning photo of brain tumor cell structures, advancing our understanding of neurodegenerative diseases. MELVILLE, N.Y., Oct. 17, 2024 /PRNewswire/ -- Nikon Instruments Inc. today announced the winners of the 50th annual Nikon Small World Photomicrography Competition, celebrating five decades of excellence in microscopy and digital imaging. This year's first place prize was awarded to Dr. Bruno Cisterna, with assistance from Dr. Eric Vitriol of Augusta University, for his groundbreaking image of differentiated mouse brain tumor cells, highlighting the actin cytoskeleton, microtubules, and nuclei. This image reveals how disruptions in the cell's cytoskeleton – the structural framework and "highways" known as microtubules – can lead to diseases like Alzheimer's and ALS. Continue Reading Differentiated mouse brain tumor cells (actin, microtubules, and nuclei) Dr. Cisterna's research revealed that profilin 1 (PFN1), a protein crucial for building the cell's structure, plays a key role in maintaining the microtubule highways essential for cellular transport. When PFN1 or related processes are disrupted, these highways can malfunction, leading to cellular damage similar to what is observed in neurodegenerative diseases. "One of the main problems with neurodegenerative diseases is that we don't fully understand what causes them," said Dr. Cisterna. "To develop effective treatments, we need to figure out the basics first. Our research is crucial for uncovering this knowledge and ultimately finding a cure. Differentiated cells could be used to study how mutations or toxic proteins that cause Alzheimer's or ALS alter neuronal morphology, as well as to screen potential drugs or gene therapies aimed at protecting neurons or restoring their function." His patience and determination were crucial in capturing his image. "I spent about three months perfecting the staining process to ensure clear visibility of the cells. After allowing five days for the cells to differentiate, I had to find the right field of view where the differentiated and non-differentiated cells interacted. This took about three hours of precise observation under the microscope to capture the right moment, involving many attempts and countless hours of work to get it just right." The hard work behind this discovery underscores its significance, bringing researchers closer to answers that could potentially transform millions of lives. "After three years of research, we finally published our findings four months ago in the Journal of Cell Biology, and there's still more work to be done," said Dr. Cisterna. "I'm deeply passionate about scientific imaging; I've been following the Nikon Small World contest for about 15 years. It's an incredible contest that highlights the beauty of photomicrography but also inspires continued exploration and innovation in the field." Eric Flem, Senior Manager, CRM and Communications at Nikon Instruments, shares a similar perspective on the competition. "At 50 years, Nikon Small World is more than just an imaging competition – it's become a gallery that pays tribute to the extraordinary individuals who make it possible. They are the driving force behind this event, masterfully blending science and art to reveal the wonders of the microscopic world and what we can learn from it to the public." He went on to add, "Sometimes, we overlook the tiny details of the world around us. Nikon Small World serves as a reminder to pause, appreciate the power and beauty of the little things, and to cultivate a deeper curiosity to explore and question." Second place was awarded to Dr. Marcel Clemens for his image of an electrical arc between a pin and a wire, produced by applying a potential difference of 10,000 volts. Third place was awarded to Chris Romaine for his image of a cannabis plant leaf. The bulbous structures are trichomes, or hair-like plant appendages, and the bubbles inside are cannabinoid vesicles, fluid-filled, blister-like structures. In total, Nikon Small World recognized 87 photos out of thousands of entries from scientists and artists across the globe. The 2024 judging panel included: Adrian Coakley, Director of Photography at National Geographic Books Michelle S. Itano, Ph.D., Assistant Professor of Cell Biology and Physiology and Director of the Neuroscience Microscopy Core at the University of North Carolina at Chapel Hill Emily Petersen, Photography Managing Editor at Science Magazine Clare Waterman, Ph.D., Cell Biologist and Member of the National Academy of Sciences Jennifer C. Waters, Ph.D., Director of the Core for Imaging Technology & Education at Harvard Medical School Samantha Yammine, Ph.D., Neuroscientist and Science Communicator For additional information, please visit , or follow the conversation on Facebook, Twitter @NikonSmallWorld and Instagram @NikonInstruments. NIKON SMALL WORLD WINNERS 1st Place Dr. Bruno Cisterna & Dr. Eric Vitriol Medical College of Georgia at Augusta University Department of Neuroscience & Regenerative Medicine Augusta, Georgia, USA Differentiated mouse brain tumor cells (actin, microtubules, and nuclei) Super-Resolution 100X (Objective Lens Magnification) 2nd Place Dr. Marcel Clemens Verona, Veneto, Italy Electrical arc between a pin and a wire Image stacking for the pin and wire combined with long exposure for the electrical arcs 10X (Objective Lens Magnification) 3rd Place Chris Romaine Kandid Kush Port Townsend, Washington, USA Leaf of a cannabis plant. The bulbous glands are trichomes. The bubbles inside are cannabinoid vesicles. Image Stacking 20X (Objective Lens Magnification) 4th Place Dr. Amy Engevik Medical University of South Carolina Department of Regenerative Medicine & Cell Biology Charleston, South Carolina, USA Section of a small intestine of a mouse Fluorescence 10X (Objective Lens Magnification) 5th Place Thomas Barlow & Connor Gibbons Columbia University Department of Neurobiology and Behavior New York, New York, USA Cluster of octopus (Octopus hummelincki) eggs Darkfield, Stereomicroscopy, Focus Stacking 3X (Objective Lens Magnification) 6th Place Henri Koskinen Helsinki University Helsinki, Uudenmaan lääni, Finland Slime mold (Cribraria cancellata) Image Stacking, Polarized Light, Reflected Light 10X (Objective Lens Magnification) 7th Place Gerhard Vlcek Maria Enzersdorf, Austria Cross section of European beach grass (Ammophila arenaria) leaf Brightfield, Image Stacking 10X (Objective Lens Magnification) 8th Place Stephanie Huang Victoria University of Wellington School of Biological Sciences; School of Psychology Wellington, New Zealand A neuron densely covered in dendritic spines from the striatum of an adult rat brain Confocal, Deconvolution, Image Stacking 60X (Objective Lens Magnification) 9th Place John-Oliver Dum Medienbunker Produktion Bendorf, Rheinland Pfalz, Germany Pollen in a garden spider (Araneus) web Image Stacking 20X (Objective Lens Magnification) 10th Place Jan Martinek Charles University Department of Experimental Plant Biology Prague, Czech Republic Spores of black truffle (Tuber melanosporum) Confocal 63X (Objective Lens Magnification) 11th Place Dr. Ferenc Halmos Bánd, Veszprém, Hungary Slime mold on a rotten twig with water droplets Image Stacking 0.7X - 4.5X (Objective Lens Magnification) 12th Place Daniel Knop Oberzent-Airlenbach, Hessen, Germany Wing scales of a butterfly (Papilio ulysses) on a medical syringe needle Image Stacking 20X (Objective Lens Magnification) 13th Place Paweł Błachowicz Bedlno, Świętokrzyskie, Poland Eyes of green crab spider (Diaea dorsata) Image Stacking, Reflected Light 20X (Objective Lens Magnification) 14th Place Marek Miś Marek Miś Photography Suwalki, Podlaskie, Poland Recrystallized mixture of hydroquinone and myoinositol Polarized Light 10X (Objective Lens Magnification) 15th Place Sébastien Malo Saint Lys, Haute-Garonne, France Isolated scales on Madagascan sunset moth wing (Chrysiridia ripheus) Darkfield, Image Stacking, Reflected Light 40X (Objective Lens Magnification) 16th Place Marek Miś Marek Miś Photography Suwalki, Podlaskie, Poland Two water fleas (Daphnia sp.) with embryos (left) and eggs (right) Darkfield, Polarized Light 10X (Objective Lens Magnification) 17th Place Dr. Frantisek Bednar Svosov, Zilinsky, Slovak Republic Stonewort algae (Chara virgata) reproductive organs - oogonia (female organs) and antheridia (male organs) Darkfield 4X (Objective Lens Magnification) 18th Place Alison Pollack San Anselmo, California, USA An insect egg parasitized by a wasp Image Stacking, Reflected Light 10X (Objective Lens Magnification) 19th Place Alison Pollack San Anselmo, California, USA Seed of a Silene plant Image Stacking, Reflected Light 10X (Objective Lens Magnification) 20th Place Dr. Bruno Cisterna & Dr. Eric Vitriol Medical College of Georgia at Augusta University Department of Neuroscience & Regenerative Medicine Augusta, Georgia, USA Early stage of mouse neuroblastoma cell differentiation (actin, microtubules, and mitochondria) Super-Resolution 100X (Objective Lens Magnification) HM Christopher Algar Hounslow, Middlesex, United Kingdom Brine shrimp Darkfield, Image Stacking, Polarized Light 4X (Objective Lens Magnification) HM Dr. Kseniia Bondarenko University of Edinburgh Institute for Immunology and Infection Research Edinburgh, MidLothian, United Kingdom Acute-stage parasites of Toxoplasma gondii in a human skin cell Expansion Microscopy, Confocal, Deconvolution 100X (Objective Lens Magnification) HM Dr. Anja de Lange University of Cape Town Neuroscience Institute & Department of Human Biology Cape Town, Western Cape, South Africa Astrocytes surrounding a blood vessel in a thin slice of human brain Confocal 40X (Objective Lens Magnification) HM Dr. Amy Engevik Medical University of South Carolina Department of Regenerative Medicine & Cell Biology Charleston, South Carolina, USA Intestinal villi Fluorescence 20X (Objective Lens Magnification) HM Daniel Evrard Aywaille, Liege, Belgium Vinyl player needle on scratched vinyl disk Image Stacking, Polarized Light 20X (Objective Lens Magnification) HM Randy Fullbright Fullbright Studio Vernal, Utah, USA Agatized dinosaur bone Image Stacking 10X (Objective Lens Magnification) HM Dr. David Maitland St. Andrews, Fife, United Kingdom Transverse section of rachis (stem) of bracken fern (Pteridium aquilinum) Differential Interference Contrast (DIC) 5X (Objective Lens Magnification) HM Angus Rae Australian National University Centre for Advanced Microscopy MacGregor, Australian Capital Territory, Australia Autofluorescence in the face of a little two-spotted ladybird (Diomus notescens) Fluorescence lifetime imaging microscopy (FLIM) 20X (Objective Lens Magnification) HM Dr. Igor Robert Siwanowicz Howard Hughes Medical Institute (HHMI), Janelia Research Campus Ashburn, Virginia, USA Antenna of a mole crab Confocal 10X (Objective Lens Magnification) HM Jochen Stern Mannheim, Baden-Wuerttemberg, Germany Golden bug eggs on a sage leaf Image Stacking 20X (Objective Lens Magnification) HM Dr. Bruce Douglas Taubert Glendale, Arizona, USA Ocelli between the compound eyes of a yellow jacket Reflected Light 10X (Objective Lens Magnification) HM Kevin Terretaz CRBM-CNRS Montpellier, Hérault, France Mosquito cells in culture with fluorescent markers for DNA and microtubules Confocal 63X (Objective Lens Magnification) IoD Dr. Sherif Abdallah Ahmed Tanta University, Faculty of Science Department of Zoology Tanta, Egypt, Arab Republic Anterior section of palm weevil Image Stacking 4X (Objective Lens Magnification) IoD Anne Patricia Algar Hounslow, Middlesex, United Kingdom Mosquito larva Darkfield, Image Stacking, Polarized Light 4X (Objective Lens Magnification) IoD Dr. Florian Alonso University of Bordeaux BioTis-INSERM U1026 Pessac, Gironde, France Mouse aortic endothelium stained for beta-catenin (green), laminin (purple), smooth muscle actin (red), and Hoechst (cyan) Confocal 63X (Objective Lens Magnification) IoD Didier Barbet Club Français de Microscopie Bailly, France Fracture surface of mica (mineral) Differential Interference Contrast (DIC) 10X (Objective Lens Magnification) IoD Timothy Boomer WildMacro.com Vacaville, California, USA Slime mold (Prototrichia metallica) Image Stacking 10X (Objective Lens Magnification) IoD Zhang Chao National Astronomical Observatories, Chinese Academy of Sciences Beijing, China Beach sand Reflected Light 10X (Objective Lens Magnification) IoD Joshua Coogler Dallas, North Carolina, USA Moss sporophyte with spores (green) Image Stacking 10X (Objective Lens Magnification) IoD Nikky Corthout & Miranda Dyson VIB (Flanders Institute of Biotechnology) Center for Brain and Disease Research Leuven, Vlaams-Brabant, Belgium Fruit fly (Drosophila) brain vasculature Confocal, Fluorescence, Image Stacking, Super-Resolution 25X (Objective Lens Magnification) IoD Nadia Efimova Amicus Therapeutics Philadelphia, Pennsylvania, USA Dandelion pappus Confocal, Fluorescence 20X (Objective Lens Magnification) IoD Dr. Laurent Formery & Dr. Nathaniel Clarke Stanford University Department of Molecular and Cell Biology Pacific Grove, California, USA Nervous system of a young sea star Confocal, Fluorescence 10X (Objective Lens Magnification) IoD Karl Gaff Dublin, Ireland Larva of a midge fly (Chironomidae) Darkfield, Image Stacking, Polarized Light 20X (Objective Lens Magnification) IoD Dr. Nick Gatford University of Oxford Nuffield Department of Clinical Neurosciences (NDCN) Oxford, Oxfordshire, United Kingdom A network of dopaminergic neurons generated from human stem cells Super-Resolution 63X (Objective Lens Magnification) IoD Dr. Saikat Ghosh National Institutes of Health NICHD Bethesda, Maryland, USA Human neurons Confocal 40X (Objective Lens Magnification) IoD Gerd A. Günther Düsseldorf, Germany Cross section of a beach grass (Ammophila arenaria) leaf Fluorescence 20X (Objective Lens Magnification) IoD Anna-Mari Elisabeth Haapanen-Saaristo University of Turku Turku Bioscience Centre / Cell Imaging & Cytometry Core and Zebrafish Core RAISIO, Varsinais-Suomi, Finland Nutrient storage cells in a tardigrade Confocal 25X (Objective Lens Magnification) IoD Dr. Martin Hein Lions Eye Institute Physiology and Pharmacology laboratory Nedlands, Western Australia, Australia Abnormal blood vessel formation in a human retina with severe diabetic retinopathy Confocal 20X (Objective Lens Magnification) IoD Wen Jie Ji Yin Works The Bureau of Microworld Exploration Beijing, China Integrated circuit chip Reflected Light 10X (Objective Lens Magnification) IoD Ted Kinsman Rochester Institute of Technology Photosciences Department Rochester, New York, USA A common house cat claw Polarized Light 10X (Objective Lens Magnification) IoD Daniel Knop Oberzent-Airlenbach, Hessen, Germany Opening of a hibiscus flower (Hibiscus moscheutos) exposing the pollen in four stages, each ten minutes apart Image Stacking 20X (Objective Lens Magnification) IoD Daniel Knop Oberzent-Airlenbach, Hessen, Germany Dorsal part of cuckoo wasp (Hedychrum gerstaeckeri) abdomen Image Stacking 20X (Objective Lens Magnification) IoD Dr. Håkan Kvarnström Bromma, Sweden Peacock plume feather Epi-Illumination, Image Stacking 4X (Objective Lens Magnification) IoD Dr. Ewa Langner Washington University in St Louis Department of Medicine - Renal Division, Mahjoub Lab St Louis, Missouri, USA Mouse embryonic kidney showing interstitial fibroblasts (yellow), tubular epithelium (cyan), and nuclei (magenta) Confocal, Fluorescence, Image Stacking 40X (Objective Lens Magnification) IoD Dr. Amir Maqbool Lovely Professional University Department of Zoology Srinagar, Jammu and Kashmir, India Small fly killed by "zombie fly" fungus (Entomophthora muscae) Image Stacking 2X (Objective Lens Magnification) IoD Dr. Robert Markus University of Nottingham School of Life Sciences, Super Resolution Microscopy Nottingham, Nottinghamshire, United Kingdom Dandelion (Traxacum officinale) cross section showing curved stigma with pollen Confocal 10X (Objective Lens Magnification) IoD Dr. Robert Markus, Dr. Zeeshan Mohammad, Dr. Sarah Pashley & Dr. Rita Tewari University of Nottingham School of Life Sciences, Super Resolution Microscopy Nottingham, Nottinghamshire, United Kingdom Malaria parasites and mouse blood cells - tubulin (green), all proteins (purple), DNA (red) Confocal 63X (Objective Lens Magnification) IoD Jan Martinek Charles University Department of Experimental Plant Biology Prague, Czech Republic Spores of a black Bagnoli truffle (Tuber mesentericum) Confocal 63X (Objective Lens Magnification) IoD Dr. Guillermo Moya Johns Hopkins University Department of Biology Baltimore, Maryland, USA Neuronal axons connecting to the muscles of the iris and the cornea Confocal, Fluorescence 10X (Objective Lens Magnification) IoD Jacek Myslowski Wloclawek, Kujawko-Pomorskie, Poland Water mite (Arrenurus) Fluorescence, Image Stacking 6.3X (Objective Lens Magnification) IoD Aryah Nagarajan Falmouth University Institute of Photography Penryn, Cornwall, United Kingdom Spores releasing from the sori of a Polypody fern (Polypodium vulgare) Reflected Light, Transmitted Light, Focus Stacking 10X (Objective Lens Magnification) IoD Thomas Neumann Tübingen, Baden-Württemberg, Germany Ink dot on Japanese washi paper Brightfield, Image Stacking 20X (Objective Lens Magnification) IoD Satu Paavonsalo & Dr. Sinem Karaman University of Helsinki Individualized Drug Therapy Research Program, Faculty of Medicine, Helsinki, Finland Helsinki, Finland Blood vessels (color gradient) and endothelial cell nuclei (white) in the intestinal villi of a mouse Confocal 10X (Objective Lens Magnification) IoD Uwe Lange Hannover, Niedersachsen, Germany Pollen on the compound eyes of a fly Image Stacking 60X (Objective Lens Magnification) IoD Dr. Marko Pende MDI Biological Laboratory Murawala Lab Bar Harbor, Maine, USA Ladybug (Coccinellidae) on a clover (Trifolium repens) Confocal, Fluorescence, Image Stacking 4X (Objective Lens Magnification) IoD Dr. Felice Placenti FP Nature and Landscape Photography Siracusa, Sicilia, Italy Potato tuber sprout Image Stacking, Reflected Light 1X (Objective Lens Magnification) IoD Alison Pollack San Anselmo, California, USA Slime mold (Lamproderma arcyrioides) Image Stacking, Reflected Light 10X (Objective Lens Magnification) IoD Dr. Gonzalo Quiroga Artigas CRBM-CNRS Montpellier, Herault, France Tardigrade (Hypsibius exemplaris) Confocal 40X (Objective Lens Magnification) IoD Chris Romaine Kandid Kush Port Townsend, Washington, USA Bract (part of the plants reproductive structures) of a cannabis plant. The bulbous glands are trichomes. Image Stacking 20X (Objective Lens Magnification) IoD Dr. Adolfo Ruiz De Segovia PARTICULAR Madrid, Spain Plant root Fiber Optic 2X (Objective Lens Magnification) IoD Yurim Seo, Dr. Mark Looney & Dr. Simon Cleary University of California, San Francisco Pulmonary, Critical Care, Allergy and Sleep Medicine San Francisco, California, USA Lymphatic vasculature (cyan) and vessels (red) of a mouse lung Confocal 4X (Objective Lens Magnification) IoD Dr. Leo Serra University of Cambridge Sainsbury Laboratory Cambridge, Cambridgeshire, United Kingdom Leaves arising from thale cress (Arabidopsis thaliana) meristem Confocal 20X (Objective Lens Magnification) IoD Dr. Igor Robert Siwanowicz Howard Hughes Medical Institute (HHMI), Janelia Research Campus Ashburn, Virginia, USA Aster anther cross section with pollen grains (green) Confocal 40X (Objective Lens Magnification) IoD Dr. Igor Robert Siwanowicz Howard Hughes Medical Institute (HHMI), Janelia Research Campus Ashburn, Virginia, USA Floret of a common chicory with pollen grains (spiky balls) Confocal 40x (Objective Lens Magnification) IoD Luna Šošo Zdravković, Michael Surala & Christian Madry Charité Universitätsmedizin Berlin Institute of Neurophysiology Berlin, Germany Pyramidal neuron in mouse hippocampus Confocal, Fluorescence, Image Stacking 30X (Objective Lens Magnification) IoD Dr. Bruce Douglas Taubert Glendale, Arizona, USA Mid-tibial tuft on a male orchid bee, used to attract mates Reflected Light 10X (Objective Lens Magnification) IoD Maxime Teixeira Laval University Department of Molecular Medicine Québec, Canada Cultured monkey kidney cells labeled for tubulin (blue) and actin (orange) showing pathological accumulation of alpha-syn aggregates (red) Confocal, Deconvolution, Image Stacking, Super-Resolution 100X (Objective Lens Magnification) IoD Dr. Theo Theune Oost-Souburg, Zeeland, Netherlands Abdominal skin of a tick that engorged with blood Image Stacking 50X (Objective Lens Magnification) IoD Dr. Grigorii Timin & Dr. Michel Milinkovitch University of Geneva Department of Genetics and Evolution Geneva, Switzerland Skin scales of a snake embryo stained with Fast Green dye Confocal 63X (Objective Lens Magnification) IoD Steven A. Valley Oregon Department of Agriculture (ODA) Entomology Lab Albany, Oregon, USA Immature male damselfly (Calopteryx aequabilis) Image Stacking, Reflected Light 5X (Objective Lens Magnification) IoD Dr. Bruno Vellutini Max Planck Institute of Molecular Cell Biology and Genetics Dresden, Saxony, Germany Gene expression patterns in a drain fly embryo (Clogmia albipunctata) with an open eggshell Confocal 20X (Objective Lens Magnification) IoD Susannah Waxman & Dr. Ian Sigal University of Pittsburgh Department of Ophthalmology Pittsburgh, Pennsylvania, USA Optic nerve head collagen of a pig Image Stacking, Multiphoton 25X (Objective Lens Magnification) IoD Shao Yang Beijing Miteyide Culture Co., Ltd. Beijing, China Fiber of nylon stockings Polarized Light 5X (Objective Lens Magnification) IoD Chew Yen Fook Woodend, Waimakiriri, New Zealand Graffiti from Berlin Wall stone section Image Stacking, Top Illumination 10X (Objective Lens Magnification) IoD Chew Yen Fook Woodend, Waimakiriri, New Zealand Water mite (Hydrachna sp.) Darkfield, Image Stacking, Polarized Light 20X (Objective Lens Magnification) IoD Elkhan Yusifov & Dr. Martina Schaettin University of Zurich Department of Molecular Life Sciences Zurich, Switzerland Developing nervous system in the eye of a 7-day-old chick embryo Stereomicroscopy 10X (Objective Lens Magnification) IoD Ou Zhilei Guangdong Radio and Television Guangzhou, Guagndong, China Stamens of flowers (Anemone cathayensis Kitag. ex Ziman & Kadota) Image Stacking 10X (Objective Lens Magnification) About Nikon Small World Photomicrography Competition The Nikon Small World Competition is open to anyone with an interest in photography or video. Participants may upload digital images and videos directly at . For additional information, contact Nikon Small World, Nikon Instruments Inc., 1300 Walt Whitman Road, Melville, NY 11747, USA, or phone (631) 547-8569. Entry forms for Nikon's 2025 Small World and Small World in Motion Competitions are available at . About Nikon Instruments Inc. Nikon Instruments Inc. is the US microscopy arm of Nikon Healthcare, a world leader in the development and manufacturing of optical, digital imaging technology and software for biomedical applications. For more information, please visit or contact us at 1-800-52-NIKON. SOURCE Nikon Instruments Inc. WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

2024年9月23日-24日，2024生物制造中试平台建设的思路和方案培训分别在中国科学院天津工业生物技术研究所和华熙生物科技股份有限公司天津中试成果转化平台顺利开展。内容扎实的议题设计、理论学习与实践参观相结合的课程安排吸引了来自政府园区、上市企业、科研院所、初创企业及产业链供应商等产业各界同仁的极大关注，首期培训超额容纳100余人到场参会。培训干货满满、交流氛围热烈，获得与会人员的一致好评。 图：超百位业界同仁到场参会 据悉，本次培训由动脉网联合中国科学院天津工业生物技术研究所、华熙生物、芳博士共同推出，旨在依托全国顶尖院所、龙头企业的成熟经验，帮助生物制造相关企业解决中试平台建设和产能放大当中可能遇到的问题。集聚各方“巨人”之力，一把攀越“死亡之谷”。自首轮通知发布到培训启动仅仅用时十天，报名量远超课程设计名额1倍以上，可见生物制造行业苦中试平台建设之困已久，亦可见本次培训课题切中行业之需尤准。 据组委会最新消息，首期报名盛况远超预期，由于场地有限而让部分同仁遗憾错过本期内容。鉴于行业同仁的迫切需求，第二期培训将于近期尽快开展，有需要、感兴趣的同仁可扫描下方二维码预报名，我们将第一时间联系。 同时也欢迎生物制造（含合成生物学）上下游产业链、供应链企业参展或宣传赞助。 第一日：从框架到模块，孙际宾、夏建业、付绍平三位专家带来纯干货指导 23日一早，百余位与会代表从全国各地抵达中国科学院天津工业生物技术研究所，首日的课程从孙际宾研究员提纲挈领的主题报告引入。 图：孙际宾研究员做主题报告 孙际宾，系中国科学院天津工业生物技术研究所研究员，系统生物学中心主任，政府特殊津贴获得者，中国科学院特聘研究员，中国科学院重要人才计划入选者，天津市劳动模范。从事系统与合成生物技术研究，发表SCI论文150篇，国内外授权发明专利70项，长期领导研究所平台建设。本次培训作《中试平台建设运行总体思路》主题分享。 从“什么是生物制造”讲起，孙际宾研究员系统地介绍了生物制造产业发展趋势、国内外形势比对和生物制造中试平台的重要性、定位和职能、建设内容与总体框架、运行模式与可持续发展等内容，为与会代表建立了中试平台建设和运行的总体思路，为后续的培训打下坚实的认知框架基础。 图：孙际宾研究员分享现场 孙际宾研究员提到，从规模来看，绝大多数有机化合物可以生物合成，生物制造将成为一种新的物质生产方式，“生物制造+”将重塑物质合成的工业基础；从体量来看，生物经济未来可达数万亿美元，未来十年将迎来生物制造产业的井喷式发展；从国际形势来看，IT+BT正是第四次工业革命的核心，正在改变人们的生活方式，美国已在2022年颁布总统行政令，发起“国家生物技术和生物制造行动”，全球生物制造产业已然进入激烈竞争阶段。 尽管生物制造产业还面临着菌种获取难，发酵、分离、提取、放大等工艺难等诸多挑战，但挑战总是与机遇并存，孙际宾研究员也对与会代表鼓励到：“正是我们在座各位的机会！” 紧接着，夏建业研究员作《面向智能化的生物制造中试平台》主题分享。 图：夏建业研究员做主题报告 夏建业研究员，系中国科学院天津工业生物技术研究所智能生物制造中心主任。师从张嗣良教授，中国科学院重要人才计划入选者，天津市领军人才，中国微生物学会生化过程模型化与控制专委会副主任委员。曾提出基于反应器流场和细胞生理相结合的发酵过程优化放大方法，在国内多家生物制造企业获得应用，曾获国家科技进步二等奖1项。 夏建业研究员深度扎根高通量发酵模块的相关研究。本次分享，他从生物制造中试平台建设的重要意义、高通量发酵优化是解决瓶颈的关键硬件系统和软件技术、生物制造中试平台建设中的数字化与智能化、生物制造中试平台建设对人才的需求、生物制造中试平台运营机制思考六大方面进行了长达3个小时的上下半场解析。 图：夏建业研究员分享现场 从发酵过程优化与放大的三个关键科学问题、生物制造中试平台的基本组成详解，到智能生物制造中试平台建设的思路、中试平台运行机制的8个方面，内容周全详尽，理论与思考并行，引发了与会代表的积极讨论与互动。 而后，付绍平正高级工程师从后处理模块进行了《生物制造中试平台后处理模块的建设背景、挑战及解决方案》主题分享。 图：付绍平正高级工程师做主题报告 付绍平系中国科学院天津工业生物技术研究所智能生物制造中心正高级工程师，中国化学会高级会员，主要从事生物发酵产品分离与纯化工艺研究，先后主持天津市科技支撑计划重点项目和国家重点研发计划项目，负责完成番茄红素、肌醇、原儿茶酸等三十多个产业化项目的分离纯化工艺开发，产生显著经济价值。 付绍平正高级工程师在发酵后处理模块进行了大量的工艺开发与实践研究，有着非常丰富的项目经验。本次分享，他从生物制造中试平台后处理模块建设背景、设备选型、项目服务、产品案例、技术体系以及数字化、柔性化、智能化生物制造中试平台六大方面进行理论分析与案例拆解相结合、鞭辟入里地讲授。 图：付绍平正高级工程师分享现场 他从斯托克斯定律开始讲起，解析离心设备选型原则，一一拆解发酵分离纯化（后处理）工程技术体系的“四梁八柱”；直面发酵中试平台后处理模块当前现状，以案例引出问题解决之道。付绍平正高级工程师的讲授充满激情，与会代表们纷纷表示收获满满，不少内容能够直接解决当前遇到的现实问题。 图：芳博士主持晚宴答疑 交流环节，与会代表充分沟通了业务产品和合作契机，在芳博士的主持下，不少“课堂提问”也得到了专家们的解答。 图：夏建业研究员晚宴中就与会代表提问进行答疑 据悉，与会代表共提出了38组超60个问题，问题的题面显示出政府园区、初创企业等不同身份的从业者当前面临的诸多挑战，对于在场的设备供应商、产业链上下游企业伙伴而言，亦看到了不少商机。与会代表兴致勃勃，交流长达两个半小时才携兴而归，氛围热烈。 第二日：深度走进华熙生物建设的全球最大中试转化平台 图：参会代表在华熙生物中试成果转化平台留影 24日，百余位与会代表走进华熙生物中试成果转化中心，这一斥资数十亿、占地3万平方米、拥有64条中试生产线的合成生物中试转化平台堪称全球最大的中试转化平台，历时6年终于全面竣工投产，通过“模块化”和“抽屉式”的先进理念优化中试环节，可承接医药级、护肤品级、食品级等多种生物活性物原料产品的中试及小规模商业化生产。 图：华熙生物董事长兼总裁 赵燕女士 值得一提的是，华熙生物董事长赵燕女士惊喜亮相培训会场，她向与会代表们表示：该中心不仅致力于推动华熙生物内部研发成果的中试转化，更以“平台化”的模式向全社会开放，提供生物制造中试转化服务。 图：王恩旭总助做主题分享 华熙生物中试成果转化中心总经理助理王恩旭首先向与会代表作该平台的建设和运营详细介绍。他从华熙生物中试平台建设的意义与定位、特点与能力、服务模式与优势以及未来展望四大方面展开。据介绍，华熙生物中试成果转化平台定位“助力实现技术成果的产业转化，打造成为产学研一体化的示范平台基地。”具有柔性化、平台化、数字化的特点，面向全行业实行“模块化”、“抽屉式”、“平台化”的开放合作模式。在未来，华熙生物希望构建一个“AI人工智能”+“生物制造大数据库”+“柔性化生产技术的中试平台”三位一体的“超级大脑”。 图：夏小乐教授做主题报告 夏小乐教授亦受邀莅临华熙生物，为与会代表作《面向食品领域的生物制造应用开发平台建设思路及解决方案》主题分享。 夏小乐教授系天津科技大学食品科学与工程学院学术院长，江南大学生物工程学院博导，长期从事基于生物和智能制造的功能食品和酿造的工艺和装备研究，着力打造全链条绿色智能制造系统集成。近5年主持国家级项目8项，荣获农业农村部国家级青年人才“神农青年英才”、国家重点研发计划项目首席科学家等称号。 夏小乐教授字字诤言，他坦言，对于体量不太大、资金力量不太雄厚的初创企业而言，相较于医药赛道的耗时耗资大体量，食品赛道或许是个好赛道，且食品行业正在面临生产方式和消费方式的变化期，机会更加丰富。在本次的分享中，夏小乐教授从食品领域的生物制造应用开发平台建设的背景与挑战、食品领域的生物制造应用开发平台技术研究与创新、食品领域生物制造平台的智能搭建和总结与展望四大方面展开，他提到：关键生物技术创新、新型食品配料、智能化生产、可持续发展和法规完善将促进食品产业转型升级，生物技术创新驱动，将引领食品产业新纪元。 图：与会代表参观华熙生物生物制造5.0科技馆 24日下午，华熙生物中试成果转化中心两位资深工艺总监薛国希和荣金雷分别从《面向妆品级、医药级产品生物制造应用开发平台建设思路及解决方案》和《生物制造相关产品的应用开发案例》作精彩分享。 图：薛国希总监做主题分享 薛国希总监主要从妆品、医药领域的生物制造应用开发平台建设的背景与挑战，妆品、医药领域中试生物制造平台的智能搭建思路和平台搭建的关键点等内容展开，他提到，当前妆品、医药生物制造平台建设主要面临技术、市场、政策与法规以及资金等方面的挑战，但平台要有科学合理的布局、配套的架构、相应的质量体系，要能够很好地解决污染和交叉污染，是薛国希总监认为妆品、医药领域生物制造平台运行过程中的关键所在。 图：荣金雷总监做主题分享 荣金雷总监则主要从中试放大需具备的条件、中试放大过程中常见问题以及华熙生物中试案例等内容详细分享了个中经验。本次与会代表中，很大一部分是各企业的研发岗位工作人员，对于荣金雷总监的分享，他们表示十分实用。 活动当天，华熙生物董事长赵燕女士也惊喜亮相培训会场，与参会代表们进行简短交流。赵燕女士热情洋溢，她提到，建设华熙生物中试成果转化平台的主要目的，是看到生物制造进入5.0时代之后，中试在科研成果到产业化之间的重要作用，“华熙生物作为一家生物制造行业的领军企业要积极承担企业责任，华熙生物投资数十亿，目的就是加速科研成果的产业转化，并向社会开放，打造一个生态链，赋能整个行业的发展。” 赵燕女士表示：“中国如何在生物制造行业取得领先地位？中试成果转化是最关键最核心的枢纽环节。希望今后能够与在座各位加强紧密合作，共同构建一个共生共赢的生态链。” 为期两天的2024生物制造中试平台建设的思路和方案培训在这一惊喜中正式落下帷幕，与会代表们满载而归，纷纷好评。 最后再次提醒行业同仁，如果您也身处生物制造这一充满希望的赛道，如果您也希望科学地规划、建设、运营中试平台，可以扫描下方二维码预报名，第二期培训将于近期尽快开展，我们将第一时间与您联系。 同时也欢迎生物制造（含合成生物学）上下游产业链、供应链企业参展或宣传赞助。 近 期 推 荐 声明：动脉网所刊载内容之知识产权为动脉网及相关权利人专属所有或持有。未经许可，禁止进行转载、摘编、复制及建立镜像等任何使用。 动脉网，未来医疗服务平台