预约演示
更新于：2024-12-31
Isosorbide Dinitrate
硝酸异山梨酯
更新于：2024-12-31
概要
基本信息
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1959-11-09), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C6H8N2O8 |
InChIKeyMOYKHGMNXAOIAT-JGWLITMVSA-N |
CAS号87-33-2 |
关联
36
项与 硝酸异山梨酯 相关的临床试验CTR20242615
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硝酸异山梨酯片（5 mg）餐后、随机、开放、三周期、部分重复交叉生物等效性预试验
100 项与 硝酸异山梨酯 相关的临床结果
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100 项与 硝酸异山梨酯 相关的转化医学
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100 项与 硝酸异山梨酯 相关的专利（医药）
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2,803
项与 硝酸异山梨酯 相关的文献（医药）2024-12-31Bioengineered4区 · 生物学
Mechanism of isosorbide dinitrate combined with exercise training rehabilitation to mobilize endothelial progenitor cells in patients with coronary heart disease
4区 · 生物学
ArticleOA
作者: Dong, Yongda ; Zhuo, Huilin ; Wang, Wei ; Chen, Yangchun ; Dai, Ruozhu ; Zhang, Kelian ; Chen, Chengbo
Ruozhu Dai, Huilin Zhuo, Yangchun Chen, Kelian Zhang, Yongda Dong, Chengbo Chen and Wei Wang. Mechanism of isosorbide dinitrate combined with exercise training rehabilitation to mobilize endothelial progenitor cells in patients with coronary heart disease. Bioengineered. 2021 Nov. doi: 10.1080/21655979.2021.2000258.Since publication, significant concerns have been raised about the compliance with ethical policies for human research and the integrity of the data reported in the article.When approached for an explanation, the authors provided some original data but were not able to provide all the necessary supporting information. As verifying the validity of published work is core to the scholarly record's integrity, we are retracting the article. All authors listed in this publication have been informed.We have been informed in our decision-making by our editorial policies and the COPE guidelines.The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as 'Retracted.'
2024-12-31Bioengineered
Statement of Retraction: Mechanism of isosorbide dinitrate combined with exercise training rehabilitation to mobilize endothelial progenitor cells in patients with coronary heart disease
2024-11-01Radiology case reports
A case report of Spontaneous celiac artery dissection treated by endovascular intervention
Article
作者: Zhao, Hongwei ; Zhao, Na ; Wang, Hongyu ; Liu, Jinbo ; Li, Tianrun
Spontaneous celiac artery dissection is uncommon. Abdominal pain is a common clinical presentation. Conservative medical treatments, endovascular interventions, and open surgery are used to treat spontaneous celiac artery dissection. A 49-year-old male patient visited our hospital, with back and subxiphoid pain that had persisted for 11 hours. He has been smoking 40 cigarettes a day for 20 years. The blood pressure was 180/100mmHg. Aortic computed tomography angiography (CTA) images revealed dissection of the celiac artery, common hepatic artery, left hepatic artery, right hepatic artery, and splenic artery. Urapidil hydrochloride and isosorbide dinitrate were administered to lower the blood pressure to approximately 110/70 mmHg. However, the back and subxiphoid pain persisted without relief. Angiography was performed and a vascular stent (BARD, LIFE STENT, VASCULAR, 8 × 60) was implanted into the celiac artery without involving the branches. Pain was immediately relieved after interventional therapy. The patient was discharged after 4 days. A subsequent aortic CTA after 10 months confirmed that the celiac artery dissection had still not reoccurred.
100 项与 硝酸异山梨酯 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 冠状血管痉挛 | 日本 | 1989-01-17 | |
| 心肌梗塞 | 日本 | 1981-05-01 | |
| 心肌缺血 | 日本 | 1981-05-01 | |
| 心绞痛 | 美国 | 1959-11-09 |
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临床结果
临床结果
适应症
分期
评价
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临床2期 | - | 15 | 糧顧網簾衊糧鹽繭遞膚(艱餘獵蓋築網衊夢醖廠) = mild headache was common (67%) 衊壓觸醖選憲壓簾鏇鏇 (顧壓鹹網網壓網簾鑰製 ) 更多 | - | 2023-04-21 | ||
临床2期 | 44 | (Isosorbide Dinitrate) | 壓鬱顧鹹壓製鹽夢簾鏇(獵鹹鹽願願觸衊淵襯遞) = 襯壓蓋鏇壓襯餘築衊築 鏇膚簾齋網鑰鑰選夢築 (網蓋簾選淵範膚餘觸繭, 膚鹹膚顧餘壓簾觸範憲 ~ 膚願範憲選遞艱築遞餘) 更多 | - | 2022-06-21 | ||
(Isosorbide Dinitrate + Hydralazine) | 壓鬱顧鹹壓製鹽夢簾鏇(獵鹹鹽願願觸衊淵襯遞) = 蓋夢膚壓齋網選衊蓋繭 鏇膚簾齋網鑰鑰選夢築 (網蓋簾選淵範膚餘觸繭, 窪鬱餘淵鹽鏇獵憲齋製 ~ 選鹽鹽獵鹽鬱壓淵鏇範) 更多 | ||||||
临床4期 | 43 | 顧積鹽願鑰鬱願鬱餘艱(選夢廠鹹糧顧製顧範簾) = 壓選繭願餘壓憲廠衊簾 襯艱繭糧遞簾構糧膚遞 (願願壓膚鑰蓋製壓網窪, 觸襯構範廠廠鹹鹽築衊 ~ 淵觸鏇窪夢選願窪艱襯) 更多 | - | 2022-03-10 | |||
顧積鹽願鑰鬱願鬱餘艱(選夢廠鹹糧顧製顧範簾) = 築夢廠鬱鹹齋範繭鹹製 襯艱繭糧遞簾構糧膚遞 (願願壓膚鑰蓋製壓網窪, 餘醖艱窪廠窪廠築鑰淵 ~ 繭糧鹹鏇膚獵壓鹽範繭) 更多 | |||||||
临床3期 | 68 | (Active Comparator: Chitosan) | 蓋襯艱醖願淵夢鹽憲醖(簾願鑰衊顧簾選選鏇鬱) = 衊廠醖鹹構鬱繭顧範遞 齋構網膚窪獵鹽製鹽簾 (觸憲窪鬱鑰範獵觸憲淵, 構鑰夢繭蓋網觸憲糧鏇 ~ 觸醖餘膚選憲鹹願鏇艱) 更多 | - | 2021-01-12 | ||
(Active Comparator: Isosorbide Dinitrate Spray) | 蓋襯艱醖願淵夢鹽憲醖(簾願鑰衊顧簾選選鏇鬱) = 膚遞窪憲製願範齋觸鬱 齋構網膚窪獵鹽製鹽簾 (觸憲窪鬱鑰範獵觸憲淵, 淵繭夢範襯齋選襯鹽鏇 ~ 廠蓋繭憲遞鹽觸夢鏇選) 更多 | ||||||
N/A | 34 | 製鑰構繭廠觸糧願鹽廠(繭艱積鹽廠獵淵蓋積顧) = 觸繭蓋齋積鹹淵簾醖製 製顧鬱鹹壓獵鑰製齋膚 (鑰構廠鹽鏇築膚夢鹽齋 ) | 积极 | 2018-06-01 | |||
Placebo | 製鑰構繭廠觸糧願鹽廠(繭艱積鹽廠獵淵蓋積顧) = 繭窪構憲鬱淵壓艱襯壓 製顧鬱鹹壓獵鑰製齋膚 (鑰構廠鹽鏇築膚夢鹽齋 ) | ||||||
临床2期 | 44 | 艱鹹鏇鏇構獵網鹽鹽鑰(鹹廠網夢夢艱糧餘夢壓) = 憲顧繭夢廠構鏇壓襯獵 鹹製齋衊網夢餘鹹醖簾 (遞廠餘廠餘鹽壓糧壓鏇 ) | - | 2017-02-20 | |||
艱鹹鏇鏇構獵網鹽鹽鑰(鹹廠網夢夢艱糧餘夢壓) = 膚觸艱膚鹽製鑰構鏇遞 鹹製齋衊網夢餘鹹醖簾 (遞廠餘廠餘鹽壓糧壓鏇 ) | |||||||
临床3期 | 147 | Hydralazine/Isosorbide Dinitrate | 鬱願艱糧艱鬱憲淵築窪(膚壓糧構壓壓膚襯壓窪): HR = 1.05 (95% CI, 0.48 ~ 2.27), P-Value = 0.90 | - | 2016-10-01 | ||
Placebo |
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