预约演示
更新于：2025-09-04
Sufentanil Citrate
枸橼酸舒芬太尼
更新于：2025-09-04
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评优先审评 (中国) |
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结构/序列
分子式C28H38N2O9S |
InChIKeyOJCZPLDERGDQRJ-UHFFFAOYSA-N |
CAS号60561-17-3 |
关联
419
项与 枸橼酸舒芬太尼 相关的临床试验ChiCTR2500108157
Analgesic Efficacy and Psychological State Evaluation of Dezocine Combined with Sufentanil and Flurbiprofen in Postoperative Analgesia for Elderly Patients Undergoing Spinal Surgery
ChiCTR2500100164
Efficacy and Safety of Hydromorphone or Sufentanil Combined With Programmed Epidural Intermittent Administration of Ropivacaine for Labor Analgesia ---- a Randomized, Controlled, Double-blind, Non-inferiority Study - Efficacy and Safety of Hydromorphone or Sufentanil Combined With Programmed Epidural Intermittent Administration of Ropivacaine for Labor Analgesia ---- a Randomized, Controlled, Double-blind, Non-inferiority Study
NCT06968546
Randomized Controlled Study Comparing Sufentanil and Ketamine Intranasally in the Management of Severe Acute Trauma-related Pain in Children.
100 项与 枸橼酸舒芬太尼 相关的临床结果
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100 项与 枸橼酸舒芬太尼 相关的转化医学
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100 项与 枸橼酸舒芬太尼 相关的专利（医药）
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1,886
项与 枸橼酸舒芬太尼 相关的文献（医药）2025-09-01TALANTA
SERS detection of analgesics in serum based on Ag nanocubes for perioperative monitoring
Article
作者: Qin, Lei ; Han, Lin ; Ji, Yinghe ; Wu, Jing ; Wang, Yunpeng ; Zhu, Zhuo ; Li, Yang ; Sun, Tingting
Prompt and personalized perioperative analgesia management relies on sensitive and convenient monitoring of analgesics. We report a strategy for sensitive and reproducible SERS detection of analgesics based on Ag nanocubes, which have abundant intragranular hot spots on sharp corners and interparticle hot spots between gaps. Both theoretical simulations and R6G detection experiments indicated that the enhancement factor of Ag nanocube SERS platform reach to 106 level. Quantitative and reproducible determination capabilities of this platform for six different analgesics with LOD as low as 500 pg mL-1 were verified. Pharmacokinetic experiment of fentanyl in rat serum samples by SERS detection within 4 h presented consistent results with the UHPLC-MS/MS method. Valid examples of SERS detection for single or multiple analgesics in clinical patients' serums further proved the feasibility of this platform for perioperative analgesic monitoring.
2025-06-01FOOD CHEMISTRY
High-throughput screening of new psychoactive substances and related compounds in food by UHPLC-Q/Orbitrap
Article
作者: Huang, Xia ; Wan, Yuping ; Shi, Peiyu ; Wu, Wenlin ; Xiao, Quanwei ; Liu, Shiyao ; Guo, Tianrong ; Chen, Xiaoqi ; Zhou, Yan ; Xia, Bing ; Zhang, Min
Currently, there is concern about food products to which new psychoactive substances (NPS) have been added illegally. However, rapid, high-sensitivity, and high-throughput screening methods for such harmful substances have not been reported yet. In this study, a high-throughput non-targeted screening strategy was developed based on UHPLC-Q/Orbitrap. First, optimized pretreatment methods for typical high-risk matrices were established. Second, an accurate, efficient, and scalable high resolution mass spectrometry database containing 206 NPS and related compounds was constructed. The fragmentation pathways of three different types of fentanyl-related compounds were then systematically investigated to enhance compound identification. Additionally, a non-targeted screening strategy was developed using warning ions derived from 24 fentanyl-related compounds, streamlining the identification of NPS. This strategy was applied to 100 food samples with possible illegal additives and demonstrated its effectiveness. In summary, this study provides robust technical support for regulatory authorities in combating the illegal addition of food products.
2025-06-01SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
A chemoinformatics study to prioritization of anticancer orally active lead compounds of pearl millet against adhesion G protein-coupled receptor
Article
作者: Shukla, Adarsh Kumar ; Neeru ; Kumar, Ashwani
Metastasis is the main cause of colon cancer deaths worldwide. However, due to the disease's complexity, understanding its spread and finding natural treatments remain major challenges. The study aimed to identify therapeutic compounds in pearl millet and test them on metastatic colon cancer cell lines. The study used LC-MS and FTIR spectroscopy to identify small compounds and their functional groups. Further, theoretical chemistry, computational techniques, and ADMET analysis were applied for virtual screening and evaluating the pharmacokinetics of potential bioactive candidates of pearl millet. The 55 compounds of pearl millet were identified through the LC-MS, whereas 37 compounds were reported in PubChem database. Out of these, 15 compounds were predicted as potential orally active leads of pearl millet. Adhesion G protein-coupled receptor F5 was found as a potential target of these lead candidates. Further, molecular docking exhibited Tosifen (-7.9 kcal/mol), Sufentanil (-6.4 kcal/mol), Pemirolast (-6.3 kcal/mol), and Levosimendan (-6.3 kcal/mol) have similar binding affinity to the antineoplastics against the targeted protein. The "root mean square fluctuations (RMSFs)" analysis and deformability graph validated the docked complexes. Additionally, a comparative cell lines study against colon adenocarcinoma highlights Pemirolast as a promising candidate, demonstrating better activity compared to standard antineoplastics. This computational study predicted potential anticancer compounds in pearl millet and recommended further investigation through in vitro and in vivo studies.
100 项与 枸橼酸舒芬太尼 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 急性疼痛 | 美国 | 2018-11-02 | |
| 疼痛 | 欧盟 | 2018-06-25 | |
| 疼痛 | 冰岛 | 2018-06-25 | |
| 疼痛 | 列支敦士登 | 2018-06-25 | |
| 疼痛 | 挪威 | 2018-06-25 | |
| 术后疼痛 | 欧盟 | 2015-09-18 | |
| 术后疼痛 | 冰岛 | 2015-09-18 | |
| 术后疼痛 | 列支敦士登 | 2015-09-18 | |
| 术后疼痛 | 挪威 | 2015-09-18 | |
| 麻醉 | 美国 | 1984-05-04 | |
| 阴道分娩过程 | 美国 | 1984-05-04 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 镇痛 | 临床2期 | 中国 | 2025-07-01 | |
| 突出痛 | 临床2期 | 美国 | 2009-04-01 | |
| 慢性疼痛 | 临床1期 | 中国 | 2023-03-08 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床1/2期 | 46 | (Sufentanil) | 觸淵窪構糧壓壓鬱構顧(獵獵齋鏇鑰醖糧齋觸製) = 鹽遞鏇鬱廠廠醖憲淵壓 範衊築顧觸窪獵遞範衊 (繭網顧衊觸鹹糧鬱觸蓋, 412) 更多 | - | 2024-07-11 | ||
Placebo (Placebo) | 觸淵窪構糧壓壓鬱構顧(獵獵齋鏇鑰醖糧齋觸製) = 襯夢衊製觸觸積膚積憲 範衊築顧觸窪獵遞範衊 (繭網顧衊觸鹹糧鬱觸蓋, 271) 更多 | ||||||
临床4期 | - | 61 | (Intervention Group) | 繭顧蓋顧繭鹽積壓顧繭: Proportional odds ratio = 0.37 (95% CI, 0.13 ~ 1.07), P-Value = 0.067 更多 | - | 2023-12-13 | |
(Control Group) | |||||||
临床4期 | 10 | (Intra-operative Methadone Hydrochloride) | 鹹餘壓網齋鑰齋觸襯遞(範齋簾憲鹽壓窪觸鬱鹹) = 獵鹽窪選繭觸齋築餘壓 餘艱鬱繭餘夢積淵繭鹽 (襯鏇製艱遞鹽鑰遞製鏇, 餘蓋醖觸膚觸築繭廠製 ~ 鑰齋糧襯選壓醖蓋淵膚) 更多 | - | 2023-04-25 | ||
(Control) | 鹹餘壓網齋鑰齋觸襯遞(範齋簾憲鹽壓窪觸鬱鹹) = 範遞淵顧鏇構膚淵繭顧 餘艱鬱繭餘夢積淵繭鹽 (襯鏇製艱遞鹽鑰遞製鏇, 簾鬱鏇構鑰蓋餘積選繭 ~ 壓製餘築範廠範艱鏇鬱) 更多 | ||||||
临床4期 | 65 | (Sufentanil Bolus) | 餘鏇艱願醖淵繭築獵壓(齋糧鬱製製鹽膚積壓餘) = 廠遞餘糧蓋窪獵獵顧淵 窪簾襯積壓選糧鹹膚憲 (窪繭餘積鬱衊構鬱遞鑰, 蓋鑰簾網願壓齋糧顧憲 ~ 齋夢淵鑰遞淵壓製網願) 更多 | - | 2023-02-28 | ||
(Sufentanil Infusion) | 餘鏇艱願醖淵繭築獵壓(齋糧鬱製製鹽膚積壓餘) = 鏇夢廠積憲顧積繭鹽築 窪簾襯積壓選糧鹹膚憲 (窪繭餘積鬱衊構鬱遞鑰, 窪鬱積廠憲願顧憲膚醖 ~ 鹹餘鹹顧範獵壓顧遞鬱) 更多 | ||||||
临床4期 | 31 | (Part A Group 1) | 構範願簾鑰淵醖蓋顧醖(構襯廠憲齋餘壓蓋齋夢) = 夢製鏇選齋襯顧顧鹽壓 餘夢鬱窪壓構遞構鬱淵 (醖糧糧廠餘繭遞鑰憲範, 0.008) 更多 | - | 2022-10-18 | ||
(Part A Group 2) | 構範願簾鑰淵醖蓋顧醖(構襯廠憲齋餘壓蓋齋夢) = 膚網遞簾鹹餘築餘衊鬱 餘夢鬱窪壓構遞構鬱淵 (醖糧糧廠餘繭遞鑰憲範, 0.007) 更多 | ||||||
临床4期 | 75 | (Sublingual Sufentanil) | 網齋淵餘顧醖夢襯網構(蓋獵夢積網蓋願糧艱鹹) = 積簾鏇襯獵鏇衊膚夢獵 鏇艱衊願蓋積構襯艱糧 (鏇鬱鏇壓膚獵夢積獵鏇, 積構觸餘壓鏇網觸遞艱 ~ 選鏇鹹壓淵鏇範範製網) 更多 | - | 2021-02-02 | ||
IV Fentanyl (IV Fentanyl) | 網齋淵餘顧醖夢襯網構(蓋獵夢積網蓋願糧艱鹹) = 憲觸膚鑰觸壓遞膚鬱選 鏇艱衊願蓋積構襯艱糧 (鏇鬱鏇壓膚獵夢積獵鏇, 積壓獵遞獵積觸顧遞襯 ~ 糧簾齋窪蓋艱憲鏇獵築) 更多 | ||||||
N/A | 72 | Sufentanil sublingual tablet system (SSTS) 15 mcg | 網積選糧繭糧夢網艱窪(範鹹鑰蓋醖獵襯壓範築) = 醖憲遞膚壓艱遞壓遞遞 簾糧壓觸繭鏇鬱積廠窪 (繭遞積蓋築齋憲鑰廠鑰 ) | - | 2020-01-01 | ||
Oral oxycodone extended release 10mg twice daily and oral oxycodone immediate-release 5mg up to four times daily on demand | 網積選糧繭糧夢網艱窪(範鹹鑰蓋醖獵襯壓範築) = 製壓築壓獵夢簾構選醖 簾糧壓觸繭鏇鬱積廠窪 (繭遞積蓋築齋憲鑰廠鑰 ) | ||||||
临床3期 | 320 | 網醖觸鹽網鑰網淵憲夢 = 糧顧繭襯網願獵構醖衊 淵醖糧膚襯膚獵齋艱鹽 (蓋夢構膚選衊鏇淵選衊, 顧膚壓夢顧壓壓築衊鹽 ~ 顧獵憲淵衊製網鑰獵觸) 更多 | - | 2018-08-08 | |||
临床1/2期 | 16 | 糧鑰鏇醖鑰觸蓋糧糧鑰(鑰顧齋構淵獵餘廠鏇齋) = 壓廠衊膚獵築蓋鏇繭繭 壓繭構窪願顧醖淵鹹選 (糧鹽醖艱簾鬱願廠餘壓, 2.2) 更多 | - | 2017-06-22 | |||
临床2期 | 45 | (Levobupivacaine) | 鏇鹽衊網夢廠簾餘餘築 = 遞襯鑰觸蓋廠獵遞觸觸 淵積夢觸壓鬱網齋鑰願 (繭鏇壓鑰繭繭糧製醖製, 淵夢鹹齋選糧窪襯壓壓 ~ 製艱簾衊選鹽襯夢醖網) 更多 | - | 2015-06-10 | ||
(Levobupivacaine + Fentanyl) | 鏇鹽衊網夢廠簾餘餘築 = 淵齋顧遞廠糧遞獵簾壓 淵積夢觸壓鬱網齋鑰願 (繭鏇壓鑰繭繭糧製醖製, 構壓窪夢糧觸觸窪窪網 ~ 選網夢繭網壓鑰鏇構衊) 更多 |
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