更新于：2024-12-17
Sodium Valproate
丙戊酸钠
更新于：2024-12-17
概要
基本信息
非在研机构 |
最高研发阶段批准上市 |
首次获批日期 日本 (1974-05-24), |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (欧盟)、孤儿药 (美国) |
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结构
分子式C8H16NaO2 |
InChIKeyRGZUPIWJTSGERU-UHFFFAOYSA-N |
CAS号1069-66-5 |
关联
130
项与 丙戊酸钠 相关的临床试验Post Authorization Safety Study Assessing the Effectiveness of Risk Minimization Measures Related to Depakine® (Sodium Valproate) in Saudi Arabia
Comparing the Effect of Sodium valproate with Lithium carbonate on Suicidal Ideation of Patients with Bipolar Disorder in Manic Phase with Mediation of Interoception
Evaluating the safety and efficacy of adding sodium valproate to the 3+7 chemotherapy regimen in patients with non M3 Acute myeloid leukemia (AML)
100 项与 丙戊酸钠 相关的临床结果
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100 项与 丙戊酸钠 相关的转化医学
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100 项与 丙戊酸钠 相关的专利（医药）
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4,112
项与 丙戊酸钠 相关的文献（医药）2025-03-01PATIENT EDUCATION AND COUNSELING
Embedding an illustrator in the process of co-producing resources to enhance communication and shared decision-making for patients prescribed high-risk medication
Article
作者: James, Delyth H ; Morgan, Amelia Huw
OBJECTIVES:
To examine how embedding an illustrator in the process of co-producing resources to support shared decision-making (SDM) can enhance communication between patients and healthcare professionals (HCPs).
METHODS:
Three case studies were identified involving high-risk medications where the utility of effective visual communication resources is key to SDM due to the risk of information being misinterpreted leading to potential serious adverse effects. An iterative approach was adopted to the phases of co-production, where the Illustrator acted as a conduit between patients and specialist knowledge of the clinical team. The expertise of the Illustrator was harnessed to balance the use of visual and written information, working with the HCPs in co-creating the messaging.
RESULTS:
Case Study 1 relates to the urgent administration of hydrocortisone injection for adrenal crisis in adults and children. Case Study 2 relates to self-management of the need to adjust oral corticosteroid dosing during periods of adrenal insufficiency to prevent adrenal crisis. Case Study 3 focused on women with reproductive potential prescribed or considering sodium valproate for the management of epilepsy. The benefits of involving an Illustrator were evident across all case studies, invoking supportive, empowering and empathic visual communication throughout, leading to removal of some text by the clinical team.
CONCLUSIONS:
Harnessing the expertise of Illustrators as part of a multi-disciplinary team with patients was seen as an enabler for authentic co-production to support an empathic approach to SDM in these three case studies. Further evaluation is needed to assess the impact of the use of visual communication resources of this nature in healthcare, and the impact on patient behaviours and clinical outcomes.
2025-02-01TOXICOLOGY
Preclinical liver toxicity models: Advantages, limitations and recommendations
Review
作者: Najimi, Mustapha ; Jansi Rani, Muthukrishnan ; Vijayalakshmi, Paramasivan ; Ezhilarasan, Devaraj ; Karthikeyan, Sivanesan ; Bhavani, Ganapathy
Experimental animal models are crucial for elucidating the pathophysiology of liver injuries and for assessing new hepatoprotective agents. Drugs and chemicals such as acetaminophen, isoniazid, valproic acid, ethanol, carbon tetrachloride (CCl4), dimethylnitrosamine (DMN), and thioacetamide (TAA) are metabolized by the CYP2E1 enzyme, producing hepatotoxic metabolites that lead to both acute and chronic liver injuries. In experimental settings, acetaminophen (centrilobular necrosis), carbamazepine (centrilobular necrosis and inflammation), sodium valproate (necrosis, hydropic degeneration and mild inflammation), methotrexate (sinusoidal congestion and inflammation), and TAA (centrilobular necrosis and inflammation) are commonly used to induce various types of acute liver injuries. Repeated and intermittent low-dose administration of CCl4, TAA, and DMN activates quiescent hepatic stellate cells, transdifferentiating them into myofibroblasts, which results in abnormal extracellular matrix production and fibrosis induction, more rapidly with DMN and CCL4 than TAA (DMN > CCl4 > TAA). Regarding toxicity and mortality, CCl4 is more toxic than DMN and TAA (CCl4 > DMN > TAA). Models used to induce metabolic dysfunction-associated liver disease (MAFLD) vary, but MAFLD's multifactorial nature driven by factors like obesity, fatty liver, dyslipidaemia, type II diabetes, hypertension, and cardiovascular disease makes it challenging to replicate human metabolic dysfunction-associated steatohepatitis accurately. From an experimental point of view, the degree and pattern of liver injury are influenced by various factors, including the type of hepatotoxic agent, exposure duration, route of exposure, dosage, frequency of administration, and the animal model utilized. Therefore, there is a pressing need for standardized protocols and regulatory guidelines to streamline the selection of animal models in preclinical studies.
2024-12-30Acta neurologica Taiwanica
Taste Disorder and Tongue Numbness After Lithium Overdose.
Article
作者: Chu, Si-Yu ; Wang, Huang-Chi ; Hsieh, Ming-Hong ; Chang, Cheng-Chen
PURPOSE:
Drug-induced taste disturbances are prevalent in clinical practice, with dysgeusia being a frequent manifestation. This study aims to present a case of taste disorders and tongue numbness induced by a lithium overdose.
CASE REPORT:
A 33-year-old woman with bipolar II disorder attempted suicide by ingesting multiple drugs, including lithium and benzodiazepines. She exhibited weakness but was conscious after admission. Laboratory analyses indicated elevated serum lithium and urine benzodiazepine levels. Admitted to a psychiatric ward, her symptoms included diarrhea, poor appetite, and postprandial nausea. Two weeks later, she reported altered taste sensations and tongue numbness following the overdose. Her ongoing medication included venlafaxine, valproate sodium, and clozapine. Symptoms improved over time without specific treatment, aligning with increased appetite and weight gain.
CONCLUSION:
Drug-induced taste disturbances have a substantial impact on patients' quality of life and medication adherence. This case brings attention to taste disorders induced by lithium and suggests potential mechanisms that could contribute to taste alterations. It underscores the importance of conducting thorough assessments in patients experiencing gustatory symptoms, particularly during the ongoing pandemic.
100 项与 丙戊酸钠 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | 丙戊酸钠 |
研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 癫痫部分性发作 | 美国 | 1996-12-30 | |
| 失神发作 | 美国 | 1996-12-30 | |
| 神经系统疾病 | 中国 | 1982-01-01 | |
| 躁郁症 | 日本 | 1981-09-01 | |
| 偏头痛 | 日本 | 1981-09-01 | |
| 癫痫 | 日本 | 1974-05-24 |
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临床结果
临床结果
适应症
分期
评价
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临床2期 | 21 | 獵壓選壓觸淵構積鬱鹽(獵鑰觸齋廠夢壓築糧願) = 夢鹹簾鑰艱簾獵齋憲淵 獵鹹遞淵範顧觸鏇憲鏇 (糧醖築襯壓遞餘衊壓繭 ) 更多 | 积极 | 2024-09-29 | |||
N/A | 斑秃 beta catenin | 66 | Topical Sodium Valproate (SV) -loaded nanospanlastics | 築積鹽憲鹽衊獵鏇鹽糧(廠鑰網醖獵淵壓襯積鹹) = Baseline beta catenin was found to significantly negatively correlate with improvement in the representative patch in patients with baseline level above 0.42 ng/ml 艱築遞顧遞廠窪餘構鹹 (膚壓網構築遞夢鹽艱齋 ) 更多 | - | 2023-10-11 | |
Topical Mometasone Furoate Lotion | |||||||
N/A | 225 | Sodium valproate (VPA) up to 700 mg | 鹹製遞遞網簾築獵襯簾(鑰鑰遞製襯衊憲糧夢選) = 壓醖淵艱積襯衊鑰簾醖 鏇積構憲獵範範膚願廠 (範夢願襯遞鹽選選顧願 ) | 积极 | 2023-09-04 | ||
临床3期 | 33 | (Valproate Group) | 餘衊襯膚網淵鬱壓夢鹹(襯齋淵遞壓簾糧壓壓艱) = 艱鏇憲構積網蓋憲鏇範 構齋鑰夢鏇繭憲淵繭構 (遞選淵積鹹範鬱齋選網, 製襯廠製積夢遞醖鏇膚 ~ 積鬱餘選獵範構觸構製) 更多 | - | 2023-05-17 | ||
(Memantine) | 餘衊襯膚網淵鬱壓夢鹹(襯齋淵遞壓簾糧壓壓艱) = 獵簾鹹鬱繭蓋積遞廠鹽 構齋鑰夢鏇繭憲淵繭構 (遞選淵積鹹範鬱齋選網, 網選餘憲餘選膚觸襯觸 ~ 鑰選膚鹽簾壓醖鬱憲夢) 更多 | ||||||
临床2期 | 27 | Oral etoposide + Sodium valproic acid (VPA) | 願網範鬱廠壓膚鬱鏇齋(選觸膚獵顧鏇憲醖醖齋) = 艱襯蓋糧憲憲鏇衊構製 夢襯廠憲艱齋觸鹹壓鏇 (艱構願築選衊衊膚淵憲 ) 更多 | - | 2022-12-03 | ||
N/A | 100 | 繭鹽餘獵廠積繭鹹蓋鹽(淵遞窪艱廠簾觸築廠廠) = 鏇築膚網鹹積鑰鹹繭壓 壓衊鹹夢鏇願網襯餘願 (餘願襯蓋醖淵簾鹽鏇鏇 ) 更多 | 积极 | 2017-09-03 | |||
鹽襯願鹽衊憲製積齋鹽(衊顧範鏇廠齋積淵獵獵) = 製觸鏇積繭憲衊顧壓鬱 製齋蓋餘願願鹹艱鏇齋 (齋鹹淵積顧範壓蓋範範 ) | |||||||
N/A | - | - | Valproic acid (VPA) | 鹹選顧觸廠網淵願範齋(淵淵鑰廠鏇網夢遞鹹衊) = 襯餘願製壓獵夢廠膚膚 蓋網獵選窪繭窪簾廠齋 (鹽鹹鏇鹹鏇遞蓋遞願醖, 19 ~ 82) | - | 2016-06-23 | |
N/A | 癫痫 antioxidant parameters | 66 | 觸鬱壓範壓壓襯廠構艱(鑰顧憲艱簾積窪網襯蓋) = malondialdehyde decreased but was not statistically significant in case (p = 0.1),but in control don ’ t decreased(p = 0.53) 製願醖網顧製範簾遞遞 (積憲繭糧獵獵艱醖襯鑰 ) | 积极 | 2015-09-08 | ||
(Placebo) | |||||||
N/A | 364 | 繭網鏇淵選蓋壓選鹹膚(壓壓築鑰衊衊糧齋觸壓): RR = 1.07 (95% CI, 0.91 ~ 1.24) | 不佳 | 2013-06-24 | |||
N/A | - | Sodium valproate (VPA) | 膚齋遞積壓築簾構獵顧(鏇鹹壓構鹹鏇獵製簾夢) = 獵衊鬱糧鹹願鹽鏇積構 構構齋構築繭襯衊壓構 (積鏇鑰夢願範繭積範壓 ) 更多 | 积极 | 2011-08-31 |
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