更新于：2024-06-20
Amoxicillin Sodium
阿莫西林钠
更新于：2024-06-20
概要
基本信息
药物类型 小分子化药 |
别名 Amoxicillin sodium (USAN) |
靶点- |
作用机制 细胞壁抑制剂 |
治疗领域- |
在研适应症- |
非在研适应症- |
原研机构- |
在研机构- |
非在研机构- |
最高研发阶段批准上市 |
首次获批日期- |
最高研发阶段(中国)批准上市 |
特殊审评- |
结构
分子式C16H19N3NaO5S |
InChIKeyMAOIJBVJXINZLX-YWUHCJSESA-N |
CAS号34642-77-8 |
关联
248
项与 阿莫西林钠 相关的临床试验Standard or Short-course Vonoprazan Non-bismuth Triple Therapy or High-dose Dual Therapy Versus Rabeprazole-bismuth Quadruple Therapy for Primary Helicobacter Pylori Eradication: A Single-center, Randomised, Controlled Trial.
Effectiveness and Tolerability of Cephalexin and Clavulanic Acid Fixed Dose Combination,Amoxicillin and Clavulanic Acid Fixed Dose Combination, and Azithromycin in Patients withPHARYngitis in India: A Real-World RetroSPective Study from ElectrOnic Medical Records(PHARYSPOR) - NIL
The Observation on the Efficacy of Dual Therapy Based on Vonoprazan in Eradicating Helicobacter Pylori
100 项与 阿莫西林钠 相关的临床结果
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100 项与 阿莫西林钠 相关的转化医学
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100 项与 阿莫西林钠 相关的专利（医药）
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1,497
项与 阿莫西林钠 相关的文献（医药）2023-08-01Research in social & administrative pharmacy : RSAP
Antibiotic prescribing trends in primary care 2014-2022.
Article
作者: McCabe, Philippa G ; Jarman, Ian ; McCloskey, Alice P ; Malabar, Lucy ; Gitsham, Andrew
Antimicrobial resistance (AMR) is a global healthcare challenge that governments and health systems are tackling primarily through antimicrobial stewardship (AMS). This should, improve antibiotic use, avoid inappropriate prescribing, reduce prescription numbers, aligning with national/international AMS targets. In primary care in the United Kingdom (UK) antibiotics are mainly prescribed for patients with urinary and respiratory symptoms (22.7% and 46% of all antibiotic prescriptions respectively). This study aimed to capture the time-series trends (2014-2022) for commonly prescribed antibiotics for respiratory and urinary tract infections in primary care in England. Trends for Amoxicillin, Amoxicillin sodium, Trimethoprim, Clarithromycin, Erythromycin, Erythromycin ethylsuccinate, Erythromycin stearate, Doxycycline hyclate, Doxycycline monohydrate and Phenoxymethylpenicillin (Penicillin V) were determined. In doing so providing evidence regarding meeting UK antibiotic prescribing rate objectives (a 15% reduction in human antibiotic use 2019-2024). Time series trend analysis of 62,949,272 antibiotic prescriptions from 6,370 General Practices in England extracted from the National Health Service (NHS) Business Services Authority web portal were explored. With additional investigation of prescribing rate trends by quintiles of the Index of Multiple Deprivation (IMD). Overall, there is a downwards trend in antibiotic prescribing for those explored. There is an association between IMD, geographical location, and higher antibiotic prescribing levels (prescribing hot spots). England has a well-documented North-South divide of health inequalities, this is reflected in antibiotic prescribing. The corona virus pandemic (COVID-19) impacted on AMS, with a rise in doxycycline and trimethoprim prescriptions notable in higher IMD areas. Since then, prescribing appears to have returned to pre-pandemic levels in all IMDs and continued to decline. AMS efforts are being adhered to in primary care in England. This study provides further evidence of the link between locality and poorer health outcomes (reflected in higher antibiotic prescribing). Further work is required to address antibiotic use in hot spot areas.
2023-07-26Journal of investigational allergology & clinical immunology
English
Article
作者: Lamoureux, F ; Varin, R ; Belaid, I ; Hervouët, C ; Martinet, J ; Tétart, F ; Gondé, H
2023-07-01Pharmaceutics
Rectal Bioavailability of Amoxicillin from Hollow-Type Suppositories: Effect of Chemical Form of Amoxicillin.
Article
作者: Amirapu, Satya ; Hanning, Sara M ; Wu, Zimei ; Purohit, Trusha J
Rectal drug administration could offer advantages in the delivery of medicines for children by avoiding swallowability issues, improving stability and enabling administration by caregivers. This study aimed to evaluate the rectal bioavailability of hollow-type suppositories (HTS) and understand the effect of two chemical forms of amoxicillin: amoxicillin sodium (AS) or amoxicillin trihydrate (AMT). HTS were prepared by incorporating a lipophilic core containing the antibiotic with a polyethylene glycol (PEG) shell. Formulations were characterised in vitro, and the absolute bioavailability was determined in a rabbit model, while drug-base interactions were evaluated using X-ray diffraction crystallography (XRD), differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy. The in vitro amoxicillin release from AMT HTS was delayed, taking 27.3 ± 4.9 h to release 50% drug compared with 1.7 h for the AS HTS, likely due to solubility differences between AMT and AS. The presence of orthorhombic AMT and anhydrous AS crystals in respective HTS was confirmed via XRD and DSC. PEG shells were able to protect the drug chemical stability when stored at 25 °C/60% RH. Despite the difference in their in vitro release rates, a similar rectal bioavailability was found in both forms of amoxicillin (absolute bioavailability 68.2 ± 6.6% vs. 72.8 ± 32.2% for AMT HTS and AS HTS, respectively; p = 0.9682). Both HTS formulations showed little or no irritation to the rectal mucosa following a single dose.
100 项与 阿莫西林钠 相关的药物交易
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研发状态
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | 112 | (High Dose Dual Therapy) | 餘觸壓憲製襯網願鏇範(鑰襯顧齋襯鬱窪獵壓衊) = 築窪鬱獵壓觸憲製遞繭 鑰製窪網簾鏇築衊築遞 (衊膚醖積鏇簾築窪觸衊, 淵糧艱夢選廠餘淵製築 ~ 築淵糧範壓積膚醖艱餘) 更多 | - | 2023-02-01 | ||
(Standard Triple Therapy) | 餘觸壓憲製襯網願鏇範(鑰襯顧齋襯鬱窪獵壓衊) = 餘觸製鹽鏇網觸範廠鏇 鑰製窪網簾鏇築衊築遞 (衊膚醖積鏇簾築窪觸衊, 齋醖觸鏇鹽獵簾糧憲窪 ~ 鏇鬱願壓簾範顧積遞衊) 更多 | ||||||
临床4期 | 385 | aminopenicillin+clavulanate+amoxicillin trihydrate+Cefdinir (Short Course) | 願獵糧鹽醖願選觸構糧(簾齋窪鹽築壓繭廠遞膚): Pr (Higher DOOR in Short-Course) = 0.69 (95% CI, 0.63 ~ 0.75), P-Value = <0.001 更多 | - | 2021-02-03 | ||
(Standard Course) | |||||||
临床4期 | 3,000 | 壓窪醖鏇鑰觸簾獵夢襯(蓋製觸範膚襯觸觸鹹鹹) = 鑰鹹襯齋衊製繭鏇齋觸 餘遞鹽壓夢獵餘齋顧蓋 (鑰襯憲壓構鹹顧鬱膚艱 ) 更多 | 积极 | 2020-07-02 | |||
壓窪醖鏇鑰觸簾獵夢襯(蓋製觸範膚襯觸觸鹹鹹) = 鹽餘網糧壓積顧糧鬱醖 餘遞鹽壓夢獵餘齋顧蓋 (鑰襯憲壓構鹹顧鬱膚艱 ) 更多 | |||||||
N/A | 4,002 | 簾獵鬱簾鹽構築齋鏇鹹(衊顧蓋網遞壓糧製糧鹹) = 繭鹹構顧齋餘網遞糧築 築鑰膚觸顧廠製網鹽餘 (網鬱鏇糧艱糧築鏇襯鬱 ) 更多 | 积极 | 2020-07-02 | |||
Placebo | 簾獵鬱簾鹽構築齋鏇鹹(衊顧蓋網遞壓糧製糧鹹) = 獵願網鬱觸憲襯範糧積 築鑰膚觸顧廠製網鹽餘 (網鬱鏇糧艱糧築鏇襯鬱 ) 更多 | ||||||
临床4期 | - | 658 | 膚鹽遞製範淵繭壓製蓋(艱願膚窪窪觸襯憲醖夢) = 餘構觸廠鹽襯淵膚夢鹽 蓋製構餘淵憲製簾鏇壓 (衊構簾餘繭積壓築網構 ) 更多 | 不佳 | 2020-05-01 | ||
膚鹽遞製範淵繭壓製蓋(艱願膚窪窪觸襯憲醖夢) = 餘窪簾衊壓鏇鑰鑰醖遞 蓋製構餘淵憲製簾鏇壓 (衊構簾餘繭積壓築網構 ) 更多 | |||||||
临床4期 | - | 選選壓壓鑰構齋糧廠選(膚鬱襯簾遞鏇鏇簾網窪) = 糧願齋襯憲糧醖淵襯襯 夢鬱壓鏇鏇願蓋艱製繭 (簾窪齋廠積遞簾餘憲簾 ) | - | 2018-12-01 | |||
選選壓壓鑰構齋糧廠選(膚鬱襯簾遞鏇鏇簾網窪) = 鏇觸衊積蓋獵構積鹽蓋 夢鬱壓鏇鏇願蓋艱製繭 (簾窪齋廠積遞簾餘憲簾 ) | |||||||
临床4期 | 幽门螺杆菌感染 一线 | 431 | 繭膚願願餘膚積鹹鑰襯(獵廠廠夢廠膚顧餘製鹽) = 繭襯鹽壓構壓醖齋餘觸 壓艱鹽糧膚醖廠鑰鹹齋 (餘艱範獵夢衊齋築憲鏇 ) | - | 2018-09-01 | ||
繭膚願願餘膚積鹹鑰襯(獵廠廠夢廠膚顧餘製鹽) = 鬱鑰鬱壓鬱鏇顧襯憲淵 壓艱鹽糧膚醖廠鑰鹹齋 (餘艱範獵夢衊齋築憲鏇 ) | |||||||
临床1/2期 | - | 獵廠簾鏇壓憲鏇餘積衊(簾襯鑰積鹹艱衊廠膚獵) = 艱餘膚繭憲餘選鑰齋築 鹹鬱鬱鏇選鬱獵獵艱齋 (簾膚積簾壓鬱遞範壓鹹 ) | 积极 | 2018-06-01 | |||
獵廠簾鏇壓憲鏇餘積衊(簾襯鑰積鹹艱衊廠膚獵) = 構範夢襯壓獵衊積廠夢 鹹鬱鬱鏇選鬱獵獵艱齋 (簾膚積簾壓鬱遞範壓鹹 ) | |||||||
临床4期 | 787 | 遞鑰餘壓顧蓋衊鏇願糧(鹽憲顧鑰簾觸膚觸壓鑰) = 簾觸壓膚鹹齋膚糧築願 壓積衊窪廠壓廠襯鑰襯 (醖蓋積膚衊選鹽窪糧繭, 8.7% ~ 13.2) 更多 | - | 2017-08-01 | |||
N/A | 2,412 | 繭鹹窪繭築鑰艱鹹夢夢(鑰艱遞鏇範獵鹽窪餘襯) = 觸遞窪積製憲繭廠鹹獵 蓋糧衊築齋齋獵構窪網 (醖鑰築觸艱製膚網顧構 ) 更多 | 不佳 | 2016-02-04 | |||
Placebo | 繭鹹窪繭築鑰艱鹹夢夢(鑰艱遞鏇範獵鹽窪餘襯) = 製夢鏇憲鹹簾廠觸窪鹽 蓋糧衊築齋齋獵構窪網 (醖鑰築觸艱製膚網顧構 ) 更多 |
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