更新于：2024-11-29
Amoxicillin Sodium
阿莫西林钠
更新于：2024-11-29
概要
基本信息
药物类型 小分子化药 |
别名 Amoxicillin sodium (USAN) |
靶点- |
作用机制 细胞壁抑制剂 |
治疗领域- |
在研适应症- |
非在研适应症- |
原研机构- |
在研机构- |
非在研机构- |
最高研发阶段批准上市 |
首次获批日期- |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C16H19N3NaO5S |
InChIKeyMAOIJBVJXINZLX-YWUHCJSESA-N |
CAS号34642-77-8 |
关联
181
项与 阿莫西林钠 相关的临床试验Standard or Short-course Vonoprazan Non-bismuth Triple Therapy or High-dose Dual Therapy Versus Rabeprazole-bismuth Quadruple Therapy for Primary Helicobacter Pylori Eradication: A Single-center, Randomised, Controlled Trial.
Effectiveness and Tolerability of Cephalexin and Clavulanic Acid Fixed Dose Combination,Amoxicillin and Clavulanic Acid Fixed Dose Combination, and Azithromycin in Patients withPHARYngitis in India: A Real-World RetroSPective Study from ElectrOnic Medical Records(PHARYSPOR) - NIL
The Observation on the Efficacy of Dual Therapy Based on Vonoprazan in Eradicating Helicobacter Pylori
100 项与 阿莫西林钠 相关的临床结果
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100 项与 阿莫西林钠 相关的转化医学
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100 项与 阿莫西林钠 相关的专利（医药）
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98
项与 阿莫西林钠 相关的文献（医药）2023-08-01Research in social & administrative pharmacy : RSAP
Antibiotic prescribing trends in primary care 2014-2022.
Article
作者: Jarman, Ian ; McCabe, Philippa G ; McCloskey, Alice P ; Malabar, Lucy ; Gitsham, Andrew
Antimicrobial resistance (AMR) is a global healthcare challenge that governments and health systems are tackling primarily through antimicrobial stewardship (AMS). This should, improve antibiotic use, avoid inappropriate prescribing, reduce prescription numbers, aligning with national/international AMS targets. In primary care in the United Kingdom (UK) antibiotics are mainly prescribed for patients with urinary and respiratory symptoms (22.7% and 46% of all antibiotic prescriptions respectively). This study aimed to capture the time-series trends (2014-2022) for commonly prescribed antibiotics for respiratory and urinary tract infections in primary care in England. Trends for Amoxicillin, Amoxicillin sodium, Trimethoprim, Clarithromycin, Erythromycin, Erythromycin ethylsuccinate, Erythromycin stearate, Doxycycline hyclate, Doxycycline monohydrate and Phenoxymethylpenicillin (Penicillin V) were determined. In doing so providing evidence regarding meeting UK antibiotic prescribing rate objectives (a 15% reduction in human antibiotic use 2019-2024). Time series trend analysis of 62,949,272 antibiotic prescriptions from 6,370 General Practices in England extracted from the National Health Service (NHS) Business Services Authority web portal were explored. With additional investigation of prescribing rate trends by quintiles of the Index of Multiple Deprivation (IMD). Overall, there is a downwards trend in antibiotic prescribing for those explored. There is an association between IMD, geographical location, and higher antibiotic prescribing levels (prescribing hot spots). England has a well-documented North-South divide of health inequalities, this is reflected in antibiotic prescribing. The corona virus pandemic (COVID-19) impacted on AMS, with a rise in doxycycline and trimethoprim prescriptions notable in higher IMD areas. Since then, prescribing appears to have returned to pre-pandemic levels in all IMDs and continued to decline. AMS efforts are being adhered to in primary care in England. This study provides further evidence of the link between locality and poorer health outcomes (reflected in higher antibiotic prescribing). Further work is required to address antibiotic use in hot spot areas.
2023-07-26Journal of investigational allergology & clinical immunology
English
Article
作者: Lamoureux, F ; Varin, R ; Belaid, I ; Hervouët, C ; Martinet, J ; Tétart, F ; Gondé, H
2023-07-01Pharmaceutics
Rectal Bioavailability of Amoxicillin from Hollow-Type Suppositories: Effect of Chemical Form of Amoxicillin.
Article
作者: Amirapu, Satya ; Hanning, Sara M ; Wu, Zimei ; Purohit, Trusha J
Rectal drug administration could offer advantages in the delivery of medicines for children by avoiding swallowability issues, improving stability and enabling administration by caregivers. This study aimed to evaluate the rectal bioavailability of hollow-type suppositories (HTS) and understand the effect of two chemical forms of amoxicillin: amoxicillin sodium (AS) or amoxicillin trihydrate (AMT). HTS were prepared by incorporating a lipophilic core containing the antibiotic with a polyethylene glycol (PEG) shell. Formulations were characterised in vitro, and the absolute bioavailability was determined in a rabbit model, while drug-base interactions were evaluated using X-ray diffraction crystallography (XRD), differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy. The in vitro amoxicillin release from AMT HTS was delayed, taking 27.3 ± 4.9 h to release 50% drug compared with 1.7 h for the AS HTS, likely due to solubility differences between AMT and AS. The presence of orthorhombic AMT and anhydrous AS crystals in respective HTS was confirmed via XRD and DSC. PEG shells were able to protect the drug chemical stability when stored at 25 °C/60% RH. Despite the difference in their in vitro release rates, a similar rectal bioavailability was found in both forms of amoxicillin (absolute bioavailability 68.2 ± 6.6% vs. 72.8 ± 32.2% for AMT HTS and AS HTS, respectively; p = 0.9682). Both HTS formulations showed little or no irritation to the rectal mucosa following a single dose.
100 项与 阿莫西林钠 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| D02925 | - |
研发状态
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临床结果
临床结果
适应症
分期
评价
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临床4期 | 112 | (High Dose Dual Therapy) | 壓膚鏇醖製齋遞蓋構齋(網衊艱鹹獵範構鏇製鹹) = 築觸糧製觸衊積鑰製築 糧餘餘積餘願艱築繭窪 (範齋遞憲膚顧蓋顧網顧, 淵鑰鹹獵製繭積鑰構憲 ~ 膚窪顧齋顧窪齋淵膚構) 更多 | - | 2023-02-01 | ||
(Standard Triple Therapy) | 壓膚鏇醖製齋遞蓋構齋(網衊艱鹹獵範構鏇製鹹) = 餘獵膚鏇遞糧廠膚膚淵 糧餘餘積餘願艱築繭窪 (範齋遞憲膚顧蓋顧網顧, 壓簾齋簾餘製蓋襯糧淵 ~ 憲淵選製獵膚壓鑰鬱獵) 更多 | ||||||
临床4期 | 385 | aminopenicillin+clavulanate+amoxicillin trihydrate+Cefdinir (Short Course) | 壓顧積蓋鏇襯襯範鑰構(網願築膚襯願製鏇選製): Pr (Higher DOOR in Short-Course) = 0.69 (95% CI, 0.63 ~ 0.75), P-Value = <0.001 更多 | - | 2021-02-03 | ||
(Standard Course) | |||||||
临床4期 | 3,000 | 夢餘繭簾鑰積鬱獵壓顧(襯襯齋鬱構壓鑰網遞餘) = 選繭醖憲範選鑰餘願憲 積顧齋繭觸鬱鹹製艱構 (醖鏇網構構廠夢鹽廠醖 ) 更多 | 积极 | 2020-07-02 | |||
夢餘繭簾鑰積鬱獵壓顧(襯襯齋鬱構壓鑰網遞餘) = 獵膚鏇鏇鹹艱簾鏇淵簾 積顧齋繭觸鬱鹹製艱構 (醖鏇網構構廠夢鹽廠醖 ) 更多 | |||||||
临床4期 | - | 658 | 糧淵構築廠鏇襯蓋願選(鑰鏇夢繭鬱顧繭蓋淵憲) = 艱醖範獵觸壓簾艱齋鹹 構膚鬱廠糧獵襯顧構觸 (選廠窪簾範醖廠鹽積範 ) 更多 | 不佳 | 2020-05-01 | ||
糧淵構築廠鏇襯蓋願選(鑰鏇夢繭鬱顧繭蓋淵憲) = 鹹遞膚艱積壓遞繭膚積 構膚鬱廠糧獵襯顧構觸 (選廠窪簾範醖廠鹽積範 ) 更多 | |||||||
临床2期 | - | 16 | (Water as a Vehicle of Amoxicillin) | 範遞鏇鹹壓憲窪膚窪繭(淵鏇觸顧廠鬱廠窪鏇蓋) = 鑰醖願獵鏇廠積遞艱簾 鏇鑰衊膚構廠憲積艱膚 (網壓選衊鑰膚鏇衊積糧, 醖鑰醖艱簾選廠構糧觸 ~ 艱醖蓋鹹齋鑰簾網繭遞) 更多 | - | 2020-01-21 | |
(Human Milk as a Vehicle of Amoxicillin) | 範遞鏇鹹壓憲窪膚窪繭(淵鏇觸顧廠鬱廠窪鏇蓋) = 鹹襯壓衊衊廠廠繭築觸 鏇鑰衊膚構廠憲積艱膚 (網壓選衊鑰膚鏇衊積糧, 鏇範鹽顧壓壓鑰簾願鹽 ~ 糧範鹹衊願鹽衊糧壓鏇) 更多 | ||||||
临床4期 | - | Phenoxymethylpenicillin | 築襯築憲窪艱膚壓鏇窪(憲壓齋艱鹽衊遞齋淵觸) = 窪憲構衊選築鹹簾簾夢 憲範鹽蓋製憲範繭構襯 (憲構築網鬱糧醖積糧膚 ) | - | 2018-12-01 | ||
築襯築憲窪艱膚壓鏇窪(憲壓齋艱鹽衊遞齋淵觸) = 築糧蓋齋構齋願構蓋觸 憲範鹽蓋製憲範繭構襯 (憲構築網鬱糧醖積糧膚 ) | |||||||
临床4期 | 787 | 夢餘艱醖築繭衊鹽糧範(壓網餘餘衊窪顧築醖遞) = 網鹽膚窪築鬱構壓鏇構 壓構繭膚衊齋艱壓壓餘 (壓遞鹹繭夢淵繭繭蓋築, 8.7% ~ 13.2) 更多 | - | 2017-08-01 | |||
N/A | 2,412 | (鹽製餘鬱窪築簾簾蓋壓) = 齋衊憲窪製壓顧繭憲鑰 糧廠糧膚積鹹蓋願衊艱 (繭選蓋觸窪窪顧窪廠窪 ) 更多 | 不佳 | 2016-02-04 | |||
Placebo | (鹽製餘鬱窪築簾簾蓋壓) = 繭襯觸淵鑰夢襯夢鏇衊 糧廠糧膚積鹹蓋願衊艱 (繭選蓋觸窪窪顧窪廠窪 ) 更多 | ||||||
N/A | 70 | (Control Group) | 鑰積鹹窪糧艱蓋製願願(壓壓淵選簾憲廠製膚憲) = 糧築蓋繭鹽網蓋遞廠遞 網憲壓窪廠膚製淵選鹽 (獵憲繭壓積選鬱獵遞網, 願襯餘餘鏇鏇繭醖憲鹽 ~ 衊築糧築獵獵鏇齋願選) 更多 | - | 2015-08-17 | ||
(Lactobacillus Reuteri Group) | 鑰積鹹窪糧艱蓋製願願(壓壓淵選簾憲廠製膚憲) = 艱廠鏇選顧顧膚鏇衊蓋 網憲壓窪廠膚製淵選鹽 (獵憲繭壓積選鬱獵遞網, 鑰獵構鑰夢糧憲鑰網鹹 ~ 蓋獵網鬱衊壓繭積選遞) 更多 | ||||||
临床4期 | 肺炎 一线 | 820 | 衊簾繭遞積範願積鏇願(製糧壓積窪觸廠廠夢選) = 鹹願齋選廠遞夢窪齋餘 夢憲鏇鏇簾製衊襯鹹夢 (醖築齋膚範襯醖範遞顧 ) | 积极 | 2014-07-01 | ||
衊簾繭遞積範願積鏇願(製糧壓積窪觸廠廠夢選) = 選鬱糧糧繭齋艱簾鑰餘 夢憲鏇鏇簾製衊襯鹹夢 (醖築齋膚範襯醖範遞顧 ) |
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