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更新于：2025-03-09
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100 项与 雅培贸易（上海）有限公司 相关的临床结果
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2018-11-01Wei sheng yan jiu = Journal of hygiene research
[Applicability of methods for determination of iodine in nutrition formula].
Article
作者: Liu, Guihua ; Zhang, Huimin ; Tian, Fang ; Chen, Lei ; Song, Chang ; Guan, Yan
OBJECTIVE:
The applicability of both inductively coupled plasma mass spectrometry( ICP-MS) and gas chromatography( GC) method to accurately determine iodine in dairy products with different matrices was assessed.
METHODS:
The performance of ICP-MS iodine method for dairy products has been validated by assessing its linearity, precision, accuracy, limit of detection( LOD) and limit of quantity( LOQ) in various food matrices. Both GC and ICP-MS method were used to determine iodine in samples with 7 different types of matrices, including milk base formula, low lactose formula, partially hydrolyzed protein formula, soy protein contained formula, high protein formula, deeply hydrolyzed protein formula and complete nutrition formula( mixed protein sources). The testing result were compared, and the root cause of the result difference between the two method was further investigated and discussed.
RESULTS:
The ICP-MSmethod showed a good precision and accuracy in different types of dairy products. The experiments demonstrated that the result differences were less than 11% between two method in milk base formula. The GC result were typically 10%-20% lower than the ICP-MS result in most foods for special medical purpose( FSMP) products. One extreme case occurred in the complete nutrition formula sample, in which the GC result was71. 1% lower than the ICP-MS result. By testing the iodine distribution by ICP-MS after each step of sample preparation of the GC method, most iodine in this formula has been removed during the protein precipitation step, causing the extremely low iodine recovery.
CONCLUSION:
ICP-MS method is more robust and has larger applicable scope, which is more suitable for the routine test of iodine in FSMP products.
Lihua Jianyan: Huaxue Fence/Physical Testing and Chemical Analysis Part B:Chemical Analysis
HPLC determination of cordycepin in nutrition products
作者: Li, Shan ; Zheng, Guojian
A high performance liquid chromatog. (HPLC) method was developed to determine cordycepin in nutrition products.The sample (10.00 g) was dissolved in water to make 50.00 g of solution2.50 G of the solution was mixed well with 30 mL water and then 1.0 mL of 30.0 g·L-1 metaphosphoric acid solution was added into the solution to precipitate the interference substances.The supernatant was separated on Phenomenex Gemini C18 chromatog. column (250 mm×4.6 mm, 5μm), with a mixture of acetonitrile and water as mobile phase for gradient elution.Cordycepin was detected with UV detector at the wavelength of 260 nm.Linear relationship was found between the peak area and the mass concentration of cordycepin in the range of 0.05-1.00 mg·L-1, with lower limit of determination (10S/N) of 5.0 mg·kg-1.Recovery rates obtained by standard addition method were in the range of 100%-102% and RSDs (n=6) were less than 5.0%.
Shipin Anquan Zhiliang Jiance Xuebao
Direct quantification of RRR-α-tocopherol in milk powder by chiral liquid chromatography
作者: Wang Mei-bo ; Song Chang ; Karen J. schimpf
Objective To establish a method for directly determining RRR-α-tocopherol in milk powder by chiral liquid chromatog.Methods The samples were saponified with potassium hydroxide and extracted with petroleum ether-iso-Pr ether.DAICEL Chiralcel OD-3(2.1 mmx150 mm, 3 μm) was directly separated on a small particle size cellulose derivative chiral column, and isocratic elution was performed using absolute ethanol-n-hexane(5:995, V:V)(A) and triethylamine-n-hexane(5:995, V:V)(B)(A:B=10:90) as the mobile phases, with the flow rate of 0.2 mL/min, the column temperature of 30 °C, the detection wavelength of 294 nm, and the quantification by external standard method.Results The resolutions of RRR-α-tocopherol and other α-tocopherol isomers were greater than 1.2.The linearities were good within the range of 0.5-50 μg/mL, with the correlation coefficient greater than 0.999.The limit of detection was 0.20 mg/100 g, and the limit of quantitation was 0.60 mg/100 g.The recoveries after standard addition were 95.0%-109.4%, and the relative standard deviation was 2.7%.Conclusion This method is rapid, accurate and sensitive, and is suitable for the determination of RRR-α-tocopherol in milk powder.
2023-05-04
2023-03-09
2023-03-07
100 项与 雅培贸易（上海）有限公司 相关的药物交易
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100 项与 雅培贸易（上海）有限公司 相关的转化医学
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