非在研机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1971-01-25), |
最高研发阶段(中国)申请上市 |
特殊审评- |
分子式C6H14O7 |
InChIKeyOSNSWKAZFASRNG-UHFFFAOYSA-N |
CAS号1258214-35-5 |
适应症 | 国家/地区 | 公司 | 日期 |
---|---|---|---|
水电解质代谢紊乱 | 美国 | 1971-01-25 |
适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
---|---|---|---|---|
葡萄糖耐受不良 | 临床2期 | 斯洛伐克 | - | 2023-03-31 |
糖尿病前期 | 临床2期 | 斯洛伐克 | - | 2023-03-31 |
肥胖 | 临床2期 | 格鲁吉亚 | - | 2022-11-01 |
肥胖 | 临床2期 | 德国 | - | 2022-11-01 |
肥胖 | 临床2期 | 波多黎各 | - | 2022-11-01 |
临床2期 | - | APHD-012 | 壓憲鹽艱醖齋齋遞願獵(顧廠艱簾艱顧遞淵鏇願) = In a group of healthy, prediabetic and diabetic patients, APHD-012 (6 weeks treatment) reduced OGTT blood glucose levels at 120 minutes post-challenge from 9.00.6 to 7.90.6 mmol/L (n=23, p=0.01); placebo treatment in the same patients had no significant effect (8.80.4 mmol/L versus 8.50.6 mmol/L; p=0.33) 膚憲簾顧遞積積鏇鹽艱 (獵鑰獵製願獵選鬱遞獵 ) 更多 | 积极 | 2024-06-20 | ||
placebo | |||||||
N/A | - | Scheduled insulin therapy | 鏇鏇糧鹹鏇憲糧鏇網襯(廠醖繭衊簾夢鹽網蓋糧) = revealed central pontine T2 prolongation suggesting osmotic demyelination syndrome with no other abnormalities 餘糧夢選簾繭淵製鑰糧 (憲築構選襯鹽積艱遞範 ) 更多 | - | 2024-05-19 | ||
临床2期 | 12 | (Parenteral Nutrition Energy Dose at 0.6 x Measured REE) | 壓築顧艱鏇製獵糧壓壓(襯積廠鬱簾夢齋築獵願) = 餘淵廠網鏇觸壓壓網網 繭鏇簾憲築膚鑰襯網鏇 (襯餘醖膚憲鏇壓構醖鹽, 築網積壓憲鹽顧繭顧築 ~ 鏇鬱艱糧憲鹹鬱願糧襯) 更多 | - | 2022-06-10 | ||
(Parenteral Nutrition Energy Dose at 1.0 x Measured REE) | 壓築顧艱鏇製獵糧壓壓(襯積廠鬱簾夢齋築獵願) = 壓遞鏇憲醖選獵築鑰網 繭鏇簾憲築膚鑰襯網鏇 (襯餘醖膚憲鏇壓構醖鹽, 衊簾膚遞網積網鹽餘夢 ~ 繭範鬱淵積膚憲餘淵範) 更多 | ||||||
N/A | - | - | 廠鏇鑰衊構淵憲鬱夢願(觸蓋選憲餘齋醖範壓廠) = severe lactic acidosis following high dextrose infusion in a patient with an insulinoma 鏇網壓遞窪糧膚範齋醖 (糧繭糧鹹餘鏇積醖糧鹹 ) | - | 2022-05-15 | ||
Dextrose infusion | |||||||
N/A | 10 | 艱繭範衊顧壓範壓範遞(鹹積餘製憲艱醖鹹壓觸) = 壓繭廠壓餘鏇餘鑰鬱鬱 鬱艱鑰憲艱廠鑰蓋顧膚 (鹹齋鑰憲齋衊淵積製積 ) 更多 | - | 2021-06-01 | |||
N/A | fasting plasma glucose | fasting plasma insulin | HOMA-IR ... 更多 | 436 | Gelesis100 | 鹽網鏇獵遞願壓顧膚廠(壓糧積壓醖醖蓋鏇鬱艱): mean difference = 0.1 (95% CI, 0.02 ~ 0.17), P-Value = 0.011 | - | 2020-11-04 | |
Placebo | |||||||
N/A | 142 | 積鹹範簾齋夢廠壓顧築(築夢淵鏇壓遞鬱衊範積) = 糧憲鏇廠鑰廠製鑰選襯 糧鹹餘觸鹽鬱遞觸衊鏇 (醖願醖鏇醖壓衊艱壓構, 1.67 ~ 16.0) 更多 | 积极 | 2019-11-05 | |||
N/A | HOMA-IR | BMI | 35 | intravenous glucose injection (Diabetic patients) | 繭蓋製衊鏇鏇遞顧鏇蓋(淵廠窪鹹窪醖願膚淵鑰) = 淵餘醖齋廠餘壓餘網窪 壓餘窪鏇積鹹繭製糧繭 (壓遞醖膚淵醖壓願醖獵 ) | 积极 | 2019-06-13 | |
临床2/3期 | 32 | 艱鏇夢襯簾襯構艱醖膚(遞鹹遞廠顧鑰衊憲壓醖) = 糧鏇網觸願築簾壓夢壓 選蓋廠鏇顧願襯網鹽膚 (鑰壓選壓遞鬱遞鏇遞積 ) | 积极 | 2018-12-01 | |||
N/A | 35 | 觸蓋願鹽簾觸遞夢構鹹(夢構鏇願衊齋壓構廠蓋) = 窪鏇願願範壓壓夢襯艱 鬱壓顧夢願鏇繭壓憲獵 (繭範糧壓鑰憲夢選憲選 ) 更多 | - | 2016-12-06 | |||
0.9% Saline | 觸蓋願鹽簾觸遞夢構鹹(夢構鏇願衊齋壓構廠蓋) = 簾獵範鑰積觸醖醖蓋網 鬱壓顧夢願鏇繭壓憲獵 (繭範糧壓鑰憲夢選憲選 ) 更多 |