Pneumococcal polysaccharide conjugate vaccine

March 26, 2025 7:45 am ET EC decision marks the fourth approval for CAPVAXIVE for pneumococcal vaccination in adults RAHWAY, N.J.--(BUSINESS WIRE)-- Merck (NYSE: MRK), known as MSD outside of the United States and Canada, announced today that the European Commission (EC) has approved CAPVAXIVE ® (Pneumococcal 21-valent Conjugate Vaccine) for active immunization for the prevention of invasive disease and pneumonia caused by Streptococcus pneumoniae serotypes 3, 6A, 7F, 8, 9N, 10A, 11A, 12F, 15A, 15B, 15C, 16F, 17F, 19A, 20A, 22F, 23A, 23B, 24F, 31, 33F and 35B in individuals 18 years of age and older. CAPVAXIVE is a pneumococcal vaccine specifically designed to help protect adults from the serotypes responsible for the majority of invasive pneumococcal disease (IPD) cases. The EC approval of CAPVAXIVE is based on safety and immunogenicity data from the Phase 3 STRIDE clinical program. This decision authorizes the marketing of CAPVAXIVE in all 27 European Union (EU) member states, as well as Iceland, Liechtenstein and Norway. The timing for availability of CAPVAXIVE in individual countries will depend on multiple factors, including the completion of reimbursement procedures. CAPVAXIVE was approved in the U.S. in June 2024, in Canada in July 2024, and in Australia in January 2025. “Pneumococcal disease continues to pose a significant risk for adults in Europe, among adults who are 65 or older, and also among younger adults who are immunocompromised or have chronic medical conditions,” said Dr. Lina Pérez Breva, Vaccine Research, Fisabio - Public Health, Valencia, Spain. “Based on data from the Phase 3 STRIDE clinical program, CAPVAXIVE offers coverage against the serotypes responsible for the majority of invasive disease cases in adults, making this approval in the EU an important step in helping to protect adults from pneumococcal disease.” “By focusing on the serotypes that have been responsible for an increasing proportion of adult invasive pneumococcal disease cases, CAPVAXIVE allows us to offer protection specifically designed for adults,” said Dr. Paula Annunziato, senior vice president, infectious diseases and vaccines, Global Clinical Development, Merck Research Laboratories. “We are proud to bring CAPVAXIVE to adults in Europe who may benefit from its broad protection and are eager to continue working with regulatory authorities to expand CAPVAXIVE availability worldwide.” European Union country-level data have demonstrated that the serotypes covered by CAPVAXIVE are responsible for more cases of IPD in adults compared to PCV20 (pneumococcal 20-valent conjugate vaccine), as shown in these selected four countries: Coverage of Serotypes Responsible for IPD in Select EU Countries Country Age Year Reported CAPVAXIVE PCV20 Germany ≥60 2020 ~84% ~58% France >65 2022 ~85% ~63% Italy >65 2023 ~77% ~64% Spain >65 2020 ~82% ~62% Data were included for select countries based on EU membership, population size and the most recent year reported. These values are based on country-level epidemiologic data and regional variations may exist; they do not reflect the efficacy of the respective vaccines. There are currently no studies comparing the efficacy of CAPVAXIVE and PCV20. The decision by the EC follows the positive recommendation from the European Medicines Agency’s Committee for Medicinal Products for Human Use released in January 2025 and was based on results from the pivotal Phase 3 STRIDE-3 trial ( NCT05425732 ), which evaluated CAPVAXIVE compared to PCV20 in adults 18 years of age and older who had not previously received a pneumococcal vaccine, and STRIDE-10 ( NCT05569954 ), which compared CAPVAXIVE to PPSV23 (pneumococcal vaccine, polyvalent [23-valent]) in adults 50 years of age and older who had not previously received a pneumococcal vaccine. The approval is also supported by results from the Phase 3 STRIDE-4 ( NCT05464420 ), STRIDE-5 ( NCT05526716 ), STRIDE-6 ( NCT05420961 ), and STRIDE-7 ( NCT05393037 ) trials (see “Clinical data supporting EC approval” below, for additional details). Clinical data supporting EC approval CAPVAXIVE was approved by the EC based on data that included Phase 3 clinical studies designed to evaluate its safety and immunogenicity in a variety of adult populations. These included: STRIDE-3 ( NCT05425732 ): A double-blind, Phase 3 study which evaluated CAPVAXIVE compared to PCV20 in individuals 18 years of age and older who had not previously received a pneumococcal vaccine. Participants 50 years of age and older were enrolled in cohort 1 (n=2,362), and participants 18 through 49 years of age were enrolled in cohort 2 (n=300). Participants were randomized to receive a single dose of either CAPVAXIVE or PCV20. Results from the study include: In adults 50 years of age and older (cohort 1), CAPVAXIVE was non-inferior to PCV20 for the 10 serotypes shared with both vaccines (3, 6A, 7F, 8, 10A, 11A, 12F, 19A, 22F, 33F), as assessed by serotype-specific opsonophagocytic activity (OPA) geometric mean titers (GMTs) one month post-vaccination; CAPVAXIVE was superior to PCV20 for 10 of 11 serotypes included in CAPVAXIVE but not in PCV20 (9N, 15A, 16F, 17F, 20A, 23A, 23B, 24F, 31, 35B), as assessed by serotype-specific OPA GMTs one month post-vaccination and the proportions of patients with a greater than or equal to four-fold increase in OPA from pre-vaccination to one month post-vaccination; Immune responses were observed for serotype 15C in participants receiving CAPVAXIVE but did not meet criteria for statistical superiority; In individuals 18 through 49 years of age (cohort 2), CAPVAXIVE elicited non-inferior immune responses (immunobridged) compared to individuals 50 through 64 years of age, as assessed by serotype-specific OPA GMTs one month post-vaccination; Across both cohorts, CAPVAXIVE had a safety profile comparable to PCV20. STRIDE-10 ( NCT05569954 ): A randomized, double-blind, Phase 3 study which evaluated CAPVAXIVE compared to PPSV23 in individuals 50 years of age or older who had not previously received a pneumococcal conjugate vaccine (n=1,484). Results from the study include: CAPVAXIVE was non-inferior to PPSV23 for the 12 common serotypes and was superior to PPSV23 for the nine unique serotypes in CAPVAXIVE, as measured by serotype-specific OPA GMTs 30 days post-vaccination; The proportion of patients with ≥4-fold rise in OPA GMT ratios from Day 1 to Day 30 for serotype-specific OPA for V116 was superior to PPSV23 for eight out of nine serotypes unique to CAPVAXIVE compared to PPSV23; CAPVAXIVE was found to have a safety profile comparable to PPSV23. STRIDE-4 ( NCT05464420 ): A randomized, double-blind, Phase 3 lot-to-lot consistency study which evaluated CAPVAXIVE in individuals 18 to 49 years of age who had not previously received a pneumococcal conjugate vaccine (n=2,162). Participants were randomized to receive a single dose of either one of three lots of CAPVAXIVE or PPSV23 (pneumococcal 23-valent polysaccharide vaccine). Results from the study include: Across the three lots, CAPVAXIVE elicited equivalent immune response, as assessed by serotype-specific OPA GMTs and Immunoglobulin G (IgG) geometric mean concentrations (GMCs) 30 days post-vaccination; OPA GMTs were generally comparable between CAPVAXIVE combined lots and PPSV23 groups for the common serotypes and were higher in the CAPVAXIVE group for serotypes unique to CAPVAXIVE; CAPVAXIVE has a safety profile comparable to PPSV23. STRIDE-5 ( NCT05526716 ): A randomized, double-blind, Phase 3 study which evaluated CAPVAXIVE when administered concomitantly or sequentially (30 days later) with QIV in adults 50 years of age and older (n=1,080). Results from the study include: For the primary immunogenicity endpoints, CAPVAXIVE administered concomitantly with QIV was non-inferior to CAPVAXIVE administered sequentially with QIV for 20 of 21 serotypes in CAPVAXIVE (as assessed by OPA GMTs at one month post-vaccination), as well as for three of four influenza strains in QIV (as assessed by hemagglutination inhibition (HAI) GMTs at one month post-vaccination); The rates and severity of solicited systemic adverse reactions and solicited local adverse reactions at the CAPVAXIVE injection site were similar when CAPVAXIVE was administered with or without inactivated QIV. STRIDE-6 ( NCT05420961 ): A randomized descriptive Phase 3 study which evaluated CAPVAXIVE in individuals 50 years of age and older who had previously received a pneumococcal vaccine at least one year before enrollment. Participants were enrolled into one of three cohorts based on their previous pneumococcal vaccination history (cohort 1: PPSV23, cohort 2: PCV13 [pneumococcal 13-valent conjugate vaccine], or cohort 3: PPSV23 followed by or preceded by PCV13, PPSV23 preceded by PCV15 [pneumococcal 15-valent conjugate vaccine], or PCV15 alone). Participants in cohort 1 were randomized to receive CAPVAXIVE (n=231) or PCV15 (n=119), participants in cohort 2 were randomized to receive CAPVAXIVE (n=176) or PPSV23 (n=85), and participants in cohort 3 were allocated to receive CAPVAXIVE (n=106). In each of the 3 cohorts, serotype-specific OPA GMTs and the proportion of individuals with ≥4-fold rise in OPA responses from baseline to one-month post-vaccination were assessed. Results from the study include: In cohort 1, CAPVAXIVE elicited OPA responses that were comparable to PCV15 for the 6 common serotypes, and higher for the 15 unique serotypes and serotype 15B; In cohort 2, CAPVAXIVE elicited OPA responses comparable to PPSV23 for the 12 common serotypes and serotype 15B, and higher for the 9 unique serotypes; OPA responses to CAPVAXIVE were similar across the 3 cohorts of participants who previously received one or more pneumococcal vaccines; CAPVAXIVE had a safety profile comparable to both PCV15 and PPSV23. STRIDE-7 ( NCT05393037 ): A randomized, double-blind, Phase 3 study which evaluated CAPVAXIVE in individuals 18 years of age or older living with human immunodeficiency virus (HIV) (n=304) who were pneumococcal vaccine-naïve or vaccine-experienced prior to the study. Participants were randomized to receive either CAPVAXIVE or PCV15 + PPSV23. Results from the study include: CAPVAXIVE was immunogenic for all serotypes covered by the vaccine, as assessed by OPA GMTs and IgG GMCs 30 days post-vaccination; CAPVAXIVE elicited comparable immune responses to PCV15+PPSV23 for all 13 shared serotypes and higher immune responses for the eight serotypes covered only by CAPVAXIVE, as assessed by serotype-specific OPA GMTs and IgG GMCs at Day 30; Fewer participants experienced adverse events (AEs) with CAPVAXIVE (71.6%) compared with PCV15+PPSV23 (91%), primarily due to fewer injection-site AEs. About CAPVAXIVE CAPVAXIVE is Merck’s FDA-approved 21-valent pneumococcal conjugate vaccine indicated for active immunization for the prevention of invasive disease and pneumonia in adults 18 years of age and older. CAPVAXIVE is specifically designed to help address Streptococcus pneumoniae serotypes predominantly responsible for adult invasive pneumococcal disease (IPD), including eight unique serotypes, 15A, 15C, 16F, 23A, 23B, 24F, 31 and 35B compared to other pneumococcal vaccines. CAPVAXIVE is administered as a single dose. CAPVAXIVE Indication in the U.S. CAPVAXIVE is indicated in the U.S. for: Active immunization for the prevention of invasive disease and pneumonia caused by Streptococcus pneumoniae serotypes 3, 6A, 7F, 8, 9N, 10A, 11A, 12F, 15A, 15B, 15C, 16F, 17F, 19A, 20A, 22F, 23A, 23B, 24F, 31, 33F and 35B in individuals 18 years of age and older; Active immunization for the prevention of pneumonia caused by S. pneumoniae serotypes 3, 6A, 7F, 8, 9N, 10A, 11A, 12F, 15A, 15C, 16F, 17F, 19A, 20A, 22F, 23A, 23B, 24F, 31, 33F and 35B in individuals 18 years of age and older. CAPVAXIVE should not be administered to individuals with a history of a severe allergic reaction (e.g., anaphylaxis) to any component of CAPVAXIVE or to diphtheria toxoid; see additional Select Safety Information below. The indication for the prevention of pneumonia caused by S. pneumoniae serotypes 3, 6A, 7F, 8, 9N, 10A, 11A, 12F, 15A, 15C, 16F, 17F, 19A, 20A, 22F, 23A, 23B, 24F, 31, 33F and 35B is approved under accelerated approval based on immune responses as measured by opsonophagocytic activity (OPA). Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial. Selected Safety Information for CAPVAXIVE in the U.S. Do not administer CAPVAXIVE to individuals with a history of a severe allergic reaction (eg, anaphylaxis) to any component of CAPVAXIVE or to diphtheria toxoid. Individuals with altered immunocompetence, including those receiving immunosuppressive therapy, may have a reduced immune response to CAPVAXIVE. The most commonly reported (>10%) solicited adverse reactions in individuals 18 through 49 years of age who received CAPVAXIVE were: injection-site pain (73.1%), fatigue (36.0%), headache (27.5%), myalgia (16.4%), injection-site erythema (13.8%), and injection-site swelling (13.3%). The most commonly reported (>10%) solicited adverse reactions in individuals 50 years of age and older who received CAPVAXIVE were: injection-site pain (41.2%), fatigue (19.7%), and headache (11.0%). Vaccination with CAPVAXIVE may not protect all vaccine recipients. About pneumococcal disease Pneumococcal disease is an infection caused by a bacteria called Streptococcus pneumoniae . There are about 100 different types (referred to as serotypes) of pneumococcal bacteria, which can affect adults differently than children. Pneumococcal disease can be invasive or non-invasive. Non-invasive pneumococcal illnesses include pneumonia (when pneumococcal disease is confined to the lungs), whereas invasive pneumococcal illnesses include pneumococcal bacteremia (infection in the bloodstream), bacteremic pneumococcal pneumonia (pneumonia with bacteremia) and pneumococcal meningitis (infection of the coverings of the brain and spinal cord). Pneumococcal pneumonia is a type of bacterial pneumonia, which is the most common clinical presentation of pneumococcal disease in adults. About Merck At Merck, known as MSD outside of the United States and Canada, we are unified around our purpose: We use the power of leading-edge science to save and improve lives around the world. For more than 130 years, we have brought hope to humanity through the development of important medicines and vaccines. We aspire to be the premier research-intensive biopharmaceutical company in the world – and today, we are at the forefront of research to deliver innovative health solutions that advance the prevention and treatment of diseases in people and animals. We foster a diverse and inclusive global workforce and operate responsibly every day to enable a safe, sustainable and healthy future for all people and communities. For more information, visit www.merck.com and connect with us on X (formerly Twitter) , Facebook , Instagram , YouTube and LinkedIn . Forward-Looking Statement of Merck & Co., Inc., Rahway, N.J., USA This news release of Merck & Co., Inc., Rahway, N.J., USA (the “company”) includes “forward-looking statements” within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995. These statements are based upon the current beliefs and expectations of the company’s management and are subject to significant risks and uncertainties. There can be no guarantees with respect to pipeline candidates that the candidates will receive the necessary regulatory approvals or that they will prove to be commercially successful. If underlying assumptions prove inaccurate or risks or uncertainties materialize, actual results may differ materially from those set forth in the forward-looking statements. Risks and uncertainties include but are not limited to, general industry conditions and competition; general economic factors, including interest rate and currency exchange rate fluctuations; the impact of pharmaceutical industry regulation and health care legislation in the United States and internationally; global trends toward health care cost containment; technological advances, new products and patents attained by competitors; challenges inherent in new product development, including obtaining regulatory approval; the company’s ability to accurately predict future market conditions; manufacturing difficulties or delays; financial instability of international economies and sovereign risk; dependence on the effectiveness of the company’s patents and other protections for innovative products; and the exposure to litigation, including patent litigation, and/or regulatory actions. The company undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events or otherwise. Additional factors that could cause results to differ materially from those described in the forward-looking statements can be found in the company’s Annual Report on Form 10-K for the year ended December 31, 2024 and the company’s other filings with the Securities and Exchange Commission (SEC) available at the SEC’s Internet site ( www.sec.gov ). Please see Prescribing Information for CAPVAXIVE (Pneumococcal 21-valent Conjugate Vaccine) at https://www-merck-com.libproxy1.nus.edu.sg/product/usa/pi_circulars/c/capvaxive/capvaxive_pi.pdf and Patient Information/Medication Guide for CAPVAXIVE at https://www-merck-com.libproxy1.nus.edu.sg/product/usa/pi_circulars/c/capvaxive/capvaxive_ppi.pdf . Media Contacts: Olivia Finucane 0044 7881 262476 Olivia.finucane@msd.com Chrissy Trank (640) 650-0694 chrissy.trank@merck.com Investor Contacts: Peter Dannenbaum (732) 594-1579 peter.dannenbaum@merck.com Damini Chokshi (732) 594-1577 damini.chokshi@merck.com Source: Merck & Co., Inc.

随着各家MNC的年报纷纷披露，大家都开始好奇，谁是MNC中卖药营收最多的那家？强生？似乎不是，虽然其总营收最高，达到了888亿美元，但是其中包括了器械等板块，其制药业务的营收为570亿美元。 真正在制药业务上营收最高的，是“宇宙药厂”辉瑞：制药业务总营收达到了636亿美元，成为2024年的全球制药营收一哥。 1 Primary Care板块——营收top1 2024年，辉瑞在primary care板块的营收达到了301亿美元。 在该板块的药物卖得最好的毫无疑问是Eliquis（阿哌沙班）——一款由BMS和辉瑞共同研发的抗凝血药物，2024年的销售额达到了133亿美元，辉瑞这边分得的营收额达到了73.66亿美元。 该药是一款新型凝血因子Xa抑制剂，迭代的是传统抗凝药物如华法林的市场。2012年获得FDA批准用于非瓣膜性心房颤动患者，以降低中风和血栓的风险。2014年，它被批准用于治疗深静脉血栓形成（DVT）和肺栓塞（PE）。现主要用于多种血栓栓塞性疾病的临床使用。 在同款沙班类药物方面，阿哌沙班是绝对的市场统治者般的存在。其实利伐沙班上市时间要更早，2008年便于加拿大和欧盟上市，但后期销量爬坡上远不如阿哌沙班。阿哌沙班销售额在2018年便超过98亿美元，2021年达到了167.32亿美元，算其销售峰值，随后销售额开始下滑。 不过，该项化合物专利也将于2026年到期，专利悬崖就在两年之内。 排名第二的药物是Prevnar family（包括Prevnar20和Prevnar13）——一款肺炎球菌疫苗，该药的2024年营收为64.11亿美元，同比2023年的65亿美元左右没有太大变化。Prevnar 13首次于2009年获得批准上市，也算是征战沙场已久。 排名第三的药物则早已火爆出圈——新冠特效药“Paxlovid”，该药的机制是阻断新冠病毒复制酶活性。该药自2021年底被FDA获批上市，2022年新冠时期销售额达到了189亿美元，随着后期疫情潮水退去，2023年销售额迅速滑坡到了12.79亿美元。而如今该药东山再起，达到了57.16亿美元。不过根据财报的解释，这主要是会计处理的问题。 排名第四的药物依然和新冠有关，它是新冠疫苗Comirnaty，不过新冠疫苗的市场目前确实已经处于非常饱和的状态。其2023年销售额超过了112亿美元，2024年销售额腰斩之后，为53.53亿美元。 总体来看，新冠抗病毒药＋新冠疫苗为辉瑞带来了超过110亿美元的年收入。 而这也是辉瑞的primary care板块中所有超过50亿美元药物营收的情况，该板块总的营收为301.35亿美元，总营收同比负增长2%，整体持平。 2 Specialty Care板块——紧随其后 该板块可以说是除了肿瘤药物之外，各种难治性疾病药物的大杂烩。 与前面的primary care板块不同的是，primary care板块主要是靠几款出色的超过50亿美元大单品撑起整个板块的营收（总体营收301.35亿美元，超过50亿美元的重磅炸弹营收总和为248.46亿美元，占比达到了82.45%），而Specialty Care板块仅仅有一款药物的营收超过了50亿美元——Vyndagel family。2024年Vyndagel family的营收达到了54.51亿美元，而该板块总体营收为166.52亿美元——超过50亿美元的重磅炸弹占总营收比例的三分之一左右。 Vyndagel family即氯苯唑酸家族药物，这是一类治疗淀粉样变性的药物。该病是由于蛋白质代谢紊乱产生的特殊淀粉样蛋白在人体一处或多处器官组织细胞间沉积，进而造成组织器官结构和功能改变的一种疾病，其主要治疗手段之一是TTR（转甲状腺素蛋白）类型疗法：使得转甲状腺素处于四聚体的稳定状态。Vyndagel family便是该类型的典型代表。 该药获批时间不算长——2019年获得FDA批准上市。目前增长速度还非常可观，2023年营收33.21亿元，而2024年营收便如上文所述达到了54.51亿元，同比增长了64%。之后还有不错的放量空间。 再往后，该板块营收排名第二的药物为Xeljanz，也是该板块唯二突破10亿美元营收的药物之一。该药是一类炎症/自免类型药物——JAK激酶抑制剂，2012年获得FDA批准治疗类风湿性关节炎。该药2016年的销售额就接近了10亿美元，2017年首次突破10亿美元达到了13.5亿美元，2019年该药的销售额突破了20亿美元，而后峰值在25亿美元左右。2024年的营收额为11.68亿美元，同比去年销售额下降了31%。 自免/炎症领域近年迭代速度较快，该药在专利到期之前面临着销售额达峰后大幅度下滑的困境，也无可厚非。 这便是该板块唯二两款10亿美元以上营收单品的情况，排名第三的是Enbrel依那西普，一款1998年上市的类风湿性关节炎老药。该药目前在美国已经有相关的生物类似药获批。不过，辉瑞对于该药的权益不包括美国和加拿大（北美权益在安进手中），这款老药如今仍能够为辉瑞带来6.9亿美元的营收，已经实属不易。 该板块总体情况便是如此，其所折射出的问题是该板块目前的青黄不接，仍然是一些上市多年的单品在苦苦支撑，除了Vyndagel近年来没有出色的重磅炸弹出来横扫市场。 不过该板块总体的营收增长却不错，2023年该板块营收为149.88亿美元，2024年为166.52亿美元，同比增长11%。这主要还是得益于Vyndagel的同比增长。 3 肿瘤板块——最受瞩目板块 对于平时行业内人士关注度来说，仍然是肿瘤板块最受关注，该板块2024年表现非常不错，2024年同比增长达到了25%。总共有4款单品营收突破了十亿美元。 该板块排名第一的重磅炸弹是lbrance（派柏西利），2024年收入为43.67亿美元，同比下降8%，其2021年销售额达到了54.3亿美元，之后便逐渐下滑。该药获批时间为2015年，其上市十年左右、不算很长时间，但对于肿瘤，尤其是乳腺癌CDK4/6抑制剂这个内卷到极致的癌种药物而言，已经面临着被后续新发管线围歼的趋势。比如礼来的阿贝西利营收已经超越了派柏西利，2024年其营收达到了53亿美元，同比增长了37%。 排名第二的药物则为Xtandi（恩杂鲁胺），雄激素受体抑制剂，用来治疗前列腺癌，同样是一条内卷的药物赛道。不过目前该药情况还算不错，2012年上市，目前营收仍然处于明显增长状态：其2024年营收为20.39亿美元，同比增长23%。 排名第三和第四的药物来源于对seagen ADC单品的收购。 排名第三的药物为Padcev，这款相信也不用作太多介绍：靶向nectin-4的ADC，主要治疗尿路上皮癌，权益在安斯泰来和辉瑞双方手中，2024年，该药为辉瑞带来了15.88亿美元的营收，2023年营收为10.3亿美元，增长还是非常可观的。 排名第四的药物为Adcetris，一款靶向CD30的ADC药物，治疗淋巴瘤，上市于2011年，2023年营收为16.5亿美元，2024年营收为10.89亿美元，目前看来还是随着上市时间日渐久远，呈现衰退势头。 排名第五是生物类似药的大杂烩，各种生物类似药营收加起来达到了10.37亿美元。 这是目前抗肿瘤药物板块的整体情况：2023年营收124.5亿美元，2024年营收156.12亿美元，增长非常可观，营收结构也较为分散，但派柏西利大单品营收的不断下滑，目前没看到能够填补该单品缺口的药物。 总体来说，肿瘤板块缺少一根“backbone”去当作万能药物，成为肿瘤药物的基石，例如PD-1单抗类型。之后，就看辉瑞会如何“出牌”。 结语：这就是全球制药营收一哥的情况，我们能看到它的辉煌，也能嗅到它的危机，不仅是special care板块缺少增长动力，在肿瘤板块也缺少“万精油”，在Primary Care这么大营收的总量背后，同比增长却是负数。总体而言，宇宙大药厂急需寻找新的增长点。 参考来源：辉瑞2024年财报 声明：本内容仅用作医药行业信息传播，为作者独立观点，不代表药智网立场。如需转载，请务必注明文章作者和来源。对本文有异议或投诉，请联系maxuelian@yaozh.com。 责任编辑 | 史蒂文 合作、投稿、转载开白 | 马老师 18323856316（同微信）  阅读原文，是受欢迎的文章哦