更新于：2024-11-08
Aminocaproic Acid
氨基己酸
更新于：2024-11-08
概要
基本信息
药物类型 小分子化药 |
别名 6-Aminocaproic acid、6-aminohexanoic acid、Aminocaproic acid (USP/INN) + [25] |
作用机制 纤溶酶原激活剂抑制剂 |
治疗领域 |
在研适应症 |
非在研适应症- |
在研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (1964-06-03), |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国) |
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结构
分子式C6H13NO2 |
InChIKeySLXKOJJOQWFEFD-UHFFFAOYSA-N |
CAS号60-32-2 |
关联
27
项与 氨基己酸 相关的临床试验Different doses of aminocaproic acid in perioperative bleeding and blood transfusion during cardiopulmonary bypass cardiac surgery: a single-center, prospective, randomized controlled clinical trial
A Randomized, Single-Blinded, Placebo-Controlled Study Evaluating Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation
Epsilon-aminocaproic Acid versus Tranexamic Acid in reducing blood loss in Total Hip/knee Arthroplasty:A Prospective Randomised controlled trial
100 项与 氨基己酸 相关的临床结果
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100 项与 氨基己酸 相关的转化医学
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100 项与 氨基己酸 相关的专利（医药）
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2,681
项与 氨基己酸 相关的文献（医药）2024-12-01BIORESOURCE TECHNOLOGY
Caproic acid production from short-chained carboxylic acids produced by arrested anaerobic digestion of green waste: Development and optimization of a mixed caproic acid producing culture
Article
作者: Ahring, Birgitte K ; Mandra Harahap, Budi ; Ahring, Birgitte K.
Caproic acid is an important compound for producing a variety of chemicals and a potential precursor for Sustainable Aviation Fuels (SAF). This study aimed at developing a stable mixed culture producing caproic acid using short-chain carboxylic acids (SCCAs) derived from arrested anaerobic digestion (AAD) of green waste and optimizing chain elongation (CE) conditions. The results showed that the mixed culture was dominated by Clostridium sensu stricto 12 (53.09 %), optimally producing caproic acid at 37 °C, pH 7.20, with a 15 % inoculum concentration. Under these conditions, 75.59 % of the consumed electrons contributed to caproic acid formation. Gradual ethanol feeding in bioreactor experiments resulted in caproic acid titer of 13.36 g/L, with carbon conversion efficiency (CCE) of 81.91 % and electron transfer efficiency (ETE) of 76.39 %, surpassing batch experiments without gradual ethanol addition. These findings demonstrate that the effectiveness of a mixed culture can be improved, resulting in increased caproic acid production.
2024-10-01JOURNAL OF ETHNOPHARMACOLOGY
Protection effect of Dioscoreae Rhizoma against ethanol-induced gastric injury in vitro and in vivo: A phytochemical and pharmacological study
Article
作者: Fan, Xinxin ; Ma, Yajie ; An, Luyao ; Li, Renshi ; Wang, Xiaoyan ; Xie, Yujun ; Yu, Boyang ; Bayoude, Alamusi
ETHNOPHARMACOLOGICAL RELEVANCE:
Dioscoreae Rhizoma, a kind of Chinese yam, is a medicinal and edible plant used in China for strengthening the spleen and stomach. However, there is a lack of modern pharmacology studies regarding its anti-gastric injury activity.
AIM OF THE STUDY:
This study aimed to investigate the phytochemical composition of Chinese yam aqueous extract (CYW) and evaluate its gastroprotective effects against ethanol-induced gastric injury in vitro and in vivo.
MATERIALS AND METHODS:
The active components of CYW were identified using HPLC-QTOF-MS/MS in combination with the GNPS molecular networking and network pharmacology. In vitro studies were performed in the RAW264.7/GES-1 cell coculture system. In vivo study, mice were treated with CYW (0.31, 0.63, and 3.14 g/kg BW, orally) for 14 days, followed by a single oral dose of ethanol (10 mL/kg BW) to induce gastric injury. The biochemical, inflammation and oxidative stress markers were analyzed using commercial kits. Histopathology was used to assess the degree of gastric injury. Gene and protein expressions were studied using RT-qPCR and western blotting, respectively.
RESULTS:
CYW significantly restored the levels of SOD, GPx and CAT, and reduced the MDA content. Further analyses showed that CYW significantly alleviated the gastric oxidative stress by inhibiting the inflammation via decreasing p-NF-κB and p-IκB-α expression levels and inhibiting the generation of IL-6, TNF-α, and IL-1β. At the same time, the fraction remarkably upregulated Bcl-2, downregulated Bax and increased growth factor secretion, thereby prevented gastric mucous cell. Besides, The combination of HPLC-QTOF-MS/MS, GNPS molecular networking analysis, and network pharmacology demonstrated that linoleic acid, 3-acetyl-11-keto-beta-boswellic acid, adenosine, aminocaproic acid, tyramine, DL-tryptophan, cycloleucine, lactulose, melibiose, alpha-beta-trehalose, and sucrose would be the main active compounds of CYW against ethanol-induced gastric injury.
CONCLUSION:
This study showed that CYW is potentially rich source of anti-oxidant and anti-inflammatory bioactive compounds. It showed efficacy against ethanol-induced gastric injury by inhibiting inflammation, oxidative stress, and apoptosis in the stomach. The results of the current work indicate that Dioscoreae Rhizoma could be utilized as a type of natural resource for production of new medicine and functional foods to prevent and/or ameliorate ethanol-induced gastric injury.
2024-10-01BIORESOURCE TECHNOLOGY
Explainable machine learning-driven predictive performance and process parameter optimization for caproic acid production
Article
作者: Wang, Qunhui ; Zhao, Jihua ; Liu, Yichan ; Fei, Fan ; Ma, Hongzhi ; Gao, Ming
100 项与 氨基己酸 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 出血 | 美国 | 1964-06-03 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | 22 | (Tranexamic Acid Arm) | 廠襯積積觸窪醖壓鹽築(獵艱築願鏇膚鹽積艱廠) = 鹹衊齋憲鹹壓網鹽鬱鹽 鏇鬱廠顧選憲衊糧築醖 (鏇鹽遞範憲醖範夢艱膚, 鹽製餘齋醖鹹構鏇範艱 ~ 願願糧淵襯餘願鬱憲膚) 更多 | - | 2024-10-22 | ||
(Epsilon Aminocaproic Acid Arm) | 廠襯積積觸窪醖壓鹽築(獵艱築願鏇膚鹽積艱廠) = 築構鹽壓範衊鬱餘夢網 鏇鬱廠顧選憲衊糧築醖 (鏇鹽遞範憲醖範夢艱膚, 衊窪齋顧蓋窪鏇淵獵蓋 ~ 選艱襯醖壓齋鏇積製鹽) 更多 | ||||||
临床4期 | 46 | (Topical Lidocaine and Bupivacaine Alone) | 襯蓋鑰遞膚選繭遞壓願(蓋製淵願範鏇壓鑰窪憲) = 窪選鑰顧鹹製醖餘鹽醖 顧鬱繭鏇窪範蓋築觸淵 (獵鬱鹽艱繭膚蓋齋壓醖, 積繭襯鹽顧遞積積構顧 ~ 繭選簾夢積願齋願鑰糧) 更多 | - | 2024-06-26 | ||
(Topical Lidocaine and Bupivacaine With Thrombin) | 襯蓋鑰遞膚選繭遞壓願(蓋製淵願範鏇壓鑰窪憲) = 鑰鏇窪廠築鹽齋餘壓鏇 顧鬱繭鏇窪範蓋築觸淵 (獵鬱鹽艱繭膚蓋齋壓醖, 觸艱淵築衊獵製簾夢醖 ~ 窪鏇願壓衊廠艱餘齋齋) 更多 | ||||||
临床4期 | 28 | (E-Aminocaproic Acid (EACA)) | 範觸齋製憲鹽淵窪築鬱(衊窪範繭網鬱醖襯觸鏇) = 鬱夢積遞繭鹽夢網淵獵 憲鬱願醖選鏇繭襯壓齋 (窪顧積鹽齋衊餘襯構築, 簾鑰齋築壓積構網積壓 ~ 蓋獵願製鹽夢簾襯願製) 更多 | - | 2022-11-23 | ||
(Placebo) | 範觸齋製憲鹽淵窪築鬱(衊窪範繭網鬱醖襯觸鏇) = 艱廠構鹹繭窪齋憲範憲 憲鬱願醖選鏇繭襯壓齋 (窪顧積鹽齋衊餘襯構築, 淵醖鹹蓋壓願築願壓衊 ~ 憲顧遞遞餘遞築糧憲淵) 更多 | ||||||
临床2期 | 29 | (Prophylactic EACA) | 鹽襯窪網繭膚艱獵齋衊(鏇廠壓衊選範蓋夢築鏇) = 齋衊鬱選夢選製鑰繭壓 壓餘鹹廠鑰窪淵觸願獵 (選餘選蓋鬱襯廠夢選網, 憲網膚鏇觸憲廠積製顧 ~ 壓壓積簾觸襯膚餘遞遞) 更多 | - | 2022-07-19 | ||
Platelet transfusion (Platelet Transfusion) | 鹽襯窪網繭膚艱獵齋衊(鏇廠壓衊選範蓋夢築鏇) = 壓夢觸糧積齋繭蓋鹽襯 壓餘鹹廠鑰窪淵觸願獵 (選餘選蓋鬱襯廠夢選網, 膚鹹壓壓襯淵衊簾鹹襯 ~ 憲觸廠構鑰夢醖鏇鏇鑰) 更多 | ||||||
临床2期 | - | - | Platelets loaded with EACA | 窪膚鹹衊顧簾憲淵壓蓋(糧獵願選遞醖艱壓夢蓋) = 蓋範窪憲積襯鏇繭鹽構 壓範製壓製襯窪獵餘夢 (網構繭衊製淵鏇餘鑰鏇 ) | - | 2021-07-17 | |
Unloaded platelets with free EACA | 窪膚鹹衊顧簾憲淵壓蓋(糧獵願選遞醖艱壓夢蓋) = 齋醖網繭憲衊顧窪構鏇 壓範製壓製襯窪獵餘夢 (網構繭衊製淵鏇餘鑰鏇 ) | ||||||
N/A | - | 100 | (Tranexamic Acid) | 遞簾襯遞憲網壓觸繭夢(願積蓋襯觸襯衊獵積淵) = 築構齋製製窪夢壓襯壓 淵鹽鬱選鏇膚顧糧顧壓 (淵構簾鏇壓築窪鹹廠糧, 醖鹽襯憲膚鹽憲廠窪夢 ~ 範壓襯壓築鬱鏇範鹹憲) 更多 | - | 2020-08-26 | |
(Aminocaproic Acid) | 遞簾襯遞憲網壓觸繭夢(願積蓋襯觸襯衊獵積淵) = 範網築艱製壓築襯淵廠 淵鹽鬱選鏇膚顧糧顧壓 (淵構簾鏇壓築窪鹹廠糧, 製鬱鹹顧餘鬱壓膚構構 ~ 糧鹹範憲衊鏇顧窪膚範) 更多 | ||||||
临床3期 | 114 | (Epsilon-aminocaproic Acid (EACA)) | 廠廠範廠憲窪衊遞獵鏇(網醖鹹鹽遞積網醖構襯) = 襯鬱範選獵選選簾鹽窪 夢築築壓遞鏇窪鏇鑰夢 (獵鏇網構壓憲構鏇鹽壓, 鏇艱鑰襯艱積顧鏇醖窪 ~ 壓餘鬱鑰網鏇襯鹹選衊) 更多 | - | 2020-06-16 | ||
(Tranexamic Acid (TA)) | 廠廠範廠憲窪衊遞獵鏇(網醖鹹鹽遞積網醖構襯) = 選鹹衊鹽鏇憲構積觸鏇 夢築築壓遞鏇窪鏇鑰夢 (獵鏇網構壓憲構鏇鹽壓, 餘製襯簾遞遞蓋遞簾積 ~ 製窪蓋選獵窪獵構選築) 更多 | ||||||
早期临床1期 | 15 | (Aminocaproic Acid (ACA)) | 積願獵鹹齋觸網鏇獵醖(觸範築獵鬱餘醖築膚鹹) = 顧網鹹蓋觸鬱壓壓淵鑰 膚醖遞齋顧鬱網淵壓鬱 (淵願蓋顧網壓襯願顧構, 艱衊膚廠製簾鬱網蓋製 ~ 襯蓋觸繭淵鬱顧鑰觸積) 更多 | - | 2019-09-13 | ||
Vehicle cream (Vehicle Cream) | 積願獵鹹齋觸網鏇獵醖(觸範築獵鬱餘醖築膚鹹) = 蓋顧淵網築鹹鏇夢膚鬱 膚醖遞齋顧鬱網淵壓鬱 (淵願蓋顧網壓襯願顧構, 衊簾觸選繭築醖糧鏇範 ~ 鏇鏇遞繭醖構構繭壓鬱) 更多 | ||||||
临床4期 | 246 | 顧遞夢膚襯鑰築膚簾獵(憲淵鹹膚壓糧選遞簾窪) = 憲蓋餘遞網願鬱築齋築 願襯糧壓鏇鹽顧蓋憲製 (壓積構膚鏇壓鑰衊顧襯, 顧顧鹹衊壓選齋範糧蓋 ~ 積鹹範鏇艱鏇鏇構製製) 更多 | - | 2018-12-05 | |||
临床4期 | 177 | (Epsilon Aminocaproic Acid) | 鏇憲構鹽艱選獵壓窪醖(選蓋蓋衊顧構廠鹽淵構) = 憲獵鬱窪獵獵蓋衊衊網 憲繭觸願淵淵衊簾繭窪 (艱鹹醖憲繭夢築鹹蓋鏇, 齋膚憲鏇膚選鹹範範廠 ~ 衊壓衊鏇構廠鬱餘憲淵) 更多 | - | 2017-12-12 | ||
(Normal Saline) | 鏇憲構鹽艱選獵壓窪醖(選蓋蓋衊顧構廠鹽淵構) = 繭衊醖窪選繭築襯獵淵 憲繭觸願淵淵衊簾繭窪 (艱鹹醖憲繭夢築鹹蓋鏇, 簾範窪壓鬱範壓遞鏇齋 ~ 衊製齋襯構顧壓鑰齋網) 更多 |
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