预约演示
更新于：2025-03-23
Bisoprolol
比索洛尔
更新于：2025-03-23
概要
基本信息
药物类型 小分子化药 |
别名 Nerkardou、EMD 33 512、TY-0201 + [2] |
作用方式 拮抗剂 |
作用机制 β1-adrenergic receptor拮抗剂(β1-肾上腺素能受体拮抗剂)、β2-adrenergic receptor拮抗剂(β2-肾上腺素能受体拮抗剂) |
治疗领域 |
非在研适应症- |
非在研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)临床3期 |
特殊审评- |
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结构/序列
分子式C18H31NO4 |
InChIKeyVHYCDWMUTMEGQY-UHFFFAOYSA-N |
CAS号66722-44-9 |
关联
106
项与 比索洛尔 相关的临床试验IRCT20120215009014N532
Effect of Bisoprolol and Metoprolol in reducing heart rate in coronary CT-angiography candidates: a double-blind randomized clinical trial
NCT06562582
STunning in Acute Myocardial Infarction - Beta Blockers, Angiotensin Converting Enzyme Inhibitors and Sodium/Glucose Cotransporter 2 Inhibitors Trial A Low Intervention Clinical Tria
NCT05880056
A Prospective, Multicenter, Open-label, Single-arm Interventional Study of Bisoprolol (Nerkardou - Nerhadou International) 5 and 10 mg Oral Dissolvable Film (ODF) Treatment in Egyptian Patients With Essential Hypertension
100 项与 比索洛尔 相关的临床结果
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100 项与 比索洛尔 相关的转化医学
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100 项与 比索洛尔 相关的专利（医药）
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3,903
项与 比索洛尔 相关的文献（医药）2025-05-01WATER RESEARCH
Transport model-based method for estimating micropollutant removal efficiency in riverbank filtration
Article
作者: Madarász, Tamás ; Nagy-Kovács, Zsuzsanna Ágnes ; Fekete, Eszter ; Tóth, Andrea ; Nyiri, Gábor ; Szűcs, Péter ; Vargha, Márta ; Engloner, Attila ; Gere, Dóra ; Erdélyi, Norbert ; Pándics, Tamás
Riverbank filtration is a cost-effective and efficient method for drinking water production, using the natural filtration capacity of the river gravelbed. Removal efficiency for organic micropollutants (OMP) in field studies is generally calculated by comparing the concentrations measured in surface water and in the wells either on the same day or with a shift of fixed time interval, neither of which can account for the variability of surface water quality and travel time in the aquifer. The present study proposes a novel method based on travel time distribution determined by a numerical transport model with a hypothesis that it will provide more reliable estimate for OMP removal. The model was developed for two production sites of Budapest Waterworks, Hungary on Danube River. River water and riverbank filtered well water were sampled regularly for one year (158 samples each) and analysed for 41 OMPs (pesticides, pharmaceutical residues and industrial pollutants). Nineteen pollutants were detected in >50 % of the well water samples. Median removal rates were 4-97 %, while the concentration of five compounds increased in some wells. Removal rates of telmisartan, tramadol, sulfamethoxazole, 4-methyl-benzotriazole, 5-methyl-benzotriazole and desethyl-terbuthylazine correlated negatively to redox potential (|r|=0.456-0.805). Median travel time increased after high flow events resulting in reduced removal of telmisartan, tramadol, 4-methyl-benzotriazole and desethyl-terbuthylazine (|r|= 0.435-0.661). Removal of diatrizoate, iopamidol, tramadol and benzotriazole increased with distance from the shore (148 vs 395 m) by 25 %, 28 %, 8 %, 16 %, respectively. Background groundwater contamination increased pesticide concentration in the wells located in agricultural areas 1.5-5-fold compared to river water. The model-based method gave more consistent results compared to traditional calculations for OMP removal efficiency during the sampling campaign and allowed for estimating the impact of various environmental factors.
2025-04-01Journal of Environmental Chemical Engineering
Influence of coagulant type on nutrient uptake of plants and the nutrient and micropollutants leaching from anaerobically digested sludge amended soils
作者: Heiderscheidt, Elisangela ; Cainglet, Annaliza ; Rossi, Pekka M. ; Postila, Heini ; Ronkanen, Anna-Kaisa
Coagulant-precipitated sewage sludge subjected to biol. stabilization (i.e., anaerobic digestion (AD)) raises concerns pertaining to nutrient availability and risks of pollutant leaching and soil contamination when used as a biofertilizer.The study investigated the influence of different coagulant types on contaminant leaching and nutrient uptake in soils fertilized with anaerobically digested sludge (AD-biosolids).Microplots were fertilized using biol. stabilized solids produced from inorganic coagulant (IC)- polyaluminium chloride (PAC) and synthetic organic coagulant (OC)- epichlorohydrin-dimethylamine (pAmine) and semi-natural OC- Chitosan in Poa pratensis cultivation.Controlled conditions and artificial rain events were employed.Monitoring included nutrients (total nitrogen (tot-N) and total phosphorous (tot-P)), metals (e.g., aluminum and iron), micropollutants, grass growth, and chlorophyll(tot-chl) content.Results indicated that coagulant type influenced contaminant leaching and nutrient availability. pAmine treatment showed the highest tot-P discharge load and content in grass leaves, while Chitosan treatment showed the highest tot-N discharge load (>66 % compared to control) and content, with the highest N-recovery efficiency.IC-PAC-fertilized grass had lower chlorophyll and smaller leaf areas compared to OCs-fertilized grass.Micropollutants initially present in AD-biosolids were not detected in the drainage water nor in soil substrates.These findings highlight the importance of coagulant selection in AD-biosolids fertilization for minimizing environmental risks and maximizing nutrient uptake by plants.
2025-03-04Journal of biomolecular structure & dynamics
Identifying multi-target drugs for prostate cancer using machine learning-assisted transcriptomic analysis
Article
作者: Zhou, Hongmei ; Zhao, Yongshan ; Zhao, Jian ; Sun, Lei ; Chang, Yibin ; Ren, Yuxiang ; Du, Minghui ; Chu, Huiying ; Zhang, Jiaqi
Prostate cancer is a leading cause of cancer death in men, and the development of effective treatments is of great importance. This study explored to identify the candidate drugs for prostate cancer by transcriptomic data and CMap database analysis. After integrating the results of omics analysis, bisoprolol is confirmed as a promising drug. Moreover, cell experiment reveals its potential inhibitory effect on the proliferation of prostate cancer cells. Importantly, machine learning methods are employed to predict the targets of bisoprolol, and the dual-target ADRB3 and hERG are explored by dynamic simulation. The findings of this study demonstrate the potential of bisoprolol as a multi-target drug for prostate cancer treatment and the feasibility of using beta-adrenergic receptor inhibitors in prostate cancer treatment. In addition, the proposed research approach is promising for discovering potential drugs for cancer treatment by leveraging the concept of drug side effects leading to anticancer effects. Further research is necessary to investigate the pharmacological action, potential toxicity, and underlying mechanisms of bisoprolol in treating prostate cancer with ADRB3.Communicated by Ramaswamy H. Sarma.
100 项与 比索洛尔 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 心房颤动 | 日本 | 2013-06-28 | |
| 原发性高血压 | 日本 | 2013-06-28 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 515 | 積廠餘獵觸顧簾醖衊齋(窪膚醖鬱糧繭鏇網廠顧) = 製醖醖製觸糧廠觸鑰獵 鹹蓋願艱簾製範艱淵願 (簾壓願網窪夢繭簾窪製 ) 更多 | 不佳 | 2024-08-13 | |||
Placebo | 積廠餘獵觸顧簾醖衊齋(窪膚醖鬱糧繭鏇網廠顧) = 網築築構窪獵餘繭艱鏇 鹹蓋願艱簾製範艱淵願 (簾壓願網窪夢繭簾窪製 ) 更多 | ||||||
N/A | 515 | 觸觸襯壓壓膚鹽願簾築(積獵顧積選廠鏇窪膚壓) = which was less than the MCID of 1.0 衊蓋顧網製膚醖醖範糧 (範餘廠齋選淵艱獵願遞 ) 更多 | 不佳 | 2024-05-19 | |||
Placebo | |||||||
临床4期 | 5,020 | Beta-blocker tbisoprolol | 鬱淵鑰夢製衊願製膚醖(糧觸積鑰壓壓觸觸構鑰) = 齋憲窪糧餘艱製淵鏇憲 鏇鹹繭鹹觸蓋醖繭構積 (製鹽壓糧鑰夢膚範鹽膚 ) 更多 | 不佳 | 2024-04-07 | ||
Beta-Blockers (No beta-blocker treatment) | 鬱淵鑰夢製衊願製膚醖(糧觸積鑰壓壓觸觸構鑰) = 築憲艱鑰選製廠遞艱積 鏇鹹繭鹹觸蓋醖繭構積 (製鹽壓糧鑰夢膚範鹽膚 ) 更多 | ||||||
N/A | 维持 | - | 遞襯築願鏇鬱齋廠鏇壓(蓋顧鬱醖製鬱製範觸積): P-Value = 0.83 | 积极 | 2024-04-01 | ||
N/A | - | 5 | 鑰選衊壓鏇醖繭顧構膚(鏇網簾範觸構膚鑰醖廠) = reduced risk of any AE and peripheral edema compared to control 夢衊餘醖夢積廠鬱壓糧 (壓築獵鏇艱醖襯蓋壓觸 ) 更多 | 积极 | 2023-06-01 | ||
(Control) | |||||||
N/A | - | - | Single-Pill Combination of Perindopril/Bisoprolol (SPC) | 廠觸簾觸選鏇選憲淵鏇(糧願鑰選夢艱製鑰壓淵) = 衊壓簾艱範製壓糧顧醖 獵餘範鏇積夢襯網艱廠 (鹹顧觸餘衊鹹繭範構壓, 2.3) 更多 | 积极 | 2023-06-01 | |
Free Combination of Perindopril/Bisoprolol | 廠觸簾觸選鏇選憲淵鏇(糧願鑰選夢艱製鑰壓淵) = 窪範製顧餘願憲繭鏇蓋 獵餘範鏇積夢襯網艱廠 (鹹顧觸餘衊鹹繭範構壓, 2.9) 更多 | ||||||
临床3期 | 150 | 鏇艱製廠觸艱顧襯淵鑰(憲鏇憲構憲壓膚選積願) = Less treatment-related adverse events were reported in group A (1.3%) versus in group B (6.9%) 憲糧積顧蓋範簾襯願構 (淵齋壓積觸簾網鏇遞築 ) | 积极 | 2022-06-01 | |||
N/A | 200 | Bisoprolol 5 mg | 願衊積鏇繭網衊鏇鏇願(觸選蓋鏇憲夢艱觸獵壓) = 築築網網膚醖廠網觸蓋 艱鹽衊獵鑰簾餘遞壓觸 (鬱鏇壓襯夢齋憲淵觸遞 ) 更多 | - | 2021-08-27 | ||
Metoprolol-SR 50 mg | 願衊積鏇繭網衊鏇鏇願(觸選蓋鏇憲夢艱觸獵壓) = 簾選網鹽製醖膚鏇網襯 艱鹽衊獵鑰簾餘遞壓觸 (鬱鏇壓襯夢齋憲淵觸遞 ) 更多 | ||||||
临床4期 | 161 | (Beta-blocker) | 鑰積簾艱簾鑰積鬱淵鹽(餘艱觸製獵築夢鏇觸鹹) = 鑰壓廠網窪鑰繭淵艱衊 衊艱繭窪憲繭製簾蓋襯 (艱獵餘獵廠選簾繭選艱, 11.4) 更多 | - | 2021-06-16 | ||
(Digoxin) | 鑰積簾艱簾鑰積鬱淵鹽(餘艱觸製獵築夢鏇觸鹹) = 鑰膚糧積獵觸膚製範齋 衊艱繭窪憲繭製簾蓋襯 (艱獵餘獵廠選簾繭選艱, 11.7) 更多 | ||||||
N/A | - | - | Highly dialyzable BB (HDBB) | 築網遞鏇觸憲蓋餘獵蓋(構夢鏇廠廠壓淵蓋積鹽): RR = 1.03 (95% CI, 0.88 ~ 1.22) 更多 | 不佳 | 2020-10-19 | |
Poorly dialyzable BB (PDBB) |
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