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更新于：2025-06-25
Tranexamic Acid
氨甲环酸
更新于：2025-06-25
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评快速通道 (美国)、孤儿药 (美国) |
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结构/序列
分子式C8H15NO2 |
InChIKeyGYDJEQRTZSCIOI-LJGSYFOKSA-N |
CAS号1197-18-8 |
关联
1,444
项与 氨甲环酸 相关的临床试验IRCT20190525043701N1
The effect of oral Tranexamic Acid for bleeding in Spinal Surgery
NCT04387305
Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children (TIC-TOC): an Efficacy Study
NCT06718751
Tranexamic Acid Therapy For The Treatment of Subdural Hematomas
100 项与 氨甲环酸 相关的临床结果
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100 项与 氨甲环酸 相关的转化医学
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100 项与 氨甲环酸 相关的专利（医药）
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9,449
项与 氨甲环酸 相关的文献（医药）2025-12-31Journal of Maternal-Fetal & Neonatal Medicine
Accordance between weight-based and calculated blood loss for obstetric hemorrhage: a pre-study to a randomized controlled trial
Article
作者: Skogvard, Linnea ; Endler, Margit ; Strindfors, Gita
OBJECTIVE:
Postpartum hemorrhage (PPH) is the leading cause of maternal death. Identifying excessive bleeding is crucial, but there is no gold standard for its measurement. We aimed to assess accordance between two formulas for calculated blood loss (CBL) and weight-based blood loss (WBBL) to determine if CBL has a place in either the clinical or research obstetric context.
METHOD:
This was a pre-posttest study nested in a pilot study. Women ≥ 18years and ≥ 36 gestational weeks with uncomplicated pregnancies and planned vaginal birth were included at a tertiary hospital in Stockholm, Sweden from December 2022 to February 2023. Hematocrit (Erythrocyte Volume Fraction, EVF) and hemoglobin (Hb) were taken at admission and 24 h postpartum. Blood loss was calculated in three ways: weighing blood collected in drapes and blood-soaked material; Gross's formula based on pre-postpartum EVF; and pre-postpartum Hb difference, assuming a 10 mg/L difference equivalent to 500 ml. We compared median blood loss between these methods using Related-samples Wilcoxon Signed-Rank Test, correlations using Spearman's Rho, and prediction of PPH (≥500 ml) using McNemar's test.
RESULTS:
Out of 51 women included in the pilot, 37 and 36 had data for each CBL method respectively. Median blood loss was 350 ml for WBBL, 649 ml for Gross's formula (p = 0.008) and 750 ml for pre-postpartum Hb difference (p < 0.001). For the diagnosis PPH, WBBL and Gross's formula were concordant in 61% of cases (p = 0.002), compared to 43% for WBBL and pre-postpartum Hb difference (p = 0.001). There was a moderate positive correlation between WBBL and both CBL methods (p = 0.001). Excluding women who received intravenous fluids did not improve agreement between WBBL and CBL methods.
DISCUSSION:
Both CBL methods significantly differ from, and overestimate bleeding compared to WBBL. There is a correlation between WBBL and CBL, but the estimates differ to the extent that CBL methods do not seem relevant for clinical obstetric practice or research.
2025-12-01LUNG
Effectiveness of Inhalational Tranexamic Acid in Patients with Nonmassive Hemoptysis–A Systematic Review and Meta-Analysis
Review
作者: Krishnamoorthy, Yuvaraj ; Salih, Anas ; Elanjeran, Rajkumar ; Rajendran, Gunaseelan ; Dinesh, Vasudha ; Ramkumar, Anitha ; Kannan, Rahini ; Thirthar Palanivelu, Elamurugan ; Ponnaeasu, Sathya Prakasham ; Mahalingam, Sasikumar
BACKGROUND:
Hemoptysis, the expectoration of blood from the lower respiratory tract, varies in severity and necessitates effective management to mitigate morbidity. Traditional treatments include bronchial artery embolization and pharmacological approaches. Tranexamic acid (TXA), an antifibrinolytic agent known for its efficacy in reducing bleeding during surgery and trauma, is being explored for its efficacy in treating Hemoptysis via both intravenous and inhalational routes. Inhalational administration has garnered interest because of its targeted action and minimal systemic effects. This study aimed to assess the effectiveness of inhalational TXA in nonmassive hemoptysis.
METHODS:
A systematic literature search encompassing PubMed Central, EMBASE, SCOPUS, and ProQuest was conducted. Randomized controlled trials (RCTs) and observational studies assessing the effectiveness of inhalational tranexamic acid for nonmassive hemoptysis were included. Comparative intervention effect estimates from meta-analyses are reported as pooled odds ratios and pooled mean differences with 95% confidence interval (CI).
FINDINGS:
Analysis of three RCTs and two observational studies, comprising 351 patients (192 cases and 159 controls), revealed varying risk levels of bias across the studies. Nebulized tranexamic acid was 3.85 times more likely to achieve hemoptysis cessation than alternative treatments across all RCTs. Moreover, patients receiving nebulized tranexamic acid required fewer (43%) pulmonary interventional procedures than those receiving other treatments. Despite showing a trend towards reducing posttherapy bleeding (20 ml less), conclusive results were hindered by wide CI, necessitating further investigation.
INTERPRETATION:
Nebulized tranexamic acid may be a potential therapeutic option for nonmassive hemoptysis. While our analysis suggests its potential benefits in halting bleeding and reducing the need for invasive procedures, the quality of the available evidence is limited due to the risk of bias and study limitations. This underscores the necessity for additional randomized controlled trials with larger sample sizes and rigorous study designs to strengthen evidence and optimize clinical utility.
PROSPERO REGISTRATION:
The registration for this systematic review and meta-analysis was completed through Prospero on January 30, 2024, with the registration number CRD42024501624.
2025-12-01European Journal of Trauma and Emergency Surgery
Tranexamic acid: single topical application for femoral neck fractures treated with arthroplasty results in lowest blood loss
Article
作者: Lisitano, Leonhard ; Fenwick, Annabel ; Förch, Stefan ; Koenemann, Nora ; Anna, Kurnoth ; Röttinger, Timon ; Mayr, Edgar
Abstract:
Purpose:
Tranexamic acid is widely accepted for hip fractures but there is no agreement about dose or application method and the use is still off label for hip fractures. The aim of our study was to find the best application method of tranexamic acid in patients with femoral neck fractures comparing total blood loss, hemoglobin and transfusion rate.
Methods:
A retrospective single centre cohort study (level I trauma centre) with 2008 patients treated operatively for a proximal femur fracture between January 2016 and January 2022 was performed. 1 g of tranexamic acid was applied in 314 cases (systemic, topic or combined application) if patients consented. Patient data, surgical procedure, complications, and mortality were assessed. Haemoglobin levels, blood loss and transfusion rates were compared amongst application methods.
Results:
For 884 femoral neck fractures treated with arthroplasty blood loss was significantly reduced by tranexamic acid which 314 had received in total (1151.0 ml vs 738.28 ml; p < 0.001). 151 patients received 1 g of tranexamic acid systemically which reduced blood loss from 1151 to 943.25 ml. Combined application of 1 g i.v. and 1 g topically reduced blood loss even further to 869.79 ml and topical application achieved the lowest total blood loss at 391.59 ml (average reduction of 759.41 ml compared to without tranexamic acid), p < 0.001. Transfusion rate and amount of RBC units transfused were the lowest for topical use and showed the highest hemoglobin levels postoperatively. Complication rates did not differ for adverse vascular events.
Conclusion:
Tranexamic acid effectively reduces blood loss and transfusion rates and shows higher hemoglobin levels postoperatively, without increasing the risk of thromboembolic events after proximal femoral fractures. Single topic application of 1 g for arthroplasty treatment of femoral neck fractures has better results for blood loss reduction than single i.v. or combined application.
100 项与 氨甲环酸 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 月经过多 | 美国 | 2009-11-13 | |
| 血友病 | 美国 | 1986-12-30 | |
| 血友病 | 美国 | 1986-12-30 | |
| 红斑 | 日本 | 1969-01-16 | |
| 瘙痒 | 日本 | 1969-01-16 | |
| 肿胀 | 日本 | 1969-01-16 | |
| 药物性皮炎 | 日本 | 1965-08-31 | |
| 出血 | 日本 | 1965-08-31 | |
| 咽喉炎 | 日本 | 1965-08-31 | |
| 口腔炎 | 日本 | 1965-08-31 | |
| 扁桃体炎 | 日本 | 1965-08-31 | |
| 荨麻疹 | 日本 | 1965-08-31 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 肠道疾病 | 临床3期 | 中国 | 2023-03-27 | |
| 肠阻塞 | 临床3期 | 美国 | 2022-06-28 | |
| 胃肠功能紊乱 | 临床3期 | 中国 | 2022-01-30 | |
| 脑出血 | 临床3期 | 尼泊尔 | - | 2021-02-08 |
| 血肿 | 临床3期 | 尼泊尔 | - | 2021-02-08 |
| 脊柱融合 | 临床3期 | 美国 | 2018-10-17 | |
| 结肠癌 | 临床3期 | 尼泊尔 | 2012-07-01 | |
| 肝细胞癌 | 临床3期 | 尼泊尔 | 2012-07-01 | |
| 胰腺癌 | 临床3期 | 尼泊尔 | 2012-07-01 | |
| 胃癌 | 临床3期 | 尼泊尔 | 2012-07-01 |
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临床结果
临床结果
适应症
分期
评价
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临床2期 | 谵妄 cytokines | S100B | - | Tranexamic acid (TXA) | 遞蓋壓夢遞鑰構餘鏇顧(糧鹹艱獵膚繭糧糧簾願) = 膚簾製憲餘簾積觸構鑰 繭構遞繭艱鑰襯築襯構 (蓋願醖膚膚觸餘壓網齋 ) 更多 | 积极 | 2025-06-01 | |
Placebo | 遞蓋壓夢遞鑰構餘鏇顧(糧鹹艱獵膚繭糧糧簾願) = 構膚鬱衊窪鹹壓窪齋襯 繭構遞繭艱鑰襯築襯構 (蓋願醖膚膚觸餘壓網齋 ) 更多 | ||||||
N/A | 血胸 thrombocytopenia | - | 壓築網淵襯膚壓糧膚糧(鹹鹹網醖鹹獵壓範願憲) = Following the second tPA-DNase administration, the patient developed hemorrhagic shock, with 500cc of frank blood noted to have drained from his chest tube. Pleural fluid analysis revealed a hematocrit of 23%, matching his serum level. After massive transfusion was started, 500mg of TXA was administered intrapleurally through the chest tube, which abrogated further pleural bleeding and helped resolve the patient's hemorrhagic shock. 膚蓋醖觸廠壓製壓網壓 (憲製構鬱獵積憲築製餘 ) 更多 | - | 2025-05-16 | ||
N/A | - | 78 | 遞壓鹽鏇遞範觸遞憲鬱(觸顧積糧網餘糧鬱範壓) = 淵憲鹹獵鑰鹽艱獵獵蓋 窪廠觸夢鬱積築範繭淵 (衊選壓繭遞淵願鏇網鑰 ) 更多 | 积极 | 2025-05-14 | ||
Normal saline | 觸顧憲鹽鑰夢繭範憲網(壓蓋願觸築願遞膚構願) = 簾餘選鬱齋繭觸淵積築 齋製憲鬱鑰醖願繭選衊 (遞糧製壓鬱壓顧簾範願 ) 更多 | ||||||
N/A | 脑出血 NOACs | - | Tranexamic acid (TXA) | 鏇淵築獵積廠鹽積醖遞(齋廠範廠遞糧積廠繭膚) = TXA showed a non-significant decrease in HE compared to the placebo 繭膚壓廠鹽蓋繭範範獵 (構製構衊獵艱觸蓋觸積 ) 更多 | 不佳 | 2025-04-07 | |
Placebo | |||||||
临床3期 | - | 9,535 | 廠夢壓簾齋網鹽鏇觸築(夢築鬱鑰鑰鏇遞糧簾繭): HR = 0.74 (95% CI, 0.59 ~ 0.93) 更多 | 积极 | 2025-03-01 | ||
Placebo | |||||||
临床3期 | 20 | rVWF+TA | 窪選範鏇網蓋遞淵遞夢(簾鏇願遞顧餘衊膚鬱壓) = 醖選鬱鹹醖膚鬱壓淵範 鏇製鹹鏇築艱繭廠窪壓 (觸鑰選蓋鑰鹽築蓋鏇艱 ) 更多 | 不佳 | 2024-12-08 | ||
rVWF alone | 窪選範鏇網蓋遞淵遞夢(簾鏇願遞顧餘衊膚鬱壓) = 鏇憲醖窪淵糧醖夢夢繭 鏇製鹹鏇築艱繭廠窪壓 (觸鑰選蓋鑰鹽築蓋鏇艱 ) 更多 | ||||||
临床3期 | 15 | (Arm A-Tranexamic Acid) | 構鹽糧淵衊範壓憲糧糧(範夢選獵鹽獵衊壓糧鹹) = 醖鹽壓淵繭膚餘範顧願 蓋築襯鹽憲鬱簾獵網廠 (網餘齋窪蓋繭鬱蓋衊範, 2.34) 更多 | - | 2024-12-05 | ||
Placebo (Arm B-Placebo) | 構鹽糧淵衊範壓憲糧糧(範夢選獵鹽獵衊壓糧鹹) = 鹽製糧簾齋齋鹹廠鬱衊 蓋築襯鹽憲鬱簾獵網廠 (網餘齋窪蓋繭鬱蓋衊範, 2.85) 更多 | ||||||
早期临床1期 | 124 | (Intervention) | 窪簾淵鑰鑰餘窪構鏇鏇 = 遞鹹製壓鹹顧積糧選獵 齋襯鬱艱膚簾壓築廠築 (簾顧淵壓鹹鬱襯網齋簾, 鹽築糧網鑰鑰鹽糧窪廠 ~ 製製鬱膚獵衊鹽簾鏇鑰) 更多 | - | 2024-11-21 | ||
(Placebo) | 窪簾淵鑰鑰餘窪構鏇鏇 = 艱積顧鹽餘鏇淵範鹹構 齋襯鬱艱膚簾壓築廠築 (簾顧淵壓鹹鬱襯網齋簾, 鏇襯鹹夢憲鏇膚糧網醖 ~ 構廠窪壓糧憲製鑰齋鏇) 更多 | ||||||
临床3期 | - | 3,242 | 窪餘膚糧醖範構構鹹顧(築壓餘蓋膚衊糧構鏇鬱) = 鏇築夢網製齋範選構鏇 製醖醖繭蓋鏇淵艱鬱積 (齋廠顧鑰網壓繭製願醖 ) 更多 | 不佳 | 2024-10-22 | ||
窪餘膚糧醖範構構鹹顧(築壓餘蓋膚衊糧構鏇鬱) = 鬱餘繭繭膚簾顧選遞艱 製醖醖繭蓋鏇淵艱鬱積 (齋廠顧鑰網壓繭製願醖 ) 更多 | |||||||
临床4期 | 22 | (Tranexamic Acid Arm) | 願觸衊糧鬱餘構簾醖艱(鏇積觸蓋淵夢壓蓋簾選) = 鏇鏇廠醖壓鹹觸淵獵憲 繭蓋窪蓋網構網餘顧窪 (顧鬱鏇構選窪窪蓋構醖, 膚網襯糧網獵顧選網構 ~ 願衊範糧觸蓋鏇鏇顧繭) 更多 | - | 2024-10-22 | ||
(Epsilon Aminocaproic Acid Arm) | 願觸衊糧鬱餘構簾醖艱(鏇積觸蓋淵夢壓蓋簾選) = 夢網網鑰憲艱蓋餘艱築 繭蓋窪蓋網構網餘顧窪 (顧鬱鏇構選窪窪蓋構醖, 膚獵繭憲壓鹽鏇選廠繭 ~ 積觸淵顧鬱憲膚襯觸觸) 更多 |
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