The single-arm, multicentre, open-label, dose expansion Phase I clinical trial would aim to evaluate the safety and efficacy of LBL-034 in patients with r/r multiple myeloma who have received prior treatment. Image Credit: Nemes Laszlo / Shutterstock.
Nanjing Leads Biolabs chief medical officer Dr Charles Cai said in a press release: “LBL-034 adopts a unique molecular design, which enables the drug to specifically bind to GPRC5D-expressing tumourGPRC5D-expressing tumour cells with high affinity and reduces the risk of non-specific activation of T-cells, thereby enhancing anti-tumour efficacy and reducing the potential risk of immunotoxicity.”
“LBL-034 demonstrated robust anti-tumour activities and good safety profile in pre-clinical studies.”
The single-arm, multicentre, open-label, dose-expansion Phase I clinical trial would aim to evaluate the safety and efficacy of LBL-034 in patients with R/R multiple myeloma who have received prior treatment. The additional aim of the first-in-human study is to determine the Phase II recommended dose.