Removal of protein aggregates from biol. products is critical due to their potential to increase antigenic response and its neg. impact on the patients. Aggregates can be formed during upstream operations, and aggregation can also occur during downstream when suboptimal purification parameters are selected. Once formed, aggregate removal and/or reduction becomes challenging for the downstream purification process development team. Chromatog. is the most common technol. used today for aggregate removal; however, chromatog. is time consuming, requires several buffers, method development, and use of costly technol. such as purification skids and columns. SystImmune and Sartorius is exploring an alternate technique exploiting the Virosart Max filter. The Virosart Max is an optimized triple-layer polyamide 0.1 μm pre-filter specifically designed to remove aggregates and protect the expensive downstream virus removal filter. The Virosart Max will be operated in a simple flow through mode to demonstrate aggregate reduction in a bi-specific antibody model. This filter based aggregate removal strategy would offer simple buffer preparation, minimal process development, and the option to replace costly chromatog. skids with inexpensive pumping equipment. The work to date is promising and results and methodol. will be presented.