更新于：2024-12-06
Chlorpheniramine Maleate
马来酸氯苯那敏
更新于：2024-12-06
概要
基本信息
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
登录后查看时间轴
结构
分子式C20H23ClN2O4 |
InChIKeyDBAKFASWICGISY-BTJKTKAUSA-N |
CAS号113-92-8 |
关联
33
项与 马来酸氯苯那敏 相关的临床试验Effect of single dose Bilastine, desloratadine, chlorpheniramine and placebo on psychomotor functions in healthy human volunteers: A double blind placebo controlled cross over design clinical Trial - NIL
Comparison of Effect of ondansetron And Chlorpheniramine in controlling nausea in adults in emergency department
First-generation OTC Antihistamine Use and Voice Function: A Preliminary Study
100 项与 马来酸氯苯那敏 相关的临床结果
登录后查看更多信息
100 项与 马来酸氯苯那敏 相关的转化医学
登录后查看更多信息
100 项与 马来酸氯苯那敏 相关的专利（医药）
登录后查看更多信息
2,477
项与 马来酸氯苯那敏 相关的文献（医药）2024-12-16JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
Effects of anthranilic diamide insecticides on metamorphosis in the common toad
Rhinella arenarum
(Hensel, 1867) at concentrations found in aquatic environments
Article
作者: Brodeur, Julie Céline ; Peña, Shirley Vivian Daniela Fonseca
Anthranilic diamides (AD) are a modern class of insecticides used as alternatives to pyrethroids and neonicotinoids, particularly against lepidopteran pests. Despite their widespread use and presence in surface waters, little is known regarding their effects on amphibians. The aim of this study was to examine the effects of environmentally-relevant concentrations of AD insecticides chlorantraniliprole (CHLO) and cyantraniliprole (CYAN) on metamorphosis of the toad Rhinella arenarum. Tadpoles were exposed to CHLO or CYAN at concentrations ranging from 5 and 5000 µg/L from stage 27 until metamorphosis completion. Both insecticides produced a non-monotonic acceleration of the time required for individuals to progress through development and a decrease in the proportion of individuals completing metamorphosis, although a delay in metamorphosis was also observed at 5 µg/L of CHLO. Snout-vent length and body weight of metamorphosed toads were not markedly affected by either insecticide. CHLO was more toxic than CYAN, with a lowest observed effect concentration (LOEC) for CHLO on time to metamorphosis defined as 5 µg/L compared to 5000 µg/L for CYAN. The LOEC for reduced metamorphic success defined as 50 µg/L for CHLO compared to 500 µg/L for CYAN. As most effects occurred after stage 39, when metamorphosis depends upon thyroid hormones, it is conceivable that that AD insecticides act as endocrine disruptors. These findings suggest that contamination of surface waters with CHLO and CYAN may disrupt amphibian development in the wild and warrant further research to investigate the possibility of endocrine-disruption by ADs.
2024-12-01EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
Preventive effects of first-generation antihistamine on emergence agitation or delirium: a systematic review
Review
作者: Noritake, Yumi ; Kotake, Kazumasa ; Matsunuma, Satoru ; Kawakami, Yasuhiro ; Kitamura, Naoya
PURPOSE:
The effects of first-generation antihistamines in preventing postoperative emergence agitation or delirium are unclear. Determining the postoperative effects of first-generation antihistamines may provide important insights into the management of patient safety. Therefore, we performed a systematic review of randomized controlled trials (RCTs) evaluating the efficacy and safety of postoperative first-generation antihistamines.
METHODS:
Patients who used first-generation antihistamines in the intensive care unit or operating room were included. Primary outcomes were assessed postoperative emergence agitation or delirium with binary and continuous variables. The secondary outcome was any adverse event.
RESULTS:
Nine studies were included. The frequency of postoperative emergence agitation, measured using binary variables, tended to be lower in patients receiving chlorpheniramine or diphenhydramine than those receiving saline. However, evaluation using the Richmond Agitation-Sedation Scale as a continuous variable revealed that only chlorpheniramine was effective at lowering postoperative emergence agitation. Only one study assessed delirium but found no benefit of first-generation antihistamines. Adverse events for first-generation antihistamines did not differ from that of other drugs.
CONCLUSION:
Our results provide limited evidence that some first-generation antihistamines may prevent postoperative emergence agitation and are safe. To further verify this possibility, new RCTs with clear and universal assessment criteria for postoperative emergence agitation or delirium should be conducted.
2024-11-05Current Drug Safety
Carbamazepine-induced Stevens-Johnson Syndrome: A Case Report with Review of the Literature
Article
作者: S, Nirenjen ; Dhansekaran, Sivaraman ; Manavalan, Mohankumar ; Raja, Sangeetha ; Subramanian, Arunkumar ; Haitharali, Rajamohamed ; T, Tamilanban ; Gnanasekaran, Sabariakilesh
Background::
Stevens-Johnson Syndrome (SJS) is an infrequent yet severe mucocutaneous
reaction that involves less than 10% of the Body Surface Area (BSA). It is predominantly
induced by certain medications, including anticonvulsants (e.g., Lamotrigine, Carbamazepine,
Phenytoin, Phenobarbitone), Allopurinol at doses above 100 mg per day, and sulphonamides
(e.g., Cotrimoxazole, Sulfasalazine). Genetic predispositions, particularly the presence of the
HLA-B*1502 allele, significantly increase the risk of developing SJS. This case report discusses
a unique presentation of SJS in a young female patient, emphasizing the critical need for genetic
screening and careful monitoring when prescribing Carbamazepine, especially in populations at
higher genetic risk.
Case Presentation::
A 19-year-old female patient, who had been on Phenytoin and Sodium
Valproate for epilepsy management over the past year, was newly prescribed Carbamazepine.
Within a week of initiating Carbamazepine, the patient experienced a seizure, followed by the
sudden onset of fever, painful sores, and blisters covering the upper body, along with mucous
discharge from both eyes. These symptoms rapidly worsened. Based on clinical presentations
and the extent of epidermal detachment, the patient was diagnosed with SJS. The severity and
mortality risks were assessed using the SCORTEN score. Therapeutic interventions included intravenous
Ranitidine, Ondansetron, Paracetamol, Midazolam, Levetiracetam, and Dexamethasone,
along with oral Fluconazole, Chlorpheniramine tablets, and Ciprofloxacin eye drops.
The patient showed significant improvement and was discharged after fourteen days with followup
advice.
Conclusion::
This case underscores the critical importance of performing genetic testing for the
HLA-B*1502 allele and conducting baseline blood tests before initiating Carbamazepine therapy.
Such precautionary measures can significantly mitigate the risk of severe adverse reactions
like SJS. This report adds to the scientific literature by highlighting the potential dangers associated
with anticonvulsant therapies and the necessity for personalized medicine approaches in
preventing life-threatening conditions. The main takeaway is the pivotal role of genetic screening
and vigilant monitoring in the management of patients requiring anticonvulsant medications to
prevent serious adverse reactions.
100 项与 马来酸氯苯那敏 相关的药物交易
登录后查看更多信息
研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 血管水肿 | 日本 | 2007-08-31 | |
| 血管性水肿 | 日本 | 1984-07-20 | |
| 湿疹 | 日本 | 1984-04-24 | |
| 皮肤疾病 | 日本 | 1984-04-24 | |
| 皮炎 | 中国 | 1981-01-01 | |
| 皮炎 | 中国 | 1981-01-01 | |
| 药物性皮炎 | 中国 | 1981-01-01 | |
| 药物性皮炎 | 中国 | 1981-01-01 | |
| 药物性皮炎 | 中国 | 1981-01-01 | |
| 药物性皮炎 | 中国 | 1981-01-01 | |
| 药物性皮炎 | 中国 | 1981-01-01 | |
| 水肿 | 日本 | 1961-01-27 | |
| 瘙痒 | 日本 | 1961-01-27 | |
| 呼吸道感染 | 日本 | 1961-01-27 | |
| 过敏性鼻炎 | 日本 | 1961-01-27 | |
| 季节性过敏性鼻炎 | 日本 | 1961-01-27 | |
| 血管舒缩性鼻炎 | 日本 | 1961-01-27 | |
| 超敏反应 | 美国 | 1949-07-13 | |
| 荨麻疹 | 美国 | 1949-07-13 |
未上市
10 条进展最快的记录, 后查看更多信息
登录
| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 新型冠状病毒感染 | 临床3期 | 洪都拉斯 | 2022-07-27 | |
| 皮肤过敏 | 临床1期 | 中国 | 2019-02-19 | |
| 神经性皮炎 | 临床1期 | 中国 | 2019-02-19 | |
| 光过敏疾患 | 临床1期 | 中国 | 2019-02-19 | |
| 瘙痒（皮肤发痒） | 临床1期 | 中国 | 2019-02-19 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | - | Chlorpheniramine Maleate (CPM) 10-day treatment | 廠壓築構淵糧獵窪遞製(齋製願夢鹹鬱觸願製醖) = 糧餘憲衊艱鹹繭鑰鹽繭 鑰積壓廠築壓積鬱構夢 (觸顧淵膚憲遞廠觸網顧, 8.6) 更多 | - | 2023-05-21 | ||
N/A | - | 範襯簾蓋壓壓膚範鏇夢(廠窪繭壓餘廠網鏇簾糧) = 齋繭鏇築壓廠蓋積壓艱 壓鑰糧遞衊窪醖鬱夢艱 (糧獵齋網網構鑰構顧鏇 ) | 积极 | 2021-07-10 | |||
Control group | 範襯簾蓋壓壓膚範鏇夢(廠窪繭壓餘廠網鏇簾糧) = 繭膚窪獵選獵簾蓋鏇積 壓鑰糧遞衊窪醖鬱夢艱 (糧獵齋網網構鑰構顧鏇 ) | ||||||
临床2/3期 | 24 | 蓋製鏇齋構醖構觸鑰網(鏇選繭築醖醖糧艱願夢) = 顧淵觸願窪衊蓋蓋積蓋 糧衊構鹽積襯鹽憲餘膚 (襯醖衊憲醖繭範簾網簾 ) 更多 | - | 2001-04-01 | |||
蓋製鏇齋構醖構觸鑰網(鏇選繭築醖醖糧艱願夢) = 糧繭網窪積繭願積網獵 糧衊構鹽積襯鹽憲餘膚 (襯醖衊憲醖繭範簾網簾 ) 更多 |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
来和芽仔聊天吧
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用