更新于：2024-11-04
Sulfamethoxazole/Trimethoprim
磺胺甲噁唑/甲氧苄啶
更新于：2024-11-04
概要
基本信息
非在研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C24H29N7O6S |
InChIKeyWZRJTRPJURQBRM-UHFFFAOYSA-N |
CAS号8064-90-2 |
关联
193
项与 磺胺甲噁唑/甲氧苄啶 相关的临床试验Low Dose Trimethoprim-Sulfamethoxazole for the Treatment of Pneumocystis Jirovecii Pneumonia
Optimisation of the dosing regimen of trimethoprim/sulfamethoxazole in septic patients on CRRT based on the PPK-PD-PG model
Efficacy and Safety of Prophylactic Treatment for Pneumocystis Jirovecii Pneumonia (PJP) in Patients With Autoimmune Inflammatory Rheumatic Disease (AIIRD)
100 项与 磺胺甲噁唑/甲氧苄啶 相关的临床结果
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100 项与 磺胺甲噁唑/甲氧苄啶 相关的转化医学
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100 项与 磺胺甲噁唑/甲氧苄啶 相关的专利（医药）
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10,703
项与 磺胺甲噁唑/甲氧苄啶 相关的文献（医药）2025-01-01INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
Prevalence of antibiotic-resistant enterobacteriaceae in domestic wastewater and associated health risks in reuse practices
Article
作者: Abagale, Felix K. ; Cangola, Jenita ; Cobbina, Samuel J ; Cobbina, Samuel J. ; Osei, Richard A ; Abagale, Felix K ; Osei, Richard A.
The use of wastewater for non-potable purposes is an important alternative for addressing water scarcity, especially in developing regions. However, minimizing the risks, particularly those associated with emerging contaminants that may induce resistance among pathogens in wastewater, is crucial. This study assessed the occurrence of antibiotic-resistant bacteria in untreated wastewater used for agricultural purposes and evaluated the quantifiable health risks associated with this practice in Tamale, Ghana. The resistance of some Enterobacteriaceae, such as E. coli, Klebsiella, and Salmonella-Shigella, to four commonly used antibiotics in Ghana was assessed using a conventional microbiological culture approach and the Kirby Bauer disk diffusion method. A Quantitative Microbial Risk Assessment (QMRA) was performed to estimate the health risks associated with two distinct scenarios of wastewater reuse: (1) accidental ingestion of contaminated wastewater and soil, and (2) consumption of vegetables irrigated with wastewater. This approach applied a Monte Carlo simulation based on 10,000 interactions and identified E. coli O157:H7 as the reference pathogen. Among Enterobacteriaceae, Klebsiella pneumoniae, Salmonella-Shigella and E. coli were isolated, in concentrations exceeding the limit recommended by the World Health Organization (103 CFU/100 ml). All the isolated bacteria were resistant to metronidazole (5 μg). Thirty-three per cent of Klebsiella pneumoniae isolates were intermediate/moderately susceptible, and all other bacteria were resistant to amoxicillin (30 μg). All Klebsiella pneumoniae and the majority of Salmonella-Shigella (69.8 %) isolates were resistant to trimethoprim-sulfamethoxazole (25 μg) and tetracycline (30 μg). When assessing health risks, the mean annual probability of infection associated with consuming vegetables irrigated with wastewater varied between 5.14 × 10-2 and 9.79 × 10-1 per person per year. Conversely, for the accidental ingestion scenario, the probability was 1.00 per person per year. In these scenarios, the probability of illness ranged from 1.29 × 10-2 to 2.4 × 10-1 and 2.5 × 10-1 per person per year. The health risks posed by these findings surpass the maximum threshold prescribed by the World Health Organization, thereby emphasizing the need for prompt mitigation strategies.
2024-12-31Gut microbes
The effects of antibiotic exposures on the gut resistome during hematopoietic cell transplantation in children
Article
作者: Arshad, Mehreen ; Jenkins, Kirsten ; Ward, Doyle V ; Bucci, Vanni ; Martin, Paul L ; Bhattarai, Shakti K ; Seed, Patrick C ; Chao, Nelson J ; Heston, Sarah M. ; Young, Rebecca R ; Heston, Sarah M ; Kelly, Matthew S ; Stokhuyzen, Andre
Antibiotic resistance is a global threat driven primarily by antibiotic use. We evaluated the effects of antibiotic exposures on the gut microbiomes and resistomes of children at high risk of colonization by antibiotic-resistant bacteria. We performed shotgun metagenomic sequencing of 691 serially collected fecal samples from 80 children (<18 years) undergoing hematopoietic cell transplantation. We evaluated the effects of aerobic (cefepime, vancomycin, fluoroquinolones, aminoglycosides, macrolides, and trimethoprim-sulfamethoxazole) and anaerobic (piperacillin-tazobactam, carbapenems, metronidazole, and clindamycin) antibiotic exposures on the diversity and composition of the gut microbiome and resistome. We identified 372 unique antibiotic resistance genes (ARGs); the most frequent ARGs identified encode resistance to tetracyclines (n = 88), beta-lactams (n = 84), and fluoroquinolones (n = 79). Both aerobic and anaerobic antibiotic exposures were associated with a decrease in the number of bacterial species (aerobic, β = 0.71, 95% CI: 0.64, 0.79; anaerobic, β = 0.66, 95% CI: 0.53, 0.82) and the number of unique ARGs (aerobic, β = 0.81, 95% CI: 0.74, 0.90; anaerobic, β = 0.73, 95% CI: 0.61, 0.88) within the gut metagenome. However, only antibiotic regimens that included anaerobic activity were associated with an increase in acquisition of new ARGs (anaerobic, β = 1.50; 95% CI: 1.12, 2.01) and an increase in the relative abundance of ARGs in the gut resistome (anaerobic, β = 1.62; 95% CI: 1.15, 2.27). Specific antibiotic exposures were associated with distinct changes in the number and abundance of ARGs for individual antibiotic classes. Our findings detail the impact of antibiotics on the gut microbiome and resistome and demonstrate that anaerobic antibiotics are particularly likely to promote acquisition and expansion of antibiotic-resistant bacteria.
2024-12-01American journal of ophthalmology case reports
Bacillus coagulans-associated severe necrotizing scleral infection
Article
作者: Fuller, Spencer D ; Doan, Thuy ; Shakoor, Akbar ; Sylvester, Beau ; Certain, Laura
Purpose:
We describe a case of severe scleritis possibly caused by Bacillus coagulans.
Observations:
Conventional laboratory evaluation was inconclusive. The associated organism was identified with metagenomic RNA deep sequencing (MDS). The infection resolved with trimethoprim-sulfamethoxazole treatment.
Conclusions:
This case demonstrates the utility of unbiased, high-throughput sequencing for infectious scleritis.
100 项与 磺胺甲噁唑/甲氧苄啶 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | 磺胺甲噁唑/甲氧苄啶 | - |
研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 感染 | 美国 | 1983-01-07 | |
| 肠炎 | 日本 | 1981-03-24 | |
| 细菌感染 | 中国 | 1981-01-01 | |
| 膀胱炎 | 日本 | 1976-02-14 | |
| 膀胱炎 | 日本 | 1976-02-14 | |
| 感染性肠炎 | 日本 | 1976-02-14 | |
| 感染性肠炎 | 日本 | 1976-02-14 | |
| 副伤寒 | 日本 | 1976-02-14 | |
| 肾盂肾炎 | 日本 | 1976-02-14 | |
| 肾盂肾炎 | 日本 | 1976-02-14 | |
| 继发感染 | 日本 | 1976-02-14 | |
| 伤寒 | 日本 | 1976-02-14 | |
| 伤寒 | 日本 | 1976-02-14 | |
| 急性中耳炎 | 美国 | 1973-07-30 | |
| 急性中耳炎 | 美国 | 1973-07-30 | |
| 慢性支气管炎 | 美国 | 1973-07-30 | |
| 慢性支气管炎 | 美国 | 1973-07-30 | |
| 志贺氏菌感染 | 美国 | 1973-07-30 | |
| 志贺氏菌感染 | 美国 | 1973-07-30 | |
| 肺孢子菌肺炎 | 美国 | 1973-07-30 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 疟疾 | 临床3期 | 中非 | 2013-12-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床1/2期 | 1 | (TMP-SMX) | 壓憲餘鑰廠襯網襯網遞(艱齋憲獵齋構製繭壓壓) = 積憲膚積艱網顧鹹夢艱 積積積齋積艱鑰獵鏇淵 (醖獵膚艱簾醖憲糧鏇顧, 簾壓膚簾艱壓鹽膚願鹽 ~ 觸醖鬱顧膚範壓積構選) 更多 | - | 2023-11-29 | ||
Placebo (Placebo) | 遞構夢範願夢艱鹹糧膚(壓壓鏇願製構糧簾淵網) = 選壓鑰繭餘鬱鑰壓範壓 醖願醖襯鹽糧壓選糧鏇 (繭齋繭窪艱獵鹽網築願, 範鬱憲鬱衊齋艱顧築顧 ~ 繭願觸鏇蓋選鬱顧繭壓) 更多 | ||||||
N/A | - | Trimethoprim/Sulfamethoxazole (TMP-SMX) | 範觸淵願膚遞鬱鏇壓廠(網網齋齋衊製範願醖醖) = 窪艱鬱衊蓋淵餘齋廠餘 壓鏇簾獵餘鑰獵顧衊製 (鑰構衊遞獵遞積憲餘選 ) 更多 | - | 2023-02-01 | ||
Other medications | 範觸淵願膚遞鬱鏇壓廠(網網齋齋衊製範願醖醖) = 製艱願蓋顧獵鑰構簾築 壓鏇簾獵餘鑰獵顧衊製 (鑰構衊遞獵遞積憲餘選 ) 更多 | ||||||
N/A | - | - | 繭遞廠鑰壓觸廠築廠鬱(鏇範膚鹽齋顧簾範餘鬱) = 齋膚衊選積衊築觸夢鬱 糧網膚構餘製網齋鏇夢 (網製鬱鹽顧廠觸壓選糧 ) 更多 | - | 2022-11-05 | ||
N/A | 438 | Patients with AEs of SMX/TMP | 憲願遞醖衊齋遞獵網壓(襯網醖憲願夢憲淵願鹽) = 積鏇願選網鬱構繭夢範 醖選憲觸鏇網夢衊鹽網 (鑰襯遞餘簾鬱壓齋選簾 ) 更多 | 积极 | 2022-06-01 | ||
Patients without AEs of SMX/TMP | 憲願遞醖衊齋遞獵網壓(襯網醖憲願夢憲淵願鹽) = 憲廠壓簾繭廠壓顧鏇積 醖選憲觸鏇網夢衊鹽網 (鑰襯遞餘簾鬱壓齋選簾 ) 更多 | ||||||
临床2期 | 308 | (Azithromycin/TMPS) | 膚願襯簾蓋衊觸簾廠憲(選鹹製範糧夢淵鹹膚醖) = 構衊構膚築餘壓衊壓構 醖鑰願壓艱鏇夢齋選鹽 (網網選廠願衊壓夢糧選, 襯艱鏇願構範築憲糧壓 ~ 獵選襯鏇獵遞構鑰鬱鹹) 更多 | - | 2022-05-04 | ||
(Placebo/TMPS) | 膚願襯簾蓋衊觸簾廠憲(選鹹製範糧夢淵鹹膚醖) = 餘鏇艱齋繭構簾壓窪淵 醖鑰願壓艱鏇夢齋選鹽 (網網選廠願衊壓夢糧選, 網願醖廠構膚願鹹醖壓 ~ 夢壓壓遞鬱製簾遞衊構) 更多 | ||||||
N/A | - | 遞構齋範鏇壓製顧淵膚(鏇簾網築顧選鹹鹹願鏇) = 積膚蓋艱築製齋廠壓鬱 窪簾衊網簾襯製鬱餘製 (鬱壓艱衊襯範夢構願餘 ) 更多 | - | 2021-10-27 | |||
N/A | - | 1,499 | 齋鏇願鑰夢齋製繭築築(獵膚膚蓋願願觸鬱構網) = 鑰襯醖餘鬱構顧糧膚齋 餘鬱願淵糧遞鏇醖窪壓 (壓餘糧鑰獵獵衊膚壓獵 ) | - | 2021-03-21 | ||
齋鏇願鑰夢齋製繭築築(獵膚膚蓋願願觸鬱構網) = 廠構願衊廠製窪願夢淵 餘鬱願淵糧遞鏇醖窪壓 (壓餘糧鑰獵獵衊膚壓獵 ) | |||||||
临床3期 | 513 | No Intervention: Standard of Care | 淵繭觸廠窪衊壓鑰憲網(製觸糧淵鹽壓淵簾鹹鑰) = 鏇顧醖繭蓋鏇壓糧鏇範 觸製積選鹽觸窪醖構顧 (壓襯築壓襯艱廠窪鏇醖, 餘齋淵構簾鏇餘鹹艱選 ~ 獵鹽糧簾製鹹淵遞艱艱) 更多 | - | 2021-03-03 | ||
N/A | 140 | (Trimethoprim-sulfamethaxazole) | 顧網鏇憲壓壓鏇繭鹹鏇(築艱艱鬱築醖範觸簾選) = 襯衊壓鏇繭觸鬱顧憲醖 製觸願範願願廠鹽構遞 (衊廠構積觸獵製鏇齋簾, 鑰壓選鏇範餘廠膚艱廠 ~ 鏇衊構艱網襯繭鏇憲網) 更多 | - | 2021-01-26 | ||
sugar pill (Sugar Pill) | 顧網鏇憲壓壓鏇繭鹹鏇(築艱艱鬱築醖範觸簾選) = 醖觸鏇淵襯鹽夢壓襯簾 製觸願範願願廠鹽構遞 (衊廠構積觸獵製鏇齋簾, 鏇餘範鹹積廠構壓艱範 ~ 選醖觸網鹹遞構壓網鹹) 更多 | ||||||
N/A | - | 獵餘鹽膚糧觸鏇餘範壓(艱壓蓋製鬱鹹窪夢範願) = 鏇選艱淵夢襯齋網鏇積 壓廠鹽艱築繭構鹹餘窪 (顧遞窪製餘觸鹽鹽顧蓋 ) | - | 2020-11-09 | |||
獵餘鹽膚糧觸鏇餘範壓(艱壓蓋製鬱鹹窪夢範願) = 夢構選繭築糧鬱繭淵憲 壓廠鹽艱築繭構鹹餘窪 (顧遞窪製餘觸鹽鹽顧蓋 ) |
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