利多卡因/肾上腺素(Lidocaine/Adrenaline) - 药物靶点：SCNA_在研适应症：麻醉_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Lidocaine/Epinephrine、アドレナリン：エピネフリン、アドレナリン：エピレナミン

+ [3]

靶点

SCNA

作用机制

SCNA阻滞剂(钠通道α亚基家族阻滞剂)

治疗领域

其他疾病

在研适应症

麻醉

非在研适应症-

原研机构

AstraZeneca PLC

在研机构

山德士有限公司

Nipro Corp.

非在研机构-

最高研发阶段批准上市

首次获批日期

日本 (1956-02-01),

麻醉

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C9H13NO3

InChIKeyUCTWMZQNUQWSLP-VIFPVBQESA-N

CAS号51-43-4

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关联

27

项与利多卡因/肾上腺素相关的临床试验

NCT06694714

/ Not yet recruiting临床4期IIT

Characterizing and Comparing the Duration of Local Anesthetic in Dermatologic Surgery - Fourth Arm

This is a research study to compare how long injectable pain medications (anesthetics) commonly used in dermatologic surgery are effective for. The investigators will investigate the role of anesthetic volume on the duration of action at highly vascular sites.

开始日期2025-01-06

申办/合作机构

Weill Medical College of Cornell University

IRCT20231030059908N5

/ Completed临床3期IIT

Evaluation of mean score of edema and ecchymosis after rhinoplasty by injection of local anesthetic with triamcinolone lidocaine adrenaline solution in comparison with lidocaine adrenaline solution.

开始日期2024-09-15

申办/合作机构-

NCT06379490

/ Recruiting临床3期IIT

Effect of Ultrasound-guided Lateral Infraclavicular Brachial Plexus Block With Lidocaine or Ropivacaine for Closed Reduction of Distal Radius Fractures - A Randomized Controlled Non-inferiority Trial

To investigate the feasibility of the lateral infraclavicular plexus brachialis (LIC) block for acute closed reduction of distal radius fractures, the investigators will compare the pain-relieving and muscle-relaxing properties of the LIC block with short- and long-acting local anesthetics in different concentrations but at the same volume. In addition to motor and sensory blockade during repositioning, feasibility will also be assessed by other patient-related and block-related factors, as well as by factors related to the repositioning and plastering procedure.

开始日期2024-04-23

申办/合作机构-

100 项与利多卡因/肾上腺素相关的临床结果

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100 项与利多卡因/肾上腺素相关的转化医学

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100 项与利多卡因/肾上腺素相关的专利（医药）

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8

项与利多卡因/肾上腺素相关的文献（医药）

2022-02-01·Hand Surgery and Rehabilitation4区 · 医学

Benefits of WALANT in palliative upper limb surgery after nerve injury

4区 · 医学

Article

作者: Dukan, R ; Masmejean, E H ; Gregory, T ; Coudane, H

Wide-Awake Local Anesthesia No Tourniquet (WALANT) may be a satisfactory anesthesia alternative for the management of upper limb peripheral nerve palsy sequelae. The main advantages are the possibility of active patient cooperation through intraoperative active mobilization, comfort and cost reduction. The legislation about WALANT in France remains unclear; the modalities of lidocaine epinephrine injection should be redefined. For palliative upper limb surgery, WALANT allows the surgeon to adjust the tension on the tendon transfer intraoperatively. Level 1 studies are needed to evaluate the effectiveness of WALANT relative to standard anesthesia techniques (regional/general anesthesia).

2021-03-31·Medecine tropicale et sante internationale

[Locoregional Anaesthesia in a Country with Limited Resources: Lidocaine 1.5% Adrenaline, Alternative to Ropivacaine 0.5% for Ultrasound-Guided Axillary Block].

Article

作者: Bah, M L ; Bangoura, A ; Donamou, J

ObjectiveThe aim of this study was to evaluate lidocaine 1.5% adrenaline as an alternative to ropivacaine 0.5% for the echo guided axillary block.MethodeWe conducted a 28-month prospective and randomized study (January 15, 2017 to May 15, 2019) conducted in the anesthesia department of the Ignace Deen National Hospital in Conakry, Guinea.ResultsA total of 38 patients were enrolled: 19 in each group. Their average age was 46 ± 17 years in the lidocaine group compared to 44 ± 20 years in the ropivacaine group. The average time to fix the block in the lidocaine group was 6.8 ± 2.1 minutes compared to 8.3 ± 2.4 minutes in the ropivacaine group (p = 0.04). The average duration of action was 233 ± 57 minutes in the lidocaine group versus 260 ± 74 minutes in the ropivacaine group (p= 0.21). The block efficiency rate was identical in both groups with 89.5% of effective blocks in the lidocaine group and in the ropivacaine group (p =1). The cost of consumables for the lidocaine group was 15 euros compared to 60 euros for the ropivacaine group.Conclusion1.5% adrenaline lidocaine is a good alternative to ropivacaine 0.5% for the production of echoguided axillary blocks in resource-limited countries.

2020-09-24·NeuroRehabilitation4区 · 医学

Effect of lidocaine iontophoresis combined with exercise intervention on gait and spasticity in children with spastic hemiplegic cerebral palsy: A randomized controlled trial

4区 · 医学

Article

作者: Salem, Yasser T. ; Hegazy, Fatma A. ; Aboelnasr, Emad A.

BACKGROUND: Gait deviations and spasticity are common impairments seen in children with cerebral palsy (CP) and may interfere with functional performance and effective walking pattern. Lidocaine iontophoresis is effective for reducing muscle spasticity in adults. PURPOSE: To investigate the effect of lidocaine epinephrine iontophoresis combined with exercises on gait and spasticity in children with spastic hemiplegic cerebral palsy (HCP). METHODS: Thirty children with spastic HCP aged 4–6 (5.20±0.32) years were randomly assigned to the experimental group (n = 15) and control group (n = 15). Children in both groups received one hour of exercises, three times a week for three months. Children in the experimental group received 2% lidocaine iontophoresis immediately before the exercises. The lidocaine iontophoresis was delivered for 20 minutes (1mA/min). Spatio-temporal gait parameters were assessed within one week before and after the intervention using 3D motion analysis. Surface electromyography was used to assess muscle tone using H/M ratio of the soleus muscle. ANOVA was used to investigate the differences between experimental and control groups. Statistical significance was set at P value less than 0.05. RESULTS: There was no difference between groups at baseline. Post-intervention, the experimental group showed significant improvements when compared to the control group for gait speed (p = 0.03), stride length (p = 0.04), cadence (p = 0.0001), cycle time (p = 0.0001), and H/M ratio (p = 0.02). CONCLUSION: Lidocaine iontophoresis combined with exercises was effective in improving gait spatiotemporal parameters and reducing spasticity in children with CP.

100 项与利多卡因/肾上腺素相关的药物交易

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研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
麻醉	日本	山德士有限公司	1956-02-01

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01981772 (CTgov)	N/A	肿胀	88	4% buffered lidocaine (Buffered Lidocaine)	製憲獵範壓顧積糧廠網(積獵築遞襯艱製壓製壓) = 築衊遞衊鹽鑰構齋製醖構餘範膚襯獵窪繭築窪 (壓壓製鬱獵網網積鏇淵, 繭鬱鹹壓獵顧範衊窪範 ~ 鏇廠願憲醖顧範襯範蓋) 更多	-	2020-10-12
				1:100,000 epinephrine+4% lidocaine (Nonbuffered Lidocaine)	製憲獵範壓顧積糧廠網(積獵築遞襯艱製壓製壓) = 遞蓋窪膚鬱廠鏇構築積構餘範膚襯獵窪繭築窪 (壓壓製鬱獵網網積鏇淵, 網鹹簾蓋製選鏇壓壓膚 ~ 艱廠積積築衊蓋鏇膚繭) 更多
NCT02285634 (CTgov)	N/A	鼻出血	68	Oxymetazoline 0.05% (Oxymetazoline 0.05%)	醖鹹願築淵糧鹹範衊願(選夢鏇膚襯艱鑰鹹選鹹) = 獵觸構夢淵窪鏇鹹窪構鹽壓構鏇願鏇網鬱壓築 (糧鑰遞願築齋鏇鹹襯遞, 鑰遞衊餘觸鹽選餘憲網 ~ 窪餘壓顧簾壓壓淵繭鬱) 更多	-	2018-10-02
				Phenylephrine 0.25% (Phenylephrine 0.25%)	醖鹹願築淵糧鹹範衊願(選夢鏇膚襯艱鑰鹹選鹹) = 窪鑰觸鏇憲獵顧齋衊繭鹽壓構鏇願鏇網鬱壓築 (糧鑰遞願築齋鏇鹹襯遞, 艱壓鏇選糧鹽醖構鹽範 ~ 艱衊鏇艱夢淵襯繭網淵) 更多
NCT02007434 (CTgov)	临床3期	局部肥胖	84	Cold Compress+Deoxycholic Acid Injection (Paradigm 1 / Deoxycholic Acid Injection)	鬱鹽築鹽齋蓋獵鏇觸範(衊顧製壓襯憲選鬱淵製) = 夢憲積鑰願壓繭餘遞獵窪鹽衊願構憲襯築鬱選 (選獵選選醖糧蓋夢醖窪, 觸襯憲選願窪觸襯夢廠 ~ 獵衊膚積蓋遞艱簾餘鏇) 更多	-	2015-07-03
				Cold Compress+Lidocaine / Epinephrine+Deoxycholic Acid Injection (Paradigm 2 / Deoxycholic Acid Injection)	鬱鹽築鹽齋蓋獵鏇觸範(衊顧製壓襯憲選鬱淵製) = 製網蓋鹽構鑰鹹窪觸簾窪鹽衊願構憲襯築鬱選 (選獵選選醖糧蓋夢醖窪, 壓壓顧醖網獵淵醖餘壓 ~ 餘憲顧鹽壓蓋醖淵糧簾) 更多